{"database": "scout", "table": "v_surface_targets", "is_view": true, "human_description_en": "where ev_map_hallmark = 1 and in_cev_map = 1 sorted by targetability_score descending", "rows": [["P11166", "SLC2A1", "Solute carrier family 2, facilitated glucose transporter member 1", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 1, 1, null, null, 5, "encephalopathy due to GLUT1 deficiency", 0.8521823225896756, null, 2.756], ["P07359", "GP1BA", "Platelet glycoprotein Ib alpha chain", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 22, "Bernard-Soulier syndrome", 0.8346884735388165, null, 2.75], ["P08514", "ITGA2B", "Integrin alpha-IIb", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 78, "Glanzmann thrombasthenia 1", 0.8224288672248264, null, 2.747], ["P14770", "GP9", "Platelet glycoprotein IX", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 2, "Bernard-Soulier syndrome", 0.8233582238860002, null, 2.747], ["P02730", "SLC4A1", "Band 3 anion transport protein", "A_surface", "HPA protein class = Blood group antigen proteins, CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 54, "hereditary spherocytosis type 4", 0.820137113225454, null, 2.746], ["P05106", "ITGB3", "Integrin beta-3", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 123, "Glanzmann thrombasthenia 1", 0.8208115968652424, null, 2.746], ["P16671", "CD36", "Platelet glycoprotein 4", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 1, "platelet-type bleeding disorder 10", 0.7360571429413174, null, 2.721], ["P08575", "PTPRC", "Receptor-type tyrosine-protein phosphatase C", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 6, "immunodeficiency 104", 0.7200430416648742, null, 2.716], ["P02786", "TFRC", "Transferrin receptor protein 1", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 22, "TFRC-related combined immunodeficiency", 0.623449899069336, null, 2.687], ["P05556", "ITGB1", "Integrin beta-1", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 22, "multiple sclerosis", 0.586769452063963, null, 2.676], ["P01764", "IGHV3-23", "Immunoglobulin heavy variable 3-23", "A_surface", "HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)", 1, 1, null, null, 6, "cutaneous Leishmaniasis", 0.5868213846274001, null, 2.676], ["P23083", "IGHV1-2", "Immunoglobulin heavy variable 1-2", "A_surface", "HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)", 1, 1, null, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001, null, 2.676], ["P06312", "IGKV4-1", "Immunoglobulin kappa variable 4-1", "A_surface", "HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)", 1, 1, null, null, 10, "cutaneous Leishmaniasis", 0.5868213846274001, null, 2.676], ["Q12913", "PTPRJ", "Receptor-type tyrosine-protein phosphatase eta", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 5, "neurodegenerative disease", 0.54699134609967, null, 2.664], ["O00161", "SNAP23", "Synaptosomal-associated protein 23", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 1, 1, null, null, 2, "neurodegenerative disease", 0.5288361677964304, null, 2.659], ["P21926", "CD9", "CD9 antigen", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 5, "diphtheria", 0.5261379875719714, null, 2.658], ["P15144", "ANPEP", "Aminopeptidase N", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 15, "cholelithiasis", 0.5030146927270738, null, 2.651], ["P01871", "IGHM", "Immunoglobulin heavy constant mu", "A_surface", "HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)", 1, 1, null, null, 30, "agammaglobulinemia", 0.4624778576025314, null, 2.639], ["P01833", "PIGR", "Polymeric immunoglobulin receptor", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 1, 1, null, null, 16, "clear cell renal carcinoma", 0.44260204134234277, null, 2.633], ["P17301", "ITGA2", "Integrin alpha-2", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 16, "Abnormality of the skeletal system", 0.4227839911251069, null, 2.627], ["P11169", "SLC2A3", "Solute carrier family 2, facilitated glucose transporter member 3", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 1, 1, null, null, 7, "neurodegenerative disease", 0.4054698468991856, null, 2.622], ["Q08722", "CD47", "Leukocyte surface antigen CD47", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 15, "myelodysplastic syndrome", 0.3682348506170252, null, 2.61], ["Q9HBI1", "PARVB", "Beta-parvin", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 1, 1, null, null, 3, "thyroiditis", 0.28021156500366357, null, 2.584], ["P02746", "C1QB", "Complement C1q subcomponent subunit B", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 1, 1, null, null, 11, null, null, null, 2.5], ["P07225", "PROS1", "Vitamin K-dependent protein S", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 3, "thrombophilia due to protein S deficiency, autosomal dominant", 0.8240418292042652, null, 1.747], ["P48740", "MASP1", "Mannan-binding lectin serine protease 1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 9, "3MC syndrome 1", 0.8185972518103526, null, 1.746], ["P21333", "FLNA", "Filamin-A", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 1, 1, null, null, 26, "Melnick-Needles syndrome", 0.8200516896124751, null, 1.746], ["Q9BWP8", "COLEC11", "Collectin-11", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 3, "3MC syndrome 2", 0.7977893521540559, null, 1.739], ["P12259", "F5", "Coagulation factor V", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 17, "thrombophilia due to activated protein C resistance", 0.7962069693286362, null, 1.739], ["P00488", "F13A1", "Coagulation factor XIII A chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 15, "Factor XIII subunit A deficiency", 0.7939842013132387, null, 1.738], ["O43707", "ACTN4", "Alpha-actinin-4", "A_assoc", "HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)", 1, 1, null, null, 5, "focal segmental glomerulosclerosis 1", 0.7778533437264424, null, 1.733], ["P26038", "MSN", "Moesin", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 