id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P23946,CMA1,Chymase,Tier 1,0.875,42,91.31,0,0,,,,1,1,30572223,0,pernicious anemia,0.17348905136256007
P13747,HLA-E,"HLA class I histocompatibility antigen, alpha chain E",Tier 1,0.865,34,87.0,0,0,,,,1,1,38473398,1,COVID-19,0.4822929100647597
Q15848,ADIPOQ,Adiponectin,Tier 1,0.806,3,79.88,0,0,,,,1,10,"41636061,38392020,36508319,35323639,34796696,34117903,33535822,31988066,25105541",1,hearing loss,0.25844907375917336
P01236,PRL,Prolactin,Tier 1,0.795,12,85.56,0,0,,,,1,6,"40327044,30834248,29277631,28263753,27679852,16947086",0,AL amyloidosis,0.4619748183558772
O14788,TNFSF11,Tumor necrosis factor ligand superfamily member 11,Tier 1,0.79,2,79.19,0,0,,,,1,2,"15562003,41226313",0,osteoporosis,0.6957850224892792
P01019,AGT,Angiotensinogen,Tier 1,0.779,22,86.44,0,0,,,,1,16,"35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235",1,renal tubular dysgenesis,0.7354947364860083
P61769,B2M,Beta-2-microglobulin,Tier 1,0.77,100,94.06,0,0,,,,1,15,"41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167",1,Immunodeficiency by defective expression of HLA class 1,0.6180318849819645
P26951,IL3RA,Interleukin-3 receptor subunit alpha,Tier 1,0.767,4,85.25,0,0,,,,1,3,"40931580,36171541,31323275",0,acute myeloid leukemia,0.46904332714118013
P05546,SERPIND1,Heparin cofactor 2,Tier 1,0.752,9,79.62,0,0,,,,1,4,"20062917,20053992,34248840,31247951",1,heparin cofactor 2 deficiency,0.719744572767547
P05164,MPO,Myeloperoxidase,Tier 1,0.745,49,89.0,0,0,,,,1,16,"41629951,41316897,40501769,38127443,33534888,33495506,37991715,37277648,34183667,34117903,33869115,31210423,30431231",1,myeloperoxidase deficiency,0.7742533340195327
P05187,ALPP,"Alkaline phosphatase, placental type",Tier 1,0.72,8,93.44,0,0,,,,1,7,"41329468,38238732,37425696,37047289,31687420,25919296,23467613",1,male reproductive organ cancer,0.16284411775950106
K7N5M4,B2M,,Tier 1,0.72,24,90.94,0,0,,,,1,3,"41850110,40373155,38904251",0,,
P29622,SERPINA4,Kallistatin,Tier 1,0.719,3,86.69,0,0,,,,1,4,"38904251,30297859,37351609,28794177",1,optic atrophy,0.28896631154492924
P42262,GRIA2,Glutamate receptor 2,Tier 1,0.715,16,84.94,0,0,,,,1,4,"28325839,19417060,17929944,17024188",0,neurodevelopmental disorder with language impairment and behavioral abnormalities,0.8328652004757138
Q96IY4,CPB2,Carboxypeptidase B2,Tier 1,0.709,10,94.12,0,0,,,,1,4,"37329944,36805075,35861072,30297859",1,type 2 diabetes mellitus,0.19338213943947646
P25311,AZGP1,Zinc-alpha-2-glycoprotein,Tier 1,0.701,9,92.88,0,0,,,,1,1,41325160,1,neoplasm,0.10887540652591159
P14207,FOLR2,Folate receptor beta,Tier 1,0.701,5,89.12,0,0,,,,1,2,28686804,0,neoplasm,0.11545394821329319
P15248,IL9,Interleukin-9,Tier 1,0.7,5,84.06,0,0,,,,1,1,40972397,0,neurodegenerative disease,0.40148548290272756
P01374,LTA,Lymphotoxin-alpha,Tier 1,0.7,3,83.44,0,0,,,,1,3,"41810142,30576605",0,,
P00746,CFD,Complement factor D,Tier 1,0.695,40,91.0,0,0,,,,1,4,"38057414,38071633,28972568,25727321",1,recurrent Neisseria infections due to factor D deficiency,0.7726408204424132
Q95460,MR1,Major histocompatibility complex class I-related protein 1,Tier 1,0.693,79,87.5,0,0,,,,1,2,"41134135,20000526",0,Immunodeficiency,0.3336382138166145
Q9NPF0,CD320,CD320 antigen,Tier 1,0.69,6,63.81,0,0,,,,1,1,39493449,0,Methylmalonic aciduria due to transcobalamin receptor defect,0.49918945650121177
