id,gene_symbol,protein_name,surface_class,surface_evidence,ev_map_hallmark,in_cev_map,in_vesiclepedia,in_exocarta,pdb_count,top_disease,disease_score,drug_count_approved,targetability_score
P21359,NF1,Neurofibromin,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,26,neurofibromatosis type 1,0.8844735398780649,,1.965
P33897,ABCD1,ATP-binding cassette sub-family D member 1,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,14,adrenoleukodystrophy,0.8656366512509434,,1.96
P04839,CYBB,NADPH oxidase 2,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,6,chronic granulomatous disease,0.8633132852459866,,1.959
P21802,FGFR2,Fibroblast growth factor receptor 2,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,62,Crouzon syndrome,0.8637438969881663,,1.959
P78504,JAG1,Protein jagged-1,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,7,Alagille syndrome due to a JAG1 point mutation,0.8586542923232751,,1.958
P00813,ADA,Adenosine deaminase,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,2,Severe combined immunodeficiency due to adenosine deaminase deficiency,0.8556816060494579,,1.957
P36021,SLC16A2,Monocarboxylate transporter 8,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,7,Allan-Herndon-Dudley syndrome,0.8533069932022032,,1.956
P51795,CLCN5,H(+)/Cl(-) exchange transporter 5,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,2,Dent disease type 1,0.850724240157394,,1.955
P29965,CD40LG,CD40 ligand,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,8,hyper-IgM syndrome type 1,0.8451678829647167,,1.954
P11362,FGFR1,Fibroblast growth factor receptor 1,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,82,hypogonadotropic hypogonadism 2 with or without anosmia,0.8472925100660907,,1.954
Q9NQ11,ATP13A2,Polyamine-transporting ATPase 13A2,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,25,Kufor-Rakeb syndrome,0.8439049037191295,,1.953
P08581,MET,Hepatocyte growth factor receptor,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,100,papillary renal cell carcinoma,0.84195976263742,,1.953
P06213,INSR,Insulin receptor,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,87,Leprechaunism,0.8448849372402896,,1.953
Q8WZ42,TTN,Titin,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,64,dilated cardiomyopathy,0.8419847660466327,,1.953
Q14524,SCN5A,Sodium channel protein type 5 subunit alpha,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,1,,,16,long QT syndrome 3,0.8448298602976083,,1.953
Q969N2,PIGT,GPI-anchor transamidase component PIGT,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,3,multiple congenital anomalies-hypotonia-seizures syndrome 3,0.8439030764005646,,1.953
P13637,ATP1A3,Sodium/potassium-transporting ATPase subunit alpha-3,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,5,alternating hemiplegia of childhood 2,0.842328126568451,,1.953
P37173,TGFBR2,TGF-beta receptor type-2,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,22,Loeys-Dietz syndrome,0.8390072008866913,,1.952
P35499,SCN4A,Sodium channel protein type 4 subunit alpha,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,1,,,3,paramyotonia congenita of Von Eulenburg,0.8401628899371881,,1.952
Q99250,SCN2A,Sodium channel protein type 2 subunit alpha,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,1,,,5,"developmental and epileptic encephalopathy, 11",0.8388748085806758,,1.952
O00571,DDX3X,ATP-dependent RNA helicase DDX3X,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,17,X-linked non-syndromic intellectual disability,0.8362533125067105,,1.951
P19438,TNFRSF1A,Tumor necrosis factor receptor superfamily member 1A,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,13,TNF receptor 1-associated periodic fever syndrome,0.8352778213184682,,1.951
P25189,MPZ,Myelin protein P0,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,2,Charcot-Marie-Tooth disease type 1B,0.8377022197539885,,1.951
P54760,EPHB4,Ephrin type-B receptor 4,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,23,Capillary malformation - arteriovenous malformation,0.8317426466005666,,1.95
Q9HAB3,SLC52A2,"Solute carrier family 52, riboflavin transporter, member 2",A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,1,riboflavin transporter deficiency,0.8333271825486935,,1.95
