{"database": "scout", "table": "v_surface_targets", "is_view": true, "human_description_en": "where in_cev_map = 1 and surface_class = \"A_surface\" sorted by targetability_score descending", "rows": [["P11166", "SLC2A1", "Solute carrier family 2, facilitated glucose transporter member 1", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 1, 1, null, null, 5, "encephalopathy due to GLUT1 deficiency", 0.8521823225896756, null, 2.756], ["P07359", "GP1BA", "Platelet glycoprotein Ib alpha chain", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 22, "Bernard-Soulier syndrome", 0.8346884735388165, null, 2.75], ["P08514", "ITGA2B", "Integrin alpha-IIb", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 78, "Glanzmann thrombasthenia 1", 0.8224288672248264, null, 2.747], ["P14770", "GP9", "Platelet glycoprotein IX", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 2, "Bernard-Soulier syndrome", 0.8233582238860002, null, 2.747], ["P02730", "SLC4A1", "Band 3 anion transport protein", "A_surface", "HPA protein class = Blood group antigen proteins, CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 54, "hereditary spherocytosis type 4", 0.820137113225454, null, 2.746], ["P05106", "ITGB3", "Integrin beta-3", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 123, "Glanzmann thrombasthenia 1", 0.8208115968652424, null, 2.746], ["P16671", "CD36", "Platelet glycoprotein 4", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 1, "platelet-type bleeding disorder 10", 0.7360571429413174, null, 2.721], ["P08575", "PTPRC", "Receptor-type tyrosine-protein phosphatase C", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 6, "immunodeficiency 104", 0.7200430416648742, null, 2.716], ["P02786", "TFRC", "Transferrin receptor protein 1", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 22, "TFRC-related combined immunodeficiency", 0.623449899069336, null, 2.687], ["P05556", "ITGB1", "Integrin beta-1", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 22, "multiple sclerosis", 0.586769452063963, null, 2.676], ["P01764", "IGHV3-23", "Immunoglobulin heavy variable 3-23", "A_surface", "HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)", 1, 1, null, null, 6, "cutaneous Leishmaniasis", 0.5868213846274001, null, 2.676], ["P23083", "IGHV1-2", "Immunoglobulin heavy variable 1-2", "A_surface", "HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)", 1, 1, null, null, 1, "cutaneous Leishmaniasis", 0.5868213846274001, null, 2.676], ["P06312", "IGKV4-1", "Immunoglobulin kappa variable 4-1", "A_surface", "HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)", 1, 1, null, null, 10, "cutaneous Leishmaniasis", 0.5868213846274001, null, 2.676], ["Q12913", "PTPRJ", "Receptor-type tyrosine-protein phosphatase eta", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 5, "neurodegenerative disease", 0.54699134609967, null, 2.664], ["O00161", "SNAP23", "Synaptosomal-associated protein 23", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 1, 1, null, null, 2, "neurodegenerative disease", 0.5288361677964304, null, 2.659], ["P21926", "CD9", "CD9 antigen", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 5, "diphtheria", 0.5261379875719714, null, 2.658], ["P15144", "ANPEP", "Aminopeptidase N", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 15, "cholelithiasis", 0.5030146927270738, null, 2.651], ["P01871", "IGHM", "Immunoglobulin heavy constant mu", "A_surface", "HPA protein class = Immunoglobulin genes (cell-surface, extracellular epitope)", 1, 1, null, null, 30, "agammaglobulinemia", 0.4624778576025314, null, 2.639], ["P01833", "PIGR", "Polymeric immunoglobulin receptor", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 1, 1, null, null, 16, "clear cell renal carcinoma", 0.44260204134234277, null, 2.633], ["P17301", "ITGA2", "Integrin alpha-2", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 16, "Abnormality of the skeletal system", 0.4227839911251069, null, 2.627], ["P11169", "SLC2A3", "Solute carrier family 2, facilitated glucose transporter member 3", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 1, 1, null, null, 7, "neurodegenerative disease", 0.4054698468991856, null, 2.622], ["Q08722", "CD47", "Leukocyte surface antigen CD47", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 1, 1, null, null, 15, "myelodysplastic syndrome", 0.3682348506170252, null, 2.61], ["Q9HBI1", "PARVB", "Beta-parvin", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 1, 1, null, null, 3, "thyroiditis", 0.28021156500366357, null, 2.584], ["P02746", "C1QB", "Complement C1q subcomponent subunit B", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 1, 1, null, null, 11, null, null, null, 2.5], ["P21359", "NF1", "Neurofibromin", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 26, "neurofibromatosis type 1", 0.8844735398780649, null, 1.965], ["P33897", "ABCD1", "ATP-binding cassette sub-family D member 1", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 14, "adrenoleukodystrophy", 0.8656366512509434, null, 1.96], ["P04839", "CYBB", "NADPH oxidase 2", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 6, "chronic granulomatous disease", 0.8633132852459866, null, 1.959], ["P21802", "FGFR2", "Fibroblast growth factor receptor 2", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 62, "Crouzon syndrome", 0.8637438969881663, null, 1.959], ["P78504", "JAG1", "Protein jagged-1", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 7, "Alagille syndrome due to a JAG1 point mutation", 0.8586542923232751, null, 1.958], ["P00813", "ADA", "Adenosine deaminase", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 