id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P25445,FAS,Tumor necrosis factor receptor superfamily member 6,Tier 1.5,0.914,7,77.88,1,0,,,,1,17,"40784034,39897575,37458448,36908619,35402075,32270033,31436946,30594071,30417194,30339905,26318819,23980164,23511245,18997060,18956014,16729304,16581027",1,autoimmune lymphoproliferative syndrome type 1,0.7377210386590284
P21583,KITLG,Kit ligand,Tier 1.5,0.848,6,71.88,1,0,,,,1,2,"36579647,23967247",0,"hyperpigmentation with or without hypopigmentation, familial progressive",0.6756727302967072
Q00975,CACNA1B,Voltage-dependent N-type calcium channel subunit alpha-1B,Tier 1.5,0.807,7,59.91,1,0,,,,1,2,"31118475,25782368",0,Seizure,0.7217241968702018
P15260,IFNGR1,Interferon gamma receptor 1,Tier 1.5,0.804,5,66.0,0,0,,,,1,2,33667716,1,disseminated atypical mycobacterial infection,0.5414012388034828
P02748,C9,Complement component C9,Tier 1.5,0.796,9,78.75,1,0,,,,1,10,"41636061,40411682,36428893,36290981,35247355,28794177,27836219,22678933,19261617,15687383",1,Immunodeficiency due to a late component of complements deficiency,0.761965409699055
Q13085,ACACA,Acetyl-CoA carboxylase 1,Tier 1.5,0.79,10,82.81,1,0,,,,1,1,41854184,1,,
P36888,FLT3,Receptor-type tyrosine-protein kinase FLT3,Tier 1.5,0.788,11,75.94,0,0,,,,1,6,"41733039,34364920,31434881,30237882,29299123,22411871",1,acute myeloid leukemia,0.8313389209288576
Q92633,LPAR1,Lysophosphatidic acid receptor 1,Tier 1.5,0.785,16,83.62,1,0,,,,1,1,32065590,1,Epiretinal membrane,0.4757255248053499
P03971,AMH,Anti-Muellerian hormone,Tier 1.5,0.783,3,68.62,1,0,,,,1,2,"41101154,27364573",0,persistent Mullerian duct syndrome,0.7847328444470535
P48023,FASLG,Tumor necrosis factor ligand superfamily member 6,Tier 1.5,0.775,3,80.19,0,0,,,,1,1,16581027,0,autoimmune lymphoproliferative syndrome type 1,0.6984292519156657
P02776,PF4,Platelet factor 4,Tier 1.5,0.77,10,75.06,0,0,,,,1,10,"33859620,32366845,31967847,23847186,23673861,34248840,32022468",1,systemic scleroderma,0.11523541376593864
P39060,COL18A1,Collagen alpha-1(XVIII) chain,Tier 1.5,0.769,9,50.62,1,0,,,,1,2,"36707842,23679916",1,Knobloch syndrome 1,0.7867122552672962
P43007,SLC1A4,Neutral amino acid transporter A,Tier 1.5,0.75,1,80.56,1,0,,,,1,6,"36219068,31989939,27571928,26811678,19046328,16139842",1,spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome,0.8025684205131692
Q9GZU2,PEG3,Paternally-expressed gene 3 protein,Tier 1.5,0.75,1,44.53,0,0,,,,1,1,16595502,0,neurodegenerative disease,0.34815912577489827
P18075,BMP7,Bone morphogenetic protein 7,Tier 1.5,0.749,4,76.19,0,0,,,,1,1,30537181,0,Inguinal hernia,0.4420059023371716
P08648,ITGA5,Integrin alpha-5,Tier 1.5,0.748,14,85.25,1,0,,,,1,2,"32174798,38258032",1,skin disease,0.28465651599598124
