{"database": "scout", "table": "v_surface_targets", "is_view": true, "human_description_en": "where ev_map_hallmark = 0, in_cev_map = 1 and surface_class = \"A2_pm_peripheral\" sorted by targetability_score descending", "rows": [["P35555", "FBN1", "Fibrillin-1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 11, "Marfan syndrome", 0.8969300970597663, null, 0.969], ["P15056", "BRAF", "Serine/threonine-protein kinase B-raf", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 100, "cardiofaciocutaneous syndrome", 0.8764542776642054, null, 0.963], ["P04049", "RAF1", "RAF proto-oncogene serine/threonine-protein kinase", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 75, "Noonan syndrome", 0.8625147809861142, null, 0.959], ["P51531", "SMARCA2", "SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 31, "intellectual disability-sparse hair-brachydactyly syndrome", 0.85547142397368, null, 0.957], ["P62873", "GNB1", "Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 100, "intellectual disability, autosomal dominant 42", 0.8462216225099116, null, 0.954], ["P52333", "JAK3", "Tyrosine-protein kinase JAK3", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 42, "T-B+ severe combined immunodeficiency due to JAK3 deficiency", 0.8450717197794638, null, 0.954], ["Q06187", "BTK", "Tyrosine-protein kinase BTK", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 100, "X-linked agammaglobulinemia", 0.8454716106068291, null, 0.954], ["P29400", "COL4A5", "Collagen alpha-5(IV) chain", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 2, "X-linked Alport syndrome", 0.8472963899466404, null, 0.954], ["Q14315", "FLNC", "Filamin-C", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 14, "hypertrophic cardiomyopathy 26", 0.8363192336142512, null, 0.951], ["O60315", "ZEB2", "Zinc finger E-box-binding homeobox 2", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 1, "Mowat-Wilson syndrome", 0.8313744323041312, null, 0.949], ["Q02750", "MAP2K1", "Dual specificity mitogen-activated protein kinase kinase 1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 94, "cardiofaciocutaneous syndrome", 0.825549979325162, null, 0.948], ["O75369", "FLNB", "Filamin-B", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 23, "Larsen syndrome", 0.826975893141549, null, 0.948], ["P06737", "PYGL", "Glycogen phosphorylase, liver form", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 19, "glycogen storage disease VI", 0.8220063508118274, null, 0.947], ["P49770", "EIF2B2", "Translation initiation factor eIF2B subunit beta", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 25, "CACH syndrome", 0.824634396744653, null, 0.947], ["P31040", "SDHA", "Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 4, "mitochondrial complex II deficiency, nuclear type 1", 0.815589203208636, null, 0.945], ["P11274", "BCR", "Breakpoint cluster region protein", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 5, "chronic myelogenous leukemia", 0.8183048540102864, null, 0.945], ["O43175", "PHGDH", "D-3-phosphoglycerate dehydrogenase", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 21, "PHGDH deficiency", 0.8128323162948055, null, 0.944], ["P01111", "NRAS", "GTPase NRas", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 35, "Noonan syndrome 6", 0.8087775198380727, null, 0.943], ["Q9Y3Z3", "SAMHD1", "Deoxynucleoside triphosphate triphosphohydrolase SAMHD1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 76, "Aicardi-Gouti\u00e8res syndrome", 0.8101030032946703, null, 0.943], ["Q8TD16", "BICD2", "Protein bicaudal D homolog 2", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 2, "autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures", 0.8072433385790271, null, 0.942], ["Q08499", "PDE4D", "3',5'-cyclic-AMP phosphodiesterase 4D", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 100, "acrodysostosis 2 with or without hormone resistance", 0.8053064772512085, null, 0.942], ["Q01831", "XPC", "DNA repair protein complementing XP-C cells", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 14, "Xeroderma pigmentosum complementation group C", 0.8056391472748724, null, 0.942], ["O95630", "STAMBP", "STAM-binding protein", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 5, "microcephaly-capillary malformation syndrome", 0.8060251236043802, null, 0.942], ["Q96BN8", "OTULIN", "Ubiquitin thioesterase otulin", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 12, "autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive", 0.804614072482804, null, 0.941], ["Q12840", "KIF5A", "Kinesin heavy chain isoform 5A", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 4, "hereditary spastic paraplegia 10", 0.8029405627392309, null, 0.941], ["O60674", "JAK2", "Tyrosine-protein kinase JAK2", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 100, "polycythemia vera", 0.8000866241942614, null, 0.94], ["P01137", "TGFB1", "Transforming growth factor beta-1 proprotein", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 20, "Camurati-Engelmann disease", 0.7995305374459716, null, 0.94], ["P98170", "XIAP", "E3 ubiquitin-protein ligase XIAP", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 74, "X-linked lymphoproliferative disease", 0.8013347966323413, null, 0.94], ["O00330", "PDHX", "Pyruvate dehydrogenase protein X component, mitochondrial", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 5, "pyruvate dehydrogenase E3-binding protein deficiency", 0.7957753555992844, null, 0.939], ["Q9NQG7", "HPS4", "BLOC-3 complex member