id,gene_symbol,protein_name,surface_class,surface_evidence,ev_map_hallmark,in_cev_map,in_vesiclepedia,in_exocarta,pdb_count,top_disease,disease_score,drug_count_approved,targetability_score
P13569,CFTR,Cystic fibrosis transmembrane conductance regulator,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,0,,,58,cystic fibrosis,0.9133535862571094,,1.674
Q14654,KCNJ11,ATP-sensitive inward rectifier potassium channel 11,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,0,,,9,type 2 diabetes mellitus,0.8651421397012851,,1.66
P07949,RET,Proto-oncogene tyrosine-protein kinase receptor Ret,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,0,,,34,medullary thyroid gland carcinoma,0.8617460262224842,,1.659
O95255,ABCC6,ATP-binding cassette sub-family C member 6,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,0,,,4,Pseudoxanthoma elasticum,0.864631668818611,,1.659
Q12809,KCNH2,Voltage-gated inwardly rectifying potassium channel KCNH2,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,0,,,23,Romano-Ward syndrome,0.8549238933917284,,1.656
P21439,ABCB4,Phosphatidylcholine translocator ABCB4,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,0,,,4,progressive familial intrahepatic cholestasis type 3,0.851728159166962,,1.656
P82251,SLC7A9,"b(0,+)-type amino acid transporter 1",A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,0,,,4,cystinuria,0.8484952668941285,,1.655
Q695T7,SLC6A19,Sodium-dependent neutral amino acid transporter B(0)AT1,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,0,,,19,Hartnup disease,0.8464240093600148,,1.654
P41180,CASR,Extracellular calcium-sensing receptor,A_surface,"HPA protein class = G-protein coupled receptors (cell-surface, extracellular epitope)",0,0,,,31,familial hypocalciuric hypercalcemia 1,0.8460848589627423,,1.654
P31785,IL2RG,Cytokine receptor common subunit gamma,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,0,,,14,gamma chain deficiency,0.8469997000418428,,1.654
Q9UM01,SLC7A7,Y+L amino acid transporter 1,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,0,,,5,lysinuric protein intolerance,0.8450026270275782,,1.654
P08100,RHO,Rhodopsin,A_surface,"HPA protein class = G-protein coupled receptors (cell-surface, extracellular epitope)",0,0,,,4,retinitis pigmentosa,0.8481942240861982,,1.654
P48029,SLC6A8,Sodium- and chloride-dependent creatine transporter 1,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,0,,,6,creatine transporter deficiency,0.847268393806457,,1.654
Q05586,GRIN1,"Glutamate receptor ionotropic, NMDA 1",A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,0,,,84,"neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant",0.8446685494288694,,1.653
P07911,UMOD,Uromodulin,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,0,,,10,familial juvenile hyperuricemic nephropathy type 1,0.8446536377993564,,1.653
O43526,KCNQ2,Potassium voltage-gated channel subfamily KQT member 2,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,0,,,24,Benign familial neonatal seizures,0.8423358217314708,,1.653
Q9UQD0,SCN8A,Sodium channel protein type 8 subunit alpha,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,0,,,4,"developmental and epileptic encephalopathy, 13",0.8437707419548253,,1.653
P07333,CSF1R,Macrophage colony-stimulating factor 1 receptor,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,0,,,26,"leukoencephalopathy, diffuse hereditary, with spheroids 1",0.8391971566583056,,1.652
Q9HBA0,TRPV4,Transient receptor potential cation channel subfamily V member 4,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,0,,,19,metatropic dysplasia,0.8356240344517467,,1.651
O95342,ABCB11,Bile salt export pump,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,0,,,8,progressive familial intrahepatic cholestasis type 2,0.8372060401943777,,1.651
P78508,KCNJ10,ATP-sensitive inward rectifier potassium channel 10,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,0,,,4,EAST syndrome,0.8357483559927158,,1.651
P42262,GRIA2,Glutamate receptor 2,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,0,,,16,neurodevelopmental disorder with language impairment and behavioral abnormalities,0.8328652004757138,,1.65
P16473,TSHR,Thyrotropin receptor,A_surface,"HPA protein class = G-protein coupled receptors (cell-surface, extracellular epitope)",0,0,,,9,hypothyroidism due to TSH receptor mutations,0.8327127196409464,,1.65
Q92736,RYR2,Ryanodine receptor 2,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,0,,,26,catecholaminergic polymorphic ventricular tachycardia 1,0.8338648743498255,,1.65
