id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,has_activation_state_pdb_pair,has_known_aptamer,opentargets_top_disease_name
P25445,FAS,Tumor necrosis factor receptor superfamily member 6,Tier 1.5,0.914,7,0,1,autoimmune lymphoproliferative syndrome type 1
P12263,,,Tier 1,0.9,7,0,0,
Q12879,GRIN2A,"Glutamate receptor ionotropic, NMDA 2A",Tier 1,0.88,37,0,0,Landau-Kleffner syndrome
Q9Y2C5,SLC17A4,Probable small intestine urate exporter,Tier 1.5,0.878,0,0,0,inflammatory bowel disease
P23946,CMA1,Chymase,Tier 1,0.875,42,0,1,pernicious anemia
Q9UJA9,ENPP5,Ectonucleotide pyrophosphatase/phosphodiesterase family member 5,Tier 1,0.87,1,0,0,neurodegenerative disease
O75581,LRP6,Low-density lipoprotein receptor-related protein 6,Tier 1,0.865,27,0,1,"tooth agenesis, selective, 7"
P13747,HLA-E,"HLA class I histocompatibility antigen, alpha chain E",Tier 1,0.865,34,0,1,COVID-19
Q9NX14,NDUFB11,"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial",Tier 1.5,0.86,0,0,0,Microphthalmia with linear skin defects syndrome
P21583,KITLG,Kit ligand,Tier 1.5,0.848,6,0,1,"hyperpigmentation with or without hypopigmentation, familial progressive"
P35346,SSTR5,Somatostatin receptor type 5,Tier 1.5,0.841,7,0,0,acromegaly
Q02094,RHAG,Ammonium transporter Rh type A,Tier 1.5,0.841,8,0,0,Rh deficiency syndrome
P01911,HLA-DRB1,"HLA class II histocompatibility antigen, DRB1 beta chain",Tier 1,0.84,100,0,0,rheumatoid arthritis
Q5T848,GPR158,Metabotropic glycine receptor,Tier 1,0.839,6,0,0,diverticular disease
Q14392,LRRC32,Transforming growth factor beta activator LRRC32,Tier 1.5,0.838,6,0,0,"cleft palate, proliferative retinopathy, and developmental delay"
P21439,ABCB4,Phosphatidylcholine translocator ABCB4,Tier 1.5,0.835,4,0,0,progressive familial intrahepatic cholestasis type 3
P12532,CKMT1A,"Creatine kinase U-type, mitochondrial",Tier 1.5,0.83,9,0,0,neurodegenerative disease
Q31135,H2-Ab1,,Tier 1,0.83,12,0,0,
P0DSE2,TRB,M1-specific T cell receptor beta chain,Tier 1,0.83,5,0,0,
O75899,GABBR2,Gamma-aminobutyric acid type B receptor subunit 2,Tier 1.5,0.824,26,0,0,"developmental and epileptic encephalopathy, 59"
A0A0E3EAY4,env,Envelope glycoprotein gp160,Tier 1,0.82,2,0,1,
P54709,ATP1B3,Sodium/potassium-transporting ATPase subunit beta-3,Tier 1.5,0.81,7,0,0,congestive heart failure
Q00975,CACNA1B,Voltage-dependent N-type calcium channel subunit alpha-1B,Tier 1.5,0.807,7,0,1,Seizure
Q15848,ADIPOQ,Adiponectin,Tier 1,0.806,3,0,1,hearing loss
P0DPK4,NOTCH2NLC,Notch homolog 2 N-terminal-like protein C,Tier 1.5,0.805,0,0,0,neuronal intranuclear inclusion disease
P43005,SLC1A1,Excitatory amino acid transporter 3,Tier 1,0.805,22,0,0,dicarboxylic aminoaciduria
P15260,IFNGR1,Interferon gamma receptor 1,Tier 1.5,0.804,5,0,1,disseminated atypical mycobacterial infection
P51679,CCR4,C-C chemokine receptor type 4,Tier 1,0.804,7,0,1,mycosis fungoides
Q9NS82,SLC7A10,Asc-type amino acid transporter 1,Tier 1,0.803,4,0,0,asthma
Q04844,CHRNE,Acetylcholine receptor subunit epsilon,Tier 1.5,0.802,13,0,0,Congenital myasthenic syndromes
