id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q9Y2C5,SLC17A4,Probable small intestine urate exporter,Tier 1.5,0.878,0,83.69,0,0,,,,0,0,,0,inflammatory bowel disease,0.09896486250497885
P23946,CMA1,Chymase,Tier 1,0.875,42,91.31,0,0,,,,1,1,30572223,0,pernicious anemia,0.17348905136256007
Q9UJA9,ENPP5,Ectonucleotide pyrophosphatase/phosphodiesterase family member 5,Tier 1,0.87,1,88.12,0,0,,,,0,0,,0,neurodegenerative disease,0.33211724272317855
P13747,HLA-E,"HLA class I histocompatibility antigen, alpha chain E",Tier 1,0.865,34,87.0,0,0,,,,1,1,38473398,1,COVID-19,0.4822929100647597
Q9NX14,NDUFB11,"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial",Tier 1.5,0.86,0,77.56,0,0,,,,0,0,,1,Microphthalmia with linear skin defects syndrome,0.7364493324598024
P01911,HLA-DRB1,"HLA class II histocompatibility antigen, DRB1 beta chain",Tier 1,0.84,100,88.44,0,0,,,,0,0,,1,rheumatoid arthritis,0.40051584219092445
Q31135,H2-Ab1,,Tier 1,0.83,12,85.12,0,0,,,,0,0,,0,,
Q15848,ADIPOQ,Adiponectin,Tier 1,0.806,3,79.88,0,0,,,,1,10,"41636061,38392020,36508319,35323639,34796696,34117903,33535822,31988066,25105541",1,hearing loss,0.25844907375917336
P0DPK4,NOTCH2NLC,Notch homolog 2 N-terminal-like protein C,Tier 1.5,0.805,0,80.81,0,0,,,,0,0,,0,neuronal intranuclear inclusion disease,0.4999829066911242
P15260,IFNGR1,Interferon gamma receptor 1,Tier 1.5,0.804,5,66.0,0,0,,,,1,2,33667716,1,disseminated atypical mycobacterial infection,0.5414012388034828
P01236,PRL,Prolactin,Tier 1,0.795,12,85.56,0,0,,,,1,6,"40327044,30834248,29277631,28263753,27679852,16947086",0,AL amyloidosis,0.4619748183558772
Q9UBT7,CTNNAL1,Alpha-catulin,Tier 1.5,0.795,0,84.06,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.31316995706583495
O14788,TNFSF11,Tumor necrosis factor ligand superfamily member 11,Tier 1,0.79,2,79.19,0,0,,,,1,2,"15562003,41226313",0,osteoporosis,0.6957850224892792
Q14031,COL4A6,Collagen alpha-6(IV) chain,Tier 1.5,0.79,0,47.41,0,0,,,,0,0,,0,Dupuytren Contracture,0.5880367459451578
P36888,FLT3,Receptor-type tyrosine-protein kinase FLT3,Tier 1.5,0.788,11,75.94,0,0,,,,1,6,"41733039,34364920,31434881,30237882,29299123,22411871",1,acute myeloid leukemia,0.8313389209288576
P35555,FBN1,Fibrillin-1,Tier 1,0.78,11,,0,0,,,,0,0,,1,Marfan syndrome,0.8969300970597663
P01019,AGT,Angiotensinogen,Tier 1,0.779,22,86.44,0,0,,,,1,16,"35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235",1,renal tubular dysgenesis,0.7354947364860083
P37023,ACVRL1,Activin receptor type-1-like,Tier 1.5,0.779,7,82.0,0,0,,,,0,0,,0,"telangiectasia, hereditary hemorrhagic, type 2",0.7951167515831324
P01568,IFNA21,Interferon alpha-21,Tier 1.5,0.777,0,85.0,0,0,,,,0,0,,0,renal cell carcinoma,0.3695798546847018
P48023,FASLG,Tumor necrosis factor ligand superfamily member 6,Tier 1.5,0.775,3,80.19,0,0,,,,1,1,16581027,0,autoimmune lymphoproliferative syndrome type 1,0.6984292519156657
A6ND01,IZUMO1R,Sperm-egg fusion protein Juno,Tier 1,0.773,7,87.38,0,0,,,,0,0,,0,placental retention,0.23306495563589497
P02671,FGA,Fibrinogen alpha chain,Tier 1,0.77,40,60.34,0,0,,,,0,0,,1,familial dysfibrinogenemia,0.7947496460990987
A0A5H2UYS3,HLA-A,,Tier 1,0.77,20,85.25,0,0,,,,0,0,,0,,
P02776,PF4,Platelet factor 4,Tier 1.5,0.77,10,75.06,0,0,,,,1,10,"33859620,32366845,31967847,23847186,23673861,34248840,32022468",1,systemic scleroderma,0.11523541376593864
P03951,F11,Coagulation factor XI,Tier 1,0.77,100,86.88,0,0,,,,0,0,,1,factor XI deficiency,0.841884208404384
