{"ok": true, "database": "scout", "query_name": null, "rows": [[1, 1, "human targets (published catalogue)", 7177, "defined-set", "Human protein targets in the PUBLISHED CATALOGUE = harvested across five evidence layers (Tier 1 PDB-anchored + Tier 1.5 AlphaFold + controls). 'Published' here means included & harvested, NOT that all are deep-curated. See the curation-stage ladder (#20-21): registry -> published -> scored. Deep LLM 5-layer curation is a smaller, growing backend subset.", "apt-scout target registry"], [2, 2, "with experimental 3D structure (PDB)", 4428, "harvested", "Targets with at least one experimental PDB structure.", "RCSB PDB (layer 1)"], [3, 3, "with cryo-EM structure", 1683, "harvested", "Targets with at least one cryo-EM structure.", "RCSB PDB / EMDB"], [4, 4, "AlphaFold-predicted only (Tier 1.5)", 3874, "predicted", "Targets with no experimental PDB; AlphaFold model only (predicted, not experimental). Completed targets only, so Tier 1 (3,300) + Tier 1.5 (3,874) + 3 controls = 7,177.", "AlphaFold DB"], [5, 5, "curated active/inactive PDB pairs", 11, "human-curated", "Targets with a hand-curated active vs inactive PDB pair.", "manual curation (layer 2)"], [6, 6, "aptamer/SELEX literature hits", 1472, "keyword-unverified", "PubMed '(gene) AND (aptamer OR SELEX)' returned a hit. Co-mention only; includes false positives; NOT a verified aptamer.", "PubMed keyword (layer 3)"], [7, 7, "detected in EV-Map plasma dataset", 3422, "detected", "apt-scout targets detected in the EV-Map plasma-EV proteome (broad detected set; NOT the conserved proteome).", "Rai & Greening 2025 Nat Cell Biol"], [8, 8, "EV-Map conserved EV-hallmark (in apt-scout)", 104, "source-derived", "Of the EV-Map 182 conserved EV-hallmark proteins, those that are apt-scout targets (gene-matched to source supp7).", "Rai & Greening 2025 supp7"], [9, 9, "verbatim-verified Kd measurements", 742, "verbatim-verified", "Distinct aptamer-target Kd measurements, each with a verbatim source quote.", "corpus literature extraction (v4)"], [10, 10, "intrinsic-equilibrium Kd (comparable)", 555, "verbatim-verified", "Kd measurements that are intrinsic equilibrium (the comparable subset for ML).", "corpus (v4)"], [11, 11, "verified aptamers (with Kd)", 560, "verbatim-verified", "Distinct aptamers with a verified, quantified Kd (contrast with the 1,472 keyword hits).", "corpus (v4)"], [12, 12, "targets in Kd layer", 300, "verbatim-verified", "Distinct targets (proteins/glycans/cells) in the binding-affinity layer.", "corpus (v4)"], [13, 13, "cell-surface / ecto targets (PREDICTED EV-surface accessible)", 1136, "predicted", "Integral membrane / ecto-domain proteins (CD markers, GPCRs, ion channels, integral membrane). EV biogenesis normally preserves topology so the ectodomain is PREDICTED to face the EV surface. NOT a measurement: HPA reports cellular (not EV) localization; lipid asymmetry can partially flip (PS via scramblase on activated/platelet EVs); cytoplasmic proteins can attach as a corona. Confirm by protease-protection / intact-EV surface labelling / immuno-EM.", "HPA subcellular + protein class (Thul 2017 / Uhl\u00e9n 2015)"], [14, 14, "EV-surface aptamer candidates (surface ecto AND EV-Map hallmark)", 24, "predicted", "Top design set: cell-surface ecto proteins that are ALSO EV-Map conserved EV-hallmark proteins (detected on circulating EVs). PREDICTED accessibility (see #13 caveats) AND-ed with EV-Map detection evidence. Ranked in v_surface_targets.", "HPA + Rai & Greening 2025"], [15, 15, "Kd records human-verified (stratified sample)", 0, "human-curated", "Kd records with a LOGGED human verdict (confirmed/corrected) from the ongoing stratified-random verification. Grows post-publication; the rest are multi-agent / extraction verified. This is the honest, version-tracked QC status.", "human verification ledger"], [16, 16, "Kd records multi-agent verified (L2)", 181, "source-derived", "Kd records that passed independent multi-agent (L2) adversarial verification but are not yet in the human sample.", "corpus L2 pipeline"], [17, 17, "Kd records with a verbatim-verified sequence", 435, "verbatim-verified", "Kd records whose aptamer sequence is verbatim-verified against the source text/SI (clean ACGTU; modifications in the chemistry columns). The rest are flagged sequence_status=pending (sequence only in a figure or paywalled SI), being curated post-submission.", "corpus sequence backfill v1 (2026-06-22)"], [18, 18, "aptamer-protein co-structures (binding-site precedent)", 114, "harvested", "Experimental aptamer-protein co-structures (PDB): demonstrated cases where an aptamer binds a protein, with the binding location known. Empirical aptamer-amenability evidence.", "RCSB PDB (corpus structure handoff)"], [19, 19, "targets with BOTH measured Kd and a co-structure", 33, "source-derived", "Targets where affinity (Kd) AND binding location (co-structure) are both known \u2014 the highest-value set for structure-guided, modification-aware design. See kd_structure_crossmatch.", "corpus Kd x PDB crossmatch"], [20, 20, "target registry (all rows, incl. queued/failed)", 7198, "defined-set", "Every target row in the registry, including those not in the published catalogue. Registry -> published (#1) -> scored (#21).", "apt-scout target registry"], [21, 21, "targets with a heuristic priority score", 6160, "heuristic", "Published targets that carry a heuristic_priority_score (the rest are unscored). The score is a model-assisted ranking AID, not a validation \u2014 its inputs are LLM-estimated (see the v_targets column note).", "apt-scout scoring (heuristic)"], [22, 22, "Kd records with a resolved DOI", 742, "source-derived", "Gold Kd records whose source publication DOI was resolved from its PMID (NCBI E-utilities). Complements the always-present PMID + verbatim quote.", "NCBI E-utilities (PMID->DOI)"], [23, 23, "Kd records with a UniProt target id", 552, "source-derived", "Gold Kd records whose protein target carries a UniProt accession (reconciled v4+260613 map, non-destructive). The remainder are small molecules / organisms / complexes with no single UniProt entry.", "apt-scout UniProt reconcile"]], "truncated": false, "columns": ["rowid", "ord", "metric", "value", "grade", "definition", "source"], "query": {"sql": "select rowid, ord, metric, value, grade, definition, source from db_stats order by ord limit 51", "params": {}}, "error": null, "private": false, "allow_execute_sql": true, "query_ms": 0.9536538273096085, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}