{"ok": true, "database": "scout", "query_name": "top_priority", "rows": [["P25445", "FAS", "Tumor necrosis factor receptor superfamily member 6", "Tier 1.5", 0.914, 7, 0, 1, "autoimmune lymphoproliferative syndrome type 1"], ["P12263", null, null, "Tier 1", 0.9, 7, 0, 0, null], ["Q12879", "GRIN2A", "Glutamate receptor ionotropic, NMDA 2A", "Tier 1", 0.88, 37, 0, 0, "Landau-Kleffner syndrome"], ["Q9Y2C5", "SLC17A4", "Probable small intestine urate exporter", "Tier 1.5", 0.878, 0, 0, 0, "inflammatory bowel disease"], ["P23946", "CMA1", "Chymase", "Tier 1", 0.875, 42, 0, 1, "pernicious anemia"], ["Q9UJA9", "ENPP5", "Ectonucleotide pyrophosphatase/phosphodiesterase family member 5", "Tier 1", 0.87, 1, 0, 0, "neurodegenerative disease"], ["O75581", "LRP6", "Low-density lipoprotein receptor-related protein 6", "Tier 1", 0.865, 27, 0, 1, "tooth agenesis, selective, 7"], ["P13747", "HLA-E", "HLA class I histocompatibility antigen, alpha chain E", "Tier 1", 0.865, 34, 0, 1, "COVID-19"], ["Q9NX14", "NDUFB11", "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial", "Tier 1.5", 0.86, 0, 0, 0, "Microphthalmia with linear skin defects syndrome"], ["P21583", "KITLG", "Kit ligand", "Tier 1.5", 0.848, 6, 0, 1, "hyperpigmentation with or without hypopigmentation, familial progressive"], ["P35346", "SSTR5", "Somatostatin receptor type 5", "Tier 1.5", 0.841, 7, 0, 0, "acromegaly"], ["Q02094", "RHAG", "Ammonium transporter Rh type A", "Tier 1.5", 0.841, 8, 0, 0, "Rh deficiency syndrome"], ["P01911", "HLA-DRB1", "HLA class II histocompatibility antigen, DRB1 beta chain", "Tier 1", 0.84, 100, 0, 0, "rheumatoid arthritis"], ["Q5T848", "GPR158", "Metabotropic glycine receptor", "Tier 1", 0.839, 6, 0, 0, "diverticular disease"], ["Q14392", "LRRC32", "Transforming growth factor beta activator LRRC32", "Tier 1.5", 0.838, 6, 0, 0, "cleft palate, proliferative retinopathy, and developmental delay"], ["P21439", "ABCB4", "Phosphatidylcholine translocator ABCB4", "Tier 1.5", 0.835, 4, 0, 0, "progressive familial intrahepatic cholestasis type 3"], ["P12532", "CKMT1A", "Creatine kinase U-type, mitochondrial", "Tier 1.5", 0.83, 9, 0, 0, "neurodegenerative disease"], ["Q31135", "H2-Ab1", null, "Tier 1", 0.83, 12, 0, 0, null], ["P0DSE2", "TRB", "M1-specific T cell receptor beta chain", "Tier 1", 0.83, 5, 0, 0, null], ["O75899", "GABBR2", "Gamma-aminobutyric acid type B receptor subunit 2", "Tier 1.5", 0.824, 26, 0, 0, "developmental and epileptic encephalopathy, 59"], ["A0A0E3EAY4", "env", "Envelope glycoprotein gp160", "Tier 1", 0.82, 2, 0, 1, null], ["P54709", "ATP1B3", "Sodium/potassium-transporting ATPase subunit beta-3", "Tier 1.5", 0.81, 7, 0, 0, "congestive heart failure"], ["Q00975", "CACNA1B", "Voltage-dependent N-type calcium channel subunit alpha-1B", "Tier 1.5", 0.807, 7, 0, 1, "Seizure"], ["Q15848", "ADIPOQ", "Adiponectin", "Tier 1", 0.806, 3, 0, 1, "hearing loss"], ["P0DPK4", "NOTCH2NLC", "Notch homolog 2 N-terminal-like