O60895,RAMP2,Receptor activity-modifying protein 2,Tier 1,0.802,10,0,0,diabetes mellitus
P29275,ADORA2B,Adenosine receptor A2b,Tier 1.5,0.801,4,0,0,migraine disorder
Q9H2X9,SLC12A5,Solute carrier family 12 member 5,Tier 1.5,0.8,2,0,0,genetic developmental and epileptic encephalopathy
P35414,APLNR,Apelin receptor,Tier 1,0.8,37,0,1,essential hypertension
P00488,F13A1,Coagulation factor XIII A chain,Tier 1,0.799,15,0,0,Factor XIII subunit A deficiency
P02748,C9,Complement component C9,Tier 1.5,0.796,9,0,1,Immunodeficiency due to a late component of complements deficiency
Q9UBT7,CTNNAL1,Alpha-catulin,Tier 1.5,0.795,0,0,0,Abnormality of the skeletal system
P13671,C6,Complement component C6,Tier 1,0.795,11,0,1,Immunodeficiency due to a late component of complements deficiency
P01236,PRL,Prolactin,Tier 1,0.795,12,0,1,AL amyloidosis
P06731,CEACAM5,Cell adhesion molecule CEACAM5,Tier 1,0.795,6,0,0,neurodegenerative disease
P01909,HLA-DQA1,"HLA class II histocompatibility antigen, DQ alpha 1 chain",Tier 1,0.792,27,0,0,Pleural Mesothelioma
Q13705,ACVR2B,Activin receptor type-2B,Tier 1.5,0.791,9,0,0,Heterotaxia
Q13085,ACACA,Acetyl-CoA carboxylase 1,Tier 1.5,0.79,10,0,1,
Q96CS2,HAUS1,HAUS augmin-like complex subunit 1,Tier 1.5,0.79,1,0,0,device complication
Q14031,COL4A6,Collagen alpha-6(IV) chain,Tier 1.5,0.79,0,0,0,Dupuytren Contracture
O14788,TNFSF11,Tumor necrosis factor ligand superfamily member 11,Tier 1,0.79,2,0,1,osteoporosis
P36888,FLT3,Receptor-type tyrosine-protein kinase FLT3,Tier 1.5,0.788,11,0,1,acute myeloid leukemia
Q92633,LPAR1,Lysophosphatidic acid receptor 1,Tier 1.5,0.785,16,0,1,Epiretinal membrane
P04156,PRNP,Major prion protein,Tier 1,0.785,70,0,1,Gerstmann-Straussler-Scheinker syndrome
P03971,AMH,Anti-Muellerian hormone,Tier 1.5,0.783,3,0,1,persistent Mullerian duct syndrome
Q5JUK3,KCNT1,Potassium channel subfamily T member 1,Tier 1.5,0.782,6,0,0,"developmental and epileptic encephalopathy, 14"
Q13639,,,Tier 1,0.781,3,0,0,schizophrenia
P35555,FBN1,Fibrillin-1,Tier 1,0.78,11,0,0,Marfan syndrome
P14210,HGF,Hepatocyte growth factor,Tier 1,0.78,36,0,1,"hearing loss, autosomal recessive"
P37023,ACVRL1,Activin receptor type-1-like,Tier 1.5,0.779,7,0,0,"telangiectasia, hereditary hemorrhagic, type 2"
P01019,AGT,Angiotensinogen,Tier 1,0.779,22,0,1,renal tubular dysgenesis
P01568,IFNA21,Interferon alpha-21,Tier 1.5,0.777,0,0,0,renal cell carcinoma
P30542,ADORA1,Adenosine receptor A1,Tier 1.5,0.777,5,0,0,asthma
P13866,SLC5A1,Sodium/glucose cotransporter 1,Tier 1.5,0.777,4,0,0,glucose-galactose malabsorption
P04839,CYBB,NADPH oxidase 2,Tier 1,0.776,6,0,1,chronic granulomatous disease
P48023,FASLG,Tumor necrosis factor ligand superfamily member 6,Tier 1.5,0.775,3,0,1,autoimmune lymphoproliferative syndrome type 1
O15393,,,Tier 1,0.775,31,0,0,COVID-19
P07911,UMOD,Uromodulin,Tier 1,0.774,10,0,1,familial juvenile hyperuricemic nephropathy type 1
A6ND01,IZUMO1R,Sperm-egg fusion protein Juno,Tier 1,0.773,7,0,0,placental retention
Q9BVX2,TMEM106C,Transmembrane protein 106C,Tier 1.5,0.77,0,0,0,prostate carcinoma
