{"database": "scout", "table": "v_surface_targets", "is_view": true, "human_description_en": "where in_cev_map = 0 and surface_class = \"A_assoc\" sorted by targetability_score descending", "rows": [["Q00604", "NDP", "Norrin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 11, "Norrie disease", 0.8566451682188412, null, 0.657], ["P15884", "TCF4", "Transcription factor 4", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 5, "Pitt-Hopkins syndrome", 0.8490531860867685, null, 0.655], ["Q9NZK5", "ADA2", "Adenosine deaminase 2", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 2, "deficiency of adenosine deaminase 2", 0.8291292532404531, null, 0.649], ["Q99972", "MYOC", "Myocilin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 24, "glaucoma 1, open angle, A", 0.8294483747483756, null, 0.649], ["O95970", "LGI1", "Leucine-rich glioma-inactivated protein 1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 9, "autosomal dominant epilepsy with auditory features", 0.8225657483127345, null, 0.647], ["Q9UBH0", "IL36RN", "Interleukin-36 receptor antagonist protein", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 3, "psoriasis 14, pustular", 0.8155144873787125, null, 0.645], ["P20062", "TCN2", "Transcobalamin-2", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 11, "transcobalamin II deficiency", 0.8116989428679681, null, 0.644], ["Q96MK3", "FAM20A", "Pseudokinase FAM20A", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 4, "amelogenesis imperfecta type 1G", 0.8106031517056754, null, 0.643], ["P55000", "SLURP1", "Secreted Ly-6/uPAR-related protein 1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 2, "mal de Meleda", 0.8064330379723671, null, 0.642], ["P45452", "MMP13", "Collagenase 3", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 49, "spondyloepimetaphyseal dysplasia, Missouri type", 0.8032079813035149, null, 0.641], ["P29460", "IL12B", "Interleukin-12 subunit beta", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 20, "psoriasis", 0.7914863943708039, null, 0.637], ["Q13253", "NOG", "Noggin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 2, "proximal symphalangism 1A", 0.7844136456463046, null, 0.635], ["P03971", "AMH", "Anti-Muellerian hormone", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 3, "persistent Mullerian duct syndrome", 0.7847328444470535, null, 0.635], ["Q96S42", "NODAL", "Nodal homolog", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 1, "heterotaxy, visceral, 5, autosomal", 0.7788051667024423, null, 0.634], ["P01138", "NGF", "Beta-nerve growth factor", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 8, "hereditary sensory and autonomic neuropathy type 5", 0.7785402119369383, null, 0.634], ["P18510", "IL1RN", "Interleukin-1 receptor antagonist protein", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 5, "sterile multifocal osteomyelitis with periostitis and pustulosis", 0.7734282711738736, null, 0.632], ["P29120", "PCSK1", "Neuroendocrine convertase 1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 3, "obesity due to prohormone convertase I deficiency", 0.773875795833803, null, 0.632], ["P00797", "REN", "Renin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 91, "familial juvenile hyperuricemic nephropathy type 2", 0.7657976389758877, null, 0.63], ["P05019", "IGF1", "Insulin-like growth factor 1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 32, "growth delay due to insulin-like growth factor type 1 deficiency", 0.7650418939376437, null, 0.63], ["Q9GZV9", "FGF23", "Fibroblast growth factor 23", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 6, "autosomal dominant hypophosphatemic rickets", 0.762326334964193, null, 0.629], ["P20849", "COL9A1", "Collagen alpha-1(IX) chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 5, "Stickler syndrome", 0.7594904923903256, null, 0.628], ["P16112", "ACAN", "Aggrecan core protein", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 4, "Familial osteochondritis dissecans", 0.7558487616449627, null, 0.627], ["P55789", "GFER", "FAD-linked sulfhydryl oxidase ALR", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 7, "congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome", 0.7556346526616893, null, 0.627], ["Q12794", "HYAL1", "Hyaluronidase-1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 1, "Hyaluronidase deficiency", 0.7412407206736383, null, 0.622], ["Q92752", "TNR", "Tenascin-R", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 2, "neurodevelopmental disorder, nonprogressive, with spasticity and transient opisthotonus", 0.7403484347367364, null, 0.622], ["O15520", "FGF10", "Fibroblast growth factor 10", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 2, "Lacrimoauriculodentodigital syndrome", 0.7344198619465704, null, 0.62], ["P35225", "IL13", "Interleukin-13", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 13, "atopic eczema", 0.7297489019498119, null, 0.619], ["Q2MKA7", "RSPO1", "R-spondin-1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 12, "palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome", 0.7285342885472184, null, 0.619], ["Q9BQB4", "SOST", "Sclerostin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 3, "sclerosteosis 1", 0.7184345506579789, null, 0.616], ["P05305", "EDN1", "Endothelin-1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 