id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q9NX14,NDUFB11,"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial",Tier 1.5,0.86,0,77.56,0,0,,,,0,0,,1,Microphthalmia with linear skin defects syndrome,0.7364493324598024
P01911,HLA-DRB1,"HLA class II histocompatibility antigen, DRB1 beta chain",Tier 1,0.84,100,88.44,0,0,,,,0,0,,1,rheumatoid arthritis,0.40051584219092445
Q9UBT7,CTNNAL1,Alpha-catulin,Tier 1.5,0.795,0,84.06,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.31316995706583495
P35555,FBN1,Fibrillin-1,Tier 1,0.78,11,,0,0,,,,0,0,,1,Marfan syndrome,0.8969300970597663
P02671,FGA,Fibrinogen alpha chain,Tier 1,0.77,40,60.34,0,0,,,,0,0,,1,familial dysfibrinogenemia,0.7947496460990987
P03951,F11,Coagulation factor XI,Tier 1,0.77,100,86.88,0,0,,,,0,0,,1,factor XI deficiency,0.841884208404384
P27037,ACVR2A,Activin receptor type-2A,Tier 1.5,0.769,5,83.56,0,0,,,,0,0,,1,hepatocellular carcinoma,0.4908023126074436
O14958,CASQ2,Calsequestrin-2,Tier 1.5,0.767,4,90.5,0,0,,,,0,0,,1,catecholaminergic polymorphic ventricular tachycardia,0.7718998507471558
Q9H3K6,BOLA2,BolA-like protein 2,Tier 1.5,0.765,0,92.69,0,0,,,,0,0,,1,hepatocellular carcinoma,0.08093942543094014
Q92956,TNFRSF14,Tumor necrosis factor receptor superfamily member 14,Tier 1.5,0.745,8,79.94,0,0,,,,0,0,,1,diffuse large B-cell lymphoma,0.5983171413833771
P16389,KCNA2,Potassium voltage-gated channel subfamily A member 2,Tier 1.5,0.735,0,77.38,0,0,,,,0,0,,1,genetic developmental and epileptic encephalopathy,0.7513374591580034
P98196,ATP11A,Phospholipid-transporting ATPase IH,Tier 1.5,0.735,0,82.94,0,0,,,,0,0,,1,"hearing loss, autosomal dominant 84",0.5506821963658654
Q9BY67,CADM1,Cell adhesion molecule 1,Tier 1,0.734,2,80.56,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.442731358018962
P20702,ITGAX,Integrin alpha-X,Tier 1.5,0.732,9,88.0,0,0,,,,0,0,,1,neurodegenerative disease,0.41708750879240836
P09603,,,Tier 1.5,0.729,8,57.41,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.39219340856589974
P22732,SLC2A5,"Solute carrier family 2, facilitated glucose transporter member 5",Tier 1.5,0.728,0,90.56,0,0,,,,0,0,,1,Prolonged QT interval,0.3326218692162316
Q9P2B2,PTGFRN,Prostaglandin F2 receptor negative regulator,Tier 1.5,0.728,0,84.12,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.48052208463481294
Q92636,NSMAF,Protein FAN,Tier 1.5,0.725,0,88.31,0,0,,,,0,0,,1,placental retention,0.36802220150078147
Q99497,PARK7,Parkinson disease protein 7,Tier 1,0.723,88,98.44,0,0,,,,0,0,,1,Young adult-onset Parkinsonism,0.7264878745993893
O95562,SFT2D2,Vesicle transport protein SFT2B,Tier 1.5,0.71,0,78.5,0,0,,,,0,0,,1,neurodegenerative disease,0.38598268164814226
P79483,HLA-DRB3,"HLA class II histocompatibility antigen, DR beta 3 chain",Tier 1.5,0.71,2,88.38,0,0,,,,0,0,,1,,
P01889,HLA-B,"HLA class I histocompatibility antigen, B alpha chain",Tier 1,0.708,100,88.06,0,0,,,,0,0,,1,COVID-19,0.48417012135481613
P03905,MT-ND4,NADH-ubiquinone oxidoreductase chain 4,Tier 1.5,0.705,0,93.94,0,0,,,,0,0,,1,Leber hereditary optic neuropathy,0.7517935125709835
P08473,MME,Neprilysin,Tier 1,0.699,16,96.19,0,0,,,,0,0,,1,Charcot-Marie-Tooth disease axonal type 2T,0.7912653398252156
P01615,IGKV2D-28,Immunoglobulin kappa variable 2D-28,Tier 1.5,0.695,0,91.0,0,0,,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001