1, 1, null, null, 10, "combined immunodeficiency due to moesin deficiency", 0.7157135146765757, null, 1.715], ["P84077", "ARF1", "ADP-ribosylation factor 1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 1, 1, null, null, 36, "periventricular nodular heterotopia 8", 0.7173626622431929, null, 1.715], ["P07948", "LYN", "Tyrosine-protein kinase Lyn", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 1, 1, null, null, 6, "autoinflammatory disease, systemic, with vasculitis", 0.7119500711989845, null, 1.714], ["O00187", "MASP2", "Mannan-binding lectin serine protease 2", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 10, "immunodeficiency due to MASP-2 deficiency", 0.6996393077218865, null, 1.71], ["P18206", "VCL", "Vinculin", "A_assoc", "HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)", 1, 1, null, null, 37, "hypertrophic cardiomyopathy", 0.6924271529635582, null, 1.708], ["P61586", "RHOA", "Transforming protein RhoA", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 1, 1, null, null, 100, "ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies", 0.6804889074382072, null, 1.704], ["P12931", "SRC", "Proto-oncogene tyrosine-protein kinase Src", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 1, 1, null, null, 78, "cancer", 0.6343904000453656, null, 1.69], ["P02745", "C1QA", "Complement C1q subcomponent subunit A", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 11, "C1Q deficiency 1", 0.6319053256658114, null, 1.69], ["P62937", "PPIA", "Peptidyl-prolyl cis-trans isomerase A", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 100, "HIV infection", 0.6219943433906236, null, 1.687], ["P02747", "C1QC", "Complement C1q subcomponent subunit C", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 11, "C1Q deficiency", 0.6233532074390745, null, 1.687], ["P04406", "GAPDH", "Glyceraldehyde-3-phosphate dehydrogenase", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 1, 1, null, null, 21, "neurodegenerative disease", 0.55307368855439, null, 1.666], ["Q14766", "LTBP1", "Latent-transforming growth factor beta-binding protein 1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 1, "Abnormality of the skeletal system", 0.5142669818409414, null, 1.654], ["O00194", "RAB27B", "Ras-related protein Rab-27B", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 1, 1, null, null, 1, "major depressive disorder", 0.4805047942947544, null, 1.644], ["P04899", "GNAI2", "Guanine nucleotide-binding protein G(i) subunit alpha-2", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 1, 1, null, null, 34, "ovarian granulosa cell tumor", 0.4157773365202895, null, 1.625], ["P06702", "S100A9", "Protein S100-A9", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 1, 1, null, null, 13, "inborn error of immunity", 0.36994943453938645, null, 1.611], ["P05109", "S100A8", "Protein S100-A8", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 13, "inborn error of immunity", 0.37050380432141355, null, 1.611], ["O43866", "CD5L", "CD5 antigen-like", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 4, "functional neutrophil defect", 0.3529395470693119, null, 1.606], ["P07996", "THBS1", "Thrombospondin-1", "A2_pm_peripheral", "HPA Plasma membrane but NOT an integral membrane protein -> peripheral/cytoplasmic-leaflet (not reachable from outside)", 1, 1, null, null, 11, "autism spectrum disorder", 0.3356118729017016, null, 1.601], ["P48059", "LIMS1", "LIM and senescent cell antigen-like-containing domain protein 1", "A_assoc", "HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)", 1, 1, null, null, 14, "Abruptio Placentae", 0.3236383460637068, null, 1.597]], "truncated": false, "filtered_table_rows_count": 56, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "surface_class", "surface_evidence", "ev_map_hallmark", "in_cev_map", "in_vesiclepedia", "in_exocarta", "pdb_count", "top_disease", "disease_score", "drug_count_approved", "targetability_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, surface_class, surface_evidence, ev_map_hallmark, in_cev_map, in_vesiclepedia, in_exocarta, pdb_count, top_disease, disease_score, drug_count_approved, targetability_score from v_surface_targets where \"ev_map_hallmark\" = :p0 and \"in_cev_map\" = :p1 order by targetability_score desc limit 51", "params": {"p0": "1", "p1": "1"}}, "facet_results": {"surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?ev_map_hallmark=1&in_cev_map=1", "results": [{"value": "A_surface", "label": "A_surface", "count": 24, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=1&in_cev_map=1&surface_class=A_surface", "selected": false}, {"value": "A_assoc", "label": "A_assoc", "count": 20, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=1&in_cev_map=1&surface_class=A_assoc", "selected": false}, {"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 12, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=1&in_cev_map=1&surface_class=A2_pm_peripheral", "selected": false}], "truncated": false}, "ev_map_hallmark": {"name": "ev_map_hallmark", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?ev_map_hallmark=1&in_cev_map=1", "results": [{"value": 1, "label": 1, "count": 56, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=1", "selected": true}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?ev_map_hallmark=1&in_cev_map=1", "results": [{"value": 1, "label": 1, "count": 56, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=1", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "surface_evidence", "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=1&in_cev_map=1&_facet=surface_evidence"}, {"name": "pdb_count", "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=1&in_cev_map=1&_facet=pdb_count"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_surface_targets.json?ev_map_hallmark=1&in_cev_map=1&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 171.38035409152508, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}