id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P10721,,,Tier 1,0.768,1,unknown,52,78.19,0,0,,,0,0,,1,gastrointestinal stromal tumor,0.8922566232622926
Q07889,,,Tier 1,0.761,1,unknown,91,76.38,0,0,,,0,0,,1,Noonan syndrome,0.8708318719184144
Q05086,,,Tier 1,0.753,1,unknown,27,80.75,1,0,,,0,0,,1,Angelman syndrome,0.8429347259838658
P06400,,,Tier 1,0.752,1,unknown,19,76.06,0,0,,,0,0,,1,retinoblastoma,0.8408754966665243
P52732,,,Tier 1,0.747,1,unknown,62,74.38,0,0,,,0,0,,1,"microcephaly with or without chorioretinopathy, lymphedema, or intellectual disability",0.8220137873148912
Q15858,,,Tier 1,0.747,1,unknown,43,69.06,1,0,,,0,0,,1,primary erythermalgia,0.8237835765987434
Q04771,,,Tier 1,0.745,1,unknown,85,83.12,0,0,,,0,0,,1,fibrodysplasia ossificans progressiva,0.8164474171712364
Q9NP72,,,Tier 1,0.745,1,unknown,1,85.56,0,0,,,0,0,,1,Micro syndrome,0.816071079017092
P35222,,,Tier 1,0.743,1,unknown,50,81.06,0,0,,,0,0,,1,severe intellectual disability-progressive spastic diplegia syndrome,0.8101632011131414
P02751,,,Tier 1,0.74,1,unknown,69,69.62,0,0,,,0,0,,1,"spondylometaphyseal dysplasia, 'corner fracture' type",0.8013288836166759
Q92608,,,Tier 1,0.734,1,unknown,6,79.81,1,0,,,0,0,,1,DOCK2 deficiency,0.7814025939223274
O43318,,,Tier 1,0.73,1,unknown,25,69.0,0,0,,,0,0,,1,frontometaphyseal dysplasia 2,0.767839253516465
P84243,,,Tier 1,0.719,1,unknown,100,85.94,0,0,,,0,0,,1,Bryant-Li-Bhoj neurodevelopmental syndrome 2,0.7290694534626342
Q8TD19,,,Tier 1,0.714,1,unknown,2,73.94,0,0,,,0,0,,1,NEK9-related lethal skeletal dysplasia,0.7132294892240114
Q9H6S3,,,Tier 1,0.705,1,unknown,2,73.06,0,0,,,0,0,,1,"hearing loss, autosomal recessive",0.6818863306678549
Q5T5Y3,,,Tier 1,0.694,1,unknown,4,54.34,1,0,,,0,0,,1,"cortical dysplasia, complex, with other brain malformations 12",0.6471266259726068
P17948,,,Tier 1,0.685,1,unknown,12,72.62,0,0,,,0,0,,1,neoplasm,0.6169964471592176
P55210,,,Tier 1,0.684,1,unknown,47,81.69,0,0,,,0,0,,1,cataract,0.6121422420887519
P01861,,,Tier 1,0.676,1,unknown,15,86.75,0,0,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001
Q08945,SSRP1,FACT complex subunit SSRP1,Tier 1,0.675,1,unknown,11,74.19,1,0,,,1,1,39653795,1,HIV infection,0.5844684701481319
P27694,,,Tier 1,0.672,1,unknown,48,83.81,0,0,,,0,0,,1,"pulmonary fibrosis and/or bone marrow failure, telomere-related, 6",0.5720870296163543
Q96PU8,,,Tier 1,0.668,1,unknown,1,68.69,0,0,,,0,0,,1,cancer,0.5616375835401949
P45985,,,Tier 1,0.665,1,unknown,4,77.0,0,0,,,0,0,,1,neurodegenerative disease,0.5507437937196141
P17676,,,Tier 1,0.661,1,unknown,16,59.69,0,0,,,0,0,,1,neurodegenerative disease,0.5352429213193124
