id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q9UJA9,ENPP5,Ectonucleotide pyrophosphatase/phosphodiesterase family member 5,Tier 1,0.87,1,88.12,0,0,,,,0,0,,0,neurodegenerative disease,0.33211724272317855
P01911,HLA-DRB1,"HLA class II histocompatibility antigen, DRB1 beta chain",Tier 1,0.84,100,88.44,0,0,,,,0,0,,1,rheumatoid arthritis,0.40051584219092445
Q31135,H2-Ab1,,Tier 1,0.83,12,85.12,0,0,,,,0,0,,0,,
P35555,FBN1,Fibrillin-1,Tier 1,0.78,11,,0,0,,,,0,0,,1,Marfan syndrome,0.8969300970597663
A6ND01,IZUMO1R,Sperm-egg fusion protein Juno,Tier 1,0.773,7,87.38,0,0,,,,0,0,,0,placental retention,0.23306495563589497
P02671,FGA,Fibrinogen alpha chain,Tier 1,0.77,40,60.34,0,0,,,,0,0,,1,familial dysfibrinogenemia,0.7947496460990987
P03951,F11,Coagulation factor XI,Tier 1,0.77,100,86.88,0,0,,,,0,0,,1,factor XI deficiency,0.841884208404384
A0A5H2UYS3,HLA-A,,Tier 1,0.77,20,85.25,0,0,,,,0,0,,0,,
P16471,PRLR,Prolactin receptor,Tier 1,0.747,12,61.03,0,0,,,,0,0,,0,familial hyperprolactinemia,0.5718636087471152
P01563,,,Tier 1,0.744,13,85.06,0,0,,,,0,0,,0,renal cell carcinoma,0.3938654263610389
Q9BY67,CADM1,Cell adhesion molecule 1,Tier 1,0.734,2,80.56,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.442731358018962
Q99497,PARK7,Parkinson disease protein 7,Tier 1,0.723,88,98.44,0,0,,,,0,0,,1,Young adult-onset Parkinsonism,0.7264878745993893
Q16878,CDO1,Cysteine dioxygenase type 1,Tier 1,0.72,17,93.62,0,0,,,,0,0,,0,adolescent idiopathic scoliosis,0.3105991982786747
Q12918,KLRB1,Killer cell lectin-like receptor subfamily B member 1,Tier 1,0.719,3,81.0,0,0,,,,0,0,,0,sensory perception of smell,0.287724180593876
Q99574,SERPINI1,Neuroserpin,Tier 1,0.712,3,88.12,0,0,,,,0,0,,0,familial encephalopathy with neuroserpin inclusion bodies,0.7162803151916303
A0A583ZB34,,,Tier 1,0.71,9,84.38,0,0,,,,0,0,,0,,
P01889,HLA-B,"HLA class I histocompatibility antigen, B alpha chain",Tier 1,0.708,100,88.06,0,0,,,,0,0,,1,COVID-19,0.48417012135481613
P14555,PLA2G2A,"Phospholipase A2, membrane associated",Tier 1,0.7,17,91.0,0,0,,,,0,0,,0,familial colorectal cancer,0.3326218692162316
Q5Y7D3,HLA-DQB1,,Tier 1,0.7,6,85.31,0,0,,,,0,0,,0,,
P08473,MME,Neprilysin,Tier 1,0.699,16,96.19,0,0,,,,0,0,,1,Charcot-Marie-Tooth disease axonal type 2T,0.7912653398252156
O43570,CA12,Carbonic anhydrase 12,Tier 1,0.695,40,87.81,0,0,,,,0,0,,0,isolated hyperchlorhidrosis,0.6794515382695604
Q96QV1,HHIP,Hedgehog-interacting protein,Tier 1,0.692,11,79.75,0,0,,,,0,0,,0,Abnormality of the skeletal system,0.5195282784554633
P04435,TRBV7-9,T cell receptor beta variable 7-9,Tier 1,0.691,2,90.06,0,0,,,,0,0,,0,neoplasm,0.11454334012562349
Q02083,NAAA,N-acylethanolamine-hydrolyzing acid amidase,Tier 1,0.69,2,92.25,0,0,,,,0,0,,0,abscess,0.2726858643799341
Q92187,ST8SIA4,"CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase",Tier 1,0.69,3,86.44,0,0,,,,0,0,,1,systemic lupus erythematosus,0.43832763677821385
