id,gene_symbol,protein_name,surface_class,surface_evidence,ev_map_hallmark,in_cev_map,in_vesiclepedia,in_exocarta,pdb_count,top_disease,disease_score,drug_count_approved,targetability_score
P11166,SLC2A1,"Solute carrier family 2, facilitated glucose transporter member 1",A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",1,1,,,5,encephalopathy due to GLUT1 deficiency,0.8521823225896756,,2.756
P07359,GP1BA,Platelet glycoprotein Ib alpha chain,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,22,Bernard-Soulier syndrome,0.8346884735388165,,2.75
P08514,ITGA2B,Integrin alpha-IIb,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,78,Glanzmann thrombasthenia 1,0.8224288672248264,,2.747
P14770,GP9,Platelet glycoprotein IX,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,2,Bernard-Soulier syndrome,0.8233582238860002,,2.747
P02730,SLC4A1,Band 3 anion transport protein,A_surface,"HPA protein class = Blood group antigen proteins, CD markers (cell-surface, extracellular epitope)",1,1,,,54,hereditary spherocytosis type 4,0.820137113225454,,2.746
P05106,ITGB3,Integrin beta-3,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,123,Glanzmann thrombasthenia 1,0.8208115968652424,,2.746
P16671,CD36,Platelet glycoprotein 4,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,1,platelet-type bleeding disorder 10,0.7360571429413174,,2.721
P08575,PTPRC,Receptor-type tyrosine-protein phosphatase C,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,6,immunodeficiency 104,0.7200430416648742,,2.716
P02786,TFRC,Transferrin receptor protein 1,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,22,TFRC-related combined immunodeficiency,0.623449899069336,,2.687
P05556,ITGB1,Integrin beta-1,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,22,multiple sclerosis,0.586769452063963,,2.676
P01764,IGHV3-23,Immunoglobulin heavy variable 3-23,A_surface,"HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)",1,1,,,6,cutaneous Leishmaniasis,0.5868213846274001,,2.676
P23083,IGHV1-2,Immunoglobulin heavy variable 1-2,A_surface,"HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)",1,1,,,1,cutaneous Leishmaniasis,0.5868213846274001,,2.676
P06312,IGKV4-1,Immunoglobulin kappa variable 4-1,A_surface,"HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)",1,1,,,10,cutaneous Leishmaniasis,0.5868213846274001,,2.676
Q12913,PTPRJ,Receptor-type tyrosine-protein phosphatase eta,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,5,neurodegenerative disease,0.54699134609967,,2.664
O00161,SNAP23,Synaptosomal-associated protein 23,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",1,1,,,2,neurodegenerative disease,0.5288361677964304,,2.659
P21926,CD9,CD9 antigen,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,5,diphtheria,0.5261379875719714,,2.658
P15144,ANPEP,Aminopeptidase N,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,15,cholelithiasis,0.5030146927270738,,2.651
P01871,IGHM,Immunoglobulin heavy constant mu,A_surface,"HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)",1,1,,,30,agammaglobulinemia,0.4624778576025314,,2.639
P01833,PIGR,Polymeric immunoglobulin receptor,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",1,1,,,16,clear cell renal carcinoma,0.44260204134234277,,2.633
P17301,ITGA2,Integrin alpha-2,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,16,Abnormality of the skeletal system,0.4227839911251069,,2.627
P11169,SLC2A3,"Solute carrier family 2, facilitated glucose transporter member 3",A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",1,1,,,7,neurodegenerative disease,0.4054698468991856,,2.622
Q08722,CD47,Leukocyte surface antigen CD47,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",1,1,,,15,myelodysplastic syndrome,0.3682348506170252,,2.61
Q9HBI1,PARVB,Beta-parvin,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",1,1,,,3,thyroiditis,0.28021156500366357,,2.584
P02746,C1QB,Complement C1q subcomponent subunit B,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",1,1,,,11,,,,2.5
P21359,NF1,Neurofibromin,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,26,neurofibromatosis type 1,0.8844735398780649,,1.965