O60884,DNAJA2,DnaJ homolog subfamily A member 2,Tier 1.5,0.73,1,83.38,1,0,,,,1,2,"41935727,33879515",1,dengue disease,0.37068859424875583
Q9Y5C1,ANGPTL3,Angiopoietin-related protein 3,Tier 1.5,0.727,1,79.62,0,0,,,,1,1,23770039,0,familial hypobetalipoproteinemia 2,0.6739043862507132
Q99988,GDF15,Growth/differentiation factor 15,Tier 1.5,0.718,4,75.69,1,0,,,,1,29,"41924874,41862097,38879214,38477735,37982669,36927042,36638554,36508319,36333824,35762561,33334063,32527800,31988066,29992704,39884764,38497478,38296402,37162508,32739349,30335547",1,hyperemesis gravidarum,0.5821658682742563
Q00604,NDP,Norrin,Tier 1.5,0.716,11,83.56,1,0,,,,1,2,"39057719,11352723",0,Norrie disease,0.8566451682188412
P46094,XCR1,Chemokine XC receptor 1,Tier 1.5,0.715,1,84.94,1,0,,,,1,1,35212764,0,COVID-19,0.459103766220463
P32239,CCKBR,Gastrin/cholecystokinin type B receptor,Tier 1.5,0.713,5,75.75,1,0,,,,1,2,"33776434,27754762",0,gastroesophageal reflux disease,0.4256110167566802
P25106,ACKR3,Atypical chemokine receptor 3,Tier 1.5,0.71,14,82.44,1,0,,,,1,2,"40401615,28670693",0,oculomotor-abducens synkinesis,0.49893280382434735
P41221,WNT5A,Protein Wnt-5a,Tier 1.5,0.71,0,87.69,0,0,,,,1,4,"40855286,32693649,22363130,18673242",1,Robinow syndrome,0.7220360983378594
A0A0C5B5G6,MT-RNR1,Mitochondrial-derived peptide MOTS-c,Tier 1.5,0.7,0,72.06,0,0,,,,1,1,35311942,0,,
P07225,PROS1,Vitamin K-dependent protein S,Tier 1.5,0.7,3,82.94,1,0,,,,1,2,"36859809,33674695",1,"thrombophilia due to protein S deficiency, autosomal dominant",0.8240418292042652
P08620,FGF4,Fibroblast growth factor 4,Tier 1.5,0.7,1,81.5,0,0,,,,1,3,"35415885,33536494,7547864",0,cancer,0.6026669167438079
P19021,PAM,Peptidyl-glycine alpha-amidating monooxygenase,Tier 1.5,0.695,0,71.69,0,0,,,,1,25,"41855944,41500123,41384307,41285544,41222440,40607956,39929897,39472107,38867016,38846799,37977804,37977780,37906116,37127012,36905684,35478209,33911033,33516855,32315032,32307868,30399413,30124431,26406332,22954359,14965210",1,type 2 diabetes mellitus,0.5754371880839976
P21359,NF1,Neurofibromin,Tier 1.5,0.695,26,87.19,1,0,,,,1,2,"32980430,22617876",1,neurofibromatosis type 1,0.8844735398780649
P21781,FGF7,Fibroblast growth factor 7,Tier 1.5,0.695,0,82.44,0,0,,,,1,5,"35415885,15719578,7547864,16462265",0,cancer,0.5963369026823151
P10586,PTPRF,Receptor-type tyrosine-protein phosphatase F,Tier 1.5,0.69,13,82.0,0,0,,,,1,4,"42101929,39087949,36594741",1,smoking initiation,0.4641111755355386
O00501,CLDN5,Claudin-5,Tier 1.5,0.685,0,83.75,0,0,,,,1,1,18951306,1,genetic disorder,0.40861362787778505
Q96RJ3,TNFRSF13C,Tumor necrosis factor receptor superfamily member 13C,Tier 1.5,0.681,8,63.03,1,0,,,,1,1,23470998,0,"immunodeficiency, common variable, 4",0.660711678987284
