rowid,ord,metric,value,grade,definition,source
1,1,human targets (published catalogue),7177,defined-set,"Human protein targets in the PUBLISHED CATALOGUE = harvested across five evidence layers (Tier 1 PDB-anchored + Tier 1.5 AlphaFold + controls). 'Published' here means included & harvested, NOT that all are deep-curated. See the curation-stage ladder (#20-21): registry -> published -> scored. Deep LLM 5-layer curation is a smaller, growing backend subset.",apt-scout target registry
2,2,with experimental 3D structure (PDB),4428,harvested,Targets with at least one experimental PDB structure.,RCSB PDB (layer 1)
3,3,with cryo-EM structure,1683,harvested,Targets with at least one cryo-EM structure.,RCSB PDB / EMDB
4,4,AlphaFold-predicted only (Tier 1.5),3874,predicted,"Targets with no experimental PDB; AlphaFold model only (predicted, not experimental). Completed targets only, so Tier 1 (3,300) + Tier 1.5 (3,874) + 3 controls = 7,177.",AlphaFold DB
5,5,curated active/inactive PDB pairs,11,human-curated,Targets with a hand-curated active vs inactive PDB pair.,manual curation (layer 2)
6,6,aptamer/SELEX literature hits,1472,keyword-unverified,PubMed '(gene) AND (aptamer OR SELEX)' returned a hit. Co-mention only; includes false positives; NOT a verified aptamer.,PubMed keyword (layer 3)
7,7,detected in EV-Map plasma dataset,3422,detected,apt-scout targets detected in the EV-Map plasma-EV proteome (broad detected set; NOT the conserved proteome).,Rai & Greening 2025 Nat Cell Biol
8,8,EV-Map conserved EV-hallmark (in apt-scout),104,source-derived,"Of the EV-Map 182 conserved EV-hallmark proteins, those that are apt-scout targets (gene-matched to source supp7).",Rai & Greening 2025 supp7
9,9,verbatim-verified Kd measurements,742,verbatim-verified,"Distinct aptamer-target Kd measurements, each with a verbatim source quote.",corpus literature extraction (v4)
10,10,intrinsic-equilibrium Kd (comparable),555,verbatim-verified,Kd measurements that are intrinsic equilibrium (the comparable subset for ML).,corpus (v4)
11,11,verified aptamers (with Kd),560,verbatim-verified,"Distinct aptamers with a verified, quantified Kd (contrast with the 1,472 keyword hits).",corpus (v4)
12,12,targets in Kd layer,300,verbatim-verified,Distinct targets (proteins/glycans/cells) in the binding-affinity layer.,corpus (v4)
13,13,cell-surface / ecto targets (PREDICTED EV-surface accessible),1136,predicted,"Integral membrane / ecto-domain proteins (CD markers, GPCRs, ion channels, integral membrane). EV biogenesis normally preserves topology so the ectodomain is PREDICTED to face the EV surface. NOT a measurement: HPA reports cellular (not EV) localization; lipid asymmetry can partially flip (PS via scramblase on activated/platelet EVs); cytoplasmic proteins can attach as a corona. Confirm by protease-protection / intact-EV surface labelling / immuno-EM.",HPA subcellular + protein class (Thul 2017 / Uhlén 2015)
14,14,EV-surface aptamer candidates (surface ecto AND EV-Map hallmark),24,predicted,Top design set: cell-surface ecto proteins that are ALSO EV-Map conserved EV-hallmark proteins (detected on circulating EVs). PREDICTED accessibility (see #13 caveats) AND-ed with EV-Map detection evidence. Ranked in v_surface_targets.,HPA + Rai & Greening 2025
15,15,Kd records human-verified (stratified sample),0,human-curated,"Kd records with a LOGGED human verdict (confirmed/corrected) from the ongoing stratified-random verification. Grows post-publication; the rest are multi-agent / extraction verified. This is the honest, version-tracked QC status.",human verification ledger
16,16,Kd records multi-agent verified (L2),181,source-derived,Kd records that passed independent multi-agent (L2) adversarial verification but are not yet in the human sample.,corpus L2 pipeline
17,17,Kd records with a verbatim-verified sequence,435,verbatim-verified,"Kd records whose aptamer sequence is verbatim-verified against the source text/SI (clean ACGTU; modifications in the chemistry columns). The rest are flagged sequence_status=pending (sequence only in a figure or paywalled SI), being curated post-submission.",corpus sequence backfill v1 (2026-06-22)
18,18,aptamer-protein co-structures (binding-site precedent),114,harvested,"Experimental aptamer-protein co-structures (PDB): demonstrated cases where an aptamer binds a protein, with the binding location known. Empirical aptamer-amenability evidence.",RCSB PDB (corpus structure handoff)
19,19,targets with BOTH measured Kd and a co-structure,33,source-derived,"Targets where affinity (Kd) AND binding location (co-structure) are both known — the highest-value set for structure-guided, modification-aware design. See kd_structure_crossmatch.",corpus Kd x PDB crossmatch
20,20,"target registry (all rows, incl. queued/failed)",7198,defined-set,"Every target row in the registry, including those not in the published catalogue. Registry -> published (#1) -> scored (#21).",apt-scout target registry
21,21,targets with a heuristic priority score,6160,heuristic,"Published targets that carry a heuristic_priority_score (the rest are unscored). The score is a model-assisted ranking AID, not a validation — its inputs are LLM-estimated (see the v_targets column note).",apt-scout scoring (heuristic)
22,22,Kd records with a resolved DOI,742,source-derived,Gold Kd records whose source publication DOI was resolved from its PMID (NCBI E-utilities). Complements the always-present PMID + verbatim quote.,NCBI E-utilities (PMID->DOI)
23,23,Kd records with a UniProt target id,552,source-derived,"Gold Kd records whose protein target carries a UniProt accession (reconciled v4+260613 map, non-destructive). The remainder are small molecules / organisms / complexes with no single UniProt entry.",apt-scout UniProt reconcile