P29017,CD1C,T-cell surface glycoprotein CD1c,Tier 1.5,0.77,10,0,0,neoplasm
P02776,PF4,Platelet factor 4,Tier 1.5,0.77,10,0,1,systemic scleroderma
P02671,FGA,Fibrinogen alpha chain,Tier 1,0.77,40,0,0,familial dysfibrinogenemia
A0A5H2UYS3,HLA-A,,Tier 1,0.77,20,0,0,
P03951,F11,Coagulation factor XI,Tier 1,0.77,100,0,0,factor XI deficiency
P61769,B2M,Beta-2-microglobulin,Tier 1,0.77,100,0,1,Immunodeficiency by defective expression of HLA class 1
P39060,COL18A1,Collagen alpha-1(XVIII) chain,Tier 1.5,0.769,9,0,1,Knobloch syndrome 1
P27037,ACVR2A,Activin receptor type-2A,Tier 1.5,0.769,5,0,0,hepatocellular carcinoma
P29460,IL12B,Interleukin-12 subunit beta,Tier 1,0.769,20,0,0,psoriasis
P43004,SLC1A2,Excitatory amino acid transporter 2,Tier 1.5,0.768,7,0,0,"developmental and epileptic encephalopathy, 41"
O14958,CASQ2,Calsequestrin-2,Tier 1.5,0.767,4,0,0,catecholaminergic polymorphic ventricular tachycardia
P26951,IL3RA,Interleukin-3 receptor subunit alpha,Tier 1,0.767,4,0,1,acute myeloid leukemia
Q9H3K6,BOLA2,BolA-like protein 2,Tier 1.5,0.765,0,0,0,hepatocellular carcinoma
O60931,CTNS,Cystinosin,Tier 1.5,0.764,6,0,0,nephropathic cystinosis
A0A1B0GTW7,CIROP,Ciliated left-right organizer metallopeptidase,Tier 1.5,0.764,0,0,0,"heterotaxy, visceral, 12, autosomal"
O60568,PLOD3,Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3,Tier 1.5,0.762,18,0,0,"bone fragility with contractures, arterial rupture, and deafness"
P02747,C1QC,Complement C1q subcomponent subunit C,Tier 1,0.762,11,0,0,C1Q deficiency
Q9Y5Y9,SCN10A,Sodium channel protein type 10 subunit alpha,Tier 1.5,0.761,8,0,0,atrial fibrillation
P98073,,,Tier 1,0.761,14,0,0,congenital enteropathy due to enteropeptidase deficiency
Q9BZR8,BCL2L14,Apoptosis facilitator Bcl-2-like protein 14,Tier 1.5,0.76,0,0,0,hypothyroidism
Q9BWF2,TRAIP,E3 ubiquitin-protein ligase TRAIP,Tier 1.5,0.76,1,0,0,Seckel syndrome 9
O15370,SOX12,Transcription factor SOX-12,Tier 1.5,0.76,0,0,0,type 2 diabetes mellitus
Q02817,MUC2,Mucin-2,Tier 1,0.76,12,0,0,
P01189,POMC,Pro-opiomelanocortin,Tier 1,0.76,13,0,1,obesity due to pro-opiomelanocortin deficiency
P40225,THPO,Thrombopoietin,Tier 1,0.76,3,0,1,thrombocythemia 1
O75762,TRPA1,Transient receptor potential cation channel subfamily A member 1,Tier 1,0.76,17,0,0,familial episodic pain syndrome with predominantly upper body involvement
O15552,FFAR2,Free fatty acid receptor 2,Tier 1.5,0.759,11,0,0,type 1 diabetes mellitus
A6NI61,MYMK,Protein myomaker,Tier 1.5,0.758,0,0,0,Carey-Fineman-Ziter  syndrome
P35462,DRD3,D(3) dopamine receptor,Tier 1.5,0.757,6,0,0,schizophrenia
P41440,SLC19A1,Reduced folate transporter,Tier 1.5,0.755,19,0,0,Knobloch syndrome
P07360,,,Tier 1,0.755,15,0,0,complement deficiency
O00591,GABRP,Gamma-aminobutyric acid receptor subunit pi,Tier 1.5,0.752,2,0,0,migraine disorder
P05546,SERPIND1,Heparin cofactor 2,Tier 1,0.752,9,0,1,heparin cofactor 2 deficiency
P55899,FCGRT,IgG receptor FcRn large subunit p51,Tier 1,0.752,31,0,0,Myasthenia gravis
P0DMS8,ADORA3,Adenosine receptor A3,Tier 1.5,0.751,5,0,0,migraine disorder