id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P35555,FBN1,Fibrillin-1,Tier 1,0.809,1,A2_pm_peripheral,11,,0,0,,,0,0,,1,Marfan syndrome,0.8969300970597663
P51531,SMARCA2,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2,Tier 1,0.797,1,A2_pm_peripheral,31,65.06,0,0,,,0,0,,1,intellectual disability-sparse hair-brachydactyly syndrome,0.85547142397368
P52333,JAK3,Tyrosine-protein kinase JAK3,Tier 1,0.794,1,A2_pm_peripheral,42,85.69,0,0,,,0,0,,1,T-B+ severe combined immunodeficiency due to JAK3 deficiency,0.8450717197794638
P29400,COL4A5,Collagen alpha-5(IV) chain,Tier 1.5,0.794,1,A2_pm_peripheral,2,48.12,0,0,,,0,0,,1,X-linked Alport syndrome,0.8472963899466404
Q14315,FLNC,Filamin-C,Tier 1.5,0.791,1,A2_pm_peripheral,14,75.06,0,0,,,0,0,,1,hypertrophic cardiomyopathy 26,0.8363192336142512
O75369,FLNB,Filamin-B,Tier 1,0.788,1,A2_pm_peripheral,23,76.25,0,0,,,0,0,,1,Larsen syndrome,0.826975893141549
O43175,PHGDH,D-3-phosphoglycerate dehydrogenase,Tier 1,0.784,1,A2_pm_peripheral,21,92.94,0,0,,,0,0,,1,PHGDH deficiency,0.8128323162948055
Q9Y3Z3,SAMHD1,Deoxynucleoside triphosphate triphosphohydrolase SAMHD1,Tier 1,0.783,1,A2_pm_peripheral,76,88.19,0,0,,,0,0,,1,Aicardi-Goutières syndrome,0.8101030032946703
Q8TD16,BICD2,Protein bicaudal D homolog 2,Tier 1,0.782,1,A2_pm_peripheral,2,78.0,0,0,,,0,0,,1,autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures,0.8072433385790271
Q08499,PDE4D,"3',5'-cyclic-AMP phosphodiesterase 4D",Tier 1,0.782,1,A2_pm_peripheral,100,67.44,0,0,,,0,0,,1,acrodysostosis 2 with or without hormone resistance,0.8053064772512085
O95630,STAMBP,STAM-binding protein,Tier 1.5,0.782,1,A2_pm_peripheral,5,84.0,0,0,,,0,0,,1,microcephaly-capillary malformation syndrome,0.8060251236043802
Q96BN8,OTULIN,Ubiquitin thioesterase otulin,Tier 1,0.781,1,A2_pm_peripheral,12,83.81,0,0,,,0,0,,1,"autoinflammation, panniculitis, and dermatosis syndrome, autosomal recessive",0.804614072482804
P49773,HINT1,Adenosine 5'-monophosphoramidase HINT1,Tier 1,0.777,1,A2_pm_peripheral,59,96.19,0,0,,,0,0,,1,Autosomal recessive axonal neuropathy with neuromyotonia,0.7895184274923306
P12814,ACTN1,Alpha-actinin-1,Tier 1.5,0.777,1,A2_pm_peripheral,4,85.25,0,0,,,0,0,,1,platelet-type bleeding disorder 15,0.7887662502912471
Q9Y263,PLAA,Phospholipase A-2-activating protein,Tier 1,0.77,1,A2_pm_peripheral,5,84.0,0,0,,,0,0,,1,"neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies",0.7656265019633831
Q9NWZ3,IRAK4,Interleukin-1 receptor-associated kinase 4,Tier 1,0.768,1,A2_pm_peripheral,96,83.94,0,0,,,0,0,,1,immunodeficiency 67,0.7593923638641371
