{"database": "scout", "table": "v_kd", "is_view": true, "human_description_en": "where verification_level = \"extraction_verified\" sorted by kd_log10_molar", "rows": [[188, "PDGF-BB", "protein", "P01127", "36aApt", null, "0.036 pM", -13.444, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "ELISA", 298.0, null, null, null, "DNA", null, "28825469", "10.1021/acscombsci.6b00163", "36aApt | 0.036 \u00b1 0.012 | - 18.33", "step2c_literal_v3"], [186, "PDGF-BB", "protein", "P01127", "38aApt", null, "0.094 pM", -13.027, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "ELISA", 298.0, null, null, null, "DNA", null, "28825469", "10.1021/acscombsci.6b00163", "38aApt | 0.094 \u00b1 0.008 | - 17.76", "step2c_literal_v3"], [44, "IL-8", "protein", "P10145", "8A-35", "GGGGGCUUAUCAUUCCAUUUAGUGUUAUGAUAACC", "1.72e-12 M", -11.764, "intrinsic", "Kd", "Gold", "v4", "extraction_verified", "verified_in_text_or_SI", "original", null, "SPR", 298.0, 7.4, "HBST running buffer (10 mM HEPES, pH 7.4, 150 mM NaCl, and 0.005% Tween 20)", null, "2'F-RNA", "2'-fluoro-pyrimidine modified", "24129312", "10.1016/j.biomaterials.2013.09.107", "| 8A-35       | 5.78 x 10 4 | 9.95 x 10 -8 | 1.72 x 10 -12 | 2.80         | 3.11 x 10 1  |", "step2c_literal_v3"], [598, "human \u03b1-Thrombin", "protein", "P00734", "A1", null, "2.0 pM", -11.699, "intrinsic", "Kd", "Gold", "elsevier", "extraction_verified", "pending_manual_supp", null, null, null, null, null, "text", null, null, null, "31129134", "10.1016/j.ab.2019.05.012", "Also for aptamer A1 we measured with MST KD values in the pico- and nanomolar range (2 pM and 52 nM). The lowest KD value is determined with MST (shown as bar) for aptamer A1, which is 2 pM.", "elsevier_step2c"], [621, "nucleolin", "protein", "P19338", "Cy5-AT11-B0", "TGGTGGTGGTTGGTGGTGGTGGTGGT", "3.3e-12 M", -11.481, "intrinsic", "Kd", "Gold", "elsevier", "extraction_verified", "verified_in_text_or_SI", "original", null, null, null, null, "text", null, null, null, "31301466", "10.1016/j.ijpharm.2019.118511", "yielding K D values of 5.2 \u00d7 10 -12 and 3.3 \u00d7 10 -12 M for Cy5-AT11 G4 C8 and Cy5-AT11-B0 G4 C8", "elsevier_step2c"], [208, "SW480 cells", "cell/EV", "Q16520", "Apt-nanovesicle", null, "3.66 pM", -11.437, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, null, null, null, null, null, "DNA", "cholesterol; multivalent", "32049531", "10.1021/jacs.9b13782", "The dissociation constant ( K d ) value of Apt-nanovesicle against SW480 cells was found to be 3.66 \u00b1 0.34 pM (Figure 2B)", "step2c_literal_v3"], [620, "nucleolin", 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"pending_manual_supp", null, null, null, null, null, null, null, "DNA", "cholesterol; crosslinked", "32049531", "10.1021/jacs.9b13782", "the K d value of fi xed Apt-nanovesicles to SW480 cells was increased to 28.06 \u00b1 3.31 pM (Figure 2D)", "step2c_literal_v3"], [146, "P-selectin", "protein", "Q14242", "PF377sl", null, "29.0 pM", -10.538, "intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_figure", null, null, "filter_binding", 310.15, 7.4, "SHMCK buffer", "1.0", "2'F-RNA", null, "9743465", "10.1089/oli.1.1998.8.265", "PF377sl | 29", "step2c_literal_v3"], [669, "bevacizumab", "protein", "P31995", "A14#1", "GCGGTTGGTGGTAGTTACGTTCGC", "44.0 pM", -10.357, "intrinsic", "Kd", "Gold", "elsevier", "extraction_verified", "verified_in_text_or_SI", "original", null, null, null, null, "abstract", null, null, null, "35114463", "10.1016/j.bios.2022.114027", "affinity of A14#1 to bevacizumab markedly increased at pH 4.7 ( K D = 44 pM)", "elsevier_step2c"], [145, "P-selectin", "protein", "Q14242", "PF377sl", null, "46.0 pM", -10.337, "intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_figure", null, null, "filter_binding", 310.15, 7.4, "SHMCK