id,gene_symbol,protein_name,surface_class,surface_evidence,ev_map_hallmark,in_cev_map,in_vesiclepedia,in_exocarta,pdb_count,top_disease,disease_score,drug_count_approved,targetability_score
P07225,PROS1,Vitamin K-dependent protein S,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,3,"thrombophilia due to protein S deficiency, autosomal dominant",0.8240418292042652,,1.747
P48740,MASP1,Mannan-binding lectin serine protease 1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,9,3MC syndrome 1,0.8185972518103526,,1.746
Q9BWP8,COLEC11,Collectin-11,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,3,3MC syndrome 2,0.7977893521540559,,1.739
P12259,F5,Coagulation factor V,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,17,thrombophilia due to activated protein C resistance,0.7962069693286362,,1.739
P00488,F13A1,Coagulation factor XIII A chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,15,Factor XIII subunit A deficiency,0.7939842013132387,,1.738
O43707,ACTN4,Alpha-actinin-4,A_assoc,"HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)",1,1,,,5,focal segmental glomerulosclerosis 1,0.7778533437264424,,1.733
O00187,MASP2,Mannan-binding lectin serine protease 2,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,10,immunodeficiency due to MASP-2 deficiency,0.6996393077218865,,1.71
P18206,VCL,Vinculin,A_assoc,"HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)",1,1,,,37,hypertrophic cardiomyopathy,0.6924271529635582,,1.708
P02745,C1QA,Complement C1q subcomponent subunit A,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,11,C1Q deficiency 1,0.6319053256658114,,1.69
P62937,PPIA,Peptidyl-prolyl cis-trans isomerase A,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,100,HIV infection,0.6219943433906236,,1.687
P02747,C1QC,Complement C1q subcomponent subunit C,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,11,C1Q deficiency,0.6233532074390745,,1.687
Q14766,LTBP1,Latent-transforming growth factor beta-binding protein 1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,1,Abnormality of the skeletal system,0.5142669818409414,,1.654
P05109,S100A8,Protein S100-A8,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,13,inborn error of immunity,0.37050380432141355,,1.611
O43866,CD5L,CD5 antigen-like,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,4,functional neutrophil defect,0.3529395470693119,,1.606
P48059,LIMS1,LIM and senescent cell antigen-like-containing domain protein 1,A_assoc,"HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)",1,1,,,14,Abruptio Placentae,0.3236383460637068,,1.597
Q15485,FCN2,Ficolin-2,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,13,hypopituitarism,0.2753784074131916,,1.583
P01023,A2M,Alpha-2-macroglobulin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,13,refractive error,0.2285030343788678,,1.569
P02775,PPBP,Platelet basic protein,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,3,neoplasm,0.10852035364075,,1.533
P20851,C4BPB,C4b-binding protein beta chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,0,venous thromboembolism,0.5408858413761136,,1.262
Q13201,MMRN1,Multimerin-1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,0,Parkinson disease,0.3658959071578607,,1.21