Q9Y653,ADGRG1,Adhesion G-protein coupled receptor G1,A_surface,"HPA protein class = G-protein coupled receptors (cell-surface, extracellular epitope)",0,1,,,1,bilateral frontoparietal polymicrogyria,0.8322298896713178,,1.95
P06744,GPI,Glucose-6-phosphate isomerase,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,13,hemolytic anemia due to glucophosphate isomerase deficiency,0.8306909118751346,,1.949
Q9NRA2,SLC17A5,Sialin,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,7,"free sialic acid storage disease, infantile form",0.8292382821211967,,1.949
P36888,FLT3,Receptor-type tyrosine-protein kinase FLT3,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,11,acute myeloid leukemia,0.8313389209288576,,1.949
P63092,GNAS,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,100,pseudohypoparathyroidism type 1A,0.826829760867455,,1.948
Q8WZA1,POMGNT1,"Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1",A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,10,"muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3",0.826104223872448,,1.948
P36897,TGFBR1,TGF-beta receptor type-1,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,44,Loeys-Dietz syndrome 1,0.8275292516338373,,1.948
P36894,BMPR1A,Bone morphogenetic protein receptor type-1A,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,11,juvenile polyposis syndrome,0.8278395086688584,,1.948
P22607,FGFR3,Fibroblast growth factor receptor 3,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,13,achondroplasia,0.8270702096931246,,1.948
Q5JWF2,GNAS,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,9,pseudohypoparathyroidism type 1A,0.826829760867455,,1.948
P13473,LAMP2,Lysosome-associated membrane glycoprotein 2,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,2,Glycogen Storage Disease Type 2b,0.8273010649608126,,1.948
P16615,ATP2A2,Sarcoplasmic/endoplasmic reticulum calcium ATPase 2,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,15,Darier disease,0.8223208039299769,,1.947
P04156,PRNP,Major prion protein,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,70,Gerstmann-Straussler-Scheinker syndrome,0.8246149684620239,,1.947
Q13936,CACNA1C,Voltage-dependent L-type calcium channel subunit alpha-1C,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,1,,,33,Timothy syndrome,0.8227725490420764,,1.947
P08069,IGF1R,Insulin-like growth factor 1 receptor,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,46,growth delay due to insulin-like growth factor I resistance,0.8166352227841136,,1.945
P16234,PDGFRA,Platelet-derived growth factor receptor alpha,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,14,gastrointestinal stromal tumor,0.8167494524079806,,1.945
Q9H3H5,DPAGT1,UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,8,DPAGT1-congenital disorder of glycosylation,0.8101246300555436,,1.943
Q13563,PKD2,Polycystin-2,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,1,,,31,polycystic kidney disease 2,0.810960823768978,,1.943
O75844,ZMPSTE24,CAAX prenyl protease 1 homolog,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,4,mandibuloacral dysplasia with type B lipodystrophy,0.8071967390737101,,1.942
P51798,CLCN7,H(+)/Cl(-) exchange transporter 7,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,9,Autosomal recessive malignant osteopetrosis,0.8065499095904218,,1.942
P25942,CD40,Tumor necrosis factor receptor superfamily member 5,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,14,hyper-IgM syndrome type 3,0.8038021669520221,,1.941
P49810,PSEN2,Presenilin-2,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,2,early-onset autosomal dominant Alzheimer disease,0.8047686386596943,,1.941
P58335,ANTXR2,Anthrax toxin receptor 2,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,14,hyaline fibromatosis syndrome,0.8028849863986661,,1.941
O94766,B3GAT3,Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,3,"Larsen-like syndrome, B3GAT3 type",0.7995331164339264,,1.94
P61073,CXCR4,C-X-C chemokine receptor type 4,A_surface,"HPA protein class = CD markers, G-protein coupled receptors (cell-surface, extracellular epitope)",0,1,,,33,WHIM syndrome,0.8009225456235435,,1.94