P30968,GNRHR,Gonadotropin-releasing hormone receptor,A_surface,"HPA protein class = G-protein coupled receptors (cell-surface, extracellular epitope)",0,0,,,1,hypogonadotropic hypogonadism,0.83100005285263,,1.649
Q16281,CNGA3,Cyclic nucleotide-gated channel alpha-3,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,0,,,10,achromatopsia,0.8315799021867489,,1.649
P10912,GHR,Growth hormone receptor,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,0,,,9,Laron syndrome,0.8304020079647765,,1.649
P13866,SLC5A1,Sodium/glucose cotransporter 1,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,0,,,4,glucose-galactose malabsorption,0.8220991027793896,,1.647
Q04844,CHRNE,Acetylcholine receptor subunit epsilon,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,0,,,13,Congenital myasthenic syndromes,0.8223287249629152,,1.647
Q8IZF0,NALCN,Sodium leak channel NALCN,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,0,,,5,"congenital contractures of the limbs and face, hypotonia, and developmental delay",0.8198033442161259,,1.646
P23942,PRPH2,Peripherin-2,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,0,,,1,retinitis pigmentosa,0.8194208847382956,,1.646
Q9BZV2,SLC19A3,Thiamine transporter 2,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,0,,,19,biotin-responsive basal ganglia disease,0.8189646480334981,,1.646
P41181,AQP2,Aquaporin-2,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,0,,,7,"diabetes insipidus, nephrogenic, autosomal",0.817870726313342,,1.645
Q9ULV1,FZD4,Frizzled-4,A_surface,"HPA protein class = CD markers, G-protein coupled receptors (cell-surface, extracellular epitope)",0,0,,,11,Familial exudative vitreoretinopathy,0.8152111103672746,,1.645
Q13651,IL10RA,Interleukin-10 receptor subunit alpha,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,0,,,7,Autosomal recessive early-onset inflammatory bowel disease,0.8151052076044897,,1.645
Q5JUK3,KCNT1,Potassium channel subfamily T member 1,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,0,,,6,"developmental and epileptic encephalopathy, 14",0.8165232785825526,,1.645
Q01974,ROR2,Tyrosine-protein kinase transmembrane receptor ROR2,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,0,,,6,autosomal recessive Robinow syndrome,0.8145559265435566,,1.644
Q9H222,ABCG5,ATP-binding cassette sub-family G member 5,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,0,,,8,sitosterolemia,0.810555184820483,,1.643
Q9UM73,ALK,ALK tyrosine kinase receptor,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,0,,,79,neuroblastoma,0.8016889264946979,,1.641
Q9NQW8,CNGB3,Cyclic nucleotide-gated channel beta-3,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,0,,,9,achromatopsia,0.8033348000666748,,1.641
Q12866,MERTK,Tyrosine-protein kinase Mer,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,0,,,42,retinitis pigmentosa,0.7985580877708576,,1.64
Q4KMG0,CDON,Cell adhesion molecule-related/down-regulated by oncogenes,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,0,,,3,holoprosencephaly,0.800378039564866,,1.64
Q01718,MC2R,Adrenocorticotropic hormone receptor,A_surface,"HPA protein class = G-protein coupled receptors (cell-surface, extracellular epitope)",0,0,,,2,familial glucocorticoid deficiency,0.8001007686411645,,1.64
Q9H1D0,TRPV6,Transient receptor potential cation channel subfamily V member 6,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,0,,,24,"hyperparathyroidism, transient neonatal",0.7964821997780153,,1.639
P16871,IL7R,Interleukin-7 receptor subunit alpha,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,0,,,8,immunodeficiency 104,0.7983119488718231,,1.639
O43525,KCNQ3,Potassium voltage-gated channel subfamily KQT member 3,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,0,,,1,Benign familial neonatal seizures,0.7961763561533409,,1.639
P37023,ACVRL1,Activin receptor type-1-like,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,0,,,7,"telangiectasia, hereditary hemorrhagic, type 2",0.7951167515831324,,1.639
P15509,CSF2RA,Granulocyte-macrophage colony-stimulating factor receptor subunit alpha,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,0,,,2,Congenital pulmonary alveolar proteinosis,0.7922592394513138,,1.638
Q14028,CNGB1,Cyclic nucleotide-gated channel beta-1,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,0,,,11,retinitis pigmentosa,0.7931901344765326,,1.638
P16410,CTLA4,Cytotoxic T-lymphocyte protein 4,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,0,,,22,autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency,0.7906408646569979,,1.637