id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q9Y2C5,SLC17A4,Probable small intestine urate exporter,Tier 1.5,0.878,0,83.69,0,0,,,,0,0,,0,inflammatory bowel disease,0.09896486250497885
Q9NX14,NDUFB11,"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial",Tier 1.5,0.86,0,77.56,0,0,,,,0,0,,1,Microphthalmia with linear skin defects syndrome,0.7364493324598024
P0DPK4,NOTCH2NLC,Notch homolog 2 N-terminal-like protein C,Tier 1.5,0.805,0,80.81,0,0,,,,0,0,,0,neuronal intranuclear inclusion disease,0.4999829066911242
Q9UBT7,CTNNAL1,Alpha-catulin,Tier 1.5,0.795,0,84.06,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.31316995706583495
Q14031,COL4A6,Collagen alpha-6(IV) chain,Tier 1.5,0.79,0,47.41,0,0,,,,0,0,,0,Dupuytren Contracture,0.5880367459451578
P37023,ACVRL1,Activin receptor type-1-like,Tier 1.5,0.779,7,82.0,0,0,,,,0,0,,0,"telangiectasia, hereditary hemorrhagic, type 2",0.7951167515831324
P01568,IFNA21,Interferon alpha-21,Tier 1.5,0.777,0,85.0,0,0,,,,0,0,,0,renal cell carcinoma,0.3695798546847018
P29017,CD1C,T-cell surface glycoprotein CD1c,Tier 1.5,0.77,10,88.56,0,0,,,,0,0,,0,neoplasm,0.1106047389635713
Q9BVX2,TMEM106C,Transmembrane protein 106C,Tier 1.5,0.77,0,80.81,0,0,,,,0,0,,0,prostate carcinoma,0.21737104399686757
P27037,ACVR2A,Activin receptor type-2A,Tier 1.5,0.769,5,83.56,0,0,,,,0,0,,1,hepatocellular carcinoma,0.4908023126074436
O14958,CASQ2,Calsequestrin-2,Tier 1.5,0.767,4,90.5,0,0,,,,0,0,,1,catecholaminergic polymorphic ventricular tachycardia,0.7718998507471558
Q9H3K6,BOLA2,BolA-like protein 2,Tier 1.5,0.765,0,92.69,0,0,,,,0,0,,1,hepatocellular carcinoma,0.08093942543094014
A0A1B0GTW7,CIROP,Ciliated left-right organizer metallopeptidase,Tier 1.5,0.764,0,73.44,0,0,,,,0,0,,0,"heterotaxy, visceral, 12, autosomal",0.6929422132808513
O15370,SOX12,Transcription factor SOX-12,Tier 1.5,0.76,0,63.0,0,0,,,,0,0,,0,type 2 diabetes mellitus,0.3277369133971199
Q9BWF2,TRAIP,E3 ubiquitin-protein ligase TRAIP,Tier 1.5,0.76,1,74.94,0,0,,,,0,0,,0,Seckel syndrome 9,0.683878095944948
Q9BZR8,BCL2L14,Apoptosis facilitator Bcl-2-like protein 14,Tier 1.5,0.76,0,62.38,0,0,,,,0,0,,0,hypothyroidism,0.33117514363294837
A6NI61,MYMK,Protein myomaker,Tier 1.5,0.758,0,90.44,0,0,,,,0,0,,0,Carey-Fineman-Ziter  syndrome,0.7790386256350393
Q16585,SGCB,Beta-sarcoglycan,Tier 1.5,0.75,0,76.44,0,0,,,,0,0,,0,autosomal recessive limb-girdle muscular dystrophy type 2E,0.8154766151472349
P56730,PRSS12,Neurotrypsin,Tier 1.5,0.746,0,77.31,0,0,,,,0,0,,0,"intellectual disability, autosomal recessive 1",0.6621935416695687
Q92956,TNFRSF14,Tumor necrosis factor receptor superfamily member 14,Tier 1.5,0.745,8,79.94,0,0,,,,0,0,,1,diffuse large B-cell lymphoma,0.5983171413833771
P16112,ACAN,Aggrecan core protein,Tier 1.5,0.74,4,51.91,0,0,,,,0,0,,0,Familial osteochondritis dissecans,0.7558487616449627
Q14246,ADGRE1,Adhesion G protein-coupled receptor E1,Tier 1.5,0.74,0,76.69,0,0,,,,0,0,,0,diabetic ketoacidosis,0.20424823130055986
Q8N6D2,RNF182,E3 ubiquitin-protein ligase RNF182,Tier 1.5,0.74,0,70.25,0,0,,,,0,0,,0,periapical tissue disease,0.304701328693288
Q00LT1,PRCD,Photoreceptor disk component PRCD,Tier 1.5,0.737,0,63.97,0,0,,,,0,0,,0,retinitis pigmentosa,0.7650522818524582
