{"database": "scout", "table": "v_surface_targets", "is_view": true, "human_description_en": "where ev_map_hallmark = 0, in_cev_map = 0 and surface_class = \"A2_pm_peripheral\" sorted by targetability_score descending", "rows": [["P25054", "APC", "Adenomatous polyposis coli protein", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 31, "familial adenomatous polyposis 1", 0.8462165290909345, null, 0.654], ["Q9Y4U1", "MMACHC", "Cyanocobalamin reductase / alkylcobalamin dealkylase", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 7, "Methylmalonic acidemia with homocystinuria, type cblC", 0.8478185420804271, null, 0.654], ["Q9Y215", "COLQ", "Acetylcholinesterase collagenic tail peptide", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 1, "Congenital myasthenic syndromes", 0.796199449860989, null, 0.639], ["Q4FZB7", "KMT5B", "Histone-lysine N-methyltransferase KMT5B", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 10, "intellectual disability, autosomal dominant 51", 0.7943209483524042, null, 0.638], ["Q68CZ1", "RPGRIP1L", "Protein fantom", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 1, "Joubert syndrome with hepatic defect", 0.7930231953177929, null, 0.638], ["Q5JVL4", "EFHC1", "EF-hand domain-containing protein 1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 2, "juvenile myoclonic epilepsy", 0.7858434985198706, null, 0.636], ["P49459", "UBE2A", "Ubiquitin-conjugating enzyme E2 A", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 5, "syndromic X-linked intellectual disability Nascimento type", 0.7867796040270276, null, 0.636], ["O75800", "ZMYND10", "Zinc finger MYND domain-containing protein 10", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 2, "primary ciliary dyskinesia", 0.7822239837882315, null, 0.635], ["Q86SQ9", "DHDDS", "Dehydrodolichyl diphosphate synthase complex subunit DHDDS", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 9, "retinitis pigmentosa 59", 0.7786578489187141, null, 0.634], ["O43586", "PSTPIP1", "Proline-serine-threonine phosphatase-interacting protein 1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 4, "pyogenic arthritis-pyoderma gangrenosum-acne syndrome", 0.7793785829807485, null, 0.634], ["Q8NFD5", "ARID1B", "AT-rich interactive domain-containing protein 1B", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 2, "Coffin-Siris syndrome 1", 0.7813407475430133, null, 0.634], ["P15104", "GLUL", "Glutamine synthetase", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 12, "congenital brain dysgenesis due to glutamine synthetase deficiency", 0.7733687702812198, null, 0.632], ["Q9NPP4", "NLRC4", "NLR family CARD domain-containing protein 4", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 6, "periodic fever-infantile enterocolitis-autoinflammatory syndrome", 0.7635956406357429, null, 0.629], ["Q15744", "CEBPE", "CCAAT/enhancer-binding protein epsilon", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 1, "Recurrent infection due to specific granule deficiency", 0.7619369036825959, null, 0.629], ["P10636", "MAPT", "Microtubule-associated protein tau", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 100, "Pick disease", 0.7600399335134378, null, 0.628], ["Q96CW9", "NTNG2", "Netrin-G2", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 3, "neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia", 0.7527757254195254, null, 0.626], ["P35716", "SOX11", "Transcription factor SOX-11", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 4, "intellectual developmental disorder with microcephaly and with or without ocular malformations or hypogonadotropic hypogonadism", 0.7470288070793535, null, 0.624], ["P48788", "TNNI2", "Troponin I, fast skeletal muscle", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 2, "distal arthrogryposis type 2B1", 0.7424838485252128, null, 0.623], ["O15350", "TP73", "Tumor protein p73", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 28, "ciliary dyskinesia, primary, 47, and lissencephaly", 0.7409037542174439, null, 0.622], ["P12643", "BMP2", "Bone morphogenetic protein 2", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 21, "short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 1", 0.7361833785834584, null, 0.621], ["O14640", "DVL1", "Segment polarity protein dishevelled homolog DVL-1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 3, "autosomal dominant Robinow syndrome", 0.7359277384599506, null, 0.621], ["Q6EMB2", "TTLL5", "Tubulin polyglutamylase TTLL5", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 1, "Cone rod dystrophy", 0.72210835127064, null, 0.617], ["P41159", "LEP", "Leptin", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 10, "obesity due to congenital leptin deficiency", 0.7197450249224271, null, 0.616], ["Q8N136", "DAW1", "Dynein assembly factor with WD repeat domains 1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 1, "ciliary dyskinesia, primary, 52", 0.6876653910907874, null, 0.606], ["Q9BWF2", "TRAIP", "E3 ubiquitin-protein ligase TRAIP", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 1, "Seckel syndrome 9", 0.683878095944948, null, 0.605], ["Q4KMQ1", "TPRN", "Taperin", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 1, "hearing loss, autosomal recessive", 0.6844134134291492, null, 0.605], ["Q9H6P5", "TASP1", "Threonine aspartase 1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 10, "Suleiman-El-Hattab syndrome", 0.6801464403674466, null, 0.604], ["Q8IUC6", "TICAM1", "TIR domain-containing adapter molecule 