protein C", "Tier 1.5", 0.805, 0, 0, 0, "neuronal intranuclear inclusion disease"], ["P43005", "SLC1A1", "Excitatory amino acid transporter 3", "Tier 1", 0.805, 22, 0, 0, "dicarboxylic aminoaciduria"], ["P15260", "IFNGR1", "Interferon gamma receptor 1", "Tier 1.5", 0.804, 5, 0, 1, "disseminated atypical mycobacterial infection"], ["P51679", "CCR4", "C-C chemokine receptor type 4", "Tier 1", 0.804, 7, 0, 1, "mycosis fungoides"], ["Q9NS82", "SLC7A10", "Asc-type amino acid transporter 1", "Tier 1", 0.803, 4, 0, 0, "asthma"], ["Q04844", "CHRNE", "Acetylcholine receptor subunit epsilon", "Tier 1.5", 0.802, 13, 0, 0, "Congenital myasthenic syndromes"], ["O60895", "RAMP2", "Receptor activity-modifying protein 2", "Tier 1", 0.802, 10, 0, 0, "diabetes mellitus"], ["P29275", "ADORA2B", "Adenosine receptor A2b", "Tier 1.5", 0.801, 4, 0, 0, "migraine disorder"], ["Q9H2X9", "SLC12A5", "Solute carrier family 12 member 5", "Tier 1.5", 0.8, 2, 0, 0, "genetic developmental and epileptic encephalopathy"], ["P35414", "APLNR", "Apelin receptor", "Tier 1", 0.8, 37, 0, 1, "essential hypertension"], ["P00488", "F13A1", "Coagulation factor XIII A chain", "Tier 1", 0.799, 15, 0, 0, "Factor XIII subunit A deficiency"], ["P02748", "C9", "Complement component C9", "Tier 1.5", 0.796, 9, 0, 1, "Immunodeficiency due to a late component of complements deficiency"], ["Q9UBT7", "CTNNAL1", "Alpha-catulin", "Tier 1.5", 0.795, 0, 0, 0, "Abnormality of the skeletal system"], ["P13671", "C6", "Complement component C6", "Tier 1", 0.795, 11, 0, 1, "Immunodeficiency due to a late component of complements deficiency"], ["P01236", "PRL", "Prolactin", "Tier 1", 0.795, 12, 0, 1, "AL amyloidosis"], ["P06731", "CEACAM5", "Cell adhesion molecule CEACAM5", "Tier 1", 0.795, 6, 0, 0, "neurodegenerative disease"], ["P01909", "HLA-DQA1", "HLA class II histocompatibility antigen, DQ alpha 1 chain", "Tier 1", 0.792, 27, 0, 0, "Pleural Mesothelioma"], ["Q13705", "ACVR2B", "Activin receptor type-2B", "Tier 1.5", 0.791, 9, 0, 0, "Heterotaxia"], ["Q13085", "ACACA", "Acetyl-CoA carboxylase 1", "Tier 1.5", 0.79, 10, 0, 1, null], ["Q96CS2", "HAUS1", "HAUS augmin-like complex subunit 1", "Tier 1.5", 0.79, 1, 0, 0, "device complication"], ["Q14031", "COL4A6", "Collagen alpha-6(IV) chain", "Tier 1.5", 0.79, 0, 0, 0, "Dupuytren Contracture"], ["O14788", "TNFSF11", "Tumor necrosis factor ligand superfamily member 11", "Tier 1", 0.79, 2, 0, 1, "osteoporosis"], ["P36888", "FLT3", "Receptor-type tyrosine-protein kinase FLT3", "Tier 1.5", 0.788, 11, 0, 1, "acute myeloid leukemia"], ["Q92633", "LPAR1", "Lysophosphatidic acid receptor 1", "Tier 1.5", 0.785, 16, 0, 1, "Epiretinal membrane"], ["P04156", "PRNP", "Major prion protein", "Tier 1", 0.785, 70, 0, 1, "Gerstmann-Straussler-Scheinker syndrome"], ["P03971", "AMH", "Anti-Muellerian hormone", "Tier 1.5", 0.783, 3, 0, 1, "persistent Mullerian duct syndrome"], ["Q5JUK3", "KCNT1", "Potassium channel subfamily