{"database": "scout", "table": "v_kd", "is_view": true, "human_description_en": "where assay_method = \"flow_cytometry\" and sequence_status = \"pending_manual_supp\" sorted by kd_log10_molar", "rows": [[465, "SARS-CoV-2 spike RBD", "protein", null, "Aptx2-L", null, "4.900000000000001e-09 M", -8.31, "avidity_multivalent", "Kd", "Gold", "v4", "multi_agent_verified", "pending_manual_supp", null, null, "flow_cytometry", 298.15, 7.4, "PBS, pH 7.4, 0.55 mM MgCl2", null, "DNA", null, "41498844", "10.1021/acsami.5c16490", "The Aptx2-L variant showed superior affinity with a dissociation constant ( K d) of 4.9 nM", "step2c_acs_v1"], [267, "Thyroid-Stimulating Hormone Receptor (TSHR) 6X His tag", "protein", null, "ZMXLY-2a", null, "11.5 nM", -7.939, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "flow_cytometry", null, null, "phosphate-buffered saline", null, "DNA", "FITC-labeled 5' primer used for synthesis", "40588369", "10.1021/acs.analchem.5c02024", "As determined by flow cytometry, the K d of ZMXLY-2a was 11.5 \u00b1 9.3 nM (Figure 2G)", "step2c_literal_v3"], [466, "SARS-CoV-2 spike RBD", "protein", null, "Aptx2-S", null, "2.17e-08 M", -7.664, "avidity_multivalent", "Kd", "Gold", "v4", "multi_agent_verified", "pending_manual_supp", null, null, "flow_cytometry", 298.15, 7.4, "PBS, pH 7.4, 0.55 mM MgCl2", null, "DNA", null, "41498844", "10.1021/acsami.5c16490", "compared to 21.7 nM for Aptx2-S", "step2c_acs_v1"], [212, "M2-like macrophage", "protein", "Q8IYS5", "A2", null, "22.81 nM", -7.642, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "flow_cytometry", 277.15, null, "Wash Buffer (WB) supplemented with 10% FBS and 100 \u03bcg/mL tRNA", null, "DNA", "Cy5-label", "32589412", "10.1021/acs.bioconjchem.0c00247", "apparent dissociation constants ( K d ) of 44.12 \u00b1 8.0 and 22.81 \u00b1 5.6 nM to M0- and M2-like macrophages, respectively", "step2c_literal_v3"], [257, "CD71", "protein", "P02786", "XQ 2d", null, "42.34 nM", -7.373, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "flow_cytometry", null, null, "PBS supplemented with 0.5 mM MgCl2 and 0.05% BSA (BB buffer)", "0.5", "DNA", "FAM", "40156524", "10.1021/acs.analchem.5c00711", "aptamers (HG1-9, K d = 43.23 \u00b1 4.62 nM and XQ-2d, K d = 42.34 \u00b1 5.15 nM))", "step2c_literal_v3"], [258, "CD71", "protein", "P02786", "HG1-9", null, "43.23 nM", -7.364, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "flow_cytometry", null, null, "PBS supplemented with 0.5 mM MgCl2 and 0.05% BSA (BB buffer)", "0.5", "DNA", "FAM", "40156524", "10.1021/acs.analchem.5c00711", "aptamers (HG1-9, K d = 43.23 \u00b1 4.62 nM and XQ-2d, K d = 42.34 \u00b1 5.15 nM))", "step2c_literal_v3"], [213, "M0-like macrophage", "protein", "P01854", "A2", null, "44.12 nM", -7.355, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "flow_cytometry", 277.15, null, "Wash Buffer (WB) supplemented with 10% FBS and 100 \u03bcg/mL tRNA", null, "DNA", "Cy5-label", "32589412", "10.1021/acs.bioconjchem.0c00247", "apparent dissociation constants ( K d ) of 44.12 \u00b1 8.0 and 22.81 \u00b1 5.6 nM to M0- and M2-like macrophages, respectively", "step2c_literal_v3"], [214, "monocyte", "protein", "P13500", "A2", null, "45.0 nM", -7.347, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "flow_cytometry", 277.15, null, "Wash Buffer (WB) supplemented with 10% FBS and 100 \u03bcg/mL tRNA", null, "DNA", "Cy5-label", "32589412", "10.1021/acs.bioconjchem.0c00247", "aptamer A2 bound CD14 + cells (monocytes) with high speci fi city ( K d \u223c 45 \u00b1 9.1 nM)", "step2c_literal_v3"], [300, "CD71", "protein", "P02786", "ATL", null, "48.17 nM", -7.317, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "flow_cytometry", 277.15, 6.5, "binding buffer", null, "DNA", "Cy5-labeled; Cy3-labeled; Triplex motif", "41412185", "10.1021/acs.nanolett.5c04783", "K(pH 6.5) = 48.17 \u00b1 2.70 nM", "step2c_literal_v3"], [268, "Thyroid-Stimulating Hormone Receptor (TSHR)", "protein", "P16473", "TSHRly-1c", null, "54.37 nM", -7.265, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "flow_cytometry", null, null, "binding buffer", null, "DNA", "AlexaFluor 647-labeled", "40588369", "10.1021/acs.analchem.5c02024", "As shown in Figure 4E, the apparent equilibrium dissociation constant ( K d) of TSHRly-1c was determined to be 54.37 \u00b1 8.22 nM.", "step2c_literal_v3"], [442, "PTK7", "protein", "Q13308", "Sgc8c-Si6", null, "5.7230000000000004e-08 M", -7.242, "apparent_cellular", "Kd", "Gold", "v4", "multi_agent_verified", "pending_manual_supp", null, null, "flow_cytometry", 277.15, null, "washing buffer supplemented