id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P00740,F9,Coagulation factor IX,Tier 1,0.866,1,A_assoc,56,80.31,0,0,,,1,8,"41890362,40266188,12027891,41217381,35036063,34248840,24922332",1,hemophilia B,0.8880186703890781
Q8NBP7,PCSK9,Proprotein convertase subtilisin/kexin type 9,Tier 1,0.858,1,A_assoc,62,85.19,0,0,,,1,23,"41924874,41707385,41683454,38796450,36579647,35817627,35388838,33177004,32884147,32415571,28544018,28265062,27679852,27397798,23770039",1,familial hypercholesterolemia,0.8604029080346239
P02461,COL3A1,Collagen alpha-1(III) chain,Tier 1,0.858,1,A_assoc,11,53.25,0,0,,,1,1,28453726,1,"Ehlers-Danlos syndrome, vascular type",0.8608667500207768
P17405,SMPD1,Sphingomyelin phosphodiesterase,Tier 1,0.857,1,A_assoc,4,88.0,0,0,,,1,1,25027855,1,Niemann-Pick disease type A,0.8567797114449874
P08709,F7,Coagulation factor VII,Tier 1,0.856,1,A_assoc,100,82.12,0,0,,,1,4,"41980687,32224381,28496951,11127866",1,factor VII deficiency,0.8542078994169972
P01008,SERPINC1,Antithrombin-III,Tier 1,0.855,1,A_assoc,27,84.69,0,0,,,1,11,"32199927,31881749,31747245,25467079,25186782,24359968,23637781,18316185,15741074,10660541,10457984",1,hereditary antithrombin deficiency,0.8494671886642873
P02458,COL2A1,Collagen alpha-1(II) chain,Tier 1,0.85,1,A_assoc,11,52.12,0,0,,,1,1,33109602,1,spondyloepiphyseal dysplasia congenita,0.8334698564095305
P08246,ELANE,Neutrophil elastase,Tier 1,0.849,1,A_assoc,38,88.19,0,0,,,1,21,"33334063,41654945,40410820,39256809,38883770,37286041,31961667,30431231,29568464,29018540,28963578,28218835,23598134,22098163,20006085,10573123,9526554,9382799,9384527,9062133,8604313",1,cyclic hematopoiesis,0.8291093803980005
P00450,CP,Ceruloplasmin,Tier 1,0.848,1,A_assoc,4,93.69,0,0,,,1,130,"41993416,41853972,41782379,41733039,41546412,41440247,41422248,41147110,41031431,40961346,40915733,40828620,40706482,40658810,40580097,40335784,40174668,40050871,40015385,39998327,39960866,39909827,39710798,39630080,39494521,39285582,39030890,39030001,38676824,38427460,38342712,38299345,38230744,38168982,38096053,38060303,38046181,38014615,37812810,37659332,37639977,37323073,37219912,37169123,37148688,37074914,37058901,36959354,36857694,36768220",1,aceruloplasminemia,0.8279493326009644
P48740,MASP1,Mannan-binding lectin serine protease 1,Tier 1,0.846,1,A_assoc,9,90.44,0,0,,,1,2,"40371468,41587892",1,3MC syndrome 1,0.8185972518103526
P06276,BCHE,Cholinesterase,Tier 1,0.842,1,A_assoc,100,93.38,0,0,,,1,13,"32676787,26003847,39665919,36801730,36359944,33096123,32872771,32143069,31170561,30544018,24299064,12852840",1,butyrylcholinesterase deficiency,0.8051740584587205
P06396,GSN,Gelsolin,Tier 1,0.841,1,A_assoc,60,89.12,0,0,,,1,6,"41924874,39263947,31862877,28794177",1,Finnish type amyloidosis,0.8048371651382773
P02679,FGG,Fibrinogen gamma chain,Tier 1,0.84,1,A_assoc,48,85.5,0,0,,,1,8,"41962371,40850274,30091854,27530235,36859809,33674695,28549218,12871549",1,familial dysfibrinogenemia,0.8002311001712851
