id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P05106,ITGB3,Integrin beta-3,Positive Control,0.715,123,87.0,1,1,8T2U,8T2V,,1,2,"22133781,23544955",1,Glanzmann thrombasthenia 1,0.8208115968652424
P11802,CDK4,Cyclin-dependent kinase 4,Tier 1,0.575,15,86.81,1,1,2W96,3G33,,1,2,"41535871,21059336",1,"melanoma, cutaneous malignant, susceptibility to, 3",0.7141203476842687
P06756,ITGAV,Integrin alpha-V,Tier 1.5,0.572,0,88.31,0,1,1L5G,1JV2,,1,8,"27693080,31361124,28191852,21848510,21136958,21071077,19235198",1,neurodegenerative disease,0.41990892731367724
P00519,ABL1,Tyrosine-protein kinase ABL1,Tier 1,0.0,85,63.38,0,1,2GQG,1OPL,,1,5,"31295447,23836560,22411871,21810089,21653319",1,chronic myelogenous leukemia,0.8219762968845584
P01116,KRAS,GTPase KRas,Tier 1,0.0,100,91.5,0,1,6GOD,6MNX,,1,21,"41132421,40824107,40766128,40148451,39215101,38784467,38784452,38604287,37637206,36229679,35473857,34097885,32871244,32370304,32010971,31583159,28639199,28514850,27936442,20565241,17461759",1,Noonan syndrome 3,0.8263697027313498
P12931,SRC,Proto-oncogene tyrosine-protein kinase Src,Tier 1,0.0,78,83.44,0,1,1Y57,2SRC,,1,19,"40569566,39664567,38471488,35928129,35859339,34757788,34083659,33530373,32668060,30970280,28701145,26458993,25645980,23842900,22693611,22323540,18985031,18682833,12842895",1,cancer,0.6343904000453656
P24941,CDK2,Cyclin-dependent kinase 2,Tier 1,0.0,100,88.44,0,1,1QMZ,1HCK,,1,24,"33981223,26972431,21616931,21059336,20394401,19320493,18495468,18186614,11071782,11106396,9826690,9826689,8606778,11566434",1,neurodegenerative disease,0.37316884263655814
P31749,AKT1,RAC-alpha serine/threonine-protein kinase,Tier 1,0.0,43,83.06,0,1,4EJN,3O96,,1,5,"40487120,33535960,27907160,27663888,24242861",1,Proteus syndrome,0.7595350815691262
O14965,AURKA,Aurora kinase A,Tier 1,,100,75.06,0,1,1OL5,1MUO,,1,2,39776073,1,neurodegenerative disease,0.520933205943212