id,gene_symbol,protein_name,surface_class,surface_evidence,ev_map_hallmark,in_cev_map,in_vesiclepedia,in_exocarta,pdb_count,top_disease,disease_score,drug_count_approved,targetability_score
Q00604,NDP,Norrin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,11,Norrie disease,0.8566451682188412,,0.657
P15884,TCF4,Transcription factor 4,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,5,Pitt-Hopkins syndrome,0.8490531860867685,,0.655
Q9NZK5,ADA2,Adenosine deaminase 2,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,2,deficiency of adenosine deaminase 2,0.8291292532404531,,0.649
Q99972,MYOC,Myocilin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,24,"glaucoma 1, open angle, A",0.8294483747483756,,0.649
O95970,LGI1,Leucine-rich glioma-inactivated protein 1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,9,autosomal dominant epilepsy with auditory features,0.8225657483127345,,0.647
Q9UBH0,IL36RN,Interleukin-36 receptor antagonist protein,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,3,"psoriasis 14, pustular",0.8155144873787125,,0.645
P20062,TCN2,Transcobalamin-2,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,11,transcobalamin II deficiency,0.8116989428679681,,0.644
Q96MK3,FAM20A,Pseudokinase FAM20A,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,4,amelogenesis imperfecta type 1G,0.8106031517056754,,0.643
P55000,SLURP1,Secreted Ly-6/uPAR-related protein 1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,2,mal de Meleda,0.8064330379723671,,0.642
P45452,MMP13,Collagenase 3,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,49,"spondyloepimetaphyseal dysplasia, Missouri type",0.8032079813035149,,0.641
P29460,IL12B,Interleukin-12 subunit beta,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,20,psoriasis,0.7914863943708039,,0.637
Q13253,NOG,Noggin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,2,proximal symphalangism 1A,0.7844136456463046,,0.635
P03971,AMH,Anti-Muellerian hormone,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,3,persistent Mullerian duct syndrome,0.7847328444470535,,0.635
Q96S42,NODAL,Nodal homolog,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,1,"heterotaxy, visceral, 5, autosomal",0.7788051667024423,,0.634
P01138,NGF,Beta-nerve growth factor,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,8,hereditary sensory and autonomic neuropathy type 5,0.7785402119369383,,0.634
P18510,IL1RN,Interleukin-1 receptor antagonist protein,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,5,sterile multifocal osteomyelitis with periostitis and pustulosis,0.7734282711738736,,0.632
P29120,PCSK1,Neuroendocrine convertase 1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,3,obesity due to prohormone convertase I deficiency,0.773875795833803,,0.632
P00797,REN,Renin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,91,familial juvenile hyperuricemic nephropathy type 2,0.7657976389758877,,0.63
P05019,IGF1,Insulin-like growth factor 1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,32,growth delay due to insulin-like growth factor type 1 deficiency,0.7650418939376437,,0.63
Q9GZV9,FGF23,Fibroblast growth factor 23,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,6,autosomal dominant hypophosphatemic rickets,0.762326334964193,,0.629
P20849,COL9A1,Collagen alpha-1(IX) chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,5,Stickler syndrome,0.7594904923903256,,0.628
P16112,ACAN,Aggrecan core protein,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,4,Familial osteochondritis dissecans,0.7558487616449627,,0.627
P55789,GFER,FAD-linked sulfhydryl oxidase ALR,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,7,congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome,0.7556346526616893,,0.627
Q12794,HYAL1,Hyaluronidase-1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,1,Hyaluronidase deficiency,0.7412407206736383,,0.622
Q92752,TNR,Tenascin-R,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,2,"neurodevelopmental disorder, nonprogressive, with spasticity and transient opisthotonus",0.7403484347367364,,0.622
O15520,FGF10,Fibroblast growth factor 10,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,2,Lacrimoauriculodentodigital syndrome,0.7344198619465704,,0.62
P35225,IL13,Interleukin-13,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,13,atopic eczema,0.7297489019498119,,0.619
Q2MKA7,RSPO1,R-spondin-1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,12,palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome,0.7285342885472184,,0.619
Q9BQB4,SOST,Sclerostin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,3,sclerosteosis 1,0.7184345506579789,,0.616
P05305,EDN1,Endothelin-1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,17,auriculocondylar syndrome,0.7193561828311311,,0.616
P12272,PTHLH,Parathyroid hormone-related protein,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,11,brachydactyly type E,0.7203484375635054,,0.616
O00300,TNFRSF11B,Tumor necrosis factor receptor superfamily member 11B,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,1,juvenile Paget disease,0.7184894548525037,,0.616
Q99574,SERPINI1,Neuroserpin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,3,familial encephalopathy with neuroserpin inclusion bodies,0.7162803151916303,,0.615
P01270,PTH,Parathyroid hormone,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,26,"hypoparathyroidism, familial isolated 1",0.7147450451832739,,0.614
P11686,SFTPC,Surfactant protein C,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,3,Congenital pulmonary alveolar proteinosis,0.7110128683619542,,0.613
O43897,TLL1,,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,1,atrial heart septal defect,0.7050140477090344,,0.612
P19835,CEL,Bile salt-activated lipase,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,7,MODY,0.6940743944678538,,0.608
O43323,DHH,Desert hedgehog protein,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,5,"46,XY gonadal dysgenesis-motor and sensory neuropathy syndrome",0.6912706692651148,,0.607
P27352,CBLIF,Cobalamin binding intrinsic factor,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,2,hereditary intrinsic factor deficiency,0.683930100359911,,0.605
Q9Y5C1,ANGPTL3,Angiopoietin-related protein 3,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,1,familial hypobetalipoproteinemia 2,0.6739043862507132,,0.602
Q9Y5K2,KLK4,Kallikrein-4,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,18,Hypomaturation amelogenesis imperfecta,0.6659029046455642,,0.6
Q8N300,SVBP,Small vasohibin-binding protein,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,24,"neurodevelopmental disorder with ataxia, hypotonia, and microcephaly",0.6640118055835142,,0.599
O95631,NTN1,Netrin-1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,5,mirror movements 4,0.6611393488240481,,0.598
P05113,IL5,Interleukin-5,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,5,asthma,0.6399821251487101,,0.592
Q16552,IL17A,Interleukin-17A,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,44,psoriasis,0.6367521314106471,,0.591
O95390,GDF11,Growth/differentiation factor 11,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,5,vertebral hypersegmentation and orofacial anomalies,0.6207007733160915,,0.586
P05230,FGF1,Fibroblast growth factor 1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,96,cancer,0.6088477966360052,,0.583
P22894,MMP8,Neutrophil collagenase,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,25,acne,0.603247809982021,,0.581
P09237,MMP7,Matrilysin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,16,acne,0.603247809982021,,0.581
O76093,FGF18,Fibroblast growth factor 18,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,0,,,1,cancer,0.6028027301556572,,0.581