O14618,,,Tier 1,0.658,1,unknown,7,87.38,0,0,,,0,0,,1,neurodegenerative disease,0.5272415940824882
P54764,,,Tier 1,0.656,1,unknown,17,83.5,0,0,,,0,0,,1,medullary thyroid gland carcinoma,0.5195314334008982
P30419,,,Tier 1,0.655,1,unknown,52,83.25,0,0,,,0,0,,1,neurodegenerative disease,0.5174483590720084
Q8N1W1,,,Tier 1,0.654,1,unknown,2,61.56,0,0,,,0,0,,1,hearing loss,0.5135177841424435
P43487,,,Tier 1,0.651,1,unknown,4,83.38,1,0,,,0,0,,1,HIV infection,0.5030392466541774
Q16611,,,Tier 1,0.639,1,unknown,55,81.31,0,0,,,0,0,,1,chronic lymphocytic leukemia,0.46377569349166126
Q13432,,,Tier 1,0.634,1,unknown,9,77.88,0,0,,,0,0,,1,idiopathic CD4 lymphocytopenia,0.4456292509980772
Q9BXB4,,,Tier 1,0.633,1,unknown,1,74.06,0,0,,,0,0,,1,neurodegenerative disease,0.4435303946057042
Q14213,,,Tier 1,0.628,1,unknown,4,87.62,1,0,,,0,0,,1,neurodegenerative disease,0.42776938116451996
F8WCM5,,,Tier 1,0.624,1,unknown,4,48.81,1,0,,,0,0,,1,neurodegenerative disease,0.4145162522265602
P57735,,,Tier 1,0.621,1,unknown,2,86.62,0,0,,,0,0,,1,atrial fibrillation,0.40258191116027553
Q13131,,,Tier 1,0.614,1,unknown,12,79.56,1,0,,,0,0,,1,cardiovascular disease,0.37913864498012223
P07360,,,Tier 1,0.611,1,unknown,15,89.75,1,0,,,0,0,,1,complement deficiency,0.3695798546847018
P20339,,,Tier 1,0.611,1,unknown,14,84.88,1,0,,,0,0,,1,tuberculosis,0.3708733841760982
P08034,,,Tier 1,0.604,1,unknown,15,80.25,1,0,,,0,0,,0,Charcot-Marie-Tooth disease X-linked dominant 1,0.8483281160610058
Q96HW7,,,Tier 1,0.599,1,unknown,11,83.19,1,0,,,0,0,,1,systemic lupus erythematosus,0.3316421846062003
Q8IYB1,,,Tier 1,0.598,1,unknown,1,83.56,0,0,,,0,0,,1,Hashimoto's thyroiditis,0.32654837821466426
Q8NBJ9,,,Tier 1,0.598,1,unknown,7,80.25,1,0,,,0,0,,1,hypothyroidism,0.32686531914177924
P23415,,,Tier 1,0.597,1,unknown,9,84.0,1,0,,,0,0,,0,hereditary hyperekplexia,0.822516157871453
Q15061,,,Tier 1,0.593,1,unknown,3,69.62,1,0,,,0,0,,1,triple-negative breast cancer,0.31136131887350776
Q96Q15,,,Tier 1,0.593,1,unknown,10,76.88,1,0,,,0,0,,1,contracture,0.30952829622581673
Q9UMX3,,,Tier 1,0.592,1,unknown,1,83.5,0,0,,,0,0,,1,"osteoarthritis, knee",0.3060308474018532
Q9Y4K1,,,Tier 1,0.592,1,unknown,3,48.94,0,0,,,0,0,,1,psoriasis,0.3053444558877832
Q13422,,,Tier 1,0.591,1,unknown,10,47.75,1,0,,,0,0,,0,pancytopenia due to IKZF1 mutations,0.8043234687306351
Q5JTC6,,,Tier 1,0.59,1,unknown,3,48.31,0,0,,,0,0,,0,osteopathia striata with cranial sclerosis,0.8010289843367673
P16333,,,Tier 1,0.589,1,unknown,15,70.75,0,0,,,0,0,,1,Abnormality of the skeletal system,0.2961979178331516