P16389,KCNA2,Potassium voltage-gated channel subfamily A member 2,Tier 1.5,0.735,0,77.38,0,0,,,,0,0,,1,genetic developmental and epileptic encephalopathy,0.7513374591580034
Q9Y4U1,MMACHC,Cyanocobalamin reductase / alkylcobalamin dealkylase,Tier 1.5,0.735,7,85.62,0,0,,,,0,0,,0,"Methylmalonic acidemia with homocystinuria, type cblC",0.8478185420804271
P98196,ATP11A,Phospholipid-transporting ATPase IH,Tier 1.5,0.735,0,82.94,0,0,,,,0,0,,1,"hearing loss, autosomal dominant 84",0.5506821963658654
Q9ULX7,CA14,Carbonic anhydrase 14,Tier 1.5,0.734,2,90.69,0,0,,,,0,0,,0,epilepsy,0.4397024990575866
Q99593,TBX5,T-box transcription factor TBX5,Tier 1.5,0.733,4,62.66,0,0,,,,0,0,,0,Holt-Oram syndrome,0.827317913681364
P20702,ITGAX,Integrin alpha-X,Tier 1.5,0.732,9,88.0,0,0,,,,0,0,,1,neurodegenerative disease,0.41708750879240836
P53539,FOSB,Protein FosB,Tier 1.5,0.73,12,59.12,0,0,,,,0,0,,0,neurodegenerative disease,0.22246010664492422
P09603,,,Tier 1.5,0.729,8,57.41,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.39219340856589974
O43914,TYROBP,TYRO protein tyrosine kinase-binding protein,Tier 1.5,0.728,5,64.62,0,0,,,,0,0,,0,Nasu-Hakola disease,0.7323368313860329
P22732,SLC2A5,"Solute carrier family 2, facilitated glucose transporter member 5",Tier 1.5,0.728,0,90.56,0,0,,,,0,0,,1,Prolonged QT interval,0.3326218692162316
Q9P2B2,PTGFRN,Prostaglandin F2 receptor negative regulator,Tier 1.5,0.728,0,84.12,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.48052208463481294
Q92636,NSMAF,Protein FAN,Tier 1.5,0.725,0,88.31,0,0,,,,0,0,,1,placental retention,0.36802220150078147
Q9NWH7,SPATA6,Spermatogenesis-associated protein 6,Tier 1.5,0.72,0,65.19,0,0,,,,0,0,,0,hypothyroidism,0.4205896274474635
Q15399,TLR1,Toll-like receptor 1,Tier 1.5,0.72,6,87.19,0,0,,,,0,0,,0,asthma,0.5956884825296496
Q6MZM0,HEPHL1,Ferroxidase HEPHL1,Tier 1.5,0.72,0,89.44,0,0,,,,0,0,,0,pili torti-developmental delay-neurological abnormalities syndrome,0.40268634456935765
P25100,ADRA1D,Alpha-1D adrenergic receptor,Tier 1.5,0.716,0,64.81,0,0,,,,0,0,,0,hypertension,0.6613200073424285
O60882,,,Tier 1.5,0.713,1,83.31,0,0,,,,0,0,,0,Hypomaturation amelogenesis imperfecta,0.7281006394540224
P30968,GNRHR,Gonadotropin-releasing hormone receptor,Tier 1.5,0.71,1,84.19,0,0,,,,0,0,,0,hypogonadotropic hypogonadism,0.83100005285263
Q8N9I5,FADS6,Fatty acid desaturase 6,Tier 1.5,0.71,0,90.62,0,0,,,,0,0,,0,,
O95562,SFT2D2,Vesicle transport protein SFT2B,Tier 1.5,0.71,0,78.5,0,0,,,,0,0,,1,neurodegenerative disease,0.38598268164814226
P79483,HLA-DRB3,"HLA class II histocompatibility antigen, DR beta 3 chain",Tier 1.5,0.71,2,88.38,0,0,,,,0,0,,1,,
Q9H2B4,SLC26A1,Sulfate anion transporter 1,Tier 1.5,0.707,0,82.62,0,0,,,,0,0,,0,nephrolithiasis susceptibility caused by SLC26A1,0.6690419713525324
P03905,MT-ND4,NADH-ubiquinone oxidoreductase chain 4,Tier 1.5,0.705,0,93.94,0,0,,,,0,0,,1,Leber hereditary optic neuropathy,0.7517935125709835
O95886,DLGAP3,Disks large-associated protein 3,Tier 1.5,0.7,0,50.16,0,0,,,,0,0,,0,benign neoplasm of adrenal gland,0.3188339358953556
Q96LB9,PGLYRP3,Peptidoglycan recognition protein 3,Tier 1.5,0.699,4,88.12,0,0,,,,0,0,,0,Romano-Ward syndrome,0.08833005834552343
Q01814,ATP2B2,Plasma membrane calcium-transporting ATPase 2,Tier 1.5,0.696,0,73.38,0,0,,,,0,0,,0,autosomal dominant nonsyndromic hearing loss,0.6637167639130592