id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P08034,,,Tier 1,0.604,1,unknown,15,80.25,1,0,,,0,0,,0,Charcot-Marie-Tooth disease X-linked dominant 1,0.8483281160610058
P23415,,,Tier 1,0.597,1,unknown,9,84.0,1,0,,,0,0,,0,hereditary hyperekplexia,0.822516157871453
Q5IJ48,,,Tier 1.5,0.593,1,unknown,1,76.44,0,0,,,0,0,,0,ventriculomegaly-cystic kidney disease,0.8112741813611002
Q13422,,,Tier 1,0.591,1,unknown,10,47.75,1,0,,,0,0,,0,pancytopenia due to IKZF1 mutations,0.8043234687306351
Q5JTC6,,,Tier 1,0.59,1,unknown,3,48.31,0,0,,,0,0,,0,osteopathia striata with cranial sclerosis,0.8010289843367673
P43146,,,Tier 1,0.587,1,unknown,9,68.19,0,0,,,0,0,,0,mirror movements 1,0.7894844854575112
Q8WYB5,,,Tier 1,0.587,1,unknown,3,48.97,0,0,,,0,0,,0,genitopatellar syndrome,0.7887666805196595
Q92794,,,Tier 1,0.587,1,unknown,21,48.66,0,0,,,0,0,,0,autosomal dominant intellectual disability-craniofacial anomalies-cardiac defects syndrome,0.7908994336990406
O60828,,,Tier 1,0.586,1,unknown,3,70.56,0,0,,,0,0,,0,Renpenning syndrome,0.7876227110842514
P01185,,,Tier 1.5,0.585,1,unknown,5,79.44,1,0,,,0,0,,0,neurohypophyseal diabetes insipidus,0.7825664629740794
O15297,,,Tier 1.5,0.583,1,unknown,1,67.88,0,0,,,0,0,,0,intellectual developmental disorder with gastrointestinal difficulties and high pain threshold,0.7779617805712467
P48067,SLC6A9,Sodium- and chloride-dependent glycine transporter 1,Tier 1,0.582,1,unknown,9,81.12,1,0,,,0,0,,0,atypical glycine encephalopathy,0.7733051820377859
O60930,,,Tier 1.5,0.574,1,unknown,7,79.56,0,0,,,0,0,,0,"progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2",0.74733857283595
Q09013,,,Tier 1,0.574,1,unknown,2,77.62,0,0,,,0,0,,0,myotonic dystrophy type 1,0.7480475113698601
Q6IQ55,,,Tier 1,0.569,1,unknown,6,48.84,0,0,,,0,0,,0,spinocerebellar ataxia type 11,0.7308755447203157
O60882,,,Tier 1.5,0.568,1,unknown,1,83.31,0,0,,,0,0,,0,Hypomaturation amelogenesis imperfecta,0.7281006394540224
P29973,,,Tier 1,0.566,1,unknown,19,76.25,1,0,,,0,0,,0,retinitis pigmentosa,0.7206608041231198
O75838,,,Tier 1.5,0.564,1,unknown,1,88.62,0,0,,,0,0,,0,"hearing loss, autosomal recessive",0.7117048435819099
P98073,,,Tier 1,0.563,1,unknown,14,81.5,1,0,,,0,0,,0,congenital enteropathy due to enteropeptidase deficiency,0.7102613227574134
Q15080,,,Tier 1,0.548,1,unknown,6,84.19,0,0,,,0,0,,0,chronic granulomatous disease,0.6592487859566178
Q5SWA1,,,Tier 1.5,0.54,1,unknown,5,49.03,1,0,,,0,0,,0,"microcephaly, short stature, and impaired glucose metabolism 2",0.6334721902580683
Q9NUW8,,,Tier 1,0.538,1,unknown,48,80.62,0,0,,,0,0,,0,"spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1",0.6250066855961889
O15393,,,Tier 1,0.535,1,unknown,31,79.38,1,0,,,0,0,,0,COVID-19,0.6157541390484623