Q9NZ09,UBAP1,Ubiquitin-associated protein 1,Tier 1.5,0.764,1,A2_pm_peripheral,3,62.5,0,0,,,0,0,,1,"spastic paraplegia 80, autosomal dominant",0.7464670113492812
Q01484,ANK2,Ankyrin-2,Tier 1,0.762,1,A2_pm_peripheral,11,61.78,0,0,,,0,0,,1,Romano-Ward syndrome,0.7390647393986454
Q6NZI2,CAVIN1,Caveolae-associated protein 1,Tier 1.5,0.76,1,A2_pm_peripheral,3,67.38,0,0,,,0,0,,1,congenital generalized lipodystrophy type 4,0.7317728549444928
Q92997,DVL3,Segment polarity protein dishevelled homolog DVL-3,Tier 1.5,0.759,1,A2_pm_peripheral,9,58.91,0,0,,,0,0,,1,autosomal dominant Robinow syndrome,0.7284158836126389
P07948,LYN,Tyrosine-protein kinase Lyn,Tier 1,0.754,1,A2_pm_peripheral,6,83.12,0,0,,,0,0,,1,"autoinflammatory disease, systemic, with vasculitis",0.7119500711989845
P22735,TGM1,Protein-glutamine gamma-glutamyltransferase K,Tier 1.5,0.754,1,A2_pm_peripheral,1,84.12,0,0,,,0,0,,1,autosomal recessive congenital ichthyosis,0.714755023666953
P31939,ATIC,Bifunctional purine biosynthesis protein ATIC,Tier 1.5,0.754,1,A2_pm_peripheral,5,97.38,0,0,,,0,0,,1,AICA-ribosiduria,0.7137167364484167
O15117,FYB1,FYN-binding protein 1,Tier 1,0.752,1,A2_pm_peripheral,3,56.59,0,0,,,0,0,,1,thrombocytopenia 3,0.7067701415491194
Q9Y5K6,CD2AP,CD2-associated protein,Tier 1,0.749,1,A2_pm_peripheral,12,62.22,0,0,,,0,0,,1,focal segmental glomerulosclerosis,0.6952333377860125
Q8IZQ1,WDFY3,WD repeat and FYVE domain-containing protein 3,Tier 1,0.748,1,A2_pm_peripheral,2,,0,0,,,0,0,,1,Autosomal dominant microcephaly,0.6934322596452817
Q8IXK2,GALNT12,Polypeptide N-acetylgalactosaminyltransferase 12,Tier 1.5,0.748,1,A2_pm_peripheral,1,93.5,0,0,,,0,0,,1,"colorectal cancer, susceptibility to, 1",0.6932727729787528
Q96CW1,AP2M1,AP-2 complex subunit mu,Tier 1,0.741,1,A2_pm_peripheral,4,89.19,0,0,,,0,0,,1,intellectual developmental disorder 60 with seizures,0.6712897942723018
O43516,WIPF1,WAS/WASL-interacting protein family member 1,Tier 1.5,0.737,1,A2_pm_peripheral,4,58.5,0,0,,,0,0,,1,Wiskott-Aldrich syndrome,0.6561328889736038
P48730,CSNK1D,Casein kinase I isoform delta,Tier 1,0.732,1,A2_pm_peripheral,46,81.0,0,0,,,0,0,,1,Familial advanced sleep-phase syndrome,0.6394614732145313
P27815,PDE4A,"3',5'-cyclic-AMP phosphodiesterase 4A",Tier 1,0.732,1,A2_pm_peripheral,5,64.5,0,0,,,0,0,,1,psoriasis,0.6394621747004946
Q12929,EPS8,Epidermal growth factor receptor kinase substrate 8,Tier 1.5,0.731,1,A2_pm_peripheral,2,70.31,0,0,,,0,0,,1,autosomal recessive nonsyndromic hearing loss 102,0.6354471967036509
