id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P21802,FGFR2,Fibroblast growth factor receptor 2,Tier 1,0.959,1,A_surface,62,73.94,0,0,,,1,5,"41786503,39759879,31357131,24242861,19212647",1,Crouzon syndrome,0.8637438969881663
P78504,JAG1,Protein jagged-1,Tier 1,0.958,1,A_surface,7,73.12,0,0,,,1,4,"37338014,37052638,23341879,18673242",1,Alagille syndrome due to a JAG1 point mutation,0.8586542923232751
P00813,ADA,Adenosine deaminase,Tier 1.5,0.957,1,A_surface,2,96.56,0,0,,,1,72,"42012076,41877526,41762796,41635914,40403280,40189053,39856849,39847085,36796307,33998617,32043202,30876536,30060448,27589406,26606306,25597304,25521724,25360869,24976151,24893272,24682016,24035856,23462984,23202335,23037591,22944024,22613226,41910181,41791686,41267360,39673485,39396299,38583236,36855421,34241023,33147453,32546280,30926472,26605646,24624989,23373863,22543727,20345118,19381549,19378312,18293985,17440909,17000903,16856187,16619330",1,Severe combined immunodeficiency due to adenosine deaminase deficiency,0.8556816060494579
P11166,SLC2A1,"Solute carrier family 2, facilitated glucose transporter member 1",Tier 1,0.956,1,A_surface,5,90.25,0,0,,,1,2,"39627234,33184583",1,encephalopathy due to GLUT1 deficiency,0.8521823225896756
P11362,FGFR1,Fibroblast growth factor receptor 1,Tier 1,0.954,1,A_surface,82,73.88,0,0,,,1,13,"41873087,41820318,40092750,39759879,39249203,37336759,33536494,31583159,31357131,30297602,28442904",1,hypogonadotropic hypogonadism 2 with or without anosmia,0.8472925100660907
P08581,MET,Hepatocyte growth factor receptor,Tier 1,0.953,1,A_surface,100,79.25,0,0,,,1,149,"42012469,41992303,41973478,41873087,41861669,41858296,41848278,41601428,41462891,41391726,41234744,41123956,41084363,41065179,41024479,40954195,40938088,40923343,40840349,40740738,40728393,40640119,40388621,40189053,40116812,40041032,39930702,39853766,39852082,39744222,39735310,39674868,39631842,39586988,39527480,39513807,39355222,39348183,39288204,39087949,38925633,38923378,38876234,38829176,38697444,38515622,38298092,38277932,38230289,38225704,30237882,29416033,26131766",1,papillary renal cell carcinoma,0.84195976263742
P06213,INSR,Insulin receptor,Tier 1,0.953,1,A_surface,87,77.62,0,0,,,1,14,"33410883,24768638,40603733,37779149,36310231,35478209,29262294,27648925,26387957,26245346,19396447,17167487",1,Leprechaunism,0.8448849372402896
Q8WZ42,TTN,Titin,Tier 1,0.953,1,A_surface,64,,0,0,,,1,1,29952259,1,dilated cardiomyopathy,0.8419847660466327
P36888,FLT3,Receptor-type tyrosine-protein kinase FLT3,Tier 1.5,0.949,1,A_surface,11,75.94,0,0,,,1,6,"41733039,34364920,31434881,30237882,29299123,22411871",1,acute myeloid leukemia,0.8313389209288576
P36894,BMPR1A,Bone morphogenetic protein receptor type-1A,Tier 1,0.948,1,A_surface,11,82.62,0,0,,,1,1,30537181,1,juvenile polyposis syndrome,0.8278395086688584
O75844,ZMPSTE24,CAAX prenyl protease 1 homolog,Tier 1,0.942,1,A_surface,4,89.44,0,0,,,1,1,37565451,1,mandibuloacral dysplasia with type B lipodystrophy,0.8071967390737101
P25942,CD40,Tumor necrosis factor receptor superfamily member 5,Tier 1,0.941,1,A_surface,14,81.19,0,0,,,1,8,"41982466,37331977,36203210,33335251,26504624,26231918,23460531,12828856",1,hyper-IgM syndrome type 3,0.8038021669520221
