id,gene_symbol,protein_name,surface_class,surface_evidence,ev_map_hallmark,in_cev_map,in_vesiclepedia,in_exocarta,pdb_count,top_disease,disease_score,drug_count_approved,targetability_score
P11166,SLC2A1,"Solute carrier family 2, facilitated glucose transporter member 1",A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",1,1,,,5,encephalopathy due to GLUT1 deficiency,0.8521823225896756,,2.756
P07359,GP1BA,Platelet glycoprotein Ib alpha chain,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,22,Bernard-Soulier syndrome,0.8346884735388165,,2.75
P08514,ITGA2B,Integrin alpha-IIb,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,78,Glanzmann thrombasthenia 1,0.8224288672248264,,2.747
P14770,GP9,Platelet glycoprotein IX,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,2,Bernard-Soulier syndrome,0.8233582238860002,,2.747
P02730,SLC4A1,Band 3 anion transport protein,A_surface,"HPA protein class = Blood group antigen proteins, CD markers (cell-surface, extracellular epitope)",1,1,,,54,hereditary spherocytosis type 4,0.820137113225454,,2.746
P05106,ITGB3,Integrin beta-3,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,123,Glanzmann thrombasthenia 1,0.8208115968652424,,2.746
P16671,CD36,Platelet glycoprotein 4,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,1,platelet-type bleeding disorder 10,0.7360571429413174,,2.721
P08575,PTPRC,Receptor-type tyrosine-protein phosphatase C,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,6,immunodeficiency 104,0.7200430416648742,,2.716
P02786,TFRC,Transferrin receptor protein 1,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,22,TFRC-related combined immunodeficiency,0.623449899069336,,2.687
P05556,ITGB1,Integrin beta-1,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,22,multiple sclerosis,0.586769452063963,,2.676
P01764,IGHV3-23,Immunoglobulin heavy variable 3-23,A_surface,"HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)",1,1,,,6,cutaneous Leishmaniasis,0.5868213846274001,,2.676
P23083,IGHV1-2,Immunoglobulin heavy variable 1-2,A_surface,"HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)",1,1,,,1,cutaneous Leishmaniasis,0.5868213846274001,,2.676
P06312,IGKV4-1,Immunoglobulin kappa variable 4-1,A_surface,"HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)",1,1,,,10,cutaneous Leishmaniasis,0.5868213846274001,,2.676
Q12913,PTPRJ,Receptor-type tyrosine-protein phosphatase eta,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,5,neurodegenerative disease,0.54699134609967,,2.664
O00161,SNAP23,Synaptosomal-associated protein 23,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",1,1,,,2,neurodegenerative disease,0.5288361677964304,,2.659
P21926,CD9,CD9 antigen,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,5,diphtheria,0.5261379875719714,,2.658
P15144,ANPEP,Aminopeptidase N,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,15,cholelithiasis,0.5030146927270738,,2.651
P01871,IGHM,Immunoglobulin heavy constant mu,A_surface,"HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)",1,1,,,30,agammaglobulinemia,0.4624778576025314,,2.639
P01833,PIGR,Polymeric immunoglobulin receptor,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",1,1,,,16,clear cell renal carcinoma,0.44260204134234277,,2.633
P17301,ITGA2,Integrin alpha-2,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,16,Abnormality of the skeletal system,0.4227839911251069,,2.627
P11169,SLC2A3,"Solute carrier family 2, facilitated glucose transporter member 3",A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",1,1,,,7,neurodegenerative disease,0.4054698468991856,,2.622
Q08722,CD47,Leukocyte surface antigen CD47,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,15,myelodysplastic syndrome,0.3682348506170252,,2.61
Q9HBI1,PARVB,Beta-parvin,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",1,1,,,3,thyroiditis,0.28021156500366357,,2.584
P02746,C1QB,Complement C1q subcomponent subunit B,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",1,1,,,11,,,,2.5
P07225,PROS1,Vitamin K-dependent protein S,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,3,"thrombophilia due to protein S deficiency, autosomal dominant",0.8240418292042652,,1.747
P48740,MASP1,Mannan-binding lectin serine protease 1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,9,3MC syndrome 1,0.8185972518103526,,1.746
P21333,FLNA,Filamin-A,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),1,1,,,26,Melnick-Needles syndrome,0.8200516896124751,,1.746
Q9BWP8,COLEC11,Collectin-11,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,3,3MC syndrome 2,0.7977893521540559,,1.739
P12259,F5,Coagulation factor V,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,17,thrombophilia due to activated protein C resistance,0.7962069693286362,,1.739
P00488,F13A1,Coagulation factor XIII A chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,15,Factor XIII subunit A deficiency,0.7939842013132387,,1.738
O43707,ACTN4,Alpha-actinin-4,A_assoc,"HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)",1,1,,,5,focal segmental glomerulosclerosis 1,0.7778533437264424,,1.733
P26038,MSN,Moesin,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),1,1,,,10,combined immunodeficiency due to moesin deficiency,0.7157135146765757,,1.715
P84077,ARF1,ADP-ribosylation factor 1,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),1,1,,,36,periventricular nodular heterotopia 8,0.7173626622431929,,1.715
P07948,LYN,Tyrosine-protein kinase Lyn,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),1,1,,,6,"autoinflammatory disease, systemic, with vasculitis",0.7119500711989845,,1.714
O00187,MASP2,Mannan-binding lectin serine protease 2,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,10,immunodeficiency due to MASP-2 deficiency,0.6996393077218865,,1.71
P18206,VCL,Vinculin,A_assoc,"HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)",1,1,,,37,hypertrophic cardiomyopathy,0.6924271529635582,,1.708
P61586,RHOA,Transforming protein RhoA,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),1,1,,,100,"ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies",0.6804889074382072,,1.704
P12931,SRC,Proto-oncogene tyrosine-protein kinase Src,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),1,1,,,78,cancer,0.6343904000453656,,1.69
P02745,C1QA,Complement C1q subcomponent subunit A,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,11,C1Q deficiency 1,0.6319053256658114,,1.69
P62937,PPIA,Peptidyl-prolyl cis-trans isomerase A,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,100,HIV infection,0.6219943433906236,,1.687
P02747,C1QC,Complement C1q subcomponent subunit C,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,11,C1Q deficiency,0.6233532074390745,,1.687
P04406,GAPDH,Glyceraldehyde-3-phosphate dehydrogenase,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),1,1,,,21,neurodegenerative disease,0.55307368855439,,1.666
Q14766,LTBP1,Latent-transforming growth factor beta-binding protein 1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,1,Abnormality of the skeletal system,0.5142669818409414,,1.654
O00194,RAB27B,Ras-related protein Rab-27B,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),1,1,,,1,major depressive disorder,0.4805047942947544,,1.644
P04899,GNAI2,Guanine nucleotide-binding protein G(i) subunit alpha-2,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),1,1,,,34,ovarian granulosa cell tumor,0.4157773365202895,,1.625
P06702,S100A9,Protein S100-A9,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),1,1,,,13,inborn error of immunity,0.36994943453938645,,1.611
P05109,S100A8,Protein S100-A8,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,13,inborn error of immunity,0.37050380432141355,,1.611
O43866,CD5L,CD5 antigen-like,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,4,functional neutrophil defect,0.3529395470693119,,1.606
P07996,THBS1,Thrombospondin-1,A2_pm_peripheral,HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside),1,1,,,11,autism spectrum disorder,0.3356118729017016,,1.601
P48059,LIMS1,LIM and senescent cell antigen-like-containing domain protein 1,A_assoc,"HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)",1,1,,,14,Abruptio Placentae,0.3236383460637068,,1.597