id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P15884,TCF4,Transcription factor 4,Tier 1,0.705,1,A_assoc,5,51.12,0,0,,,1,4,"36252203,17909039,41851110,37805109",0,Pitt-Hopkins syndrome,0.8490531860867685
Q9NZK5,ADA2,Adenosine deaminase 2,Tier 1,0.699,1,A_assoc,2,95.81,0,0,,,0,0,,0,deficiency of adenosine deaminase 2,0.8291292532404531
Q99972,MYOC,Myocilin,Tier 1,0.699,1,A_assoc,24,78.94,0,0,,,0,0,,0,"glaucoma 1, open angle, A",0.8294483747483756
Q9UBH0,IL36RN,Interleukin-36 receptor antagonist protein,Tier 1,0.695,1,A_assoc,3,92.44,0,0,,,0,0,,0,"psoriasis 14, pustular",0.8155144873787125
P20062,TCN2,Transcobalamin-2,Tier 1,0.694,1,A_assoc,11,91.5,0,0,,,1,3,"41935727,39493449",0,transcobalamin II deficiency,0.8116989428679681
Q96MK3,FAM20A,Pseudokinase FAM20A,Tier 1,0.693,1,A_assoc,4,85.25,0,0,,,0,0,,0,amelogenesis imperfecta type 1G,0.8106031517056754
P55000,SLURP1,Secreted Ly-6/uPAR-related protein 1,Tier 1,0.692,1,A_assoc,2,84.19,0,0,,,0,0,,0,mal de Meleda,0.8064330379723671
P45452,MMP13,Collagenase 3,Tier 1,0.691,1,A_assoc,49,88.62,0,0,,,1,4,"41754778,40893365,38471488,38750696",0,"spondyloepimetaphyseal dysplasia, Missouri type",0.8032079813035149
Q13253,NOG,Noggin,Tier 1.5,0.685,1,A_assoc,2,86.06,0,0,,,1,2,38397086,0,proximal symphalangism 1A,0.7844136456463046
Q96S42,NODAL,Nodal homolog,Tier 1,0.684,1,A_assoc,1,75.44,0,0,,,1,3,"38155321,24146916,23918801",0,"heterotaxy, visceral, 5, autosomal",0.7788051667024423
P01138,NGF,Beta-nerve growth factor,Tier 1.5,0.684,1,A_assoc,8,73.25,0,0,,,1,6,"42015870,38780008,32982626,21216401,7545283,29754498",0,hereditary sensory and autonomic neuropathy type 5,0.7785402119369383
P18510,IL1RN,Interleukin-1 receptor antagonist protein,Tier 1.5,0.682,1,A_assoc,5,87.06,0,0,,,1,1,38928037,0,sterile multifocal osteomyelitis with periostitis and pustulosis,0.7734282711738736
P29120,PCSK1,Neuroendocrine convertase 1,Tier 1.5,0.682,1,A_assoc,3,82.5,0,0,,,0,0,,0,obesity due to prohormone convertase I deficiency,0.773875795833803
P00797,REN,Renin,Tier 1,0.68,1,A_assoc,91,85.44,0,0,,,1,456,"42025056,42000159,41992303,41979049,41942404,41934998,41909751,41904852,41851110,41849890,41794534,41780402,41770936,41718462,41711853,41698160,41671930,41659919,41629318,41545413,41538945,41529264,41519163,41454539,41443106,41386094,41330678,41327249,41249026,41234744,41207040,41205456,41175848,41172349,41171135,41164194,41161441,41148632,41118515,41089000,41067030,41024479,41002305,40994449,40968863,40963922,40893365,40891676,40870790,40801503,41906877,40832436,39923730,39263947,39129649,38811951,36190914,35983901,35907639,35187107,34619249,34248841,32981365,32838280,32527800,31988066,26746799,21147843",0,familial juvenile hyperuricemic nephropathy type 2,0.7657976389758877
P20849,COL9A1,Collagen alpha-1(IX) chain,Tier 1,0.678,1,A_assoc,5,61.5,0,0,,,0,0,,0,Stickler syndrome,0.7594904923903256
P16112,ACAN,Aggrecan core protein,Tier 1.5,0.677,1,A_assoc,4,51.91,0,0,,,0,0,,0,Familial osteochondritis dissecans,0.7558487616449627
P55789,GFER,FAD-linked sulfhydryl oxidase ALR,Tier 1.5,0.677,1,A_assoc,7,76.88,0,0,,,0,0,,0,congenital cataract-progressive muscular hypotonia-hearing loss-developmental delay syndrome,0.7556346526616893
Q12794,HYAL1,Hyaluronidase-1,Tier 1.5,0.672,1,A_assoc,1,94.0,0,0,,,0,0,,0,Hyaluronidase deficiency,0.7412407206736383
