id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P15260,IFNGR1,Interferon gamma receptor 1,Tier 1.5,0.804,5,66.0,0,0,,,,1,2,33667716,1,disseminated atypical mycobacterial infection,0.5414012388034828
P36888,FLT3,Receptor-type tyrosine-protein kinase FLT3,Tier 1.5,0.788,11,75.94,0,0,,,,1,6,"41733039,34364920,31434881,30237882,29299123,22411871",1,acute myeloid leukemia,0.8313389209288576
P48023,FASLG,Tumor necrosis factor ligand superfamily member 6,Tier 1.5,0.775,3,80.19,0,0,,,,1,1,16581027,0,autoimmune lymphoproliferative syndrome type 1,0.6984292519156657
P02776,PF4,Platelet factor 4,Tier 1.5,0.77,10,75.06,0,0,,,,1,10,"33859620,32366845,31967847,23847186,23673861,34248840,32022468",1,systemic scleroderma,0.11523541376593864
Q9GZU2,PEG3,Paternally-expressed gene 3 protein,Tier 1.5,0.75,1,44.53,0,0,,,,1,1,16595502,0,neurodegenerative disease,0.34815912577489827
P18075,BMP7,Bone morphogenetic protein 7,Tier 1.5,0.749,4,76.19,0,0,,,,1,1,30537181,0,Inguinal hernia,0.4420059023371716
Q9Y5C1,ANGPTL3,Angiopoietin-related protein 3,Tier 1.5,0.727,1,79.62,0,0,,,,1,1,23770039,0,familial hypobetalipoproteinemia 2,0.6739043862507132
P41221,WNT5A,Protein Wnt-5a,Tier 1.5,0.71,0,87.69,0,0,,,,1,4,"40855286,32693649,22363130,18673242",1,Robinow syndrome,0.7220360983378594
A0A0C5B5G6,MT-RNR1,Mitochondrial-derived peptide MOTS-c,Tier 1.5,0.7,0,72.06,0,0,,,,1,1,35311942,0,,
P08620,FGF4,Fibroblast growth factor 4,Tier 1.5,0.7,1,81.5,0,0,,,,1,3,"35415885,33536494,7547864",0,cancer,0.6026669167438079
P19021,PAM,Peptidyl-glycine alpha-amidating monooxygenase,Tier 1.5,0.695,0,71.69,0,0,,,,1,25,"41855944,41500123,41384307,41285544,41222440,40607956,39929897,39472107,38867016,38846799,37977804,37977780,37906116,37127012,36905684,35478209,33911033,33516855,32315032,32307868,30399413,30124431,26406332,22954359,14965210",1,type 2 diabetes mellitus,0.5754371880839976
P21781,FGF7,Fibroblast growth factor 7,Tier 1.5,0.695,0,82.44,0,0,,,,1,5,"35415885,15719578,7547864,16462265",0,cancer,0.5963369026823151
P10586,PTPRF,Receptor-type tyrosine-protein phosphatase F,Tier 1.5,0.69,13,82.0,0,0,,,,1,4,"42101929,39087949,36594741",1,smoking initiation,0.4641111755355386
O00501,CLDN5,Claudin-5,Tier 1.5,0.685,0,83.75,0,0,,,,1,1,18951306,1,genetic disorder,0.40861362787778505
P14384,CPM,Carboxypeptidase M,Tier 1.5,0.68,1,90.31,0,0,,,,1,3,"38876068,38060303,36768220",1,hydronephrosis,0.3163273148871551
P26718,KLRK1,NKG2-D type II integral membrane protein,Tier 1.5,0.679,22,79.19,0,0,,,,1,1,24629635,0,Behcet's syndrome,0.18614538678991077
P09758,TACSTD2,Tumor-associated calcium signal transducer 2,Tier 1.5,0.673,7,82.69,0,0,,,,1,4,"41384307,41241473,40050871,39250993",1,gelatinous drop-like corneal dystrophy,0.7293087728162646
