id,gene_symbol,protein_name,surface_class,surface_evidence,ev_map_hallmark,in_cev_map,in_vesiclepedia,in_exocarta,pdb_count,top_disease,disease_score,drug_count_approved,targetability_score
P07225,PROS1,Vitamin K-dependent protein S,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,3,"thrombophilia due to protein S deficiency, autosomal dominant",0.8240418292042652,,1.747
P48740,MASP1,Mannan-binding lectin serine protease 1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,9,3MC syndrome 1,0.8185972518103526,,1.746
Q9BWP8,COLEC11,Collectin-11,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,3,3MC syndrome 2,0.7977893521540559,,1.739
P12259,F5,Coagulation factor V,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,17,thrombophilia due to activated protein C resistance,0.7962069693286362,,1.739
P00488,F13A1,Coagulation factor XIII A chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,15,Factor XIII subunit A deficiency,0.7939842013132387,,1.738
O43707,ACTN4,Alpha-actinin-4,A_assoc,"HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)",1,1,,,5,focal segmental glomerulosclerosis 1,0.7778533437264424,,1.733
O00187,MASP2,Mannan-binding lectin serine protease 2,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,10,immunodeficiency due to MASP-2 deficiency,0.6996393077218865,,1.71
P18206,VCL,Vinculin,A_assoc,"HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)",1,1,,,37,hypertrophic cardiomyopathy,0.6924271529635582,,1.708
P02745,C1QA,Complement C1q subcomponent subunit A,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,11,C1Q deficiency 1,0.6319053256658114,,1.69
P62937,PPIA,Peptidyl-prolyl cis-trans isomerase A,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,100,HIV infection,0.6219943433906236,,1.687
P02747,C1QC,Complement C1q subcomponent subunit C,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,11,C1Q deficiency,0.6233532074390745,,1.687
Q14766,LTBP1,Latent-transforming growth factor beta-binding protein 1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,1,Abnormality of the skeletal system,0.5142669818409414,,1.654
P05109,S100A8,Protein S100-A8,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,13,inborn error of immunity,0.37050380432141355,,1.611
O43866,CD5L,CD5 antigen-like,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,4,functional neutrophil defect,0.3529395470693119,,1.606
P48059,LIMS1,LIM and senescent cell antigen-like-containing domain protein 1,A_assoc,"HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)",1,1,,,14,Abruptio Placentae,0.3236383460637068,,1.597
Q15485,FCN2,Ficolin-2,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,13,hypopituitarism,0.2753784074131916,,1.583
P01023,A2M,Alpha-2-macroglobulin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,13,refractive error,0.2285030343788678,,1.569
P02775,PPBP,Platelet basic protein,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,3,neoplasm,0.10852035364075,,1.533
P20851,C4BPB,C4b-binding protein beta chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,0,venous thromboembolism,0.5408858413761136,,1.262
Q13201,MMRN1,Multimerin-1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",1,1,,,0,Parkinson disease,0.3658959071578607,,1.21
P00451,F8,Coagulation factor VIII,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,25,hemophilia A,0.9108044347811838,,0.973
P12883,MYH7,Myosin-7,A_assoc,"HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)",0,1,,,43,hypertrophic cardiomyopathy,0.9029865147265421,,0.971
P00740,F9,Coagulation factor IX,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,56,hemophilia B,0.8880186703890781,,0.966
Q8NBP7,PCSK9,Proprotein convertase subtilisin/kexin type 9,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,62,familial hypercholesterolemia,0.8604029080346239,,0.958
P02461,COL3A1,Collagen alpha-1(III) chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,11,"Ehlers-Danlos syndrome, vascular type",0.8608667500207768,,0.958
P17405,SMPD1,Sphingomyelin phosphodiesterase,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,4,Niemann-Pick disease type A,0.8567797114449874,,0.957
P08709,F7,Coagulation factor VII,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,100,factor VII deficiency,0.8542078994169972,,0.956
P01008,SERPINC1,Antithrombin-III,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,27,hereditary antithrombin deficiency,0.8494671886642873,,0.955
P02452,COL1A1,Collagen alpha-1(I) chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,14,osteogenesis imperfecta type 2,0.8471150130101988,,0.954
P02462,COL4A1,Collagen alpha-1(IV) chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,4,brain small vessel disease 1 with or without ocular anomalies,0.84655287380359,,0.954
P03951,F11,Coagulation factor XI,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,100,factor XI deficiency,0.841884208404384,,0.953
P45379,TNNT2,"Troponin T, cardiac muscle",A_assoc,"HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)",0,1,,,25,hypertrophic cardiomyopathy,0.8329996050513441,,0.95
P02458,COL2A1,Collagen alpha-1(II) chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,11,spondyloepiphyseal dysplasia congenita,0.8334698564095305,,0.95
P08246,ELANE,Neutrophil elastase,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,38,cyclic hematopoiesis,0.8291093803980005,,0.949
P00450,CP,Ceruloplasmin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,4,aceruloplasminemia,0.8279493326009644,,0.948
P04180,LCAT,Phosphatidylcholine-sterol acyltransferase,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,7,Fish-eye disease,0.8273460309828392,,0.948
P00747,PLG,Plasminogen,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,49,hypoplasminogenemia,0.8240321266100769,,0.947
Q15582,TGFBI,Transforming growth factor-beta-induced protein ig-h3,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,10,lattice corneal dystrophy type I,0.8242841141270143,,0.947
P02649,APOE,Apolipoprotein E,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,29,coronary artery disease,0.81626595063263,,0.945
P06276,BCHE,Cholinesterase,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,100,butyrylcholinesterase deficiency,0.8051740584587205,,0.942
P06396,GSN,Gelsolin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,60,Finnish type amyloidosis,0.8048371651382773,,0.941
P02679,FGG,Fibrinogen gamma chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,48,familial dysfibrinogenemia,0.8002311001712851,,0.94
P07942,LAMB1,Laminin subunit beta-1,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,3,cobblestone lissencephaly without muscular or ocular involvement,0.8016665947624902,,0.94
P20908,COL5A1,Collagen alpha-1(V) chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,1,"Ehlers-Danlos syndrome, classic type, 1",0.7979601586599098,,0.939
P02671,FGA,Fibrinogen alpha chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,40,familial dysfibrinogenemia,0.7947496460990987,,0.938
P02675,FGB,Fibrinogen beta chain,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,42,congenital afibrinogenemia,0.7892438060719716,,0.937
P22105,TNXB,Tenascin-X,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,3,Ehlers-Danlos syndrome due to tenascin-X deficiency,0.7916412481554758,,0.937
P03950,ANG,Angiogenin,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,56,amyotrophic lateral sclerosis,0.7865457274017922,,0.936
P08253,MMP2,72 kDa type IV collagenase,A_assoc,"HPA Predicted secreted (soluble; may form EV surface corona, not integral)",0,1,,,14,Torg-Winchester syndrome,0.7862502046091417,,0.936
P35609,ACTN2,Alpha-actinin-2,A_assoc,"HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)",0,1,,,16,dilated cardiomyopathy 1AA,0.7856813926513253,,0.936