{"database": "scout", "table": "v_surface_targets", "is_view": true, "human_description_en": "where ev_map_hallmark = 0, in_cev_map = 1 and surface_class = \"A_assoc\" sorted by targetability_score descending", "rows": [["P00451", "F8", "Coagulation factor VIII", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 25, "hemophilia A", 0.9108044347811838, null, 0.973], ["P12883", "MYH7", "Myosin-7", "A_assoc", "HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)", 0, 1, null, null, 43, "hypertrophic cardiomyopathy", 0.9029865147265421, null, 0.971], ["P00740", "F9", "Coagulation factor IX", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 56, "hemophilia B", 0.8880186703890781, null, 0.966], ["Q8NBP7", "PCSK9", "Proprotein convertase subtilisin/kexin type 9", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 62, "familial hypercholesterolemia", 0.8604029080346239, null, 0.958], ["P02461", "COL3A1", "Collagen alpha-1(III) chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 11, "Ehlers-Danlos syndrome, vascular type", 0.8608667500207768, null, 0.958], ["P17405", "SMPD1", "Sphingomyelin phosphodiesterase", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 4, "Niemann-Pick disease type A", 0.8567797114449874, null, 0.957], ["P08709", "F7", "Coagulation factor VII", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 100, "factor VII deficiency", 0.8542078994169972, null, 0.956], ["P01008", "SERPINC1", "Antithrombin-III", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 27, "hereditary antithrombin deficiency", 0.8494671886642873, null, 0.955], ["P02452", "COL1A1", "Collagen alpha-1(I) chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 14, "osteogenesis imperfecta type 2", 0.8471150130101988, null, 0.954], ["P02462", "COL4A1", "Collagen alpha-1(IV) chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 4, "brain small vessel disease 1 with or without ocular anomalies", 0.84655287380359, null, 0.954], ["P03951", "F11", "Coagulation factor XI", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 100, "factor XI deficiency", 0.841884208404384, null, 0.953], ["P45379", "TNNT2", "Troponin T, cardiac muscle", "A_assoc", "HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)", 0, 1, null, null, 25, "hypertrophic cardiomyopathy", 0.8329996050513441, null, 0.95], ["P02458", "COL2A1", "Collagen alpha-1(II) chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 11, "spondyloepiphyseal dysplasia congenita", 0.8334698564095305, null, 0.95], ["P08246", "ELANE", "Neutrophil elastase", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 38, "cyclic hematopoiesis", 0.8291093803980005, null, 0.949], ["P00450", "CP", "Ceruloplasmin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 4, "aceruloplasminemia", 0.8279493326009644, null, 0.948], ["P04180", "LCAT", "Phosphatidylcholine-sterol acyltransferase", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 7, "Fish-eye disease", 0.8273460309828392, null, 0.948], ["P00747", "PLG", "Plasminogen", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 49, "hypoplasminogenemia", 0.8240321266100769, null, 0.947], ["Q15582", "TGFBI", "Transforming growth factor-beta-induced protein ig-h3", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 10, "lattice corneal dystrophy type I", 0.8242841141270143, null, 0.947], ["P02649", "APOE", "Apolipoprotein E", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 29, "coronary artery disease", 0.81626595063263, null, 0.945], ["P06276", "BCHE", "Cholinesterase", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 100, "butyrylcholinesterase deficiency", 0.8051740584587205, null, 0.942], ["P06396", "GSN", "Gelsolin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 60, "Finnish type amyloidosis", 0.8048371651382773, null, 0.941], ["P02679", "FGG", "Fibrinogen gamma chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 48, "familial dysfibrinogenemia", 0.8002311001712851, null, 0.94], ["P07942", "LAMB1", "Laminin subunit beta-1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 3, "cobblestone lissencephaly without muscular or ocular involvement", 0.8016665947624902, null, 0.94], ["P20908", "COL5A1", "Collagen alpha-1(V) chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 1, "Ehlers-Danlos syndrome, classic type, 1", 0.7979601586599098, null, 0.939], ["P02671", "FGA", "Fibrinogen alpha chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 40, "familial dysfibrinogenemia", 0.7947496460990987, null, 0.938], ["P02675", "FGB", "Fibrinogen beta chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 42, "congenital afibrinogenemia", 0.7892438060719716, null, 0.937], ["P22105", "TNXB", "Tenascin-X", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 3, "Ehlers-Danlos syndrome due to tenascin-X deficiency", 0.7916412481554758, null, 0.937], ["P03950", "ANG", "Angiogenin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 56, "amyotrophic lateral sclerosis", 0.7865457274017922, null, 0.936], ["P08253", "MMP2", "72 kDa type IV collagenase", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 14, "Torg-Winchester syndrome", 0.7862502046091417, null, 0.936], ["P35609", "ACTN2", "Alpha-actinin-2", "A_assoc", "HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)", 0, 1, null, null, 16, "dilated cardiomyopathy 1AA", 0.7856813926513253, null, 0.936], ["Q14623", "IHH", "Indian hedgehog