P98066,TNFAIP6,Tumor necrosis factor-inducible gene 6 protein,Tier 1.5,0.671,5,81.12,0,0,,,,1,1,39263947,1,type 2 diabetes mellitus,0.30862220597837015
O95750,FGF19,Fibroblast growth factor 19,Tier 1.5,0.668,4,79.81,0,0,,,,1,4,"35415885,31967847,27679852",0,cancer,0.38540691230511315
O00744,WNT10B,Protein Wnt-10b,Tier 1.5,0.668,0,80.06,0,0,,,,1,2,"32810272,18673242",0,Split hand-split foot malformation,0.7755225395358214
Q9HCK4,ROBO2,Roundabout homolog 2,Tier 1.5,0.665,6,67.38,0,0,,,,1,2,"40616090,31640794",0,familial vesicoureteral reflux,0.6460375744556555
Q6PCB0,VWA1,von Willebrand factor A domain-containing protein 1,Tier 1.5,0.664,0,78.38,0,0,,,,1,4,"41906877,41693575,38904251,38299345",0,"neuronopathy, distal hereditary motor, autosomal recessive 7",0.7420531156755253
A2RU14,TMEM218,Transmembrane protein 218,Tier 1.5,0.663,0,87.62,0,0,,,,1,6,"41360349,34861273,31349094,29277631,26580576,26248137",0,Joubert syndrome 39,0.7308441626389979
P16870,CPE,Carboxypeptidase E,Tier 1.5,0.66,0,90.38,0,0,,,,1,16,"39863729,39793371,38861005,36832010,36773630,27886773,27219679,25738486,28706644,24768847,23875581,22280349,21419619,20949139,20491465,19174227",1,BDV syndrome,0.7029731914682913
P18510,IL1RN,Interleukin-1 receptor antagonist protein,Tier 1.5,0.66,5,87.06,0,0,,,,1,1,38928037,0,sterile multifocal osteomyelitis with periostitis and pustulosis,0.7734282711738736
Q86YL7,PDPN,Podoplanin,Tier 1.5,0.66,6,57.97,0,0,,,,1,4,"41304780,41292412,39451677",0,Microscopic hematuria,0.41183796492083136
P22692,IGFBP4,Insulin-like growth factor-binding protein 4,Tier 1.5,0.66,4,77.25,0,0,,,,1,6,"35323639,32515246,31930684",1,allergic rhinitis,0.35214760515440524
Q13433,SLC39A6,Zinc transporter ZIP6,Tier 1.5,0.66,0,60.44,0,0,,,,1,1,40132409,1,breast cancer,0.11188167100061543
O15389,SIGLEC5,Sialic acid-binding Ig-like lectin 5,Tier 1.5,0.656,3,77.75,0,0,,,,1,3,"33584010,27678199,24405684",0,dentures,0.15815607474115415
Q9Y625,GPC6,Glypican-6,Tier 1.5,0.655,0,82.0,0,0,,,,1,1,40093223,1,autosomal recessive omodysplasia,0.7503216726357611
P02766,TTR,Transthyretin,Tier 1.5,0.655,0,88.0,0,0,,,,1,11,"39737993,32616928,23770039,21875107,21314458,39596348,38399458,36881759,33572452",1,"amyloidosis, hereditary systemic 1",0.846421986844374
Q9H0R3,TMEM222,Transmembrane protein 222,Tier 1.5,0.654,0,84.81,0,0,,,,1,3,"41643149,36174865,25998051",1,neurodevelopmental disorder with motor and speech delay and behavioral abnormalities,0.6449281600938256
O15263,DEFB4A,Defensin beta 4A,Tier 1.5,0.65,6,78.0,0,0,,,,1,2,"40362575,32067984",0,ulcerative colitis,0.09865892368546408