P02675,FGB,Fibrinogen beta chain,Tier 1,0.837,1,A_assoc,42,84.06,0,0,,,1,1,40850274,1,congenital afibrinogenemia,0.7892438060719716
P03950,ANG,Angiogenin,Tier 1,0.836,1,A_assoc,56,89.81,0,0,,,1,99,"41948065,41736700,41688234,41686152,41625383,41551985,41550856,41338305,41194434,40839054,40825091,40233536,40046817,39891801,39871473,39727889,39700796,39226945,39078660,38458987,38282417,37683754,37585601,37556929,37527337,37367006,37284580,37185488,37100807,36520671,36315359,36291000,36087171,35731347,35489276,35408368,35290881,35218097,35084794,34987275,34964948,34902643,34617153,34523638,34500620,34474207,34464491,34439828,34350496,34232998,27841380,25461163,25422408,22018671,21774079,18585145,18533682,17260069,9578572",1,amyotrophic lateral sclerosis,0.7865457274017922
P08253,MMP2,72 kDa type IV collagenase,Tier 1,0.836,1,A_assoc,14,89.75,0,0,,,1,20,"38866788,38608631,37379799,36606583,35474272,34779093,33813091,33627152,33545845,33124760,32447200,32192327,30681205,30540162,30276134,30086306,24589243,23623988,22693611,18985031",1,Torg-Winchester syndrome,0.7862502046091417
P35609,ACTN2,Alpha-actinin-2,Tier 1,0.836,1,A_assoc,16,84.81,0,0,,,1,1,38497478,1,dilated cardiomyopathy 1AA,0.7856813926513253
Q14623,IHH,Indian hedgehog protein,Tier 1,0.836,1,A_assoc,8,84.31,0,0,,,1,1,18698484,1,brachydactyly type A1,0.7871957785711762
P00746,CFD,Complement factor D,Tier 1,0.832,1,A_assoc,40,91.0,0,0,,,1,4,"38057414,38071633,28972568,25727321",1,recurrent Neisseria infections due to factor D deficiency,0.7726408204424132
P35625,TIMP3,Metalloproteinase inhibitor 3,Tier 1.5,0.831,1,A_assoc,1,87.0,0,0,,,1,3,"42105605,36768220",1,Sorsby fundus dystrophy,0.7684253675298044
P07988,SFTPB,Pulmonary surfactant-associated protein B,Tier 1,0.83,1,A_assoc,9,73.06,0,0,,,1,1,35438610,1,Neonatal acute respiratory distress with surfactant metabolism deficiency,0.767375558073721
P01009,SERPINA1,Alpha-1-antitrypsin,Tier 1,0.829,1,A_assoc,46,88.62,0,0,,,1,12,"33534888,26070325,41021277,36980195,35581077,31747245,29065688,24121966,16242704,11584020,11017916",1,Alpha-1-antitrypsin deficiency,0.764279219769394
P08603,CFH,Complement factor H,Tier 1,0.825,1,A_assoc,51,78.31,0,0,,,1,4,"40001558,37566081,36630488,36004048",1,complement factor H deficiency,0.7508822531277052
P05121,SERPINE1,Plasminogen activator inhibitor 1,Tier 1,0.82,1,A_assoc,29,88.88,0,0,,,1,25,"41699153,32784904,24922319,24012635,41371773,38963794,36882463,36859809,36203210,33674695,32199927,28051346,27813404,27755560,26163061,25582325,24138169,22103403,21147843,20962041,20387790,19284310",1,congenital plasminogen activator inhibitor type 1 deficiency,0.7325368931195121
P11597,CETP,Cholesteryl ester transfer protein,Tier 1,0.817,1,A_assoc,3,91.12,0,0,,,1,1,31461490,1,cholesterol-ester transfer protein deficiency,0.724152309221595
P05546,SERPIND1,Heparin cofactor 2,Tier 1,0.816,1,A_assoc,9,79.62,0,0,,,1,4,"20062917,20053992,34248840,31247951",1,heparin cofactor 2 deficiency,0.719744572767547
