id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P23946,CMA1,Chymase,Tier 1,0.875,42,91.31,0,0,,,,1,1,30572223,0,pernicious anemia,0.17348905136256007
P01236,PRL,Prolactin,Tier 1,0.795,12,85.56,0,0,,,,1,6,"40327044,30834248,29277631,28263753,27679852,16947086",0,AL amyloidosis,0.4619748183558772
O14788,TNFSF11,Tumor necrosis factor ligand superfamily member 11,Tier 1,0.79,2,79.19,0,0,,,,1,2,"15562003,41226313",0,osteoporosis,0.6957850224892792
P48023,FASLG,Tumor necrosis factor ligand superfamily member 6,Tier 1.5,0.775,3,80.19,0,0,,,,1,1,16581027,0,autoimmune lymphoproliferative syndrome type 1,0.6984292519156657
P26951,IL3RA,Interleukin-3 receptor subunit alpha,Tier 1,0.767,4,85.25,0,0,,,,1,3,"40931580,36171541,31323275",0,acute myeloid leukemia,0.46904332714118013
Q9GZU2,PEG3,Paternally-expressed gene 3 protein,Tier 1.5,0.75,1,44.53,0,0,,,,1,1,16595502,0,neurodegenerative disease,0.34815912577489827
P18075,BMP7,Bone morphogenetic protein 7,Tier 1.5,0.749,4,76.19,0,0,,,,1,1,30537181,0,Inguinal hernia,0.4420059023371716
Q9Y5C1,ANGPTL3,Angiopoietin-related protein 3,Tier 1.5,0.727,1,79.62,0,0,,,,1,1,23770039,0,familial hypobetalipoproteinemia 2,0.6739043862507132
K7N5M4,B2M,,Tier 1,0.72,24,90.94,0,0,,,,1,3,"41850110,40373155,38904251",0,,
P42262,GRIA2,Glutamate receptor 2,Tier 1,0.715,16,84.94,0,0,,,,1,4,"28325839,19417060,17929944,17024188",0,neurodevelopmental disorder with language impairment and behavioral abnormalities,0.8328652004757138
P14207,FOLR2,Folate receptor beta,Tier 1,0.701,5,89.12,0,0,,,,1,2,28686804,0,neoplasm,0.11545394821329319
P15248,IL9,Interleukin-9,Tier 1,0.7,5,84.06,0,0,,,,1,1,40972397,0,neurodegenerative disease,0.40148548290272756
P01374,LTA,Lymphotoxin-alpha,Tier 1,0.7,3,83.44,0,0,,,,1,3,"41810142,30576605",0,,
A0A0C5B5G6,MT-RNR1,Mitochondrial-derived peptide MOTS-c,Tier 1.5,0.7,0,72.06,0,0,,,,1,1,35311942,0,,
P08620,FGF4,Fibroblast growth factor 4,Tier 1.5,0.7,1,81.5,0,0,,,,1,3,"35415885,33536494,7547864",0,cancer,0.6026669167438079
P21781,FGF7,Fibroblast growth factor 7,Tier 1.5,0.695,0,82.44,0,0,,,,1,5,"35415885,15719578,7547864,16462265",0,cancer,0.5963369026823151
Q95460,MR1,Major histocompatibility complex class I-related protein 1,Tier 1,0.693,79,87.5,0,0,,,,1,2,"41134135,20000526",0,Immunodeficiency,0.3336382138166145
Q9NPF0,CD320,CD320 antigen,Tier 1,0.69,6,63.81,0,0,,,,1,1,39493449,0,Methylmalonic aciduria due to transcobalamin receptor defect,0.49918945650121177
P39900,MMP12,Macrophage metalloelastase,Tier 1,0.68,86,86.94,0,0,,,,1,8,"41861669,38477735,38296402,37015819,35120890,34183667,27530235",0,atopic eczema,0.4795677061208266
P26718,KLRK1,NKG2-D type II integral membrane protein,Tier 1.5,0.679,22,79.19,0,0,,,,1,1,24629635,0,Behcet's syndrome,0.18614538678991077