P14384,CPM,Carboxypeptidase M,Tier 1.5,0.68,1,90.31,0,0,,,,1,3,"38876068,38060303,36768220",1,hydronephrosis,0.3163273148871551
P26718,KLRK1,NKG2-D type II integral membrane protein,Tier 1.5,0.679,22,79.19,0,0,,,,1,1,24629635,0,Behcet's syndrome,0.18614538678991077
P09758,TACSTD2,Tumor-associated calcium signal transducer 2,Tier 1.5,0.673,7,82.69,0,0,,,,1,4,"41384307,41241473,40050871,39250993",1,gelatinous drop-like corneal dystrophy,0.7293087728162646
P98066,TNFAIP6,Tumor necrosis factor-inducible gene 6 protein,Tier 1.5,0.671,5,81.12,0,0,,,,1,1,39263947,1,type 2 diabetes mellitus,0.30862220597837015
O00744,WNT10B,Protein Wnt-10b,Tier 1.5,0.668,0,80.06,0,0,,,,1,2,"32810272,18673242",0,Split hand-split foot malformation,0.7755225395358214
O95750,FGF19,Fibroblast growth factor 19,Tier 1.5,0.668,4,79.81,0,0,,,,1,4,"35415885,31967847,27679852",0,cancer,0.38540691230511315
Q9HCK4,ROBO2,Roundabout homolog 2,Tier 1.5,0.665,6,67.38,0,0,,,,1,2,"40616090,31640794",0,familial vesicoureteral reflux,0.6460375744556555
Q6PCB0,VWA1,von Willebrand factor A domain-containing protein 1,Tier 1.5,0.664,0,78.38,0,0,,,,1,4,"41906877,41693575,38904251,38299345",0,"neuronopathy, distal hereditary motor, autosomal recessive 7",0.7420531156755253
A2RU14,TMEM218,Transmembrane protein 218,Tier 1.5,0.663,0,87.62,0,0,,,,1,6,"41360349,34861273,31349094,29277631,26580576,26248137",0,Joubert syndrome 39,0.7308441626389979
P16870,CPE,Carboxypeptidase E,Tier 1.5,0.66,0,90.38,0,0,,,,1,16,"39863729,39793371,38861005,36832010,36773630,27886773,27219679,25738486,28706644,24768847,23875581,22280349,21419619,20949139,20491465,19174227",1,BDV syndrome,0.7029731914682913
P18510,IL1RN,Interleukin-1 receptor antagonist protein,Tier 1.5,0.66,5,87.06,0,0,,,,1,1,38928037,0,sterile multifocal osteomyelitis with periostitis and pustulosis,0.7734282711738736
P22692,IGFBP4,Insulin-like growth factor-binding protein 4,Tier 1.5,0.66,4,77.25,0,0,,,,1,6,"35323639,32515246,31930684",1,allergic rhinitis,0.35214760515440524
P98155,VLDLR,Very low-density lipoprotein receptor,Tier 1.5,0.66,27,75.69,1,0,,,,1,1,19188685,1,Dysequilibrium syndrome,0.790164037509625
Q13433,SLC39A6,Zinc transporter ZIP6,Tier 1.5,0.66,0,60.44,0,0,,,,1,1,40132409,1,breast cancer,0.11188167100061543
Q86YL7,PDPN,Podoplanin,Tier 1.5,0.66,6,57.97,0,0,,,,1,4,"41304780,41292412,39451677",0,Microscopic hematuria,0.41183796492083136
O15389,SIGLEC5,Sialic acid-binding Ig-like lectin 5,Tier 1.5,0.656,3,77.75,0,0,,,,1,3,"33584010,27678199,24405684",0,dentures,0.15815607474115415
P02766,TTR,Transthyretin,Tier 1.5,0.655,0,88.0,0,0,,,,1,11,"39737993,32616928,23770039,21875107,21314458,39596348,38399458,36881759,33572452",1,"amyloidosis, hereditary systemic 1",0.846421986844374