Q5VST9,OBSCN,Obscurin,Tier 1,0.73,1,A2_pm_peripheral,25,,0,0,,,0,0,,1,Abnormality of the skeletal system,0.6328288822708418
Q9NZ56,FMN2,Formin-2,Tier 1.5,0.729,1,A2_pm_peripheral,2,49.97,0,0,,,0,0,,1,autosomal recessive non-syndromic intellectual disability,0.6298956049368037
P11233,RALA,Ras-related protein Ral-A,Tier 1,0.723,1,A2_pm_peripheral,16,89.31,0,0,,,0,0,,1,Hiatt-Neu-Cooper neurodevelopmental syndrome,0.6092132376035464
Q16186,ADRM1,Proteasomal ubiquitin receptor ADRM1,Tier 1,0.722,1,A2_pm_peripheral,21,62.28,0,0,,,0,0,,1,multiple myeloma,0.6073517074927846
Q96RT1,ERBIN,Erbin,Tier 1,0.719,1,A2_pm_peripheral,11,55.66,0,0,,,0,0,,1,cancer,0.5976773185991211
Q32MZ4,LRRFIP1,Leucine-rich repeat flightless-interacting protein 1,Tier 1,0.719,1,A2_pm_peripheral,1,55.0,0,0,,,0,0,,1,cancer,0.5961939963929208
O95425,SVIL,Supervillin,Tier 1.5,0.718,1,A2_pm_peripheral,2,53.44,0,0,,,0,0,,1,myofibrillar myopathy 10,0.5924877747412329
P08631,HCK,Tyrosine-protein kinase HCK,Tier 1,0.717,1,A2_pm_peripheral,40,83.12,0,0,,,0,0,,1,chronic myelogenous leukemia,0.5900239698979759
P48736,PIK3CG,"Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform",Tier 1,0.713,1,A2_pm_peripheral,100,87.81,0,0,,,0,0,,1,chronic lymphocytic leukemia,0.5769181159547517
P10398,ARAF,Serine/threonine-protein kinase A-Raf,Tier 1.5,0.709,1,A2_pm_peripheral,6,70.06,0,0,,,0,0,,1,cancer,0.5616780822043126
Q14160,SCRIB,Protein scribble homolog,Tier 1,0.708,1,A2_pm_peripheral,36,62.53,0,0,,,0,0,,1,spina bifida,0.5598219103770152
Q01581,HMGCS1,"Hydroxymethylglutaryl-CoA synthase, cytoplasmic",Tier 1.5,0.707,1,A2_pm_peripheral,1,91.31,0,0,,,0,0,,1,neurodegenerative disease,0.55518193177393
Q9NT62,ATG3,Ubiquitin-like-conjugating enzyme ATG3,Tier 1.5,0.707,1,A2_pm_peripheral,4,73.38,0,0,,,0,0,,1,neurodegenerative disease,0.5571514462681344
Q9NZ08,ERAP1,Endoplasmic reticulum aminopeptidase 1,Tier 1,0.706,1,A2_pm_peripheral,23,92.38,0,0,,,0,0,,1,psoriasis,0.5539585583227815
P56945,BCAR1,Breast cancer anti-estrogen resistance protein 1,Tier 1,0.706,1,A2_pm_peripheral,5,61.69,0,0,,,0,0,,1,neurodegenerative disease,0.5525303421948999
Q02156,PRKCE,Protein kinase C epsilon type,Tier 1.5,0.706,1,A2_pm_peripheral,2,79.94,0,0,,,0,0,,1,acute myeloid leukemia,0.5549599198877609
P00326,ADH1C,Alcohol dehydrogenase 1C,Tier 1.5,0.704,1,A2_pm_peripheral,2,98.12,0,0,,,0,0,,1,alcohol drinking,0.5465864505308649
Q9NZN5,ARHGEF12,Rho guanine nucleotide exchange factor 12,Tier 1,0.703,1,A2_pm_peripheral,4,60.22,0,0,,,0,0,,1,glaucoma,0.5425904569436921