Q15788,NCOA1,Nuclear receptor coactivator 1,Tier 1,0.69,100,46.72,0,0,,,,0,0,,0,neurodegenerative disease,0.48697450901885614
A0A9P1NJI6,,,Tier 1,0.69,6,,0,0,,,,0,0,,0,,
Q9UBH0,IL36RN,Interleukin-36 receptor antagonist protein,Tier 1,0.687,3,92.44,0,0,,,,0,0,,0,"psoriasis 14, pustular",0.8155144873787125
O95399,UTS2,Urotensin-2,Tier 1,0.685,2,58.44,0,0,,,,0,0,,1,hair color,0.35316475479030335
A0A0C4DH28,TRGV4,T cell receptor gamma variable 4,Tier 1,0.681,4,84.06,0,0,,,,0,0,,0,Townes-Brocks syndrome,0.006652437384324632
Q99584,S100A13,Protein S100-A13,Tier 1,0.681,12,80.81,0,0,,,,0,0,,1,neurodegenerative disease,0.41302685279153983
U5YJJ6,HLA-A,,Tier 1,0.68,3,89.0,0,0,,,,0,0,,0,,
Q16651,PRSS8,Prostasin,Tier 1,0.68,9,83.75,0,0,,,,0,0,,0,Alzheimer disease,0.4223067864061274
Q9HBI1,PARVB,Beta-parvin,Tier 1,0.68,3,81.75,0,0,,,,0,0,,1,thyroiditis,0.28021156500366357
O00602,FCN1,Ficolin-1,Tier 1,0.675,7,84.94,0,0,,,,0,0,,1,neurodegenerative disease,0.351581018821974
Q9UK55,SERPINA10,Protein Z-dependent protease inhibitor,Tier 1,0.672,4,86.75,0,0,,,,0,0,,1,macular degeneration,0.3247169581531489
P02749,APOH,Beta-2-glycoprotein 1,Tier 1,0.67,14,93.12,0,0,,,,0,0,,1,atrial fibrillation,0.5456247991985232
P06703,S100A6,Protein S100-A6,Tier 1,0.67,6,87.19,0,0,,,,0,0,,1,neoplasm,0.10449825238323361
P78552,IL13RA1,Interleukin-13 receptor subunit alpha-1,Tier 1,0.67,4,81.56,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.48627783096767857
P14867,GABRA1,Gamma-aminobutyric acid receptor subunit alpha-1,Tier 1,0.667,0,81.69,0,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 19",0.7734302780200346
P54762,EPHB1,Ephrin type-B receptor 1,Tier 1,0.665,8,83.62,0,0,,,,0,0,,1,medullary thyroid gland carcinoma,0.5204553830376101
Q9UHV8,LGALS13,Galactoside-binding soluble lectin 13,Tier 1,0.66,11,97.5,0,0,,,,0,0,,0,preeclampsia,0.11027592759014439
Q6IQ20,NAPEPLD,N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D,Tier 1,0.66,4,87.25,0,0,,,,0,0,,0,reticular dystrophy of the retinal pigment epithelium,0.3695798546847018
A0A0U5Q247,,,Tier 1,0.66,3,85.12,0,0,,,,0,0,,0,,
Q7L2H7,EIF3M,Eukaryotic translation initiation factor 3 subunit M,Tier 1,0.66,0,55.28,0,0,,,,0,0,,1,Hernia,0.2963310523049043
Q8IYV9,IZUMO1,Izumo sperm-egg fusion protein 1,Tier 1,0.659,7,81.06,0,0,,,,0,0,,0,cholelithiasis,0.18873738346588434
P48552,NRIP1,Nuclear receptor-interacting protein 1,Tier 1,0.657,17,45.91,0,0,,,,0,0,,0,neurodegenerative disease,0.5654759320154787
P05543,SERPINA7,Thyroxine-binding globulin,Tier 1,0.655,9,87.06,0,0,,,,0,0,,1,neoplasm,0.09631257418600654
P20701,ITGAL,Integrin alpha-L,Tier 1,0.655,41,82.62,0,0,,,,0,0,,1,psoriasis,0.5899795223699872
A8MUM7,LGALS16,Galectin-16,Tier 1,0.654,3,94.62,0,0,,,,0,0,,0,neurodegenerative disease,0.536067027639694