{"database": "scout", "table": "v_surface_targets", "is_view": true, "human_description_en": "where ev_map_hallmark = 0, in_cev_map = 1 and surface_class = \"A_surface\" sorted by targetability_score descending", "rows": [["P21359", "NF1", "Neurofibromin", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 26, "neurofibromatosis type 1", 0.8844735398780649, null, 1.965], ["P33897", "ABCD1", "ATP-binding cassette sub-family D member 1", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 14, "adrenoleukodystrophy", 0.8656366512509434, null, 1.96], ["P04839", "CYBB", "NADPH oxidase 2", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 6, "chronic granulomatous disease", 0.8633132852459866, null, 1.959], ["P21802", "FGFR2", "Fibroblast growth factor receptor 2", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 62, "Crouzon syndrome", 0.8637438969881663, null, 1.959], ["P78504", "JAG1", "Protein jagged-1", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 7, "Alagille syndrome due to a JAG1 point mutation", 0.8586542923232751, null, 1.958], ["P00813", "ADA", "Adenosine deaminase", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 2, "Severe combined immunodeficiency due to adenosine deaminase deficiency", 0.8556816060494579, null, 1.957], ["P36021", "SLC16A2", "Monocarboxylate transporter 8", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 7, "Allan-Herndon-Dudley syndrome", 0.8533069932022032, null, 1.956], ["P51795", "CLCN5", "H(+)/Cl(-) exchange transporter 5", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 2, "Dent disease type 1", 0.850724240157394, null, 1.955], ["P29965", "CD40LG", "CD40 ligand", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 8, "hyper-IgM syndrome type 1", 0.8451678829647167, null, 1.954], ["P11362", "FGFR1", "Fibroblast growth factor receptor 1", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 82, "hypogonadotropic hypogonadism 2 with or without anosmia", 0.8472925100660907, null, 1.954], ["Q9NQ11", "ATP13A2", "Polyamine-transporting ATPase 13A2", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 25, "Kufor-Rakeb syndrome", 0.8439049037191295, null, 1.953], ["P08581", "MET", "Hepatocyte growth factor receptor", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 100, "papillary renal cell carcinoma", 0.84195976263742, null, 1.953], ["P06213", "INSR", "Insulin receptor", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 87, "Leprechaunism", 0.8448849372402896, null, 1.953], ["Q8WZ42", "TTN", "Titin", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 64, "dilated cardiomyopathy", 0.8419847660466327, null, 1.953], ["Q14524", "SCN5A", "Sodium channel protein type 5 subunit alpha", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 1, null, null, 16, "long QT syndrome 3", 0.8448298602976083, null, 1.953], ["Q969N2", "PIGT", "GPI-anchor transamidase component PIGT", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 3, "multiple congenital anomalies-hypotonia-seizures syndrome 3", 0.8439030764005646, null, 1.953], ["P13637", "ATP1A3", "Sodium/potassium-transporting ATPase subunit alpha-3", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 5, "alternating hemiplegia of childhood 2", 0.842328126568451, null, 1.953], ["P37173", "TGFBR2", "TGF-beta receptor type-2", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 22, "Loeys-Dietz syndrome", 0.8390072008866913, null, 1.952], ["P35499", "SCN4A", "Sodium channel protein type 4 subunit alpha", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 1, null, null, 3, "paramyotonia congenita of Von Eulenburg", 0.8401628899371881, null, 1.952], ["Q99250", "SCN2A", "Sodium channel protein type 2 subunit alpha", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 1, null, null, 5, "developmental and epileptic encephalopathy, 11", 0.8388748085806758, null, 1.952], ["O00571", "DDX3X", "ATP-dependent RNA helicase DDX3X", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 17, "X-linked non-syndromic intellectual disability", 0.8362533125067105, null, 1.951], ["P19438", "TNFRSF1A", "Tumor necrosis factor receptor superfamily member 1A", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 13, "TNF receptor 1-associated periodic fever syndrome", 0.8352778213184682, null, 1.951], ["P25189", "MPZ", "Myelin protein P0", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 2, "Charcot-Marie-Tooth disease type 1B", 0.8377022197539885, null, 1.951], ["P54760", "EPHB4", "Ephrin type-B receptor 4", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 23, "Capillary malformation - arteriovenous malformation", 0.8317426466005666, null, 1.95], ["Q9HAB3", "SLC52A2", "Solute carrier family 52, riboflavin transporter, member 2", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 1, "riboflavin transporter deficiency", 0.8333271825486935, null, 1.95], ["Q9Y653", "ADGRG1", "Adhesion G-protein coupled receptor G1", "A_surface", "HPA protein class = G-protein coupled receptors (cell-surface, extracellular epitope)", 0, 1, null, null, 1, "bilateral frontoparietal polymicrogyria", 0.8322298896713178, null, 1.95], ["P06744", "GPI", "Glucose-6-phosphate isomerase", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 13, "hemolytic anemia due to glucophosphate isomerase deficiency", 0.8306909118751346, null, 1.949], ["Q9NRA2", "SLC17A5", "Sialin", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 7, "free sialic acid storage disease, infantile form", 0.8292382821211967, null, 1.949], ["P36888", "FLT3", "Receptor-type tyrosine-protein kinase FLT3", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 11, "acute myeloid leukemia", 0.8313389209288576, null, 1.949], ["P63092", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms short", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 100, "pseudohypoparathyroidism type 1A", 0.826829760867455, null, 1.948], ["Q8WZA1", "POMGNT1", "Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 10, "muscular dystrophy-dystroglycanopathy (congenital with brain and eye anomalies), type A3", 0.826104223872448, null, 1.948], ["P36897", "TGFBR1", "TGF-beta receptor type-1", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 44, "Loeys-Dietz syndrome 1", 0.8275292516338373, null, 1.948], ["P36894", "BMPR1A", "Bone morphogenetic protein receptor type-1A", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 11, "juvenile polyposis syndrome", 0.8278395086688584, null, 1.948], ["P22607", "FGFR3", "Fibroblast growth factor receptor 3", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 13, "achondroplasia", 0.8270702096931246, null, 1.948], ["Q5JWF2", "GNAS", "Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 9, "pseudohypoparathyroidism type 1A", 0.826829760867455, null, 1.948], ["P13473", "LAMP2", "Lysosome-associated membrane glycoprotein 2", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 2, "Glycogen Storage Disease Type 2b", 0.8273010649608126, null, 1.948], ["P16615", "ATP2A2", "Sarcoplasmic/endoplasmic reticulum calcium ATPase 2", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 15, "Darier disease", 0.8223208039299769, null, 1.947], ["P04156", "PRNP", "Major prion protein", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 70, "Gerstmann-Straussler-Scheinker syndrome", 0.8246149684620239, null, 1.947], ["Q13936", "CACNA1C", "Voltage-dependent L-type calcium channel subunit alpha-1C", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 1, null, null, 33, "Timothy syndrome", 0.8227725490420764, null, 1.947], ["P08069", "IGF1R", "Insulin-like growth factor 1 receptor", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 46, "growth delay due to insulin-like growth factor I resistance", 0.8166352227841136, null, 1.945], ["P16234", "PDGFRA", "Platelet-derived growth factor receptor alpha", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 14, "gastrointestinal stromal tumor", 0.8167494524079806, null, 1.945], ["Q9H3H5", "DPAGT1", "UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 8, "DPAGT1-congenital disorder of glycosylation", 0.8101246300555436, null, 1.943], ["Q13563", "PKD2", "Polycystin-2", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 1, null, null, 31, "polycystic kidney disease 2", 0.810960823768978, null, 1.943], ["O75844", "ZMPSTE24", "CAAX prenyl protease 1 homolog", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 4, "mandibuloacral dysplasia with type B lipodystrophy", 0.8071967390737101, null, 1.942], ["P51798", "CLCN7", "H(+)/Cl(-) exchange transporter 7", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 9, "Autosomal recessive malignant osteopetrosis", 0.8065499095904218, null, 1.942], ["P25942", "CD40", "Tumor necrosis factor receptor superfamily member 5", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 14, "hyper-IgM syndrome type 3", 0.8038021669520221, null, 1.941], ["P49810", "PSEN2", "Presenilin-2", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 2, "early-onset autosomal dominant Alzheimer disease", 0.8047686386596943, null, 1.941], ["P58335", "ANTXR2", "Anthrax toxin receptor 2", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 14, "hyaline fibromatosis syndrome", 0.8028849863986661, null, 1.941], ["O94766", "B3GAT3", "Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 3, "Larsen-like syndrome, B3GAT3 type", 0.7995331164339264, null, 1.94], ["P61073", "CXCR4", "C-X-C chemokine receptor type 4", "A_surface", "HPA protein class = CD markers, G-protein coupled receptors (cell-surface, extracellular epitope)", 0, 1, null, null, 33, "WHIM syndrome", 0.8009225456235435, null, 1.94]], "truncated": false, "filtered_table_rows_count": 404, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "surface_class", "surface_evidence", "ev_map_hallmark", "in_cev_map", "in_vesiclepedia", "in_exocarta", "pdb_count", "top_disease", "disease_score", "drug_count_approved", "targetability_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, surface_class, surface_evidence, ev_map_hallmark, in_cev_map, in_vesiclepedia, in_exocarta, pdb_count, top_disease, disease_score, drug_count_approved, targetability_score from v_surface_targets where \"ev_map_hallmark\" = :p0 and \"in_cev_map\" = :p1 and \"surface_class\" = :p2 order by targetability_score desc limit 51", "params": {"p0": "0", "p1": "1", "p2": "A_surface"}}, "facet_results": {"surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1&surface_class=A_surface", "results": [{"value": "A_surface", "label": "A_surface", "count": 404, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1", "selected": true}], "truncated": false}, "ev_map_hallmark": {"name": "ev_map_hallmark", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1&surface_class=A_surface", "results": [{"value": 0, "label": 0, "count": 404, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=1&surface_class=A_surface", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1&surface_class=A_surface", "results": [{"value": 1, "label": 1, "count": 404, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=0&surface_class=A_surface", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "surface_evidence", "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1&surface_class=A_surface&_facet=surface_evidence"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=0&in_cev_map=1&surface_class=A_surface&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 143.5402068309486, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}