with 1 mg/mL BSA and 1 mM yeast tRNA", null, "DNA", "poly-Si", "40415219", "10.1021/acs.analchem.5c01062", "Sgc8c-Si6 maintained strong binding affinity ( K d = 57.23 nM)", "step2c_acs_v1"], [301, "CD71", "protein", "P02786", "ATL", null, "696.7 nM", -6.157, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "flow_cytometry", 277.15, 7.5, "binding buffer", null, "DNA", "Cy5-labeled; Cy3-labeled; Triplex motif", "41412185", "10.1021/acs.nanolett.5c04783", "K(pH 7.5)= 696.7 \u00b1 68.03 nM", "step2c_literal_v3"]], "truncated": false, "filtered_table_rows_count": 12, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "target_name_canonical", "target_type", "target_uniprot", "aptamer_name", "aptamer_seq", "kd_reported", "kd_log10_molar", "measurement_class", "binding_constant_type", "tier", "source_origin", "verification_level", "sequence_status", "seq_source", "pi_provenance_flag", "assay_method", "assay_temperature_k", "assay_ph", "assay_buffer", "assay_cations", "aptamer_chemistry", "aptamer_modifications", "source_pmid", "doi", "verbatim_quote", "source_db"], "primary_keys": [], "units": {}, "query": {"sql": "select id, target_name_canonical, target_type, target_uniprot, aptamer_name, aptamer_seq, kd_reported, kd_log10_molar, measurement_class, binding_constant_type, tier, source_origin, verification_level, sequence_status, seq_source, pi_provenance_flag, assay_method, assay_temperature_k, assay_ph, assay_buffer, assay_cations, aptamer_chemistry, aptamer_modifications, source_pmid, doi, verbatim_quote, source_db from v_kd where \"assay_method\" = :p0 and \"sequence_status\" = :p1 order by kd_log10_molar limit 51", "params": {"p0": "flow_cytometry", "p1": "pending_manual_supp"}}, "facet_results": {"measurement_class": {"name": "measurement_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_kd.json?assay_method=flow_cytometry&sequence_status=pending_manual_supp", "results": [{"value": "non_intrinsic", "label": "non_intrinsic", "count": 9, "toggle_url": "https://apt-scout.org/scout/v_kd.json?assay_method=flow_cytometry&sequence_status=pending_manual_supp&measurement_class=non_intrinsic", "selected": false}, {"value": "avidity_multivalent", "label": "avidity_multivalent", "count": 2, "toggle_url": "https://apt-scout.org/scout/v_kd.json?assay_method=flow_cytometry&sequence_status=pending_manual_supp&measurement_class=avidity_multivalent", "selected": false}, {"value": "apparent_cellular", "label": "apparent_cellular", "count": 1, "toggle_url": "https://apt-scout.org/scout/v_kd.json?assay_method=flow_cytometry&sequence_status=pending_manual_supp&measurement_class=apparent_cellular", "selected": false}], "truncated": false}, "target_type": {"name": "target_type", "type": "column", "hideable": false, "toggle_url": "/scout/v_kd.json?assay_method=flow_cytometry&sequence_status=pending_manual_supp", "results": [{"value": "protein", "label": "protein", "count": 12, "toggle_url": "https://apt-scout.org/scout/v_kd.json?assay_method=flow_cytometry&sequence_status=pending_manual_supp&target_type=protein", "selected": false}], "truncated": false}, "tier": {"name": "tier", "type": "column", "hideable": false, "toggle_url": "/scout/v_kd.json?assay_method=flow_cytometry&sequence_status=pending_manual_supp", "results": [{"value": "Gold", "label": "Gold", "count": 12, "toggle_url": "https://apt-scout.org/scout/v_kd.json?assay_method=flow_cytometry&sequence_status=pending_manual_supp&tier=Gold", "selected": false}], "truncated": false}, "assay_method": {"name": "assay_method", "type": "column", "hideable": false, "toggle_url": "/scout/v_kd.json?assay_method=flow_cytometry&sequence_status=pending_manual_supp", "results": [{"value": "flow_cytometry", "label": "flow_cytometry", "count": 12, "toggle_url": "https://apt-scout.org/scout/v_kd.json?sequence_status=pending_manual_supp", "selected": true}], "truncated": false}, "binding_constant_type": {"name": 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"toggle_url": "https://apt-scout.org/scout/v_kd.json?assay_method=flow_cytometry&sequence_status=pending_manual_supp&_facet=doi"}, {"name": "verbatim_quote", "toggle_url": "https://apt-scout.org/scout/v_kd.json?assay_method=flow_cytometry&sequence_status=pending_manual_supp&_facet=verbatim_quote"}, {"name": "source_db", "toggle_url": "https://apt-scout.org/scout/v_kd.json?assay_method=flow_cytometry&sequence_status=pending_manual_supp&_facet=source_db"}], "next": null, "next_url": null, "private": false, "allow_execute_sql": true, "query_ms": 39.36785692349076, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}