id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P15056,BRAF,Serine/threonine-protein kinase B-raf,Tier 1,0.803,1,A2_pm_peripheral,100,66.38,0,0,,,1,6,"39624124,34874026,33497198,31726389,24486214,11856330",1,cardiofaciocutaneous syndrome,0.8764542776642054
P04049,RAF1,RAF proto-oncogene serine/threonine-protein kinase,Tier 1,0.799,1,A2_pm_peripheral,75,67.5,0,0,,,1,4,"15112994,12173045,11856330,9883908",1,Noonan syndrome,0.8625147809861142
Q06187,BTK,Tyrosine-protein kinase BTK,Tier 1,0.794,1,A2_pm_peripheral,100,84.44,0,0,,,1,1,41951939,1,X-linked agammaglobulinemia,0.8454716106068291
O60315,ZEB2,Zinc finger E-box-binding homeobox 2,Tier 1.5,0.789,1,A2_pm_peripheral,1,48.16,0,0,,,1,3,"27719642,24146916,18698484",1,Mowat-Wilson syndrome,0.8313744323041312
Q02750,MAP2K1,Dual specificity mitogen-activated protein kinase kinase 1,Tier 1,0.788,1,A2_pm_peripheral,94,83.25,0,0,,,1,1,29580944,1,cardiofaciocutaneous syndrome,0.825549979325162
P11274,BCR,Breakpoint cluster region protein,Tier 1.5,0.785,1,A2_pm_peripheral,5,64.81,0,0,,,1,20,"41951939,41535871,40882628,37937247,37103734,32929022,32507237,31825964,31650445,31295447,29299123,28686804,25809097,23836560,22411871,21810089,21653319,21030439,16990253,11713794",1,chronic myelogenous leukemia,0.8183048540102864
P01111,NRAS,GTPase NRas,Tier 1,0.783,1,A2_pm_peripheral,35,92.06,0,0,,,1,2,"39952900,39371477",1,Noonan syndrome 6,0.8087775198380727
O60674,JAK2,Tyrosine-protein kinase JAK2,Tier 1,0.78,1,A2_pm_peripheral,100,86.88,0,0,,,1,8,"41455398,34121564,32985358,31279934,30415442,25809097,22411871,20711698",1,polycythemia vera,0.8000866241942614
P98170,XIAP,E3 ubiquitin-protein ligase XIAP,Tier 1,0.78,1,A2_pm_peripheral,74,74.25,0,0,,,1,4,"35383192,29864441,27514505,26318819",1,X-linked lymphoproliferative disease,0.8013347966323413
Q9UHD9,UBQLN2,Ubiquilin-2,Tier 1,0.778,1,A2_pm_peripheral,4,61.03,0,0,,,1,2,23541532,1,amyotrophic lateral sclerosis type 15,0.7942015735994536
O15294,OGT,UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit,Tier 1,0.77,1,A2_pm_peripheral,44,93.06,0,0,,,1,2,"36868188,36626902",1,"intellectual disability, X-linked 106",0.7660009745204424
P55263,ADK,Adenosine kinase,Tier 1.5,0.769,1,A2_pm_peripheral,4,93.31,0,0,,,1,2,26051465,1,adenosine kinase deficiency,0.7617058236708037
P26038,MSN,Moesin,Tier 1,0.755,1,A2_pm_peripheral,10,86.38,0,0,,,1,65,"41813080,41784619,41611946,40904334,40886652,40258621,40222299,39454415,39053429,38856817,38759442,38687941,38561432,38446130,38349197,38295649,38266273,37869770,37806507,37423650,37353120,37062561,37058944,36982925,36843953,36700559,36562728,36179642,35026109,34893239,34538325,33960345,33727809,33528465,33149582,32882423,32291531,32170403,31872318,31792209,31213813,31072481,30985076,30865739,32254866,29955964,29568450,29136862,28917759,28832225",1,combined immunodeficiency due to moesin deficiency,0.7157135146765757
Q13153,PAK1,Serine/threonine-protein kinase PAK 1,Tier 1,0.753,1,A2_pm_peripheral,41,73.69,0,0,,,1,2,"32636813,20564698",1,"intellectual developmental disorder with macrocephaly, seizures, and speech delay",0.7110292416229067
P35241,RDX,Radixin,Tier 1.5,0.749,1,A2_pm_peripheral,2,86.56,0,0,,,1,2,"33253235,30700648",1,"hearing loss, autosomal recessive",0.6973070672344621
P61586,RHOA,Transforming protein RhoA,Tier 1,0.744,1,A2_pm_peripheral,100,93.56,0,0,,,1,4,"25645980,19389625,12927206,12123800",1,"ectodermal dysplasia with facial dysmorphism and acral, ocular, and brain anomalies",0.6804889074382072