T member 1", "Tier 1.5", 0.782, 6, 0, 0, "developmental and epileptic encephalopathy, 14"], ["Q13639", null, null, "Tier 1", 0.781, 3, 0, 0, "schizophrenia"], ["P35555", "FBN1", "Fibrillin-1", "Tier 1", 0.78, 11, 0, 0, "Marfan syndrome"], ["P14210", "HGF", "Hepatocyte growth factor", "Tier 1", 0.78, 36, 0, 1, "hearing loss, autosomal recessive"], ["P37023", "ACVRL1", "Activin receptor type-1-like", "Tier 1.5", 0.779, 7, 0, 0, "telangiectasia, hereditary hemorrhagic, type 2"], ["P01019", "AGT", "Angiotensinogen", "Tier 1", 0.779, 22, 0, 1, "renal tubular dysgenesis"], ["P01568", "IFNA21", "Interferon alpha-21", "Tier 1.5", 0.777, 0, 0, 0, "renal cell carcinoma"], ["P30542", "ADORA1", "Adenosine receptor A1", "Tier 1.5", 0.777, 5, 0, 0, "asthma"], ["P13866", "SLC5A1", "Sodium/glucose cotransporter 1", "Tier 1.5", 0.777, 4, 0, 0, "glucose-galactose malabsorption"], ["P04839", "CYBB", "NADPH oxidase 2", "Tier 1", 0.776, 6, 0, 1, "chronic granulomatous disease"], ["P48023", "FASLG", "Tumor necrosis factor ligand superfamily member 6", "Tier 1.5", 0.775, 3, 0, 1, "autoimmune lymphoproliferative syndrome type 1"], ["O15393", null, null, "Tier 1", 0.775, 31, 0, 0, "COVID-19"], ["P07911", "UMOD", "Uromodulin", "Tier 1", 0.774, 10, 0, 1, "familial juvenile hyperuricemic nephropathy type 1"], ["A6ND01", "IZUMO1R", "Sperm-egg fusion protein Juno", "Tier 1", 0.773, 7, 0, 0, "placental retention"], ["Q9BVX2", "TMEM106C", "Transmembrane protein 106C", "Tier 1.5", 0.77, 0, 0, 0, "prostate carcinoma"], ["P29017", "CD1C", "T-cell surface glycoprotein CD1c", "Tier 1.5", 0.77, 10, 0, 0, "neoplasm"], ["P02776", "PF4", "Platelet factor 4", "Tier 1.5", 0.77, 10, 0, 1, "systemic scleroderma"], ["P02671", "FGA", "Fibrinogen alpha chain", "Tier 1", 0.77, 40, 0, 0, "familial dysfibrinogenemia"], ["A0A5H2UYS3", "HLA-A", null, "Tier 1", 0.77, 20, 0, 0, null], ["P03951", "F11", "Coagulation factor XI", "Tier 1", 0.77, 100, 0, 0, "factor XI deficiency"], ["P61769", "B2M", "Beta-2-microglobulin", "Tier 1", 0.77, 100, 0, 1, "Immunodeficiency by defective expression of HLA class 1"], ["P39060", "COL18A1", "Collagen alpha-1(XVIII) chain", "Tier 1.5", 0.769, 9, 0, 1, "Knobloch syndrome 1"], ["P27037", "ACVR2A", "Activin receptor type-2A", "Tier 1.5", 0.769, 5, 0, 0, "hepatocellular carcinoma"], ["P29460", "IL12B", "Interleukin-12 subunit beta", "Tier 1", 0.769, 20, 0, 0, "psoriasis"], ["P43004", "SLC1A2", "Excitatory amino acid transporter 2", "Tier 1.5", 0.768, 7, 0, 0, "developmental and epileptic encephalopathy, 41"], ["O14958", "CASQ2", "Calsequestrin-2", "Tier 1.5", 0.767, 4, 0, 0, "catecholaminergic polymorphic ventricular tachycardia"], ["P26951", "IL3RA", "Interleukin-3 receptor subunit alpha", "Tier 1", 0.767, 4, 0, 1, "acute myeloid leukemia"], ["Q9H3K6", "BOLA2", "BolA-like protein 2", "Tier 1.5", 0.765, 0, 0, 0, "hepatocellular carcinoma"], ["O60931", "CTNS", "Cystinosin", "Tier 1.5", 0.764, 6, 0, 0, "nephropathic