Q16832,DDR2,Discoidin domain-containing receptor 2,Tier 1,0.936,1,A_surface,5,75.81,0,0,,,1,1,26067556,1,spondyloepimetaphyseal dysplasia-short limb-abnormal calcification syndrome,0.7854778386444168
P04626,ERBB2,Receptor tyrosine-protein kinase erbB-2,Tier 1.5,0.934,1,A_surface,63,74.0,0,0,,,1,119,"41836728,41744190,41540559,41494763,41413339,41321156,41297941,40851486,40761795,40494827,40403699,40382399,40223744,40220375,40120226,40080161,40056884,39873777,39809083,39756158,39748051,39643321,39609809,39539244,39263860,39233482,39177424,38901393,38813974,38789508,38693181,38679242,38604040,38409854,38066021,37729138,37659641,37591183,37522239,37392577,37038354,36272296,36255496,36001395,35504229,34952586,34476602,34236165,33876310,33627408",1,non-small cell lung carcinoma,0.7789523142843545
Q13554,CAMK2B,Calcium/calmodulin-dependent protein kinase type II subunit beta,Tier 1,0.932,1,A_surface,4,70.56,0,0,,,1,2,"29784938,26594036",1,"intellectual disability, autosomal dominant 54",0.7745713380655789
P29317,EPHA2,Ephrin type-A receptor 2,Tier 1,0.931,1,A_surface,100,82.25,0,0,,,1,16,"40563410,40408544,39259047,37251690,35700603,35397426,32169805,34541193,28235049,24586375,21902173,21793789",1,Total congenital cataract,0.7690993612962792
P12821,ACE,Angiotensin-converting enzyme,Tier 1,0.93,1,A_surface,97,90.94,0,0,,,1,108,"41505229,41326371,41315058,41027166,40975918,40578246,40549055,40494268,40394224,40157106,39796148,39643350,39638470,39368201,39326115,39277931,38989925,38783134,38559166,38454949,38189917,37692001,37526583,37422510,37385465,37231283,37191170,36924636,36327903,36128975,36069206,35985229,35831655,34248841,34227370,34213110,34109445,33362222,32981365,32969502,31542417,30707214,29367662,29244716,28507681,25035238,24861783,24125636,20373790,20119964,41716474,41274248,40642289,40333723,40321580,40227272,39964138,39923730,38553521,37932762,37808754,37375202,36822303,36714461,36581924,36288301,36170362,36073793,35972202,35910791,35748608,35542182,34953639,34876524,34855379,34798263,34696413,34619249,34458322,34282416,34230708,34230707,34166652,33684258,33683787,33629859,33561300,32838280,32551560,21147843,18209324,16607776",1,diabetic nephropathy,0.7656590329495216
P24394,IL4R,Interleukin-4 receptor subunit alpha,Tier 1.5,0.923,1,A_surface,10,54.75,0,0,,,1,3,"32751068,27819142,22282665",1,asthma,0.742115080702623
P01019,AGT,Angiotensinogen,Tier 1,0.921,1,A_surface,22,86.44,0,0,,,1,16,"35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235",1,renal tubular dysgenesis,0.7354947364860083
P01730,CD4,T-cell surface glycoprotein CD4,Tier 1,0.921,1,A_surface,85,85.25,0,0,,,1,96,"41889731,41761629,41654945,41542672,41395530,41338305,41206244,40972397,40877519,40788329,40448637,39920212,39269432,38744189,38661725,37895096,37881079,37836456,37170724,37141264,37110712,36352911,36149728,34386332,33389440,32786336,32567629,32157125,31778957,31707227,31434881,31316164,30393236,29881374,29556342,29375127,29277631,29145483,28934318,28800954,28290464,27959341,27529508,28955932,26792955,25757623,25754473,25241192,25189099,24661998",1,HIV infection,0.7364522622142639
P16671,CD36,Platelet glycoprotein 4,Tier 1.5,0.921,1,A_surface,1,93.94,0,0,,,1,6,"41713143,41140242,39762152,33596054,33291667,31904170",1,platelet-type bleeding disorder 10,0.7360571429413174
P09758,TACSTD2,Tumor-associated calcium signal transducer 2,Tier 1.5,0.919,1,A_surface,7,82.69,0,0,,,1,4,"41384307,41241473,40050871,39250993",1,gelatinous drop-like corneal dystrophy,0.7293087728162646