P36955,SERPINF1,Pigment epithelium-derived factor,Tier 1.5,0.811,1,A_assoc,3,90.12,0,0,,,1,17,"41503480,40965986,24311895,21546514,19668729,17628122,16787141,16724865,16136393,15947805",1,osteogenesis imperfecta,0.701995723393119
O00187,MASP2,Mannan-binding lectin serine protease 2,Tier 1.5,0.81,1,A_assoc,10,89.44,0,0,,,1,1,40371468,1,immunodeficiency due to MASP-2 deficiency,0.6996393077218865
P14174,MIF,Macrophage migration inhibitory factor,Tier 1,0.809,1,A_assoc,100,98.56,0,0,,,1,2,"38152968,32784904",1,rheumatoid arthritis,0.6976629981150114
P02753,RBP4,Retinol-binding protein 4,Tier 1,0.806,1,A_assoc,23,90.25,0,0,,,1,16,"40904334,38392020,36551028,35695183,34814699,31953481,28279618,27511589,18324839",1,progressive retinal dystrophy due to retinol transport defect,0.6881202726053139
P08519,LPA,Apolipoprotein(a),Tier 1,0.801,1,A_assoc,16,60.06,0,0,,,1,8,"36579647,32065590,18702051,41925578,36756582,34111486,30834248,24008390",1,cardiovascular disease,0.6699718665639547
P14780,MMP9,Matrix metalloproteinase-9,Tier 1,0.798,1,A_assoc,29,82.06,0,0,,,1,69,"42007960,41819327,41654945,41325860,41123219,40621756,40586733,40452137,40415371,40280078,39427007,39408993,39400726,39063106,38608631,38471488,38386014,38240894,37379799,36579647,34703762,34607961,34216852,34183667,34117903,33742062,33716989,35019523,33124760,32935949,32539349,32192327,31418072,30540162,30417194,30339905,30276134,30086306,30041514,30005287,29617556,27819142,26901393,26514999,24561613,23043415,34974872,32784904",1,metaphyseal anadysplasia,0.6602426382399271
P00749,PLAU,Urokinase-type plasminogen activator,Tier 1,0.797,1,A_assoc,100,82.12,0,0,,,1,15,"41335958,36358641,36156780,35563278,35197258,33918821,27755560,26926041,25793507,25620243,24922319,23038812,20962041,20387790,15560078",1,Quebec platelet disorder,0.6566580092553626
Q13093,PLA2G7,Platelet-activating factor acetylhydrolase,Tier 1,0.792,1,A_assoc,33,87.81,0,0,,,1,1,35187107,1,Platelet-activating factor acetylhydrolase deficiency,0.6405981442654826
P09038,FGF2,Fibroblast growth factor 2,Tier 1,0.788,1,A_assoc,25,70.25,0,0,,,1,53,"41873087,41800529,40626724,40514411,39249203,38569854,38036609,37704353,35415885,34228298,34203430,33952673,33536494,31454678,30965238,30005872,29050945,27506449,24832383,24611155,21546514,15947805,15037076,12871718,10989176,9916931,9873529,8743324,7547864,7504300",1,cancer,0.6250165466551852
P62937,PPIA,Peptidyl-prolyl cis-trans isomerase A,Tier 1,0.787,1,A_assoc,100,98.06,0,0,,,1,1,30121422,1,HIV infection,0.6219943433906236
Q13009,TIAM1,Rho guanine nucleotide exchange factor TIAM1,Tier 1,0.787,1,A_assoc,10,58.94,0,0,,,1,1,23757206,1,neurodevelopmental disorder with language delay and seizures,0.6239819350488075
P61626,LYZ,Lysozyme C,Tier 1,0.786,1,A_assoc,100,94.06,0,0,,,1,10,"40414677,38754187,37975892,34731261,34384745,27750421,32261784,24980600,23486781,32974084",1,Familial renal amyloidosis,0.6187831136072062