cystinosis"], ["A0A1B0GTW7", "CIROP", "Ciliated left-right organizer metallopeptidase", "Tier 1.5", 0.764, 0, 0, 0, "heterotaxy, visceral, 12, autosomal"], ["O60568", "PLOD3", "Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3", "Tier 1.5", 0.762, 18, 0, 0, "bone fragility with contractures, arterial rupture, and deafness"], ["P02747", "C1QC", "Complement C1q subcomponent subunit C", "Tier 1", 0.762, 11, 0, 0, "C1Q deficiency"], ["Q9Y5Y9", "SCN10A", "Sodium channel protein type 10 subunit alpha", "Tier 1.5", 0.761, 8, 0, 0, "atrial fibrillation"], ["P98073", null, null, "Tier 1", 0.761, 14, 0, 0, "congenital enteropathy due to enteropeptidase deficiency"], ["Q9BZR8", "BCL2L14", "Apoptosis facilitator Bcl-2-like protein 14", "Tier 1.5", 0.76, 0, 0, 0, "hypothyroidism"], ["Q9BWF2", "TRAIP", "E3 ubiquitin-protein ligase TRAIP", "Tier 1.5", 0.76, 1, 0, 0, "Seckel syndrome 9"], ["O15370", "SOX12", "Transcription factor SOX-12", "Tier 1.5", 0.76, 0, 0, 0, "type 2 diabetes mellitus"], ["Q02817", "MUC2", "Mucin-2", "Tier 1", 0.76, 12, 0, 0, null], ["P01189", "POMC", "Pro-opiomelanocortin", "Tier 1", 0.76, 13, 0, 1, "obesity due to pro-opiomelanocortin deficiency"], ["P40225", "THPO", "Thrombopoietin", "Tier 1", 0.76, 3, 0, 1, "thrombocythemia 1"], ["O75762", "TRPA1", "Transient receptor potential cation channel subfamily A member 1", "Tier 1", 0.76, 17, 0, 0, "familial episodic pain syndrome with predominantly upper body involvement"], ["O15552", "FFAR2", "Free fatty acid receptor 2", "Tier 1.5", 0.759, 11, 0, 0, "type 1 diabetes mellitus"], ["A6NI61", "MYMK", "Protein myomaker", "Tier 1.5", 0.758, 0, 0, 0, "Carey-Fineman-Ziter  syndrome"], ["P35462", "DRD3", "D(3) dopamine receptor", "Tier 1.5", 0.757, 6, 0, 0, "schizophrenia"], ["P41440", "SLC19A1", "Reduced folate transporter", "Tier 1.5", 0.755, 19, 0, 0, "Knobloch syndrome"], ["P07360", null, null, "Tier 1", 0.755, 15, 0, 0, "complement deficiency"], ["O00591", "GABRP", "Gamma-aminobutyric acid receptor subunit pi", "Tier 1.5", 0.752, 2, 0, 0, "migraine disorder"], ["P05546", "SERPIND1", "Heparin cofactor 2", "Tier 1", 0.752, 9, 0, 1, "heparin cofactor 2 deficiency"], ["P55899", "FCGRT", "IgG receptor FcRn large subunit p51", "Tier 1", 0.752, 31, 0, 0, "Myasthenia gravis"], ["P0DMS8", "ADORA3", "Adenosine receptor A3", "Tier 1.5", 0.751, 5, 0, 0, "migraine disorder"]], "truncated": false, "columns": ["id", "gene_symbol", "protein_name", "tier", "priority_score", "pdb_count_total", "has_activation_state_pdb_pair", "has_known_aptamer", "opentargets_top_disease_name"], "query": {"sql": "SELECT id, gene_symbol, protein_name, tier, priority_score, pdb_count_total, has_activation_state_pdb_pair, has_known_aptamer, opentargets_top_disease_name FROM v_targets ORDER BY priority_score DESC LIMIT 100", "params": {}}, "error": null, "private": false, "allow_execute_sql": true, "query_ms": 2.127300002030097, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}