Q86Z14,KLB,Beta-klotho,Tier 1,0.676,5,89.38,0,0,,,,1,1,40514411,0,congenital hypogonadotropic hypogonadism,0.462898767992589
P62576,nanA,Sialidase A,Tier 1,0.67,5,81.19,0,0,,,,1,4,"37350189,34976356,34341854,32034503",0,,
Q9GZX9,TWSG1,Twisted gastrulation protein homolog 1,Tier 1,0.67,6,80.38,0,0,,,,1,1,39299474,0,Abruptio Placentae,0.29495361755469174
O95750,FGF19,Fibroblast growth factor 19,Tier 1.5,0.668,4,79.81,0,0,,,,1,4,"35415885,31967847,27679852",0,cancer,0.38540691230511315
O00744,WNT10B,Protein Wnt-10b,Tier 1.5,0.668,0,80.06,0,0,,,,1,2,"32810272,18673242",0,Split hand-split foot malformation,0.7755225395358214
Q9HCK4,ROBO2,Roundabout homolog 2,Tier 1.5,0.665,6,67.38,0,0,,,,1,2,"40616090,31640794",0,familial vesicoureteral reflux,0.6460375744556555
O15169,AXIN1,Axin-1,Tier 1,0.664,22,61.09,0,0,,,,1,2,28129128,0,hepatocellular carcinoma,0.7864172882686208
Q6PCB0,VWA1,von Willebrand factor A domain-containing protein 1,Tier 1.5,0.664,0,78.38,0,0,,,,1,4,"41906877,41693575,38904251,38299345",0,"neuronopathy, distal hereditary motor, autosomal recessive 7",0.7420531156755253
A2RU14,TMEM218,Transmembrane protein 218,Tier 1.5,0.663,0,87.62,0,0,,,,1,6,"41360349,34861273,31349094,29277631,26580576,26248137",0,Joubert syndrome 39,0.7308441626389979
P15941,MUC1,Mucin-1,Tier 1,0.66,23,47.41,0,0,,,,1,686,"42025056,41988862,41954302,41771296,41744704,41744190,41657320,41627316,41621292,41582516,41535857,41471303,41362016,41352919,41346179,41330302,41243570,41205458,41185018,41101154,41047832,41027169,40682599,40665615,40627939,40607530,40590839,40578633,40568899,40556592,40504676,40500890,40499867,40479828,40432219,40422041,40360093,40286646,40274149,40158809,40119836,39978149,39910821,39705316,39679901,39626346,39579679,39566700,39552005,39550818,41997681,41247195,40813258,39454542,39454415,39440615,39421884,39406784,39256285,39243449,39154820,39142532,39136402,39119745,39118454,38923850,38912896",0,"tubulointerstitial kidney disease, autosomal dominant, 2",0.7040398435219726
P18510,IL1RN,Interleukin-1 receptor antagonist protein,Tier 1.5,0.66,5,87.06,0,0,,,,1,1,38928037,0,sterile multifocal osteomyelitis with periostitis and pustulosis,0.7734282711738736
Q86YL7,PDPN,Podoplanin,Tier 1.5,0.66,6,57.97,0,0,,,,1,4,"41304780,41292412,39451677",0,Microscopic hematuria,0.41183796492083136
Q92876,KLK6,Kallikrein-6,Tier 1,0.659,21,91.75,0,0,,,,1,2,"30114962,22505517",0,neuroinflammatory disorder,0.1901077464611955
O15389,SIGLEC5,Sialic acid-binding Ig-like lectin 5,Tier 1.5,0.656,3,77.75,0,0,,,,1,3,"33584010,27678199,24405684",0,dentures,0.15815607474115415
P22894,MMP8,Neutrophil collagenase,Tier 1,0.655,25,90.38,0,0,,,,1,4,"35821507,34183667,33534888,30197987",0,acne,0.603247809982021