buffer", "1.0", "2'F-RNA", null, "9743465", "10.1089/oli.1.1998.8.265", "PF377sl | 46", "step2c_literal_v3"], [148, "P-selectin", "protein", "Q14242", "PF373sl", null, "56.0 pM", -10.252, "intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_figure", null, null, "filter_binding", 310.15, 7.4, "SHMCK buffer", "1.0", "2'F-RNA", null, "9743465", "10.1089/oli.1.1998.8.265", "PF373sl | 56", "step2c_literal_v3"], [9, "sLe X -BSA", "glycan/conjugate", "Q9NSU2", "Clone 5", "GGUGCAGGUCACUUCGAUGAGUGUAAAGCACAGGUAAGUGUCUUGGUAGAAUCGGAGUCGGUGACCGUU", "5.7e-11 M", -10.244, "intrinsic", "Kd", "Gold", "v4", "extraction_verified", "verified_in_text_or_SI", "original", "KEEP_seq_in_figure", "SPR", 298.15, 7.4, "RNA binding buffer [150 mM NaCl, 20 mM Hepes (pH 7.4), 1 mM CaCl2, 1 mM MgCl2]", "1.0", "RNA", null, "11178986", "10.1006/bbrc.2001.4327", "sLe X -BSA | 6.4 3 10 7 | 3.7 3 10 2 3 | 1.7 3 10 10 | 5.7 3 10 2 11", "step2c_literal_v3"], [56, "von Willebrand factor A1-domain", "protein", "P04275", "Rn-DsDsDs-53mh", null, "61.3 pM", -10.213, "intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "SPR", 310.15, null, "1 \u00d7 PBS supplemented with 0.05% (w/v) Nonidet P-40", null, "DNA", "Ds (7-(2-thienyl)imidazo[4,5b]pyridine); mini-hairpin DNA", "27966933", "10.1021/jacs.6b10767", "RnDsDsDs-53mh ( K D = 61.3 pM)", "step2c_literal_v3"], [542, "Myoglobin", "protein", "P02144", "anti-Mb aptamer", null, "65.0 pM", -10.187, "intrinsic", "Kd", "Gold", "elsevier", "extraction_verified", "pending_manual_supp", null, null, null, null, null, "text", null, null, null, "25957831", "10.1016/j.bios.2015.04.089", "The corresponding af fi nity, K D, values calculated from the ratio between dissociation ( k d) and association ( k a ) was found to be  65 pM.", "elsevier_step2c"], [53, "von Willebrand factor A1-domain", "protein", "P04275", "Rn-DsDsDs-44", null, "74.9 pM", -10.126, "intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "SPR", 310.15, null, "1 \u00d7 PBS supplemented with 0.05% (w/v) Nonidet P-40", null, "DNA", "Ds (7-(2-thienyl)imidazo[4,5b]pyridine)", "27966933", "10.1021/jacs.6b10767", "Rn-DsDsDs-44 ( K D = 74.9 pM) exhibited the highest a ffi nity", "step2c_literal_v3"], [219, "CCRF-CEM cells", "cell/EV", "Q9NRR3", "CDN-sgc8", null, "0.08 nM", -10.097, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "fluorescence", null, null, "1 \u00d7 PBS, 5 mM MgCl2", "5.0", "DNA", "biotinylated", "35670775", "10.1021/acs.analchem.2c01359", "Kd=0.08\u00b10.01 nM", "step2c_literal_v3"], [3, "sLe X -BSA", "glycan/conjugate", "Q9NSU2", "Clone 5", "GGUGCAGGUCACUUCGAUGAGUGUAAAGCACAGGUAAGUGUCUUGGUAGAAUCGGAGUCGGUGACCGUU", "8.5e-11 M", -10.071, "intrinsic", 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nM", -9.959, "intrinsic", "Kd", "Gold", "elsevier", "extraction_verified", "verified_in_text_or_SI", "original", null, null, null, null, "text", null, null, null, "26547431", "10.1016/j.bios.2015.10.069", "Their K D values were calculated at K D 1\u20444 0.11 nM ( 7 0.06) for aptamer Q2", "elsevier_step2c"], [245, "MPO", "protein", "P05164", "MPO-16", "GTCTGGAAACGACGAGGGCCACTGATTAACGTAGTTAATTGGTCTTGTCG", "166.0 pM", -9.78, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "verified_in_text_or_SI", "backfill_text_verified", null, "flow_cytometry", null, null, "selection buffer (DPBS with 2.5 mM MgCl2 , 1 mM CaCl 2 , 0.01% TWEEN-20, 0.2% BSA)", "2.5", "DNA", null, "37277648", "10.1038/s41557-023-01207-z", "MPO16 revealed the highest binding affinity ( K d = 166 pM)", "step2c_literal_v3"], [149, "P-selectin", "protein", "Q14242", "PF398sl", null, "178.0 pM", -9.75, "intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_figure", null, null, "filter_binding", 310.15, 7.4, "SHMCK buffer", "1.0", "2'F-RNA", null, "9743465", "10.1089/oli.1.1998.8.265", "PF398sl | 178", "step2c_literal_v3"], [57, "von Willebrand