P22303,ACHE,Acetylcholinesterase,Tier 1,0.685,78,92.94,0,0,,,,1,135,"41985393,41898380,41654945,41639270,41639254,41565777,41276911,41237904,41230502,41086326,41006757,40855286,40500390,40487355,40452137,40444021,40277325,40262341,40215752,40154972,40128122,39834132,39728786,39689579,39665919,39282962,39102642,38996565,38953438,38949022,38722683,38569854,38559166,38544485,38462144,38410271,38168820,38026177,37905115,37759795,37622311,37506391,37117194,36741760,36551106,36368824,36047811,35842727,35770801,35439419,36971430,36375221,36359944,35479481,35402070,35235478,35057959,34509014,33218485,33096123,32143069,31748191,31170561,26003847,25569873,24756130,24299064,12852840",1,Alzheimer disease,0.628678841772617
P03950,ANG,Angiogenin,Tier 1,0.685,56,89.81,0,0,,,,1,99,"41948065,41736700,41688234,41686152,41625383,41551985,41550856,41338305,41194434,40839054,40825091,40233536,40046817,39891801,39871473,39727889,39700796,39226945,39078660,38458987,38282417,37683754,37585601,37556929,37527337,37367006,37284580,37185488,37100807,36520671,36315359,36291000,36087171,35731347,35489276,35408368,35290881,35218097,35084794,34987275,34964948,34902643,34617153,34523638,34500620,34474207,34464491,34439828,34350496,34232998,27841380,25461163,25422408,22018671,21774079,18585145,18533682,17260069,9578572",1,amyotrophic lateral sclerosis,0.7865457274017922
P01008,SERPINC1,Antithrombin-III,Tier 1,0.685,27,84.69,0,0,,,,1,11,"32199927,31881749,31747245,25467079,25186782,24359968,23637781,18316185,15741074,10660541,10457984",1,hereditary antithrombin deficiency,0.8494671886642873
Q15485,FCN2,Ficolin-2,Tier 1,0.682,13,85.12,0,0,,,,1,2,27490795,1,hypopituitarism,0.2753784074131916
Q07954,LRP1,Prolow-density lipoprotein receptor-related protein 1,Tier 1,0.682,7,79.19,0,0,,,,1,3,"41599761,38996211,25855589",1,developmental dysplasia of the hip,0.6197148309275711
P00918,CA2,Carbonic anhydrase 2,Tier 1,0.68,100,97.38,0,0,,,,1,109,"41955789,41543229,41513346,40854266,40783389,40744710,40660917,40411663,40380946,40321028,39978259,39928524,39716707,39536855,39515698,38946763,38693181,38462338,38409486,37997814,37726778,37148800,37103734,36792529,36410157,36140102,36107718,35490167,35344667,35211356,35194086,35022247,35006986,34619285,34607961,34440571,34399193,34362425,34166652,33832411,33479839,33410656,33230701,33080851,32991252,35516485,32700526,32493583,32331372,32304233",1,Osteopetrosis with renal tubular acidosis,0.7929568656592082
P39900,MMP12,Macrophage metalloelastase,Tier 1,0.68,86,86.94,0,0,,,,1,8,"41861669,38477735,38296402,37015819,35120890,34183667,27530235",0,atopic eczema,0.4795677061208266
P09958,FURIN,Furin,Tier 1,0.68,48,84.75,0,0,,,,1,4,"36291832,24808863",1,coronary artery disease,0.5783535503692275
Q86Z14,KLB,Beta-klotho,Tier 1,0.676,5,89.38,0,0,,,,1,1,40514411,0,congenital hypogonadotropic hypogonadism,0.462898767992589
P09382,LGALS1,Galectin-1,Tier 1,0.675,41,96.5,0,0,,,,1,6,"37141264,33006019,31778957",1,glaucoma,0.2854257184852107
P62576,nanA,Sialidase A,Tier 1,0.67,5,81.19,0,0,,,,1,4,"37350189,34976356,34341854,32034503",0,,
P25942,CD40,Tumor necrosis factor receptor superfamily member 5,Tier 1,0.67,14,81.19,0,0,,,,1,8,"41982466,37331977,36203210,33335251,26504624,26231918,23460531,12828856",1,hyper-IgM syndrome type 3,0.8038021669520221
