id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P01112,HRAS,GTPase HRas,Tier 1,0.765,1,B_cargo,100,91.94,0,1,5P21,4Q21,0,0,,1,Costello syndrome,0.8839339324666988
P01116,KRAS,GTPase KRas,Tier 1,0.748,1,B_cargo,100,91.5,0,1,6GOD,6MNX,1,21,"41132421,40824107,40766128,40148451,39215101,38784467,38784452,38604287,37637206,36229679,35473857,34097885,32871244,32370304,32010971,31583159,28639199,28514850,27936442,20565241,17461759",1,Noonan syndrome 3,0.8263697027313498
P00519,ABL1,Tyrosine-protein kinase ABL1,Tier 1,0.747,1,B_cargo,85,63.38,0,1,2GQG,1OPL,1,5,"31295447,23836560,22411871,21810089,21653319",1,chronic myelogenous leukemia,0.8219762968845584
P31749,AKT1,RAC-alpha serine/threonine-protein kinase,Tier 1,0.728,1,B_cargo,43,83.06,0,1,4EJN,3O96,1,5,"40487120,33535960,27907160,27663888,24242861",1,Proteus syndrome,0.7595350815691262
P11802,CDK4,Cyclin-dependent kinase 4,Tier 1,0.714,1,B_cargo,15,86.81,1,1,2W96,3G33,1,2,"41535871,21059336",1,"melanoma, cutaneous malignant, susceptibility to, 3",0.7141203476842687
O14965,AURKA,Aurora kinase A,Tier 1,0.656,1,B_cargo,100,75.06,0,1,1OL5,1MUO,1,2,39776073,1,neurodegenerative disease,0.520933205943212