{"database": "scout", "table": "v_surface_targets", "is_view": true, "human_description_en": "where in_cev_map = 0 sorted by targetability_score descending", "rows": [["P13569", "CFTR", "Cystic fibrosis transmembrane conductance regulator", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 0, null, null, 58, "cystic fibrosis", 0.9133535862571094, null, 1.674], ["Q14654", "KCNJ11", "ATP-sensitive inward rectifier potassium channel 11", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 0, null, null, 9, "type 2 diabetes mellitus", 0.8651421397012851, null, 1.66], ["P07949", "RET", "Proto-oncogene tyrosine-protein kinase receptor Ret", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 0, null, null, 34, "medullary thyroid gland carcinoma", 0.8617460262224842, null, 1.659], ["O95255", "ABCC6", "ATP-binding cassette sub-family C member 6", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 0, null, null, 4, "Pseudoxanthoma elasticum", 0.864631668818611, null, 1.659], ["Q12809", "KCNH2", "Voltage-gated inwardly rectifying potassium channel KCNH2", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 0, null, null, 23, "Romano-Ward syndrome", 0.8549238933917284, null, 1.656], ["P21439", "ABCB4", "Phosphatidylcholine translocator ABCB4", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 0, null, null, 4, "progressive familial intrahepatic cholestasis type 3", 0.851728159166962, null, 1.656], ["P82251", "SLC7A9", "b(0,+)-type amino acid transporter 1", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 0, null, null, 4, "cystinuria", 0.8484952668941285, null, 1.655], ["Q695T7", "SLC6A19", "Sodium-dependent neutral amino acid transporter B(0)AT1", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 0, null, null, 19, "Hartnup disease", 0.8464240093600148, null, 1.654], ["P41180", "CASR", "Extracellular calcium-sensing receptor", "A_surface", "HPA protein class = G-protein coupled receptors (cell-surface, extracellular epitope)", 0, 0, null, null, 31, "familial hypocalciuric hypercalcemia 1", 0.8460848589627423, null, 1.654], ["P31785", "IL2RG", "Cytokine receptor common subunit gamma", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 0, null, null, 14, "gamma chain deficiency", 0.8469997000418428, null, 1.654], ["Q9UM01", "SLC7A7", "Y+L amino acid transporter 1", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 0, null, null, 5, "lysinuric protein intolerance", 0.8450026270275782, null, 1.654], ["P08100", "RHO", "Rhodopsin", "A_surface", "HPA protein class = G-protein coupled receptors (cell-surface, extracellular epitope)", 0, 0, null, null, 4, "retinitis pigmentosa", 0.8481942240861982, null, 1.654], ["P48029", "SLC6A8", "Sodium- and chloride-dependent creatine transporter 1", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 0, null, null, 6, "creatine transporter deficiency", 0.847268393806457, null, 1.654], ["Q05586", "GRIN1", "Glutamate receptor ionotropic, NMDA 1", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 0, null, null, 84, "neurodevelopmental disorder with or without hyperkinetic movements and seizures, autosomal dominant", 0.8446685494288694, null, 1.653], ["P07911", "UMOD", "Uromodulin", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 0, null, null, 10, "familial juvenile hyperuricemic nephropathy type 1", 0.8446536377993564, null, 1.653], ["O43526", "KCNQ2", "Potassium voltage-gated channel subfamily KQT member 2", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 0, null, null, 24, "Benign familial neonatal seizures", 0.8423358217314708, null, 1.653], ["Q9UQD0", "SCN8A", "Sodium channel protein type 8 subunit alpha", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 0, null, null, 4, "developmental and epileptic encephalopathy, 13", 0.8437707419548253, null, 1.653], ["P07333", "CSF1R", "Macrophage colony-stimulating factor 1 receptor", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 0, null, null, 26, "leukoencephalopathy, diffuse hereditary, with spheroids 1", 0.8391971566583056, null, 1.652], ["Q9HBA0", "TRPV4", "Transient receptor potential cation channel subfamily V member 4", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 0, null, null, 19, "metatropic dysplasia", 