id,target_name_canonical,target_type,target_uniprot,aptamer_name,aptamer_seq,kd_reported,kd_log10_molar,measurement_class,binding_constant_type,tier,source_origin,verification_level,sequence_status,seq_source,pi_provenance_flag,assay_method,assay_temperature_k,assay_ph,assay_buffer,assay_cations,aptamer_chemistry,aptamer_modifications,source_pmid,doi,verbatim_quote,source_db
478,FLRPp (O serotype),protein,,FMD_1,,3.46e-10 M,-9.461,intrinsic,Kd,Gold,v4,multi_agent_verified,pending_manual_supp,,,SPR,,,,,DNA,,42010751,10.1021/acs.analchem.5c04748,dissociation constants ( KD ) of 3.46 × 10 -10 M,step2c_acs_v1
337,human α-thrombin,protein,P00734,LOOPER modified thrombin aptamer,,1.6000000000000003e-09 M,-8.796,intrinsic,Kd,Gold,v4,multi_agent_verified,pending_manual_supp,,,SPR,,,,,DNA,diversely functionalized; heteromultivalent,28938065,10.1021/jacs.7b07241,"Using single-cycle kinetics surface plasmon resonance (SPR), the LOOPER aptamer exhibited a Kd of 1.6 nM",step2c_acs_v1
314,hMMP-9,protein,,F3Bomf,,2e-08 M,-7.699,intrinsic,Kd,Gold,v4,multi_agent_verified,pending_manual_supp,,,SPR,296.15,,PBS buffer,,2'-OMe-RNA,2'-O-methyl purine; 2'-fluoro pyrimidine; 5'-hexylamino linker; 5'-MAG3 conjugate,23043415,10.1021/bc300146c,"The K d was taken as the concentration leading to half saturation, i.e., about 20 nM.",step2c_acs_v1
388,patulin,protein,,PAT Rep,,4e-05 M,-4.398,intrinsic,Kd,Gold,v4,multi_agent_verified,pending_manual_supp,,,SPR,,,PBS,,DNA,5' biotin,35546052,10.1021/acs.jafc.2c01591,PAT Rep showed a K D value of 4.0 × 10 -5 M,step2c_acs_v1