Q00535,CDK5,Cyclin-dependent kinase 5,Tier 1,0.744,1,A2_pm_peripheral,10,91.56,0,0,,,1,4,"33291667,33200349",1,Alzheimer disease,0.6800338890220147
P26196,DDX6,Probable ATP-dependent RNA helicase DDX6,Tier 1,0.734,1,A2_pm_peripheral,9,84.06,0,0,,,1,2,34132569,1,intellectual developmental disorder with impaired language and dysmorphic facies,0.6482686715821397
P12931,SRC,Proto-oncogene tyrosine-protein kinase Src,Tier 1,0.73,1,A2_pm_peripheral,78,83.44,0,1,1Y57,2SRC,1,19,"40569566,39664567,38471488,35928129,35859339,34757788,34083659,33530373,32668060,30970280,28701145,26458993,25645980,23842900,22693611,22323540,18985031,18682833,12842895",1,cancer,0.6343904000453656
P61769,B2M,Beta-2-microglobulin,Tier 1,0.725,1,A2_pm_peripheral,100,94.06,0,0,,,1,15,"41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167",1,Immunodeficiency by defective expression of HLA class 1,0.6180318849819645
P43405,SYK,Tyrosine-protein kinase SYK,Tier 1,0.723,1,A2_pm_peripheral,93,84.0,0,0,,,1,2,"35782912,31825964",1,immunodeficiency 82 with systemic inflammation,0.608506293550361
P06241,FYN,Tyrosine-protein kinase Fyn,Tier 1,0.721,1,A2_pm_peripheral,53,80.81,0,0,,,1,5,"38559166,37149826,34757788,32668060,29754498",1,chronic myelogenous leukemia,0.6018224074412558
P07947,YES1,Tyrosine-protein kinase Yes,Tier 1,0.716,1,A2_pm_peripheral,1,81.88,0,0,,,1,1,34757788,1,chronic myelogenous leukemia,0.5851678597856559
P09769,FGR,Tyrosine-protein kinase Fgr,Tier 1.5,0.716,1,A2_pm_peripheral,3,82.19,0,0,,,1,1,39564692,1,chronic myelogenous leukemia,0.5869168331059803
P45984,MAPK9,Mitogen-activated protein kinase 9,Tier 1,0.707,1,A2_pm_peripheral,5,81.44,0,0,,,1,1,41505229,1,cancer,0.5569349147269519
P42680,TEC,Tyrosine-protein kinase Tec,Tier 1.5,0.705,1,A2_pm_peripheral,1,85.0,0,0,,,1,13,"39352470,39329798,36414190,36105684,35624657,35462326,35006795,30578658,30398689,27548775,26843427,25016253,24875764",1,alopecia areata,0.5491699656070116
O75534,CSDE1,Cold shock domain-containing protein E1,Tier 1,0.704,1,A2_pm_peripheral,5,79.56,0,0,,,1,1,10101203,1,neurodegenerative disease,0.5472997885061864
P17252,PRKCA,Protein kinase C alpha type,Tier 1.5,0.704,1,A2_pm_peripheral,6,86.38,0,0,,,1,1,41505229,1,acute myeloid leukemia,0.547429504944985
P67809,YBX1,Y-box-binding protein 1,Tier 1,0.703,1,A2_pm_peripheral,11,61.84,0,0,,,1,9,"31989173,31160337,22730292,21245151,16093451",1,dengue disease,0.5435698373845997
P34947,GRK5,G protein-coupled receptor kinase 5,Tier 1,0.702,1,A2_pm_peripheral,23,90.38,0,0,,,1,1,18230760,1,venous thromboembolism,0.5394311062516939
Q92888,ARHGEF1,Rho guanine nucleotide exchange factor 1,Tier 1,0.695,1,A2_pm_peripheral,7,73.19,0,0,,,1,6,"25645980,23757206,25033804,22689339,19389625,12123800",1,immunodeficiency 62,0.5170912094162261
Q96PY5,FMNL2,Formin-like protein 2,Tier 1.5,0.695,1,A2_pm_peripheral,1,76.44,0,0,,,1,1,41149482,1,open-angle glaucoma,0.5157968177633478
P09543,CNP,"2',3'-cyclic-nucleotide 3'-phosphodiesterase",Tier 1.5,0.689,1,A2_pm_peripheral,1,87.25,0,0,,,1,9,"40034273,38569854,37704353,35528922,31171207,30089209,27192549,19021295",1,"myopia 2, autosomal dominant",0.49606855995054094
Q07812,BAX,Apoptosis regulator BAX,Tier 1,0.679,1,A2_pm_peripheral,37,85.94,0,0,,,1,21,"41323565,41237573,40761795,40148451,39946362,39318128,37301952,36907299,36843953,36309655,32987067,32486412,31747745,30005287,27843907,26325285,24481451,23582862,23528042,21563784,21362508",1,T-cell acute lymphoblastic leukemia,0.4626258720529755
P09104,ENO2,Gamma-enolase,Tier 1,0.676,1,A2_pm_peripheral,16,97.06,0,0,,,1,1,36384120,1,neurodegenerative disease,0.4533558777394424