P33897,ABCD1,ATP-binding cassette sub-family D member 1,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,14,adrenoleukodystrophy,0.8656366512509434,,1.96
P04839,CYBB,NADPH oxidase 2,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,6,chronic granulomatous disease,0.8633132852459866,,1.959
P21802,FGFR2,Fibroblast growth factor receptor 2,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,62,Crouzon syndrome,0.8637438969881663,,1.959
P78504,JAG1,Protein jagged-1,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,7,Alagille syndrome due to a JAG1 point mutation,0.8586542923232751,,1.958
P00813,ADA,Adenosine deaminase,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,2,Severe combined immunodeficiency due to adenosine deaminase deficiency,0.8556816060494579,,1.957
P36021,SLC16A2,Monocarboxylate transporter 8,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,7,Allan-Herndon-Dudley syndrome,0.8533069932022032,,1.956
P51795,CLCN5,H(+)/Cl(-) exchange transporter 5,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,2,Dent disease type 1,0.850724240157394,,1.955
P29965,CD40LG,CD40 ligand,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,8,hyper-IgM syndrome type 1,0.8451678829647167,,1.954
P11362,FGFR1,Fibroblast growth factor receptor 1,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,82,hypogonadotropic hypogonadism 2 with or without anosmia,0.8472925100660907,,1.954
Q9NQ11,ATP13A2,Polyamine-transporting ATPase 13A2,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,25,Kufor-Rakeb syndrome,0.8439049037191295,,1.953
P08581,MET,Hepatocyte growth factor receptor,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,100,papillary renal cell carcinoma,0.84195976263742,,1.953
P06213,INSR,Insulin receptor,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,87,Leprechaunism,0.8448849372402896,,1.953
Q8WZ42,TTN,Titin,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,64,dilated cardiomyopathy,0.8419847660466327,,1.953
Q14524,SCN5A,Sodium channel protein type 5 subunit alpha,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,1,,,16,long QT syndrome 3,0.8448298602976083,,1.953
Q969N2,PIGT,GPI-anchor transamidase component PIGT,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,3,multiple congenital anomalies-hypotonia-seizures syndrome 3,0.8439030764005646,,1.953
P13637,ATP1A3,Sodium/potassium-transporting ATPase subunit alpha-3,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,5,alternating hemiplegia of childhood 2,0.842328126568451,,1.953
P37173,TGFBR2,TGF-beta receptor type-2,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,22,Loeys-Dietz syndrome,0.8390072008866913,,1.952
P35499,SCN4A,Sodium channel protein type 4 subunit alpha,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,1,,,3,paramyotonia congenita of Von Eulenburg,0.8401628899371881,,1.952
Q99250,SCN2A,Sodium channel protein type 2 subunit alpha,A_surface,"HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)",0,1,,,5,"developmental and epileptic encephalopathy, 11",0.8388748085806758,,1.952
O00571,DDX3X,ATP-dependent RNA helicase DDX3X,A_surface,"HPA integral membrane protein, Plasma membrane (extracellular domain reachable)",0,1,,,17,X-linked non-syndromic intellectual disability,0.8362533125067105,,1.951
P19438,TNFRSF1A,Tumor necrosis factor receptor superfamily member 1A,A_surface,"HPA protein class = CD markers (cell-surface, extracellular epitope)",0,1,,,13,TNF receptor 1-associated periodic fever syndrome,0.8352778213184682,,1.951
P25189,MPZ,Myelin protein P0,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,2,Charcot-Marie-Tooth disease type 1B,0.8377022197539885,,1.951
P54760,EPHB4,Ephrin type-B receptor 4,A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,23,Capillary malformation - arteriovenous malformation,0.8317426466005666,,1.95
Q9HAB3,SLC52A2,"Solute carrier family 52, riboflavin transporter, member 2",A_surface,"HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)",0,1,,,1,riboflavin transporter deficiency,0.8333271825486935,,1.95
Q9Y653,ADGRG1,Adhesion G-protein coupled receptor G1,A_surface,"HPA protein class = G-protein coupled receptors (cell-surface, extracellular epitope)",0,1,,,1,bilateral frontoparietal polymicrogyria,0.8322298896713178,,1.95