P21589,NT5E,5'-nucleotidase,Tier 1,0.916,1,A_surface,50,91.88,0,0,,,1,3,"38689291,30472954,25720604",1,hereditary arterial and articular multiple calcification syndrome,0.7199342086353593
P22455,FGFR4,Fibroblast growth factor receptor 4,Tier 1,0.915,1,A_surface,52,73.62,0,0,,,1,2,"39759879,30297602",1,cancer,0.7150377661800104
P08637,FCGR3A,Low affinity immunoglobulin gamma Fc region receptor III-A,Tier 1.5,0.912,1,A_surface,15,85.69,0,0,,,1,2,"41249026,21531729",1,autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity,0.7061437347032623
P09601,HMOX1,Heme oxygenase 1,Tier 1,0.905,1,A_surface,26,82.88,0,0,,,1,6,"37533140,40526855,40509588,39812275,37457170",1,heme oxygenase 1 deficiency,0.6838783130237968
P35968,KDR,Vascular endothelial growth factor receptor 2,Tier 1,0.904,1,A_surface,54,71.12,0,0,,,1,22,"29608400,27490795,26125598,10548435,9685413,41572478,41187655,39225423,33191671,32199927,30626772,21970900,21907194,20237249,19135441,18499900,17347807,16842232,16787141",1,neoplasm,0.681272749535704
Q9NZQ7,CD274,Programmed cell death 1 ligand 1,Tier 1,0.903,1,A_surface,74,88.25,0,0,,,1,67,"41855853,41830812,41781380,41770936,41629133,41479885,41205458,41195987,41173800,40972397,40811947,40789156,40758411,40682599,40581004,40516668,40209314,40188671,40119836,40016918,40012368,39929085,39916963,39824759,39805944,39532409,39454136,39440615,39417693,39352679,39344385,39332044,39222892,39003918,38940673,38859589,38763821,38636085,38621341,38446717,37944524,37923412,37531891,37364303,36484532,35972912,35624582,35268583,34523014,34156677",1,non-small cell lung carcinoma,0.6769230776549127
P17181,IFNAR1,Interferon alpha/beta receptor 1,Tier 1,0.901,1,A_surface,5,78.0,0,0,,,1,1,27068091,1,"immunodeficiency 106, susceptibility to viral infections",0.6703994774055272
Q07075,ENPEP,Glutamyl aminopeptidase,Tier 1,0.9,1,A_surface,7,93.5,0,0,,,1,2,38467937,1,hypertension,0.6677707312760746
P27487,DPP4,Dipeptidyl peptidase 4,Tier 1,0.893,1,A_surface,100,96.25,0,0,,,1,4,"30056058,26605646",1,type 2 diabetes mellitus,0.6432827162361505
P27338,MAOB,Amine oxidase [flavin-containing] B,Tier 1,0.889,1,A_surface,56,95.62,0,0,,,1,1,26841904,1,Parkinson disease,0.6302940908016386
P22303,ACHE,Acetylcholinesterase,Tier 1,0.889,1,A_surface,78,92.94,0,0,,,1,135,"41985393,41898380,41654945,41639270,41639254,41565777,41276911,41237904,41230502,41086326,41006757,40855286,40500390,40487355,40452137,40444021,40277325,40262341,40215752,40154972,40128122,39834132,39728786,39689579,39665919,39282962,39102642,38996565,38953438,38949022,38722683,38569854,38559166,38544485,38462144,38410271,38168820,38026177,37905115,37759795,37622311,37506391,37117194,36741760,36551106,36368824,36047811,35842727,35770801,35439419,36971430,36375221,36359944,35479481,35402070,35235478,35057959,34509014,33218485,33096123,32143069,31748191,31170561,26003847,25569873,24756130,24299064,12852840",1,Alzheimer disease,0.628678841772617
Q13557,CAMK2D,Calcium/calmodulin-dependent protein kinase type II subunit delta,Tier 1,0.889,1,A_surface,9,83.38,0,0,,,1,1,29784938,1,Neurodevelopmental disorder,0.6312857608660509
P28907,CD38,ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1,Tier 1,0.887,1,A_surface,55,90.88,0,0,,,1,5,"40931580,34364920,33742062,26242462",1,multiple myeloma,0.6233037747334318