0.8356240344517467, null, 1.651], ["O95342", "ABCB11", "Bile salt export pump", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 0, null, null, 8, "progressive familial intrahepatic cholestasis type 2", 0.8372060401943777, null, 1.651], ["P78508", "KCNJ10", "ATP-sensitive inward rectifier potassium channel 10", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 0, null, null, 4, "EAST syndrome", 0.8357483559927158, null, 1.651], ["P42262", "GRIA2", "Glutamate receptor 2", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 0, null, null, 16, "neurodevelopmental disorder with language impairment and behavioral abnormalities", 0.8328652004757138, null, 1.65], ["P16473", "TSHR", "Thyrotropin receptor", "A_surface", "HPA protein class = G-protein coupled receptors (cell-surface, extracellular epitope)", 0, 0, null, null, 9, "hypothyroidism due to TSH receptor mutations", 0.8327127196409464, null, 1.65], ["Q92736", "RYR2", "Ryanodine receptor 2", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 0, null, null, 26, "catecholaminergic polymorphic ventricular tachycardia 1", 0.8338648743498255, null, 1.65], ["P30968", "GNRHR", "Gonadotropin-releasing hormone receptor", "A_surface", "HPA protein class = G-protein coupled receptors (cell-surface, extracellular epitope)", 0, 0, null, null, 1, "hypogonadotropic hypogonadism", 0.83100005285263, null, 1.649], ["Q16281", "CNGA3", "Cyclic nucleotide-gated channel alpha-3", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 0, null, null, 10, "achromatopsia", 0.8315799021867489, null, 1.649], ["P10912", "GHR", "Growth hormone receptor", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 0, null, null, 9, "Laron syndrome", 0.8304020079647765, null, 1.649], ["P13866", "SLC5A1", "Sodium/glucose cotransporter 1", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 0, null, null, 4, "glucose-galactose malabsorption", 0.8220991027793896, null, 1.647], ["Q04844", "CHRNE", "Acetylcholine receptor subunit epsilon", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 0, null, null, 13, "Congenital myasthenic syndromes", 0.8223287249629152, null, 1.647], ["Q8IZF0", "NALCN", "Sodium leak channel NALCN", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 0, null, null, 5, "congenital contractures of the limbs and face, hypotonia, and developmental delay", 0.8198033442161259, null, 1.646], ["P23942", "PRPH2", "Peripherin-2", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 0, null, null, 1, "retinitis pigmentosa", 0.8194208847382956, null, 1.646], ["Q9BZV2", "SLC19A3", "Thiamine transporter 2", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 0, null, null, 19, "biotin-responsive basal ganglia disease", 0.8189646480334981, null, 1.646], ["P41181", "AQP2", "Aquaporin-2", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 0, null, null, 7, "diabetes insipidus, nephrogenic, autosomal", 0.817870726313342, null, 1.645], ["Q9ULV1", "FZD4", "Frizzled-4", "A_surface", "HPA protein class = CD markers, G-protein coupled receptors (cell-surface, extracellular epitope)", 0, 0, null, null, 11, "Familial exudative vitreoretinopathy", 0.8152111103672746, null, 1.645], ["Q13651", "IL10RA", "Interleukin-10 receptor subunit alpha", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 0, null, null, 7, "Autosomal recessive early-onset inflammatory bowel disease", 0.8151052076044897, null, 1.645], ["Q5JUK3", "KCNT1", "Potassium channel subfamily T member 1", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 0, null, null, 6, "developmental and epileptic encephalopathy, 14", 0.8165232785825526, null, 1.645], ["Q01974", "ROR2", "Tyrosine-protein kinase transmembrane receptor ROR2", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 0, null, null, 6, "autosomal recessive Robinow syndrome", 0.8145559265435566, null, 1.644], ["Q9H222", "ABCG5", "ATP-binding cassette sub-family G member 5", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 0, null, null, 8, "sitosterolemia", 0.810555184820483, null, 1.643], ["Q9UM73", "ALK", "ALK tyrosine kinase receptor", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 0, null, null, 79, "neuroblastoma", 0.8016889264946979, null, 1.641], ["Q9NQW8", "CNGB3", "Cyclic