1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 8, "Herpetic encephalitis", 0.6364986386236531, null, 0.591], ["P50607", "TUB", "Tubby protein homolog", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 1, "retinitis pigmentosa", 0.631297844631827, null, 0.589], ["Q2Q1W2", "TRIM71", "E3 ubiquitin-protein ligase TRIM71", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 2, "hydrocephalus, congenital communicating, 1", 0.6276048232841862, null, 0.588], ["Q9UQC2", "GAB2", "GRB2-associated-binding protein 2", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 10, "cancer", 0.6072358553557748, null, 0.582], ["Q8IWB6", "TEX14", "Inactive serine/threonine-protein kinase TEX14", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 2, "spermatogenic failure 23", 0.603775324929283, null, 0.581], ["P56597", "NME5", "Nucleoside diphosphate kinase 5", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 1, "ciliary dyskinesia, primary, 48, without situs inversus", 0.5766985649142533, null, 0.573], ["Q13882", "PTK6", "Protein-tyrosine kinase 6", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 9, "medullary thyroid gland carcinoma", 0.5657289152364859, null, 0.57], ["P51813", "BMX", "Cytoplasmic tyrosine-protein kinase BMX", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 6, "alopecia areata", 0.5491699656070116, null, 0.565], ["O76083", "PDE9A", "High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 25, "coronary artery disease", 0.5429744031742744, null, 0.563], ["Q96RU8", "TRIB1", "Tribbles homolog 1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 5, "neurodegenerative disease", 0.5397808385585621, null, 0.562], ["Q9BVS4", "RIOK2", "Serine/threonine-protein kinase RIO2", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 10, "neurodegenerative disease", 0.539818754658029, null, 0.562], ["Q86T24", "ZBTB33", "Transcriptional regulator Kaiso", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 19, "neurodegenerative disease", 0.5355170277816887, null, 0.561], ["Q9NXF7", "DCAF16", "DDB1- and CUL4-associated factor 16", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 2, "neurodegenerative disease", 0.5251061120759617, null, 0.558], ["Q8WWN9", "IPCEF1", "Interactor protein for cytohesin exchange factors 1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 1, "response to tramadol", 0.5225136314922196, null, 0.557], ["Q14678", "KANK1", "KN motif and ankyrin repeat domain-containing protein 1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 5, "basal cell carcinoma", 0.5204468359739138, null, 0.556], ["Q8N8R7", "ARL14EP", "ARL14 effector protein", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 1, "endometriosis", 0.5215169504121038, null, 0.556], ["Q5TC82", "RC3H1", "Roquin-1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 6, "hemophagocytic lymphohistiocytosis, familial, 6", 0.5161798637096334, null, 0.555], ["O43663", "PRC1", "Protein regulator of cytokinesis 1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 6, "neurodegenerative disease", 0.5139662839321523, null, 0.554], ["P49789", "FHIT", "Bis(5'-adenosyl)-triphosphatase", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 9, "Abnormality of the skeletal system", 0.505651828927915, null, 0.552], ["P48775", "TDO2", "Tryptophan 2,3-dioxygenase", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 22, "Hypertryptophanemia", 0.5037265368575525, null, 0.551], ["Q5UIP0", "RIF1", "Telomere-associated protein RIF1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 1, "neurodegenerative disease", 0.5038900373620092, null, 0.551], ["Q96AT9", "RPE", "Ribulose-phosphate 3-epimerase", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 4, "neurodegenerative disease", 0.4992627094132485, null, 0.55], ["P11712", "CYP2C9", "Cytochrome P450 2C9", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 0, null, null, 15, "cholesterol embolism", 0.4868290635834234, null, 0.546]], "truncated": false, "filtered_table_rows_count": 173, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "surface_class", "surface_evidence", "ev_map_hallmark", "in_cev_map", "in_vesiclepedia", "in_exocarta", "pdb_count", "top_disease", "disease_score", "drug_count_approved", "targetability_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, surface_class, surface_evidence, ev_map_hallmark, in_cev_map, in_vesiclepedia, in_exocarta, pdb_count, top_disease, disease_score, drug_count_approved, targetability_score from v_surface_targets where \"ev_map_hallmark\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by targetability_score desc limit 51", "params": {"p0": "0", "p1": "0", "p2": "A2_pm_peripheral"}}, "facet_results": {"surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 173, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=0", "selected": true}], "truncated": false}, "ev_map_hallmark": {"name": "ev_map_hallmark", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 173, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=0&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 173, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=0&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "pdb_count", "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=0&surface_class=A2_pm_peripheral&_facet=pdb_count"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=0&surface_class=A2_pm_peripheral&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 141.77343109622598, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}