id,gene_symbol,protein_name,surface_class,surface_evidence,ev_map_hallmark,in_cev_map,in_vesiclepedia,in_exocarta,pdb_count,top_disease,disease_score,drug_count_approved,targetability_score
P00451,F8,Coagulation factor VIII,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,25,hemophilia A,0.9108044347811838,,0.973
P12883,MYH7,Myosin-7,A_assoc,"HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)",0,1,,,43,hypertrophic cardiomyopathy,0.9029865147265421,,0.971
P00740,F9,Coagulation factor IX,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,56,hemophilia B,0.8880186703890781,,0.966
Q8NBP7,PCSK9,Proprotein convertase subtilisin/kexin type 9,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,62,familial hypercholesterolemia,0.8604029080346239,,0.958
P02461,COL3A1,Collagen alpha-1(III) chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,11,"Ehlers-Danlos syndrome, vascular type",0.8608667500207768,,0.958
P17405,SMPD1,Sphingomyelin phosphodiesterase,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,4,Niemann-Pick disease type A,0.8567797114449874,,0.957
P08709,F7,Coagulation factor VII,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,100,factor VII deficiency,0.8542078994169972,,0.956
P01008,SERPINC1,Antithrombin-III,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,27,hereditary antithrombin deficiency,0.8494671886642873,,0.955
P02452,COL1A1,Collagen alpha-1(I) chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,14,osteogenesis imperfecta type 2,0.8471150130101988,,0.954
P02462,COL4A1,Collagen alpha-1(IV) chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,4,brain small vessel disease 1 with or without ocular anomalies,0.84655287380359,,0.954
P03951,F11,Coagulation factor XI,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,100,factor XI deficiency,0.841884208404384,,0.953
P45379,TNNT2,"Troponin T, cardiac muscle",A_assoc,"HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)",0,1,,,25,hypertrophic cardiomyopathy,0.8329996050513441,,0.95
P02458,COL2A1,Collagen alpha-1(II) chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,11,spondyloepiphyseal dysplasia congenita,0.8334698564095305,,0.95
P08246,ELANE,Neutrophil elastase,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,38,cyclic hematopoiesis,0.8291093803980005,,0.949
P00450,CP,Ceruloplasmin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,4,aceruloplasminemia,0.8279493326009644,,0.948
P04180,LCAT,Phosphatidylcholine-sterol acyltransferase,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,7,Fish-eye disease,0.8273460309828392,,0.948
P00747,PLG,Plasminogen,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,49,hypoplasminogenemia,0.8240321266100769,,0.947
Q15582,TGFBI,Transforming growth factor-beta-induced protein ig-h3,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,10,lattice corneal dystrophy type I,0.8242841141270143,,0.947
P02649,APOE,Apolipoprotein E,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,29,coronary artery disease,0.81626595063263,,0.945
P06276,BCHE,Cholinesterase,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,100,butyrylcholinesterase deficiency,0.8051740584587205,,0.942
P06396,GSN,Gelsolin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,60,Finnish type amyloidosis,0.8048371651382773,,0.941
P02679,FGG,Fibrinogen gamma chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,48,familial dysfibrinogenemia,0.8002311001712851,,0.94
P07942,LAMB1,Laminin subunit beta-1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,3,cobblestone lissencephaly without muscular or ocular involvement,0.8016665947624902,,0.94
P20908,COL5A1,Collagen alpha-1(V) chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,1,"Ehlers-Danlos syndrome, classic type, 1",0.7979601586599098,,0.939
P02671,FGA,Fibrinogen alpha chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,40,familial dysfibrinogenemia,0.7947496460990987,,0.938
P02675,FGB,Fibrinogen beta chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,42,congenital afibrinogenemia,0.7892438060719716,,0.937
P22105,TNXB,Tenascin-X,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,3,Ehlers-Danlos syndrome due to tenascin-X deficiency,0.7916412481554758,,0.937
P03950,ANG,Angiogenin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,56,amyotrophic lateral sclerosis,0.7865457274017922,,0.936
P08253,MMP2,72 kDa type IV collagenase,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,14,Torg-Winchester syndrome,0.7862502046091417,,0.936
P35609,ACTN2,Alpha-actinin-2,A_assoc,"HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)",0,1,,,16,dilated cardiomyopathy 1AA,0.7856813926513253,,0.936
Q14623,IHH,Indian hedgehog protein,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,8,brachydactyly type A1,0.7871957785711762,,0.936
P10643,C7,Complement component C7,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,8,Immunodeficiency due to a late component of complements deficiency,0.7859621873711432,,0.936
P13645,KRT10,"Keratin, type I cytoskeletal 10",A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,6,"epidermolytic hyperkeratosis 2A, autosomal dominant",0.7860749239386174,,0.936
P39060,COL18A1,Collagen alpha-1(XVIII) chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,9,Knobloch syndrome 1,0.7867122552672962,,0.936
A6XGL2,INS,Insulin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,2,"diabetes mellitus, permanent neonatal 4",0.784300463357018,,0.935
Q12904,AIMP1,Aminoacyl tRNA synthase complex-interacting multifunctional protein 1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,6,hypomyelinating leukodystrophy 3,0.7806847123659254,,0.934
P35858,IGFALS,Insulin-like growth factor-binding protein complex acid labile subunit,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,1,Reduced insulin like growth factor binding protein acid labile subunit concentration,0.7760522769257892,,0.933
P02647,APOA1,Apolipoprotein A-I,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,32,"hypoalphalipoproteinemia, primary, 2",0.7727382344191134,,0.932
P02787,TF,Serotransferrin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,66,atransferrinemia,0.7724190608888654,,0.932
P00746,CFD,Complement factor D,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,40,recurrent Neisseria infections due to factor D deficiency,0.7726408204424132,,0.932
P35625,TIMP3,Metalloproteinase inhibitor 3,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,1,Sorsby fundus dystrophy,0.7684253675298044,,0.931
P07988,SFTPB,Pulmonary surfactant-associated protein B,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,9,Neonatal acute respiratory distress with surfactant metabolism deficiency,0.767375558073721,,0.93
P01009,SERPINA1,Alpha-1-antitrypsin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,46,Alpha-1-antitrypsin deficiency,0.764279219769394,,0.929
P02748,C9,Complement component C9,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,9,Immunodeficiency due to a late component of complements deficiency,0.761965409699055,,0.929
P27918,CFP,Properdin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,14,Properdin deficiency,0.7610265174382485,,0.928
O15230,LAMA5,Laminin subunit alpha-5,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,2,"nephrotic syndrome, IIa 26",0.7594872666460903,,0.928
P13671,C6,Complement component C6,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,11,Immunodeficiency due to a late component of complements deficiency,0.75437296887129,,0.926
P08603,CFH,Complement factor H,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,51,complement factor H deficiency,0.7508822531277052,,0.925
P01042,KNG1,Kininogen-1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,19,congenital high-molecular-weight kininogen deficiency,0.7480490551878497,,0.924
P05121,SERPINE1,Plasminogen activator inhibitor 1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,29,congenital plasminogen activator inhibitor type 1 deficiency,0.7325368931195121,,0.92