{"database": "scout", "table": "v_kd", "is_view": true, "human_description_en": "where measurement_class = \"avidity_multivalent\", sequence_status = \"pending_manual_supp\" and tier = \"Gold\" sorted by kd_log10_molar", "rows": [[406, "SARS-CoV-2 spike protein (wild type)", "protein", null, "DSA1N5", null, "3e-12 M", -11.523, "avidity_multivalent", "Kd", "Gold", "v4", "multi_agent_verified", "pending_manual_supp", null, null, "dot_blot", null, null, "undiluted wastewater", null, "DNA", "dimeric", "36926840", "10.1021/acssensors.2c02655", "DSA1N5 also demonstrated high binding affinity in undiluted wastewater samples ( K d = 3.0 -3.9 pM for WTPV, Figure S1A,B).", "step2c_acs_v1"], [743, "SARS-CoV-2 spike protein (wild type)", "protein", null, "DSA1N5", null, "3.9e-12 M", -11.409, "avidity_multivalent", "Kd", "Gold", "ACS", "multi_agent_verified", "pending_manual_supp", null, null, "dot_blot", null, null, "undiluted wastewater", null, "DNA", "dimeric", "36926840", 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"PBS, pH 7.4, 0.55 mM MgCl2", null, "DNA", null, "41498844", "10.1021/acsami.5c16490", "The Aptx2-L variant showed superior affinity with a dissociation constant ( K d) of 4.9 nM", "step2c_acs_v1"], [412, "Salmonella typhimurium", "protein", "Q8IWE5", "NTri-triApt", null, "1.1890000000000001e-08 M", -7.925, "avidity_multivalent", "Kd", "Gold", "v4", "multi_agent_verified", "pending_manual_supp", null, null, "ELISA", 310.15, 7.5, "PBS", null, "DNA", "biotin", "37893744", "10.3390/foods12203853", "the Kds of the NTri-monoApt, NTri-biApt, and NTri-triApt were measured to be 57.32 nM, 43.09 nM, and 11.89 nM, respectively", "step2c_acs_v1"], [466, "SARS-CoV-2 spike RBD", "protein", null, "Aptx2-S", null, "2.17e-08 M", -7.664, "avidity_multivalent", "Kd", "Gold", "v4", "multi_agent_verified", "pending_manual_supp", null, null, "flow_cytometry", 298.15, 7.4, "PBS, pH 7.4, 0.55 mM MgCl2", null, "DNA", null, "41498844", "10.1021/acsami.5c16490", "compared to 21.7 nM for Aptx2-S", 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"https://apt-scout.org/scout/v_kd.json?measurement_class=avidity_multivalent&sequence_status=pending_manual_supp&tier=Gold&_facet=assay_buffer"}, {"name": "aptamer_modifications", "toggle_url": "https://apt-scout.org/scout/v_kd.json?measurement_class=avidity_multivalent&sequence_status=pending_manual_supp&tier=Gold&_facet=aptamer_modifications"}, {"name": "source_pmid", "toggle_url": "https://apt-scout.org/scout/v_kd.json?measurement_class=avidity_multivalent&sequence_status=pending_manual_supp&tier=Gold&_facet=source_pmid"}, {"name": "doi", "toggle_url": "https://apt-scout.org/scout/v_kd.json?measurement_class=avidity_multivalent&sequence_status=pending_manual_supp&tier=Gold&_facet=doi"}, {"name": "verbatim_quote", "toggle_url": "https://apt-scout.org/scout/v_kd.json?measurement_class=avidity_multivalent&sequence_status=pending_manual_supp&tier=Gold&_facet=verbatim_quote"}], "next": null, "next_url": null, "private": false, "allow_execute_sql": true, "query_ms": 1102.6360397227108, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}