id,target_name_canonical,target_type,target_uniprot,aptamer_name,aptamer_seq,kd_reported,kd_log10_molar,measurement_class,binding_constant_type,tier,source_origin,verification_level,sequence_status,seq_source,pi_provenance_flag,assay_method,assay_temperature_k,assay_ph,assay_buffer,assay_cations,aptamer_chemistry,aptamer_modifications,source_pmid,doi,verbatim_quote,source_db
343,PlanarAu,protein,,1N,TATGCATGTGTAGTAAGACCTAGTCCACAATCAACG,5.600000000000001e-10 M,-9.252,intrinsic,Kd,Gold,v4,multi_agent_verified,verified_in_text_or_SI,original,,QCM,,,AIB,,DNA,,30189130,10.1021/acscombsci.8b00048,aptamer 1N showing the highest affinity (0.56 nM),step2c_acs_v1
59,RAGE,protein,P80511,RAGE-aptamer (clone #2),TCTGTTCAGGTTGGTACGGTGGAAGGTGTGATTCACGAGG,4.44 nM,-8.353,intrinsic,Kd,Gold,v4,extraction_verified,verified_in_text_or_SI,original,,QCM,,,,,DNA,phosphorothioate,28385802,10.2337/db16-1281,#2RAGE-aptamer | tcTgTTcAggTTggTAcggTggAAggTgTgATTcAcgAgg | 4.44±0.56,step2c_literal_v3
58,RAGE,protein,P80511,RAGE-aptamer (clone #1),CCTGATATGGTGTCACCGCCGCCTTAGTATTGGTGTCTAC,5.68 nM,-8.246,intrinsic,Kd,Gold,v4,extraction_verified,verified_in_text_or_SI,original,,QCM,,,,,DNA,phosphorothioate,28385802,10.2337/db16-1281,#1RAGE-aptamer | ccTgATATggTgTcAccgccgccTTAgTATTggTgTcTAc | 5.68±1.10,step2c_literal_v3
60,RAGE,protein,P80511,RAGE-aptamer (clone #3),TTCCACTGAGTGCCGCGGACTGTTGTTGGGAGGTGGTGTG,12.44 nM,-7.905,intrinsic,Kd,Gold,v4,extraction_verified,verified_in_text_or_SI,original,,QCM,,,,,DNA,phosphorothioate,28385802,10.2337/db16-1281,#3RAGE-aptamer | tTccAcTgAgTgccgcggAcTgTTgTTgggAggTggTgTg | 12.44±1.52,step2c_literal_v3
344,PlanarAu,protein,,1N truncated,TATGCATGTGTATATCAACACTCCGGGTCTAATCGTTCA,1.304e-08 M,-7.885,intrinsic,Kd,Gold,v4,multi_agent_verified,verified_in_text_or_SI,original,,QCM,,,AIB,,DNA,,30189130,10.1021/acscombsci.8b00048,1N truncated (Kd = 13.04 nM),step2c_acs_v1
19,thrombin,protein,P00734,LOOP,GGTTGGTGTGGTTGGCAACC,39.0 nM,-7.409,intrinsic,Kd,Gold,v4,extraction_verified,verified_in_text_or_SI,original,,QCM,,7.4,"140 mM NaCl, 5 mM KCl, 1 mM CaCl2, 1 mM MgCl2, 20 mM TRIS, pH 7.4",1.0,DNA,biotin at 3' end,16725379,10.1016/j.bioelechem.2006.03.012,LOOP | 3.27±1.22 | 127±100 | 0.026±0.018 | 39±27,step2c_literal_v3
18,thrombin,protein,P00734,APTA,GGGTTTTCACTTTTGTGGGTTGGACGGGATGG,88.0 nM,-7.056,intrinsic,Kd,Gold,v4,extraction_verified,verified_in_text_or_SI,original,,QCM,,7.4,"140 mM NaCl, 5 mM KCl, 1 mM CaCl2, 1 mM MgCl2, 20 mM TRIS, pH 7.4",1.0,DNA,biotin at 3' end,16725379,10.1016/j.bioelechem.2006.03.012,APTA | 0.97±0.45 | 86±73 | 0.011±0.006 | 88±52,step2c_literal_v3