protein", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 8, "brachydactyly type A1", 0.7871957785711762, null, 0.936], ["P10643", "C7", "Complement component C7", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 8, "Immunodeficiency due to a late component of complements deficiency", 0.7859621873711432, null, 0.936], ["P13645", "KRT10", "Keratin, type I cytoskeletal 10", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 6, "epidermolytic hyperkeratosis 2A, autosomal dominant", 0.7860749239386174, null, 0.936], ["P39060", "COL18A1", "Collagen alpha-1(XVIII) chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 9, "Knobloch syndrome 1", 0.7867122552672962, null, 0.936], ["A6XGL2", "INS", "Insulin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 2, "diabetes mellitus, permanent neonatal 4", 0.784300463357018, null, 0.935], ["Q12904", "AIMP1", "Aminoacyl tRNA synthase complex-interacting multifunctional protein 1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 6, "hypomyelinating leukodystrophy 3", 0.7806847123659254, null, 0.934], ["P35858", "IGFALS", "Insulin-like growth factor-binding protein complex acid labile subunit", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 1, "Reduced insulin like growth factor binding protein acid labile subunit concentration", 0.7760522769257892, null, 0.933], ["P02647", "APOA1", "Apolipoprotein A-I", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 32, "hypoalphalipoproteinemia, primary, 2", 0.7727382344191134, null, 0.932], ["P02787", "TF", "Serotransferrin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 66, "atransferrinemia", 0.7724190608888654, null, 0.932], ["P00746", "CFD", "Complement factor D", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 40, "recurrent Neisseria infections due to factor D deficiency", 0.7726408204424132, null, 0.932], ["P35625", "TIMP3", "Metalloproteinase inhibitor 3", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 1, "Sorsby fundus dystrophy", 0.7684253675298044, null, 0.931], ["P07988", "SFTPB", "Pulmonary surfactant-associated protein B", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 9, "Neonatal acute respiratory distress with surfactant metabolism deficiency", 0.767375558073721, null, 0.93], ["P01009", "SERPINA1", "Alpha-1-antitrypsin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 46, "Alpha-1-antitrypsin deficiency", 0.764279219769394, null, 0.929], ["P02748", "C9", "Complement component C9", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 9, "Immunodeficiency due to a late component of complements deficiency", 0.761965409699055, null, 0.929], ["P27918", "CFP", "Properdin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 14, "Properdin deficiency", 0.7610265174382485, null, 0.928], ["O15230", "LAMA5", "Laminin subunit alpha-5", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 2, "nephrotic syndrome, IIa 26", 0.7594872666460903, null, 0.928], ["P13671", "C6", "Complement component C6", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 11, "Immunodeficiency due to a late component of complements deficiency", 0.75437296887129, null, 0.926], ["P08603", "CFH", "Complement factor H", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 51, "complement factor H deficiency", 0.7508822531277052, null, 0.925], ["P01042", "KNG1", "Kininogen-1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 19, "congenital high-molecular-weight kininogen deficiency", 0.7480490551878497, null, 0.924], ["P05121", "SERPINE1", "Plasminogen activator inhibitor 1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 29, "congenital plasminogen activator inhibitor type 1 deficiency", 0.7325368931195121, null, 0.92]], "truncated": false, "filtered_table_rows_count": 216, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "surface_class", "surface_evidence", "ev_map_hallmark", "in_cev_map", "in_vesiclepedia", "in_exocarta", "pdb_count", "top_disease", "disease_score", "drug_count_approved", "targetability_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, surface_class, surface_evidence, ev_map_hallmark, in_cev_map, in_vesiclepedia, in_exocarta, pdb_count, top_disease, disease_score, drug_count_approved, targetability_score from v_surface_targets where \"ev_map_hallmark\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by targetability_score desc limit 51", "params": {"p0": "0", "p1": "1", "p2": "A_assoc"}}, "facet_results": {"surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1&surface_class=A_assoc", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 216, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1", "selected": true}], "truncated": false}, "ev_map_hallmark": {"name": "ev_map_hallmark", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 216, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=1&surface_class=A_assoc", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1&surface_class=A_assoc", "results": [{"value": 1, "label": 1, "count": 216, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=0&surface_class=A_assoc", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "surface_evidence", "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1&surface_class=A_assoc&_facet=surface_evidence"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1&surface_class=A_assoc&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 106.27294005826116, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}