Q9GZX9,TWSG1,Twisted gastrulation protein homolog 1,Tier 1,0.67,6,80.38,0,0,,,,1,1,39299474,0,Abruptio Placentae,0.29495361755469174
P08581,MET,Hepatocyte growth factor receptor,Tier 1,0.669,100,79.25,0,0,,,,1,149,"42012469,41992303,41973478,41873087,41861669,41858296,41848278,41601428,41462891,41391726,41234744,41123956,41084363,41065179,41024479,40954195,40938088,40923343,40840349,40740738,40728393,40640119,40388621,40189053,40116812,40041032,39930702,39853766,39852082,39744222,39735310,39674868,39631842,39586988,39527480,39513807,39355222,39348183,39288204,39087949,38925633,38923378,38876234,38829176,38697444,38515622,38298092,38277932,38230289,38225704,30237882,29416033,26131766",1,papillary renal cell carcinoma,0.84195976263742
P56817,BACE1,Beta-secretase 1,Tier 1,0.668,100,87.5,0,0,,,,1,9,"39241336,36149663,35402070,31513457,30959405,29327496,26473367,23832586,16888322",1,metabolic disease,0.42482013576989197
P08311,CTSG,Cathepsin G,Tier 1,0.667,16,91.38,0,0,,,,1,6,"41316897,40501769,9062133,23598134,19325843",1,tuberculosis,0.37188972877648113
O15169,AXIN1,Axin-1,Tier 1,0.664,22,61.09,0,0,,,,1,2,28129128,0,hepatocellular carcinoma,0.7864172882686208
Q9Y251,HPSE,Heparanase,Tier 1,0.66,58,94.69,0,0,,,,1,7,"41363219,31252265,30086306,28150826,25295847,23968994,22719856",1,Vitiligo,0.3120033501413742
Q13093,PLA2G7,Platelet-activating factor acetylhydrolase,Tier 1,0.66,33,87.81,0,0,,,,1,1,35187107,1,Platelet-activating factor acetylhydrolase deficiency,0.6405981442654826
P15941,MUC1,Mucin-1,Tier 1,0.66,23,47.41,0,0,,,,1,686,"42025056,41988862,41954302,41771296,41744704,41744190,41657320,41627316,41621292,41582516,41535857,41471303,41362016,41352919,41346179,41330302,41243570,41205458,41185018,41101154,41047832,41027169,40682599,40665615,40627939,40607530,40590839,40578633,40568899,40556592,40504676,40500890,40499867,40479828,40432219,40422041,40360093,40286646,40274149,40158809,40119836,39978149,39910821,39705316,39679901,39626346,39579679,39566700,39552005,39550818,41997681,41247195,40813258,39454542,39454415,39440615,39421884,39406784,39256285,39243449,39154820,39142532,39136402,39119745,39118454,38923850,38912896",0,"tubulointerstitial kidney disease, autosomal dominant, 2",0.7040398435219726
Q92876,KLK6,Kallikrein-6,Tier 1,0.659,21,91.75,0,0,,,,1,2,"30114962,22505517",0,neuroinflammatory disorder,0.1901077464611955
P02461,COL3A1,Collagen alpha-1(III) chain,Tier 1,0.656,11,53.25,0,0,,,,1,1,28453726,1,"Ehlers-Danlos syndrome, vascular type",0.8608667500207768
P22894,MMP8,Neutrophil collagenase,Tier 1,0.655,25,90.38,0,0,,,,1,4,"35821507,34183667,33534888,30197987",0,acne,0.603247809982021
P15907,ST6GAL1,"Beta-galactoside alpha-2,6-sialyltransferase 1",Tier 1,0.655,4,88.12,0,0,,,,1,1,41889102,1,COVID-19,0.5471103766359176
P08709,F7,Coagulation factor VII,Tier 1,0.655,100,82.12,0,0,,,,1,4,"41980687,32224381,28496951,11127866",1,factor VII deficiency,0.8542078994169972
P36894,BMPR1A,Bone morphogenetic protein receptor type-1A,Tier 1,0.653,11,82.62,0,0,,,,1,1,30537181,1,juvenile polyposis syndrome,0.8278395086688584
P62937,PPIA,Peptidyl-prolyl cis-trans isomerase A,Tier 1,0.652,100,98.06,0,0,,,,1,1,30121422,1,HIV infection,0.6219943433906236
P45452,MMP13,Collagenase 3,Tier 1,0.65,49,88.62,0,0,,,,1,4,"41754778,40893365,38471488,38750696",0,"spondyloepimetaphyseal dysplasia, Missouri type",0.8032079813035149