factor A1-domain", "protein", "P04275", "Rn-DsDs-51mh2", null, "182.0 pM", -9.74, "intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "SPR", 310.15, null, "1 \u00d7 PBS supplemented with 0.05% (w/v) Nonidet P-40", null, "DNA", "Ds (7-(2-thienyl)imidazo[4,5b]pyridine); mini-hairpin DNA", "27966933", "10.1021/jacs.6b10767", "Rn-DsDs-51mh2 ( K D = 182 pM)", "step2c_literal_v3"], [548, "ofloxacin", "protein", "Q9H015", "Q8", "ATACCAGCTTATTCAATTAGTTGTGTATTGAGGTTTGATCTAGGCATAGTCAACAGAGCACGATCGATCTGGCTTGTTCTACAATCGTAATCAGTTAG", "0.2 nM", -9.699, "intrinsic", "Kd", "Gold", "elsevier", "extraction_verified", "verified_in_text_or_SI", "original", null, null, null, null, "text", null, null, null, "26547431", "10.1016/j.bios.2015.10.069", "K D 1\u20444 0.20 nM ( 7 0.09) for aptamer Q8", "elsevier_step2c"], [558, "OH-BDE47", "protein", null, "BDE-A-8", "GACAGCCGGGGCATCAGAGCAGCCGATTGTCTGTTGTGCC", "0.2 nM", -9.699, "intrinsic", "Kd", "Gold", "elsevier", "extraction_verified", "verified_in_text_or_SI", "original", null, null, null, null, "text", null, null, null, "27566357", "10.1016/j.aca.2016.06.040", "The dissociation constant (Kd) of BDE-A-8 and BDE-A-12 were 0.20 nM (~0.08 ppb) and 1.53 nM (~0.8 ppb), respectively, in PBS buffer condition.", "elsevier_step2c"], [234, "MPO", "protein", "P05164", "MPO-02", "TATGCGATTTCAAAAATGTTACGATGGATATTGACATTTAAATATGTCGG", "227.0 pM", -9.644, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "verified_in_text_or_SI", "backfill_text_verified", null, "flow_cytometry", null, null, "selection buffer (DPBS with 2.5 mM MgCl2 , 1 mM CaCl 2 , 0.01% TWEEN-20, 0.2% BSA)", "2.5", "DNA", null, "37277648", "10.1038/s41557-023-01207-z", "MPO-02 ... 227", "step2c_literal_v3"], [307, "P-selectin", "protein", "Q14242", "PF377sl", null, "250.0 pM", -9.602, "non_intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_figure", null, null, "flow_cytometry", 296.15, 7.4, "SHMCK buffer", "1.0", "2'F-RNA", null, "9743465", "10.1089/oli.1.1998.8.265", "PF377sl | 250", "step2c_literal_v3"], [639, "thrombin", "protein", "P00734", "29-mer thrombin-specific aptamer", "AGTCCGTGGTAGGGCAGGTTGGGGTGACT", "298.0 pM", -9.526, "intrinsic", "Kd", "Gold", "elsevier", "extraction_verified", "verified_in_text_or_SI", "original", null, null, null, null, "text", null, null, null, "32570818", "10.3390/s20123442", "The n-curve analysis provided a Kd of 298 pM ( + 111 / 81 pM)", "elsevier_step2c"], [660, "20 Methyl Spirolide G", "protein", null, "SPX 7", "GGCGGTGTGGGTACCACGAGGTTTGGACGCGCGTAGCACCCCATTCAGC", "3e-10 M", -9.523, "intrinsic", "Kd", "Gold", "elsevier", "extraction_verified", "verified_in_text_or_SI", "original", null, null, null, null, "text", null, null, null, "34144421", "10.1016/j.foodchem.2021.130332", "The present study, among the aptamers selected, the aptamer with highest affinity had a dissociation constant of 0.3 nM for SPX G", "elsevier_step2c"], [554, "chimeric-tPA", "protein", null, "Chi-tPA 1", "TTCCAACGGTTGGTGGGTGGTT", "0.32 nM", -9.495, "intrinsic", "Kd", "Gold", "elsevier", "extraction_verified", "verified_in_text_or_SI", "original", null, null, null, null, "abstract", null, null, null, "26876003", "10.1016/j.pep.2016.02.004", "selected aptamer having KD values of 0.320 nM", "elsevier_step2c"], [55, "von Willebrand factor A1-domain", "protein", "P04275", "ARC1172-41", null, "326.0 pM", -9.487, "intrinsic", "Kd", "Gold", "v4", "extraction_verified", "pending_manual_supp", null, null, "SPR", 310.15, null, "1 \u00d7 PBS supplemented with 0.05% (w/v) Nonidet P-40", null, "DNA", null, "27966933", "10.1021/jacs.6b10767", "ARC1172-41 ( K D = 326 pM)", "step2c_literal_v3"], [247, "Human thrombin", "protein", "P00734", "Lin08-08", null, "0.4 nM", -9.398, "non_intrinsic", "Kd", "Gold", "v4", 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