P84996,GNAS,Protein ALEX,Tier 1.5,0.65,0,43.59,0,0,,,,1,9,"39154820,37963924,36037714,34488577,31129134,30979095,30682825,29146902,28626560",0,,
P32942,ICAM3,Intercellular adhesion molecule 3,Tier 1.5,0.648,1,87.12,0,0,,,,1,3,"40650261,34730968,17660953",1,lymphatic system disease,0.28331776251399693
P01138,NGF,Beta-nerve growth factor,Tier 1.5,0.648,8,73.25,0,0,,,,1,6,"42015870,38780008,32982626,21216401,7545283,29754498",0,hereditary sensory and autonomic neuropathy type 5,0.7785402119369383
Q2I0M5,RSPO4,R-spondin-4,Tier 1.5,0.646,0,78.56,0,0,,,,1,3,"38238732,37425696",0,nonsyndromic congenital nail disorder 4,0.7604902779349189
Q9BQ51,PDCD1LG2,Programmed cell death 1 ligand 2,Tier 1.5,0.645,2,86.38,0,0,,,,1,1,38928037,0,melanoma,0.42716921377769757
Q9UKP5,ADAMTS6,A disintegrin and metalloproteinase with thrombospondin motifs 6,Tier 1.5,0.644,0,77.5,0,0,,,,1,1,35700850,0,Abnormality of the skeletal system,0.5444162515485208
Q14242,SELPLG,P-selectin glycoprotein ligand 1,Tier 1.5,0.64,1,50.38,0,0,,,,1,1,25979951,1,glaucoma,0.40058604767334977
P07202,TPO,Thyroid peroxidase,Tier 1.5,0.64,0,83.44,0,0,,,,1,1,29881374,0,familial thyroid dyshormonogenesis,0.6710562308468054
P31994,FCGR2B,Low affinity immunoglobulin gamma Fc region receptor II-b,Tier 1.5,0.636,5,78.44,0,0,,,,1,1,38928037,0,systemic lupus erythematosus,0.460465747544726
Q16674,MIA,Melanoma-derived growth regulatory protein,Tier 1.5,0.636,4,86.38,0,0,,,,1,15,"41768714,40943389,40444021,38899488,37853818,35842727,35593028,35061691,34038704,32957732,31878307,31289496,29499935,28059418,26840019",0,neurodegenerative disease,0.36367051545295126
P01732,CD8A,T-cell surface glycoprotein CD8 alpha chain,Tier 1.5,0.635,8,78.19,0,0,,,,1,2,"38487531,36979667",1,progressive supranuclear palsy,0.2036023725502463
Q92563,SPOCK2,Testican-2,Tier 1.5,0.627,0,66.94,0,0,,,,1,8,"39695715,35474272,32958645,28794177,38656806,36288905",0,Back pain,0.3687304175767662
P34810,CD68,Macrosialin,Tier 1.5,0.627,0,73.19,0,0,,,,1,4,"37422510,33321636,28315675,27940247",0,neurodegenerative disease,0.3710186480081222
P51884,LUM,Lumican,Tier 1.5,0.625,0,90.38,0,0,,,,1,7,"41744190,36785906,28453726,26230699,24180352,23890607",1,lumbar disc herniation,0.3492311458288365
P49862,KLK7,Kallikrein-7,Tier 1.5,0.624,12,91.56,0,0,,,,1,1,30114962,1,neurodegenerative disease,0.2420324965785189
P21926,CD9,CD9 antigen,Tier 1.5,0.623,5,88.56,0,0,,,,1,17,"41999228,41625383,40618375,39266887,38866706,38057814,37585601,37351166,37019008,36704890,34647460,34505435,33304477,32730952,32207293,28959386",1,diphtheria,0.5261379875719714
Q96NZ8,WFIKKN1,"WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 1",Tier 1.5,0.621,2,78.06,0,0,,,,1,1,33591955,0,neurodegenerative disease,0.3060887002952384