{"database": "scout", "table": "v_surface_targets", "is_view": true, "human_description_en": "where surface_class = \"A_assoc\" sorted by targetability_score descending", "rows": [["P07225", "PROS1", "Vitamin K-dependent protein S", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 3, "thrombophilia due to protein S deficiency, autosomal dominant", 0.8240418292042652, null, 1.747], ["P48740", "MASP1", "Mannan-binding lectin serine protease 1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 9, "3MC syndrome 1", 0.8185972518103526, null, 1.746], ["Q9BWP8", "COLEC11", "Collectin-11", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 3, "3MC syndrome 2", 0.7977893521540559, null, 1.739], ["P12259", "F5", "Coagulation factor V", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 17, "thrombophilia due to activated protein C resistance", 0.7962069693286362, null, 1.739], ["P00488", "F13A1", "Coagulation factor XIII A chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 15, "Factor XIII subunit A deficiency", 0.7939842013132387, null, 1.738], ["O43707", "ACTN4", "Alpha-actinin-4", "A_assoc", "HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)", 1, 1, null, null, 5, "focal segmental glomerulosclerosis 1", 0.7778533437264424, null, 1.733], ["O00187", "MASP2", "Mannan-binding lectin serine protease 2", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 10, "immunodeficiency due to MASP-2 deficiency", 0.6996393077218865, null, 1.71], ["P18206", "VCL", "Vinculin", "A_assoc", "HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)", 1, 1, null, null, 37, "hypertrophic cardiomyopathy", 0.6924271529635582, null, 1.708], ["P02745", "C1QA", "Complement C1q subcomponent subunit A", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 11, "C1Q deficiency 1", 0.6319053256658114, null, 1.69], ["P62937", "PPIA", "Peptidyl-prolyl cis-trans isomerase A", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 100, "HIV infection", 0.6219943433906236, null, 1.687], ["P02747", "C1QC", "Complement C1q subcomponent subunit C", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 11, "C1Q deficiency", 0.6233532074390745, null, 1.687], ["Q14766", "LTBP1", "Latent-transforming growth factor beta-binding protein 1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 1, "Abnormality of the skeletal system", 0.5142669818409414, null, 1.654], ["P05109", "S100A8", "Protein S100-A8", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 13, "inborn error of immunity", 0.37050380432141355, null, 1.611], ["O43866", "CD5L", "CD5 antigen-like", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 4, "functional neutrophil defect", 0.3529395470693119, null, 1.606], ["P48059", "LIMS1", "LIM and senescent cell antigen-like-containing domain protein 1", "A_assoc", "HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)", 1, 1, null, null, 14, "Abruptio Placentae", 0.3236383460637068, null, 1.597], ["Q15485", "FCN2", "Ficolin-2", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 13, "hypopituitarism", 0.2753784074131916, null, 1.583], ["P01023", "A2M", "Alpha-2-macroglobulin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 13, "refractive error", 0.2285030343788678, null, 1.569], ["P02775", "PPBP", "Platelet basic protein", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 3, "neoplasm", 0.10852035364075, null, 1.533], ["P20851", "C4BPB", "C4b-binding protein beta chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 0, "venous thromboembolism", 0.5408858413761136, null, 1.262], ["Q13201", "MMRN1", "Multimerin-1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 1, 1, null, null, 0, "Parkinson disease", 0.3658959071578607, null, 1.21], ["P00451", "F8", "Coagulation factor VIII", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 25, "hemophilia A", 0.9108044347811838, null, 0.973], ["P12883", "MYH7", "Myosin-7", "A_assoc", "HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)", 0, 1, null, null, 43, "hypertrophic cardiomyopathy", 0.9029865147265421, null, 0.971], ["P00740", "F9", "Coagulation factor IX", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 56, "hemophilia B", 0.8880186703890781, null, 0.966], ["Q8NBP7", "PCSK9", "Proprotein convertase subtilisin/kexin type 9", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 62, "familial hypercholesterolemia", 0.8604029080346239, null, 0.958], ["P02461", "COL3A1", "Collagen alpha-1(III) chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 11, "Ehlers-Danlos syndrome, vascular type", 0.8608667500207768, null, 0.958], ["P17405", "SMPD1", "Sphingomyelin phosphodiesterase", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 4, "Niemann-Pick disease type A", 0.8567797114449874, null, 0.957], ["P08709", "F7", "Coagulation factor VII", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 100, "factor VII deficiency", 0.8542078994169972, null, 0.956], ["P01008", "SERPINC1", "Antithrombin-III", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 27, "hereditary antithrombin deficiency", 0.8494671886642873, null, 0.955], ["P02452", "COL1A1", "Collagen alpha-1(I) chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 14, "osteogenesis imperfecta type 2", 0.8471150130101988, null, 0.954], ["P02462", "COL4A1", "Collagen alpha-1(IV) chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 4, "brain small vessel disease 1 with or without ocular anomalies", 0.84655287380359, null, 0.954], ["P03951", "F11", "Coagulation factor XI", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 100, "factor XI deficiency", 0.841884208404384, null, 0.953], ["P45379", "TNNT2", "Troponin T, cardiac muscle", "A_assoc", "HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)", 