id,gene_symbol,protein_name,surface_class,surface_evidence,ev_map_hallmark,in_cev_map,in_vesiclepedia,in_exocarta,pdb_count,top_disease,disease_score,drug_count_approved,targetability_score
P35555,FBN1,Fibrillin-1,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,11,Marfan syndrome,0.8969300970597663,,0.969
P15056,BRAF,Serine/threonine-protein kinase B-raf,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,100,cardiofaciocutaneous syndrome,0.8764542776642054,,0.963
P04049,RAF1,RAF proto-oncogene serine/threonine-protein kinase,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,75,Noonan syndrome,0.8625147809861142,,0.959
P51531,SMARCA2,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,31,intellectual disability-sparse hair-brachydactyly syndrome,0.85547142397368,,0.957
P62873,GNB1,Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,100,"intellectual disability, autosomal dominant 42",0.8462216225099116,,0.954
P52333,JAK3,Tyrosine-protein kinase JAK3,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,42,T-B+ severe combined immunodeficiency due to JAK3 deficiency,0.8450717197794638,,0.954
Q06187,BTK,Tyrosine-protein kinase BTK,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,100,X-linked agammaglobulinemia,0.8454716106068291,,0.954
P29400,COL4A5,Collagen alpha-5(IV) chain,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,2,X-linked Alport syndrome,0.8472963899466404,,0.954
Q14315,FLNC,Filamin-C,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,14,hypertrophic cardiomyopathy 26,0.8363192336142512,,0.951
O60315,ZEB2,Zinc finger E-box-binding homeobox 2,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,1,Mowat-Wilson syndrome,0.8313744323041312,,0.949
Q02750,MAP2K1,Dual specificity mitogen-activated protein kinase kinase 1,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,94,cardiofaciocutaneous syndrome,0.825549979325162,,0.948
O75369,FLNB,Filamin-B,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,23,Larsen syndrome,0.826975893141549,,0.948
P06737,PYGL,"Glycogen phosphorylase, liver form",A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,19,glycogen storage disease VI,0.8220063508118274,,0.947
P49770,EIF2B2,Translation initiation factor eIF2B subunit beta,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,25,CACH syndrome,0.824634396744653,,0.947
P31040,SDHA,"Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial",A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,4,"mitochondrial complex II deficiency, nuclear type 1",0.815589203208636,,0.945
P11274,BCR,Breakpoint cluster region protein,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,5,chronic myelogenous leukemia,0.8183048540102864,,0.945
O43175,PHGDH,D-3-phosphoglycerate dehydrogenase,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,21,PHGDH deficiency,0.8128323162948055,,0.944
P01111,NRAS,GTPase NRas,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,35,Noonan syndrome 6,0.8087775198380727,,0.943
Q9Y3Z3,SAMHD1,Deoxynucleoside triphosphate triphosphohydrolase SAMHD1,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,76,Aicardi-Goutières syndrome,0.8101030032946703,,0.943
Q8TD16,BICD2,Protein bicaudal D homolog 2,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,2,autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures,0.8072433385790271,,0.942
Q08499,PDE4D,"3',5'-cyclic-AMP phosphodiesterase 4D",A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,100,acrodysostosis 2 with or without hormone resistance,0.8053064772512085,,0.942
Q01831,XPC,DNA repair protein complementing XP-C cells,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,14,Xeroderma pigmentosum complementation group C,0.8056391472748724,,0.942
O95630,STAMBP,STAM-binding protein,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,5,microcephaly-capillary malformation syndrome,0.8060251236043802,,0.942
Q96BN8,OTULIN,Ubiquitin thioesterase otulin,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,12,"autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive",0.804614072482804,,0.941
Q12840,KIF5A,Kinesin heavy chain isoform 5A,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,4,hereditary spastic paraplegia 10,0.8029405627392309,,0.941
O60674,JAK2,Tyrosine-protein kinase JAK2,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,100,polycythemia vera,0.8000866241942614,,0.94
P01137,TGFB1,Transforming growth factor beta-1 proprotein,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,20,Camurati-Engelmann disease,0.7995305374459716,,0.94
P98170,XIAP,E3 ubiquitin-protein ligase XIAP,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,74,X-linked lymphoproliferative disease,0.8013347966323413,,0.94
O00330,PDHX,"Pyruvate dehydrogenase protein X component, mitochondrial",A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,5,pyruvate dehydrogenase E3-binding protein deficiency,0.7957753555992844,,0.939
Q9NQG7,HPS4,BLOC-3 complex member HPS4,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,1,Hermansky-Pudlak syndrome with pulmonary fibrosis,0.7967575753847002,,0.939
Q9UHD9,UBQLN2,Ubiquilin-2,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,4,amyotrophic lateral sclerosis type 15,0.7942015735994536,,0.938
P49773,HINT1,Adenosine 5'-monophosphoramidase HINT1,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,59,Autosomal recessive axonal neuropathy with neuromyotonia,0.7895184274923306,,0.937
P12814,ACTN1,Alpha-actinin-1,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,4,platelet-type bleeding disorder 15,0.7887662502912471,,0.937
O00468,AGRN,Agrin,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,1,congenital myasthenic syndrome 8,0.7912009864338403,,0.937
Q9ULC3,RAB23,Ras-related protein Rab-23,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,6,RAB23-related Carpenter syndrome,0.7879955689930709,,0.936
O15294,OGT,UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,44,"intellectual disability, X-linked 106",0.7660009745204424,,0.93
Q9Y263,PLAA,Phospholipase A-2-activating protein,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,5,"neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies",0.7656265019633831,,0.93
P55263,ADK,Adenosine kinase,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,4,adenosine kinase deficiency,0.7617058236708037,,0.929
Q9NWZ3,IRAK4,Interleukin-1 receptor-associated kinase 4,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,96,immunodeficiency 67,0.7593923638641371,,0.928
Q92743,HTRA1,Serine protease HTRA1,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,18,"cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2",0.7611877816680132,,0.928
Q9BYI3,HYCC1,Hyccin,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,5,Hypomyelination - congenital cataract,0.7528702184568328,,0.926
P35221,CTNNA1,Catenin alpha-1,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,10,Butterfly-shaped pigment dystrophy,0.7487735496199569,,0.925
Q9NZ09,UBAP1,Ubiquitin-associated protein 1,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,3,"spastic paraplegia 80, autosomal dominant",0.7464670113492812,,0.924
Q01484,ANK2,Ankyrin-2,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,11,Romano-Ward syndrome,0.7390647393986454,,0.922
Q6NZI2,CAVIN1,Caveolae-associated protein 1,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,3,congenital generalized lipodystrophy type 4,0.7317728549444928,,0.92
Q92997,DVL3,Segment polarity protein dishevelled homolog DVL-3,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,9,autosomal dominant Robinow syndrome,0.7284158836126389,,0.919
P13797,PLS3,Plastin-3,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,6,X-linked osteoporosis with fractures,0.721756781312783,,0.917
P22735,TGM1,Protein-glutamine gamma-glutamyltransferase K,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,1,autosomal recessive congenital ichthyosis,0.714755023666953,,0.914
P31939,ATIC,Bifunctional purine biosynthesis protein ATIC,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,5,AICA-ribosiduria,0.7137167364484167,,0.914
Q13153,PAK1,Serine/threonine-protein kinase PAK 1,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),0,1,,,41,"intellectual developmental disorder with macrocephaly, seizures, and speech delay",0.7110292416229067,,0.913