Q30154,HLA-DRB5,"HLA class II histocompatibility antigen, DR beta 5 chain",Tier 1.5,0.694,4,86.75,0,0,,,,0,0,,1,seasonal allergic rhinitis,0.19424611770933498
Q9Y678,COPG1,Coatomer subunit gamma-1,Tier 1.5,0.692,1,87.88,0,0,,,,0,0,,1,neurodegenerative disease,0.4905625531390244
P36980,CFHR2,Complement factor H-related protein 2,Tier 1.5,0.691,4,90.62,0,0,,,,0,0,,1,age-related macular degeneration,0.5100732932209376
Q92187,ST8SIA4,"CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase",Tier 1,0.69,3,86.44,0,0,,,,0,0,,1,systemic lupus erythematosus,0.43832763677821385
Q8IUH8,SPPL2C,Signal peptide peptidase-like 2C,Tier 1.5,0.69,0,67.06,0,0,,,,0,0,,1,"osteoarthritis, hip",0.35379836590273994
Q14520,HABP2,Factor VII-activating protease,Tier 1.5,0.686,0,77.62,0,0,,,,0,0,,1,follicular thyroid carcinoma,0.46213907606907034
O95399,UTS2,Urotensin-2,Tier 1,0.685,2,58.44,0,0,,,,0,0,,1,hair color,0.35316475479030335
Q96MP8,KCTD7,BTB/POZ domain-containing protein KCTD7,Tier 1.5,0.685,0,81.12,0,0,,,,0,0,,1,progressive myoclonic epilepsy type 3,0.8021556079083692
Q99584,S100A13,Protein S100-A13,Tier 1,0.681,12,80.81,0,0,,,,0,0,,1,neurodegenerative disease,0.41302685279153983
Q9HBI1,PARVB,Beta-parvin,Tier 1,0.68,3,81.75,0,0,,,,0,0,,1,thyroiditis,0.28021156500366357
O94842,TOX4,TOX high mobility group box family member 4,Tier 1.5,0.68,1,54.72,0,0,,,,0,0,,1,neurodegenerative disease,0.43085410155338943
Q96DA2,RAB39B,Ras-related protein Rab-39B,Tier 1.5,0.678,1,88.38,0,0,,,,0,0,,1,early-onset parkinsonism-intellectual disability syndrome,0.7782306319395635
O00602,FCN1,Ficolin-1,Tier 1,0.675,7,84.94,0,0,,,,0,0,,1,neurodegenerative disease,0.351581018821974
Q9UI42,CPA4,Carboxypeptidase A4,Tier 1.5,0.674,5,93.69,0,0,,,,0,0,,1,rheumatoid arthritis,0.19026118958920038
P08572,COL4A2,Collagen alpha-2(IV) chain,Tier 1.5,0.673,4,47.25,0,0,,,,0,0,,1,porencephaly 2,0.7294975109351518
P78357,CNTNAP1,Contactin-associated protein 1,Tier 1.5,0.673,0,81.12,0,0,,,,0,0,,1,Hypomyelination neuropathy - arthrogryposis,0.8286745612673082
Q9UK55,SERPINA10,Protein Z-dependent protease inhibitor,Tier 1,0.672,4,86.75,0,0,,,,0,0,,1,macular degeneration,0.3247169581531489
P02749,APOH,Beta-2-glycoprotein 1,Tier 1,0.67,14,93.12,0,0,,,,0,0,,1,atrial fibrillation,0.5456247991985232
P06703,S100A6,Protein S100-A6,Tier 1,0.67,6,87.19,0,0,,,,0,0,,1,neoplasm,0.10449825238323361
P78552,IL13RA1,Interleukin-13 receptor subunit alpha-1,Tier 1,0.67,4,81.56,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.48627783096767857
Q14C86,GAPVD1,GTPase-activating protein and VPS9 domain-containing protein 1,Tier 1.5,0.67,0,62.19,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.46694942126454214
Q92997,DVL3,Segment polarity protein dishevelled homolog DVL-3,Tier 1.5,0.67,9,58.91,0,0,,,,0,0,,1,autosomal dominant Robinow syndrome,0.7284158836126389
Q9BXX0,EMILIN2,EMILIN-2,Tier 1.5,0.67,0,65.12,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.3471636502626859
Q9NVH1,DNAJC11,DnaJ homolog subfamily C member 11,Tier 1.5,0.67,0,84.75,0,0,,,,0,0,,1,smoking initiation,0.2238015008808092
Q4L180,FILIP1L,Filamin A-interacting protein 1-like,Tier 1.5,0.67,0,67.56,0,0,,,,0,0,,1,Umbilical hernia,0.375022308318664