17, "auriculocondylar syndrome", 0.7193561828311311, null, 0.616], ["P12272", "PTHLH", "Parathyroid hormone-related protein", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 11, "brachydactyly type E", 0.7203484375635054, null, 0.616], ["O00300", "TNFRSF11B", "Tumor necrosis factor receptor superfamily member 11B", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 1, "juvenile Paget disease", 0.7184894548525037, null, 0.616], ["Q99574", "SERPINI1", "Neuroserpin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 3, "familial encephalopathy with neuroserpin inclusion bodies", 0.7162803151916303, null, 0.615], ["P01270", "PTH", "Parathyroid hormone", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 26, "hypoparathyroidism, familial isolated 1", 0.7147450451832739, null, 0.614], ["P11686", "SFTPC", "Surfactant protein C", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 3, "Congenital pulmonary alveolar proteinosis", 0.7110128683619542, null, 0.613], ["O43897", "TLL1", null, "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 1, "atrial heart septal defect", 0.7050140477090344, null, 0.612], ["P19835", "CEL", "Bile salt-activated lipase", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 7, "MODY", 0.6940743944678538, null, 0.608], ["O43323", "DHH", "Desert hedgehog protein", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 5, "46,XY gonadal dysgenesis-motor and sensory neuropathy syndrome", 0.6912706692651148, null, 0.607], ["P27352", "CBLIF", "Cobalamin binding intrinsic factor", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 2, "hereditary intrinsic factor deficiency", 0.683930100359911, null, 0.605], ["Q9Y5C1", "ANGPTL3", "Angiopoietin-related protein 3", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 1, "familial hypobetalipoproteinemia 2", 0.6739043862507132, null, 0.602], ["Q9Y5K2", "KLK4", "Kallikrein-4", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 18, "Hypomaturation amelogenesis imperfecta", 0.6659029046455642, null, 0.6], ["Q8N300", "SVBP", "Small vasohibin-binding protein", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 24, "neurodevelopmental disorder with ataxia, hypotonia, and microcephaly", 0.6640118055835142, null, 0.599], ["O95631", "NTN1", "Netrin-1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 5, "mirror movements 4", 0.6611393488240481, null, 0.598], ["P05113", "IL5", "Interleukin-5", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 5, "asthma", 0.6399821251487101, null, 0.592], ["Q16552", "IL17A", "Interleukin-17A", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 44, "psoriasis", 0.6367521314106471, null, 0.591], ["O95390", "GDF11", "Growth/differentiation factor 11", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 5, "vertebral hypersegmentation and orofacial anomalies", 0.6207007733160915, null, 0.586], ["P05230", "FGF1", "Fibroblast growth factor 1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 96, "cancer", 0.6088477966360052, null, 0.583], ["P22894", "MMP8", "Neutrophil collagenase", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 25, "acne", 0.603247809982021, null, 0.581], ["P09237", "MMP7", "Matrilysin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 16, "acne", 0.603247809982021, null, 0.581], ["O76093", "FGF18", "Fibroblast growth factor 18", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 0, null, null, 1, "cancer", 0.6028027301556572, null, 0.581]], "truncated": false, "filtered_table_rows_count": 303, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "surface_class", "surface_evidence", "ev_map_hallmark", "in_cev_map", "in_vesiclepedia", "in_exocarta", "pdb_count", "top_disease", "disease_score", "drug_count_approved", "targetability_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, surface_class, surface_evidence, ev_map_hallmark, in_cev_map, in_vesiclepedia, in_exocarta, pdb_count, top_disease, disease_score, drug_count_approved, targetability_score from v_surface_targets where \"in_cev_map\" = :p0 and \"surface_class\" = :p1 order by targetability_score desc limit 51", "params": {"p0": "0", "p1": "A_assoc"}}, "facet_results": {"surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?in_cev_map=0&surface_class=A_assoc", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 303, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=0", "selected": true}], "truncated": false}, "ev_map_hallmark": {"name": "ev_map_hallmark", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?in_cev_map=0&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 303, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=0&surface_class=A_assoc&ev_map_hallmark=0", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?in_cev_map=0&surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 303, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?surface_class=A_assoc", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "surface_evidence", "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=0&surface_class=A_assoc&_facet=surface_evidence"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=0&surface_class=A_assoc&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 173.16912207752466, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}