P24821,TNC,Tenascin,Tier 1,0.786,1,A_assoc,21,74.88,0,0,,,1,49,"40903908,39861681,38642843,38081519,32593416,28084479,25423301,23280617,22595970,21902632,21071077,19707307,11590140,41775779,38377941,37222166,31728288,31301870,29876225,27604884,26316749,25924917,25871725,25698784,24432373,24275961,23764997,22938903,22241292,19377996,20641927,21825780,17172400,16820689,16595502,16595486,15509871,14676325",1,autosomal dominant nonsyndromic hearing loss,0.6185860577919765
Q16270,IGFBP7,Insulin-like growth factor-binding protein 7,Tier 1.5,0.785,1,A_assoc,1,84.44,0,0,,,1,4,"41192243,27679852,41280530",1,familial retinal arterial macroaneurysm,0.6182241349863704
P03956,MMP1,Interstitial collagenase,Tier 1,0.784,1,A_assoc,15,91.25,0,0,,,1,5,"39408993,38750696,36508319,31844116",1,acne,0.6124579024864619
P00750,PLAT,Tissue-type plasminogen activator,Tier 1,0.78,1,A_assoc,11,80.94,0,0,,,1,9,"25855589,41371773,35563278,33918821,28051346,26876003,24922319,21142878",1,stroke,0.5991628609680393
P01034,CST3,Cystatin-C,Tier 1,0.778,1,A_assoc,11,88.69,0,0,,,1,13,"41693575,35026285,41967274,40658810,40611738,38732117,37982669,36705086,35197258,34182410,31390526,29281176",1,Hereditary cerebral hemorrhage with amyloidosis,0.5935657159840635
Q15369,ELOC,Elongin-C,Tier 1,0.776,1,A_assoc,100,89.81,0,0,,,1,1,38740386,1,HIV infection,0.5879620631912417
P10451,SPP1,Osteopontin,Tier 1.5,0.772,1,A_assoc,3,53.41,0,0,,,1,62,"41690559,41223977,39422353,38600327,32943056,32042311,31603904,30307407,28916037,28453726,25278703,21147843,42136308,42108056,40845664,40479828,39677448,39340832,38834269,37162508,36508319,36284815,35433114,35190123,34420232,32166466,31987218,31879964,31806966,31301870,30135425,29441346,28988933,28706912,26529285,25949891,25930003,25713073,24902765,24491763,24438228,23889968,23619316,22880609,22241292,21962803,21801960,20967826,19570203,18985031",1,osteoporosis,0.5729473764531288
P01584,IL1B,Interleukin-1 beta,Tier 1,0.769,1,A_assoc,64,76.25,0,0,,,1,8,"32486412,29961347,27068091,41226313,40396427,35895511,32901590",1,cryopyrin-associated periodic syndrome,0.5633659522588867
P02774,GC,Vitamin D-binding protein,Tier 1,0.768,1,A_assoc,6,92.69,0,0,,,1,295,"41963583,41948065,41833083,41819327,41732038,41639270,41604759,41556568,41419615,41400746,41167817,41149287,41110250,41094207,41027132,41000039,40942102,40935807,40897008,40823025,40754186,40728393,40711581,40682599,40633058,40613290,40603464,40476227,40451960,40449002,40434271,40382920,40285964,40280078,40216226,40215095,40069570,40059332,40052949,39940838,39904249,39862582,39777471,39721592,39658807,39591843,39532406,39499329,39362888,39326490",1,vitamin D deficiency,0.5614290925372006
P10909,CLU,Clusterin,Tier 1.5,0.766,1,A_assoc,2,77.31,0,0,,,1,5,"42041411,37179603,36980195,35383192,26061649",1,Alzheimer disease,0.5545645077431476
P13497,BMP1,Bone morphogenetic protein 1,Tier 1.5,0.766,1,A_assoc,8,81.44,0,0,,,1,1,39939919,1,osteogenesis imperfecta,0.5547577676549571
Q05397,PTK2,Focal adhesion kinase 1,Tier 1,0.765,1,A_assoc,40,74.5,0,0,,,1,3,"32042311,31257851",1,neurodegenerative disease,0.5508127971159216