nucleotide-gated channel beta-3", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 0, null, null, 9, "achromatopsia", 0.8033348000666748, null, 1.641], ["Q12866", "MERTK", "Tyrosine-protein kinase Mer", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 0, null, null, 42, "retinitis pigmentosa", 0.7985580877708576, null, 1.64], ["Q4KMG0", "CDON", "Cell adhesion molecule-related/down-regulated by oncogenes", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 0, null, null, 3, "holoprosencephaly", 0.800378039564866, null, 1.64], ["Q01718", "MC2R", "Adrenocorticotropic hormone receptor", "A_surface", "HPA protein class = G-protein coupled receptors (cell-surface, extracellular epitope)", 0, 0, null, null, 2, "familial glucocorticoid deficiency", 0.8001007686411645, null, 1.64], ["Q9H1D0", "TRPV6", "Transient receptor potential cation channel subfamily V member 6", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 0, null, null, 24, "hyperparathyroidism, transient neonatal", 0.7964821997780153, null, 1.639], ["P16871", "IL7R", "Interleukin-7 receptor subunit alpha", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 0, null, null, 8, "immunodeficiency 104", 0.7983119488718231, null, 1.639], ["O43525", "KCNQ3", "Potassium voltage-gated channel subfamily KQT member 3", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 0, null, null, 1, "Benign familial neonatal seizures", 0.7961763561533409, null, 1.639], ["P37023", "ACVRL1", "Activin receptor type-1-like", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 0, null, null, 7, "telangiectasia, hereditary hemorrhagic, type 2", 0.7951167515831324, null, 1.639], ["P15509", "CSF2RA", "Granulocyte-macrophage colony-stimulating factor receptor subunit alpha", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 0, null, null, 2, "Congenital pulmonary alveolar proteinosis", 0.7922592394513138, null, 1.638], ["Q14028", "CNGB1", "Cyclic nucleotide-gated channel beta-1", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 0, null, null, 11, "retinitis pigmentosa", 0.7931901344765326, null, 1.638], ["P16410", "CTLA4", "Cytotoxic T-lymphocyte protein 4", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 0, null, null, 22, "autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency", 0.7906408646569979, null, 1.637]], "truncated": false, "filtered_table_rows_count": 1184, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "surface_class", "surface_evidence", "ev_map_hallmark", "in_cev_map", "in_vesiclepedia", "in_exocarta", "pdb_count", "top_disease", "disease_score", "drug_count_approved", "targetability_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, surface_class, surface_evidence, ev_map_hallmark, in_cev_map, in_vesiclepedia, in_exocarta, pdb_count, top_disease, disease_score, drug_count_approved, targetability_score from v_surface_targets where \"in_cev_map\" = :p0 order by targetability_score desc limit 51", "params": {"p0": "0"}}, "facet_results": {"surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?in_cev_map=0", "results": [{"value": "A_surface", "label": "A_surface", "count": 708, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=0&surface_class=A_surface", "selected": false}, {"value": "A_assoc", "label": "A_assoc", "count": 303, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=0&surface_class=A_assoc", "selected": false}, {"value": "A2_pm_peripheral", "label": "A2_pm_peripheral", "count": 173, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=0&surface_class=A2_pm_peripheral", "selected": false}], "truncated": false}, "ev_map_hallmark": {"name": "ev_map_hallmark", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 1184, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=0&ev_map_hallmark=0", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?in_cev_map=0", "results": [{"value": 0, "label": 0, "count": 1184, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "surface_evidence", "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=0&_facet=surface_evidence"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=0&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 242.07951687276363, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}