P45452,MMP13,Collagenase 3,Tier 1,0.65,49,88.62,0,0,,,,1,4,"41754778,40893365,38471488,38750696",0,"spondyloepimetaphyseal dysplasia, Missouri type",0.8032079813035149
O15263,DEFB4A,Defensin beta 4A,Tier 1.5,0.65,6,78.0,0,0,,,,1,2,"40362575,32067984",0,ulcerative colitis,0.09865892368546408
P84996,GNAS,Protein ALEX,Tier 1.5,0.65,0,43.59,0,0,,,,1,9,"39154820,37963924,36037714,34488577,31129134,30979095,30682825,29146902,28626560",0,,
P01138,NGF,Beta-nerve growth factor,Tier 1.5,0.648,8,73.25,0,0,,,,1,6,"42015870,38780008,32982626,21216401,7545283,29754498",0,hereditary sensory and autonomic neuropathy type 5,0.7785402119369383
Q2I0M5,RSPO4,R-spondin-4,Tier 1.5,0.646,0,78.56,0,0,,,,1,3,"38238732,37425696",0,nonsyndromic congenital nail disorder 4,0.7604902779349189
Q9BQ51,PDCD1LG2,Programmed cell death 1 ligand 2,Tier 1.5,0.645,2,86.38,0,0,,,,1,1,38928037,0,melanoma,0.42716921377769757
Q9UKP5,ADAMTS6,A disintegrin and metalloproteinase with thrombospondin motifs 6,Tier 1.5,0.644,0,77.5,0,0,,,,1,1,35700850,0,Abnormality of the skeletal system,0.5444162515485208
P10747,CD28,T-cell-specific surface glycoprotein CD28,Tier 1,0.641,10,81.31,0,0,,,,1,12,"40702285,40479828,36979667,36126113,32584540,32280743,32024070,26999456,26992239,26320067,23756353,10435754",0,HIV infection,0.5105949023227331
Q04609,FOLH1,Glutamate carboxypeptidase 2,Tier 1,0.64,88,93.81,0,0,,,,1,47,"41855944,41683470,41548790,41478044,41126016,40684732,39388218,39187748,38769597,34341883,33794195,33061374,33025277,32721116,32611993,32525981,32208602,29313393,28794625,28746182,27574424,27456457,27228412,27077564,26985893,26472453,26438155,25938427,25620467,25620167,25473281,24954476,24337602,24321253,23590171,21980237,21641946,21555850,21147500,20550178,20407731,19701187,19514954,19488725,18776550,15520166,12124337",0,prostate cancer,0.5500818985644047
P07202,TPO,Thyroid peroxidase,Tier 1.5,0.64,0,83.44,0,0,,,,1,1,29881374,0,familial thyroid dyshormonogenesis,0.6710562308468054
P31994,FCGR2B,Low affinity immunoglobulin gamma Fc region receptor II-b,Tier 1.5,0.636,5,78.44,0,0,,,,1,1,38928037,0,systemic lupus erythematosus,0.460465747544726
Q16674,MIA,Melanoma-derived growth regulatory protein,Tier 1.5,0.636,4,86.38,0,0,,,,1,15,"41768714,40943389,40444021,38899488,37853818,35842727,35593028,35061691,34038704,32957732,31878307,31289496,29499935,28059418,26840019",0,neurodegenerative disease,0.36367051545295126
Q92563,SPOCK2,Testican-2,Tier 1.5,0.627,0,66.94,0,0,,,,1,8,"39695715,35474272,32958645,28794177,38656806,36288905",0,Back pain,0.3687304175767662
P34810,CD68,Macrosialin,Tier 1.5,0.627,0,73.19,0,0,,,,1,4,"37422510,33321636,28315675,27940247",0,neurodegenerative disease,0.3710186480081222
Q96NZ8,WFIKKN1,"WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1",Tier 1.5,0.621,2,78.06,0,0,,,,1,1,33591955,0,neurodegenerative disease,0.3060887002952384