P07355,ANXA2,Annexin A2,Tier 1,0.673,1,A2_pm_peripheral,41,94.25,0,0,,,1,12,"40685636,31029658,29906496,24489826,35211356,29982617,27890659,27777972,26061649",1,neurodegenerative disease,0.4424399692174707
Q15828,CST6,Cystatin-M,Tier 1,0.673,1,A2_pm_peripheral,5,90.44,0,0,,,1,1,27679852,1,autosomal recessive hypohidrotic ectodermal dysplasia,0.44403998062712996
P52209,PGD,"6-phosphogluconate dehydrogenase, decarboxylating",Tier 1,0.666,1,A2_pm_peripheral,4,96.81,0,0,,,1,1,31557732,1,neurodegenerative disease,0.4205455366275092
Q8NB16,MLKL,Mixed lineage kinase domain-like protein,Tier 1,0.665,1,A2_pm_peripheral,22,83.12,0,0,,,1,5,"42019750,38744189,35919280",1,chronic recurrent multifocal osteomyelitis,0.41771763075738416
P02686,MBP,Myelin basic protein,Tier 1,0.658,1,A2_pm_peripheral,6,54.12,0,0,,,1,21,"42058742,39442496,38852383,38217663,38070612,37500079,33676686,33195056,32365011,29484603,26686919,25202925,23998713,22736004,10848986,30982509,24512542,19457263",1,alcohol drinking,0.391844482483692
P24941,CDK2,Cyclin-dependent kinase 2,Tier 1,0.652,1,A2_pm_peripheral,100,88.44,0,1,1QMZ,1HCK,1,24,"33981223,26972431,21616931,21059336,20394401,19320493,18495468,18186614,11071782,11106396,9826690,9826689,8606778,11566434",1,neurodegenerative disease,0.37316884263655814
Q99418,CYTH2,Cytohesin-2,Tier 1,0.651,1,A2_pm_peripheral,11,84.62,0,0,,,1,2,"23757206,15277685",1,neurodegenerative disease,0.3695798546847018
P43652,AFM,Afamin,Tier 1,0.649,1,A2_pm_peripheral,3,90.5,0,0,,,1,181,"41981590,41644987,41639270,41592438,41405386,41252929,41187335,41065720,41003495,40817942,40487293,40430051,40279903,40200829,39916299,39863729,39852074,39772502,39421963,39349658,39299186,39282756,39167342,39131199,39032299,38925633,38646165,38224944,38136647,38094082,38074684,37975892,37678120,37630325,37611441,37444259,37442003,37329944,37232893,37166710,37144950,37127843,36861067,36819738,36759615,36694259,36587435,36551097,36340178,36227568,37400771,27530235",1,Abnormality of the skeletal system,0.3630438694285995
Q86UW9,DTX2,Probable E3 ubiquitin-protein ligase DTX2,Tier 1,0.645,1,A2_pm_peripheral,4,71.81,0,0,,,1,3,"36623457,35569274,24164310",1,neurodegenerative disease,0.34889093978477204
P25054,APC,Adenomatous polyposis coli protein,Tier 1,0.644,1,A2_pm_peripheral,31,,0,0,,,1,39,"41471356,40788329,40207978,39796151,39335496,39189513,38710049,38509823,37199793,37185533,36894782,36882463,36827736,36252203,35544380,35490167,34837173,34708097,34240523,34008621,32486960,32429721,32386347,31937772,31295701,31249960,30609568,29886066,29666278,27736370,27427891,26552824,26552816,25059182,24681393,22236082,19389630,19029139,9546673",0,familial adenomatous polyposis 1,0.8462165290909345
P07996,THBS1,Thrombospondin-1,Tier 1,0.641,1,A2_pm_peripheral,11,84.25,0,0,,,1,6,"35990694,34248840,31640794,30884317,24434496,22314602",1,autism spectrum disorder,0.3356118729017016
P28676,GCA,Grancalcin,Tier 1,0.641,1,A2_pm_peripheral,4,81.31,0,0,,,1,7,"40480702,39153834,35029036,24818254,22915350,17673982,11058113",1,intelligence,0.33779315817113664
Q9NYA1,SPHK1,Sphingosine kinase 1,Tier 1,0.64,1,A2_pm_peripheral,5,91.12,0,0,,,1,1,41226313,1,neurodegenerative disease,0.33320538506824465
O00244,ATOX1,Copper transport protein ATOX1,Tier 1,0.639,1,A2_pm_peripheral,17,97.69,0,0,,,1,1,31916740,1,neurodegenerative disease,0.3313604919498173
O00214,LGALS8,Galectin-8,Tier 1,0.63,1,A2_pm_peripheral,39,90.69,0,0,,,1,1,24629635,1,alcohol drinking,0.2995075005631608