P39086,,,Tier 1,0.532,1,unknown,11,81.12,0,0,,,0,0,,0,epilepsy,0.6079292940174927
Q13639,,,Tier 1,0.532,1,unknown,3,80.88,1,0,,,0,0,,0,schizophrenia,0.6060830827022777
O43614,,,Tier 1,0.53,1,unknown,11,78.94,1,0,,,0,0,,0,insomnia,0.5988748728311054
O43543,,,Tier 1.5,0.529,1,unknown,16,87.12,1,0,,,0,0,,0,spermatogenic failure 50,0.5955217891975265
Q6PCD5,,,Tier 1,0.525,1,unknown,1,70.12,0,0,,,0,0,,0,"Fanconi anemia, complementation group W",0.5849156442856244
Q496J9,,,Tier 1,0.521,1,unknown,6,78.0,0,0,,,0,0,,0,botulism,0.569067134332723
P35568,,,Tier 1,0.518,1,unknown,8,49.0,0,0,,,0,0,,0,Abnormality of the skeletal system,0.5600726776459989
P29074,,,Tier 1,0.511,1,unknown,8,77.19,0,0,,,0,0,,0,neurodegenerative disease,0.5366583695296713
Q9BZC1,,,Tier 1,0.509,1,unknown,2,61.47,0,0,,,0,0,,0,major depressive disorder,0.5312056211019677
O75616,ERAL1,"GTPase Era, mitochondrial",Tier 1,0.504,1,unknown,2,77.94,1,0,,,0,0,,0,neurodegenerative disease,0.5128349940245936
Q15291,,,Tier 1,0.5,1,unknown,27,77.75,1,0,,,0,0,,0,neurodegenerative disease,0.500512770014237
P25025,,,Tier 1,0.499,1,unknown,18,79.56,1,0,,,0,0,,0,WHIM syndrome 2,0.4956521666475962
P01579,,,Tier 1.5,0.498,1,unknown,8,85.31,0,0,,,0,0,,0,Primary hemophagocytic lymphohistiocytosis,0.49197933519665166
Q96QB1,,,Tier 1,0.494,1,unknown,7,55.88,0,0,,,0,0,,0,Abnormality of the skeletal system,0.4815591361203349
Q58F21,,,Tier 1,0.491,1,unknown,21,62.44,0,0,,,0,0,,0,male infertility with teratozoospermia due to single gene mutation,0.46995568999565185
Q9UHK0,,,Tier 1,0.491,1,unknown,1,55.25,0,0,,,0,0,,0,neurodegenerative disease,0.4706636090264093
P06307,,,Tier 1,0.487,1,unknown,9,65.12,1,0,,,0,0,,0,Abnormality of the skeletal system,0.45523854320041374
Q6NW34,RMP64,Ribonuclease MRP subunit P64,Tier 1.5,0.485,1,unknown,3,64.0,1,0,,,0,0,,0,anauxetic dysplasia 3,0.44914218451265836
Q9UNN5,,,Tier 1,0.475,1,unknown,16,77.0,1,0,,,0,0,,0,atrial fibrillation,0.41761152415302133
O15075,,,Tier 1,0.474,1,unknown,11,72.19,0,0,,,0,0,,0,mathematical ability,0.414033055781774
P01563,,,Tier 1,0.468,1,unknown,13,85.06,0,0,,,0,0,,0,renal cell carcinoma,0.3938654263610389
Q9NVH2,,,Tier 1,0.465,1,unknown,8,88.06,1,0,,,0,0,,0,neurodegenerative disease,0.38183943401611947
Q86X95,CIRSR,Corepressor of RBPJ and splicing regulator,Tier 1,0.463,1,unknown,2,59.72,1,0,,,0,0,,0,major depressive disorder,0.3767349972483621
Q14416,,,Tier 1,0.461,1,unknown,31,85.69,1,0,,,0,0,,0,schizophrenia,0.36850365898315596
P42679,,,Tier 1,0.459,1,unknown,3,83.75,0,0,,,0,0,,0,neurodegenerative disease,0.36332514256792015
Q1MX18,,,Tier 1,0.455,1,unknown,1,83.12,0,0,,,0,0,,0,diverticular disease,0.34835781104015423
P49765,VEGFB,Vascular endothelial growth factor B,Tier 1,0.451,1,unknown,4,73.5,0,0,,,1,2,27189805,0,diabetic macular edema,0.3361465485773345