HPS4", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 1, "Hermansky-Pudlak syndrome with pulmonary fibrosis", 0.7967575753847002, null, 0.939], ["Q9UHD9", "UBQLN2", "Ubiquilin-2", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 4, "amyotrophic lateral sclerosis type 15", 0.7942015735994536, null, 0.938], ["P49773", "HINT1", "Adenosine 5'-monophosphoramidase HINT1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 59, "Autosomal recessive axonal neuropathy with neuromyotonia", 0.7895184274923306, null, 0.937], ["P12814", "ACTN1", "Alpha-actinin-1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 4, "platelet-type bleeding disorder 15", 0.7887662502912471, null, 0.937], ["O00468", "AGRN", "Agrin", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 1, "congenital myasthenic syndrome 8", 0.7912009864338403, null, 0.937], ["Q9ULC3", "RAB23", "Ras-related protein Rab-23", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 6, "RAB23-related Carpenter syndrome", 0.7879955689930709, null, 0.936], ["O15294", "OGT", "UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 44, "intellectual disability, X-linked 106", 0.7660009745204424, null, 0.93], ["Q9Y263", "PLAA", "Phospholipase A-2-activating protein", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 5, "neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies", 0.7656265019633831, null, 0.93], ["P55263", "ADK", "Adenosine kinase", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 4, "adenosine kinase deficiency", 0.7617058236708037, null, 0.929], ["Q9NWZ3", "IRAK4", "Interleukin-1 receptor-associated kinase 4", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 96, "immunodeficiency 67", 0.7593923638641371, null, 0.928], ["Q92743", "HTRA1", "Serine protease HTRA1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 18, "cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2", 0.7611877816680132, null, 0.928], ["Q9BYI3", "HYCC1", "Hyccin", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 5, "Hypomyelination - congenital cataract", 0.7528702184568328, null, 0.926], ["P35221", "CTNNA1", "Catenin alpha-1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 10, "Butterfly-shaped pigment dystrophy", 0.7487735496199569, null, 0.925], ["Q9NZ09", "UBAP1", "Ubiquitin-associated protein 1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 3, "spastic paraplegia 80, autosomal dominant", 0.7464670113492812, null, 0.924], ["Q01484", "ANK2", "Ankyrin-2", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 11, "Romano-Ward syndrome", 0.7390647393986454, null, 0.922], ["Q6NZI2", "CAVIN1", "Caveolae-associated protein 1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 3, "congenital generalized lipodystrophy type 4", 0.7317728549444928, null, 0.92], ["Q92997", "DVL3", "Segment polarity protein dishevelled homolog DVL-3", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 9, "autosomal dominant Robinow syndrome", 0.7284158836126389, null, 0.919], ["P13797", "PLS3", "Plastin-3", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 6, "X-linked osteoporosis with fractures", 0.721756781312783, null, 0.917], ["P22735", "TGM1", "Protein-glutamine gamma-glutamyltransferase K", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 1, "autosomal recessive congenital ichthyosis", 0.714755023666953, null, 0.914], ["P31939", "ATIC", "Bifunctional purine biosynthesis protein ATIC", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 5, "AICA-ribosiduria", 0.7137167364484167, null, 0.914], ["Q13153", "PAK1", "Serine/threonine-protein kinase PAK 1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 0, 1, null, null, 41, "intellectual developmental disorder with macrocephaly, seizures, and speech delay", 0.7110292416229067, null, 0.913]], "truncated": false, "filtered_table_rows_count": 301, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "surface_class", "surface_evidence", "ev_map_hallmark", "in_cev_map", "in_vesiclepedia", "in_exocarta", "pdb_count", "top_disease", "disease_score", "drug_count_approved", "targetability_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, surface_class, surface_evidence, ev_map_hallmark, in_cev_map, in_vesiclepedia, in_exocarta, pdb_count, top_disease, disease_score, drug_count_approved, targetability_score from v_surface_targets where \"ev_map_hallmark\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by targetability_score desc limit 51", "params": {"p0": "0", "p1": "1", "p2": "A2_pm_peripheral"}}, "facet_results": {"surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1&surface_class=A2_pm_peripheral", "results": [{"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 301, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1", "selected": true}], "truncated": false}, "ev_map_hallmark": {"name": "ev_map_hallmark", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1&surface_class=A2_pm_peripheral", "results": [{"value": 0, "label": 0, "count": 301, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=1&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1&surface_class=A2_pm_peripheral", "results": [{"value": 1, "label": 1, "count": 301, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=0&surface_class=A2_pm_peripheral", "selected": true}], "truncated": false}}, "suggested_facets": [], "next": "50", "next_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1&surface_class=A2_pm_peripheral&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 139.18207911774516, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}