Q07954,LRP1,Prolow-density lipoprotein receptor-related protein 1,Tier 1,0.886,1,A_surface,7,79.19,0,0,,,1,3,"41599761,38996211,25855589",1,developmental dysplasia of the hip,0.6197148309275711
P27448,MARK3,MAP/microtubule affinity-regulating kinase 3,Tier 1,0.879,1,A_surface,14,68.25,0,0,,,1,2,"33328453,32637948",1,cancer,0.5979109389232433
P30530,AXL,Tyrosine-protein kinase receptor UFO,Tier 1,0.876,1,A_surface,4,75.06,0,0,,,1,22,"40751315,40566927,40479828,39788632,39440615,39347825,37961806,35116429,33988982,33251048,32486489,32174798,31684958,31276956,30340138,29246304,27448441,27111415,25998051,24881764,24441398,22910292",1,acute myeloid leukemia,0.5870034687571098
P13726,F3,Tissue factor,Tier 1,0.867,1,A_surface,54,84.81,0,0,,,1,36,"40611414,40001558,38811951,36291832,33892482,38776649,36203210,35036063,34386338,32224381,30302740,27563744,25953802,25521966,24998782,24880800,24319161,24263002,23876036,23528042,22951415,22658294,22632032,22116094,21696535,21389323,21144556,20139356,20135076,20004955,18826387,18235012,17272750,16676065,11127866,8578509",1,cervical cancer,0.5555433402271651
P15260,IFNGR1,Interferon gamma receptor 1,Tier 1.5,0.862,1,A_surface,5,66.0,0,0,,,1,2,33667716,1,disseminated atypical mycobacterial infection,0.5414012388034828
P29323,EPHB2,Ephrin type-B receptor 2,Tier 1,0.858,1,A_surface,5,80.0,0,0,,,1,1,26824783,1,medullary thyroid gland carcinoma,0.5261243162992855
P21926,CD9,CD9 antigen,Tier 1.5,0.858,1,A_surface,5,88.56,0,0,,,1,17,"41999228,41625383,40618375,39266887,38866706,38057814,37585601,37351166,37019008,36704890,34647460,34505435,33304477,32730952,32207293,28959386",1,diphtheria,0.5261379875719714
P56199,ITGA1,Integrin alpha-1,Tier 1,0.853,1,A_surface,7,83.62,0,0,,,1,1,27530235,1,type 2 diabetes mellitus,0.5103800749495139
P13591,NCAM1,Neural cell adhesion molecule 1,Tier 1.5,0.852,1,A_surface,7,79.5,0,0,,,1,1,36649818,1,smoking initiation,0.5071020926446286
P17693,HLA-G,"HLA class I histocompatibility antigen, alpha chain G",Tier 1,0.847,1,A_surface,10,90.44,0,0,,,1,2,"39903971,32170897",1,COVID-19,0.4890123845550627
O14786,NRP1,Neuropilin-1,Tier 1,0.846,1,A_surface,25,79.12,0,0,,,1,10,"41574287,34248841,31840081,24397988,21907194,27189805",1,COVID-19,0.4856596500618517
P13747,HLA-E,"HLA class I histocompatibility antigen, alpha chain E",Tier 1,0.845,1,A_surface,34,87.0,0,0,,,1,1,38473398,1,COVID-19,0.4822929100647597
P06729,CD2,T-cell surface antigen CD2,Tier 1,0.842,1,A_surface,7,77.75,0,0,,,1,86,"41962371,41915456,41513346,41099671,40969833,40710088,40441114,40439059,39934406,39740433,39298804,39143932,38809225,38730197,38646918,38509823,38237283,38182840,38100966,38025856,37977780,37812810,37622335,37598831,37451780,37366977,37074785,37013991,37000503,36866250,36863194,36769237,36463799,36417325,36402100,36291024,36257744,35738991,35558841,35526481,35149468,35146864,35051799,35009645,34738809,34736691,34585255,34074399,33922514,33742515",1,rheumatoid arthritis,0.47222372970997034
Q13332,PTPRS,Receptor-type tyrosine-protein phosphatase S,Tier 1,0.835,1,A_surface,6,81.5,0,0,,,1,1,41861669,1,atrial fibrillation,0.4497956707317952
Q16790,CA9,Carbonic anhydrase 9,Tier 1,0.832,1,A_surface,30,76.56,0,0,,,1,1,17912235,1,epilepsy,0.43896333934821724