2, "Severe combined immunodeficiency due to adenosine deaminase deficiency", 0.8556816060494579, null, 1.957], ["P36021", "SLC16A2", "Monocarboxylate transporter 8", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 7, "Allan-Herndon-Dudley syndrome", 0.8533069932022032, null, 1.956], ["P51795", "CLCN5", "H(+)/Cl(-) exchange transporter 5", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 2, "Dent disease type 1", 0.850724240157394, null, 1.955], ["P29965", "CD40LG", "CD40 ligand", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 8, "hyper-IgM syndrome type 1", 0.8451678829647167, null, 1.954], ["P11362", "FGFR1", "Fibroblast growth factor receptor 1", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 82, "hypogonadotropic hypogonadism 2 with or without anosmia", 0.8472925100660907, null, 1.954], ["Q9NQ11", "ATP13A2", "Polyamine-transporting ATPase 13A2", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 25, "Kufor-Rakeb syndrome", 0.8439049037191295, null, 1.953], ["P08581", "MET", "Hepatocyte growth factor receptor", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 100, "papillary renal cell carcinoma", 0.84195976263742, null, 1.953], ["P06213", "INSR", "Insulin receptor", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 87, "Leprechaunism", 0.8448849372402896, null, 1.953], ["Q8WZ42", "TTN", "Titin", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 64, "dilated cardiomyopathy", 0.8419847660466327, null, 1.953], ["Q14524", "SCN5A", "Sodium channel protein type 5 subunit alpha", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 1, null, null, 16, "long QT syndrome 3", 0.8448298602976083, null, 1.953], ["Q969N2", "PIGT", "GPI-anchor transamidase component PIGT", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 3, "multiple congenital anomalies-hypotonia-seizures syndrome 3", 0.8439030764005646, null, 1.953], ["P13637", "ATP1A3", "Sodium/potassium-transporting ATPase subunit alpha-3", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 5, "alternating hemiplegia of childhood 2", 0.842328126568451, null, 1.953], ["P37173", "TGFBR2", "TGF-beta receptor type-2", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 22, "Loeys-Dietz syndrome", 0.8390072008866913, null, 1.952], ["P35499", "SCN4A", "Sodium channel protein type 4 subunit alpha", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 1, null, null, 3, "paramyotonia congenita of Von Eulenburg", 0.8401628899371881, null, 1.952], ["Q99250", "SCN2A", "Sodium channel protein type 2 subunit alpha", "A_surface", "HPA protein class = Voltage-gated ion channels (cell-surface, extracellular epitope)", 0, 1, null, null, 5, "developmental and epileptic encephalopathy, 11", 0.8388748085806758, null, 1.952], ["O00571", "DDX3X", "ATP-dependent RNA helicase DDX3X", "A_surface", "HPA integral membrane protein, Plasma membrane (extracellular domain reachable)", 0, 1, null, null, 17, "X-linked non-syndromic intellectual disability", 0.8362533125067105, null, 1.951], ["P19438", "TNFRSF1A", "Tumor necrosis factor receptor superfamily member 1A", "A_surface", "HPA protein class = CD markers (cell-surface, extracellular epitope)", 0, 1, null, null, 13, "TNF receptor 1-associated periodic fever syndrome", 0.8352778213184682, null, 1.951], ["P25189", "MPZ", "Myelin protein P0", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 2, "Charcot-Marie-Tooth disease type 1B", 0.8377022197539885, null, 1.951], ["P54760", "EPHB4", "Ephrin type-B receptor 4", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 23, "Capillary malformation - arteriovenous malformation", 0.8317426466005666, null, 1.95], ["Q9HAB3", "SLC52A2", "Solute carrier family 52, riboflavin transporter, member 2", "A_surface", "HPA integral membrane protein, no intracellular-only localization (extracellular domain reachable)", 0, 1, null, null, 1, "riboflavin transporter deficiency", 0.8333271825486935, null, 1.95], ["Q9Y653", "ADGRG1", "Adhesion G-protein coupled receptor G1", "A_surface", "HPA protein class = G-protein coupled receptors (cell-surface, extracellular epitope)", 0, 1, null, null, 1, "bilateral frontoparietal polymicrogyria", 0.8322298896713178, null, 1.95]], "truncated": false, "filtered_table_rows_count": 428, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "surface_class", "surface_evidence", "ev_map_hallmark", "in_cev_map", "in_vesiclepedia", "in_exocarta", "pdb_count", "top_disease", "disease_score", "drug_count_approved", "targetability_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, surface_class, surface_evidence, ev_map_hallmark, in_cev_map, in_vesiclepedia, in_exocarta, pdb_count, top_disease, disease_score, drug_count_approved, targetability_score from v_surface_targets where \"in_cev_map\" = :p0 and \"surface_class\" = :p1 order by targetability_score desc limit 51", "params": {"p0": "1", "p1": "A_surface"}}, 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"hideable": false, "toggle_url": "/scout/v_surface_targets.json?in_cev_map=1&surface_class=A_surface", "results": [{"value": 1, "label": 1, "count": 428, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?surface_class=A_surface", "selected": true}], "truncated": false}}, "suggested_facets": [{"name": "surface_evidence", "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=1&surface_class=A_surface&_facet=surface_evidence"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_surface_targets.json?in_cev_map=1&surface_class=A_surface&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 175.78853014856577, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}