P29017,CD1C,T-cell surface glycoprotein CD1c,Tier 1.5,0.77,10,88.56,0,0,,,,0,0,,0,neoplasm,0.1106047389635713
P61769,B2M,Beta-2-microglobulin,Tier 1,0.77,100,94.06,0,0,,,,1,15,"41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167",1,Immunodeficiency by defective expression of HLA class 1,0.6180318849819645
Q9BVX2,TMEM106C,Transmembrane protein 106C,Tier 1.5,0.77,0,80.81,0,0,,,,0,0,,0,prostate carcinoma,0.21737104399686757
P27037,ACVR2A,Activin receptor type-2A,Tier 1.5,0.769,5,83.56,0,0,,,,0,0,,1,hepatocellular carcinoma,0.4908023126074436
O14958,CASQ2,Calsequestrin-2,Tier 1.5,0.767,4,90.5,0,0,,,,0,0,,1,catecholaminergic polymorphic ventricular tachycardia,0.7718998507471558
P26951,IL3RA,Interleukin-3 receptor subunit alpha,Tier 1,0.767,4,85.25,0,0,,,,1,3,"40931580,36171541,31323275",0,acute myeloid leukemia,0.46904332714118013
Q9H3K6,BOLA2,BolA-like protein 2,Tier 1.5,0.765,0,92.69,0,0,,,,0,0,,1,hepatocellular carcinoma,0.08093942543094014
A0A1B0GTW7,CIROP,Ciliated left-right organizer metallopeptidase,Tier 1.5,0.764,0,73.44,0,0,,,,0,0,,0,"heterotaxy, visceral, 12, autosomal",0.6929422132808513
O15370,SOX12,Transcription factor SOX-12,Tier 1.5,0.76,0,63.0,0,0,,,,0,0,,0,type 2 diabetes mellitus,0.3277369133971199
Q9BWF2,TRAIP,E3 ubiquitin-protein ligase TRAIP,Tier 1.5,0.76,1,74.94,0,0,,,,0,0,,0,Seckel syndrome 9,0.683878095944948
Q9BZR8,BCL2L14,Apoptosis facilitator Bcl-2-like protein 14,Tier 1.5,0.76,0,62.38,0,0,,,,0,0,,0,hypothyroidism,0.33117514363294837
A6NI61,MYMK,Protein myomaker,Tier 1.5,0.758,0,90.44,0,0,,,,0,0,,0,Carey-Fineman-Ziter  syndrome,0.7790386256350393
P05546,SERPIND1,Heparin cofactor 2,Tier 1,0.752,9,79.62,0,0,,,,1,4,"20062917,20053992,34248840,31247951",1,heparin cofactor 2 deficiency,0.719744572767547
Q16585,SGCB,Beta-sarcoglycan,Tier 1.5,0.75,0,76.44,0,0,,,,0,0,,0,autosomal recessive limb-girdle muscular dystrophy type 2E,0.8154766151472349
Q9GZU2,PEG3,Paternally-expressed gene 3 protein,Tier 1.5,0.75,1,44.53,0,0,,,,1,1,16595502,0,neurodegenerative disease,0.34815912577489827
P18075,BMP7,Bone morphogenetic protein 7,Tier 1.5,0.749,4,76.19,0,0,,,,1,1,30537181,0,Inguinal hernia,0.4420059023371716
P16471,PRLR,Prolactin receptor,Tier 1,0.747,12,61.03,0,0,,,,0,0,,0,familial hyperprolactinemia,0.5718636087471152
P56730,PRSS12,Neurotrypsin,Tier 1.5,0.746,0,77.31,0,0,,,,0,0,,0,"intellectual disability, autosomal recessive 1",0.6621935416695687
P05164,MPO,Myeloperoxidase,Tier 1,0.745,49,89.0,0,0,,,,1,16,"41629951,41316897,40501769,38127443,33534888,33495506,37991715,37277648,34183667,34117903,33869115,31210423,30431231",1,myeloperoxidase deficiency,0.7742533340195327
Q92956,TNFRSF14,Tumor necrosis factor receptor superfamily member 14,Tier 1.5,0.745,8,79.94,0,0,,,,0,0,,1,diffuse large B-cell lymphoma,0.5983171413833771
P01563,,,Tier 1,0.744,13,85.06,0,0,,,,0,0,,0,renal cell carcinoma,0.3938654263610389
P16112,ACAN,Aggrecan core protein,Tier 1.5,0.74,4,51.91,0,0,,,,0,0,,0,Familial osteochondritis dissecans,0.7558487616449627
Q14246,ADGRE1,Adhesion G protein-coupled receptor E1,Tier 1.5,0.74,0,76.69,0,0,,,,0,0,,0,diabetic ketoacidosis,0.20424823130055986
Q8N6D2,RNF182,E3 ubiquitin-protein ligase RNF182,Tier 1.5,0.74,0,70.25,0,0,,,,0,0,,0,periapical tissue disease,0.304701328693288
Q00LT1,PRCD,Photoreceptor disk component PRCD,Tier 1.5,0.737,0,63.97,0,0,,,,0,0,,0,retinitis pigmentosa,0.7650522818524582