0, 1, null, null, 25, "hypertrophic cardiomyopathy", 0.8329996050513441, null, 0.95], ["P02458", "COL2A1", "Collagen alpha-1(II) chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 11, "spondyloepiphyseal dysplasia congenita", 0.8334698564095305, null, 0.95], ["P08246", "ELANE", "Neutrophil elastase", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 38, "cyclic hematopoiesis", 0.8291093803980005, null, 0.949], ["P00450", "CP", "Ceruloplasmin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 4, "aceruloplasminemia", 0.8279493326009644, null, 0.948], ["P04180", "LCAT", "Phosphatidylcholine-sterol acyltransferase", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 7, "Fish-eye disease", 0.8273460309828392, null, 0.948], ["P00747", "PLG", "Plasminogen", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 49, "hypoplasminogenemia", 0.8240321266100769, null, 0.947], ["Q15582", "TGFBI", "Transforming growth factor-beta-induced protein ig-h3", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 10, "lattice corneal dystrophy type I", 0.8242841141270143, null, 0.947], ["P02649", "APOE", "Apolipoprotein E", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 29, "coronary artery disease", 0.81626595063263, null, 0.945], ["P06276", "BCHE", "Cholinesterase", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 100, "butyrylcholinesterase deficiency", 0.8051740584587205, null, 0.942], ["P06396", "GSN", "Gelsolin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 60, "Finnish type amyloidosis", 0.8048371651382773, null, 0.941], ["P02679", "FGG", "Fibrinogen gamma chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 48, "familial dysfibrinogenemia", 0.8002311001712851, null, 0.94], ["P07942", "LAMB1", "Laminin subunit beta-1", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 3, "cobblestone lissencephaly without muscular or ocular involvement", 0.8016665947624902, null, 0.94], ["P20908", "COL5A1", "Collagen alpha-1(V) chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 1, "Ehlers-Danlos syndrome, classic type, 1", 0.7979601586599098, null, 0.939], ["P02671", "FGA", "Fibrinogen alpha chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 40, "familial dysfibrinogenemia", 0.7947496460990987, null, 0.938], ["P02675", "FGB", "Fibrinogen beta chain", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 42, "congenital afibrinogenemia", 0.7892438060719716, null, 0.937], ["P22105", "TNXB", "Tenascin-X", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 3, "Ehlers-Danlos syndrome due to tenascin-X deficiency", 0.7916412481554758, null, 0.937], ["P03950", "ANG", "Angiogenin", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 56, "amyotrophic lateral sclerosis", 0.7865457274017922, null, 0.936], ["P08253", "MMP2", "72 kDa type IV collagenase", "A_assoc", "HPA Predicted secreted (soluble; may form EV surface corona, not integral)", 0, 1, null, null, 14, "Torg-Winchester syndrome", 0.7862502046091417, null, 0.936], ["P35609", "ACTN2", "Alpha-actinin-2", "A_assoc", "HPA subcellular = Focal adhesion sites (adhesion/junction, surface-associated)", 0, 1, null, null, 16, "dilated cardiomyopathy 1AA", 0.7856813926513253, null, 0.936]], "truncated": false, "filtered_table_rows_count": 539, "expanded_columns": [], "expandable_columns": [], "columns": ["id", "gene_symbol", "protein_name", "surface_class", "surface_evidence", "ev_map_hallmark", "in_cev_map", "in_vesiclepedia", "in_exocarta", "pdb_count", "top_disease", "disease_score", "drug_count_approved", "targetability_score"], "primary_keys": [], "units": {}, "query": {"sql": "select id, gene_symbol, protein_name, surface_class, surface_evidence, ev_map_hallmark, in_cev_map, in_vesiclepedia, in_exocarta, pdb_count, top_disease, disease_score, drug_count_approved, targetability_score from v_surface_targets where \"surface_class\" = :p0 order by targetability_score desc limit 51", "params": {"p0": "A_assoc"}}, "facet_results": {"surface_class": {"name": "surface_class", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?surface_class=A_assoc", "results": [{"value": "A_assoc", "label": "A_assoc", "count": 539, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json", "selected": true}], "truncated": false}, "ev_map_hallmark": {"name": "ev_map_hallmark", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 519, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?surface_class=A_assoc&ev_map_hallmark=0", "selected": false}, {"value": 1, "label": 1, "count": 20, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?surface_class=A_assoc&ev_map_hallmark=1", "selected": false}], "truncated": false}, "in_cev_map": {"name": "in_cev_map", "type": "column", "hideable": false, "toggle_url": "/scout/v_surface_targets.json?surface_class=A_assoc", "results": [{"value": 0, "label": 0, "count": 303, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?surface_class=A_assoc&in_cev_map=0", "selected": false}, {"value": 1, "label": 1, "count": 236, "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?surface_class=A_assoc&in_cev_map=1", "selected": false}], "truncated": false}}, "suggested_facets": [{"name": "surface_evidence", "toggle_url": "https://apt-scout.org/scout/v_surface_targets.json?surface_class=A_assoc&_facet=surface_evidence"}], "next": "50", "next_url": "https://apt-scout.org/scout/v_surface_targets.json?surface_class=A_assoc&_next=50", "private": false, "allow_execute_sql": true, "query_ms": 123.14670905470848, "source": "apt-scout automated curation pipeline (E. Dohi, NCNP) \u2014 values harvested from public databases; raw source stored per target", "source_url": "https://apt-scout.org", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/"}