Q92752,TNR,Tenascin-R,Tier 1.5,0.672,1,A_assoc,2,78.5,0,0,,,0,0,,0,"neurodevelopmental disorder, nonprogressive, with spasticity and transient opisthotonus",0.7403484347367364
O15520,FGF10,Fibroblast growth factor 10,Tier 1.5,0.67,1,A_assoc,2,80.0,0,0,,,1,1,35415885,0,Lacrimoauriculodentodigital syndrome,0.7344198619465704
Q9BQB4,SOST,Sclerostin,Tier 1,0.666,1,A_assoc,3,70.81,0,0,,,1,32,"42031715,41736700,41545413,41276911,41242313,40464222,40429697,34361085,33717084,33334063,21204783,42030934,41450662,41226313,39470582,39007037,38444701,38074899,37481136,35966595,35869074,35646527",0,sclerosteosis 1,0.7184345506579789
O00300,TNFRSF11B,Tumor necrosis factor receptor superfamily member 11B,Tier 1.5,0.666,1,A_assoc,1,86.5,0,0,,,1,1,15562003,0,juvenile Paget disease,0.7184894548525037
Q99574,SERPINI1,Neuroserpin,Tier 1,0.665,1,A_assoc,3,88.12,0,0,,,0,0,,0,familial encephalopathy with neuroserpin inclusion bodies,0.7162803151916303
P11686,SFTPC,Surfactant protein C,Tier 1.5,0.663,1,A_assoc,3,70.06,0,0,,,0,0,,0,Congenital pulmonary alveolar proteinosis,0.7110128683619542
O43897,TLL1,,Tier 1.5,0.662,1,A_assoc,1,80.31,0,0,,,0,0,,0,atrial heart septal defect,0.7050140477090344
P19835,CEL,Bile salt-activated lipase,Tier 1.5,0.658,1,A_assoc,7,82.56,0,0,,,1,2,"39653009,34940276",0,MODY,0.6940743944678538
O43323,DHH,Desert hedgehog protein,Tier 1,0.657,1,A_assoc,5,84.38,0,0,,,1,1,18698484,0,"46,XY gonadal dysgenesis-motor and sensory neuropathy syndrome",0.6912706692651148
P27352,CBLIF,Cobalamin binding intrinsic factor,Tier 1.5,0.655,1,A_assoc,2,90.5,0,0,,,0,0,,0,hereditary intrinsic factor deficiency,0.683930100359911
Q9Y5C1,ANGPTL3,Angiopoietin-related protein 3,Tier 1.5,0.652,1,A_assoc,1,79.62,0,0,,,1,1,23770039,0,familial hypobetalipoproteinemia 2,0.6739043862507132
Q9Y5K2,KLK4,Kallikrein-4,Tier 1,0.65,1,A_assoc,18,90.12,0,0,,,1,2,"30114962,35323639",0,Hypomaturation amelogenesis imperfecta,0.6659029046455642
O95390,GDF11,Growth/differentiation factor 11,Tier 1,0.636,1,A_assoc,5,73.12,0,0,,,1,7,"40664633,39909827,31638376,23663781,32408813",0,vertebral hypersegmentation and orofacial anomalies,0.6207007733160915
P05230,FGF1,Fibroblast growth factor 1,Tier 1,0.633,1,A_assoc,96,90.69,0,0,,,1,3,"35415885,33536494,27663888",0,cancer,0.6088477966360052
P22894,MMP8,Neutrophil collagenase,Tier 1,0.631,1,A_assoc,25,90.38,0,0,,,1,4,"35821507,34183667,33534888,30197987",0,acne,0.603247809982021
P09237,MMP7,Matrilysin,Tier 1,0.631,1,A_assoc,16,87.81,0,0,,,1,9,"41890985,37022120,36508319,33742062,31844116,30553167,28738067,27836219",0,acne,0.603247809982021
O76093,FGF18,Fibroblast growth factor 18,Tier 1.5,0.631,1,A_assoc,1,87.56,0,0,,,1,1,35415885,0,cancer,0.6028027301556572
P08620,FGF4,Fibroblast growth factor 4,Tier 1.5,0.631,1,A_assoc,1,81.5,0,0,,,1,3,"35415885,33536494,7547864",0,cancer,0.6026669167438079
Q15818,NPTX1,Neuronal pentraxin-1,Tier 1.5,0.628,1,A_assoc,1,75.75,0,0,,,0,0,,0,spinocerebellar ataxia 50,0.5937598292127286
P07098,LIPF,Gastric triacylglycerol lipase,Tier 1.5,0.626,1,A_assoc,1,89.75,0,0,,,0,0,,0,obesity,0.5864662753480862
P35247,SFTPD,Pulmonary surfactant-associated protein D,Tier 1,0.624,1,A_assoc,31,65.5,0,0,,,1,1,39884764,0,COVID-19,0.5808114412785164
Q9GZX6,IL22,Interleukin-22,Tier 1.5,0.619,1,A_assoc,6,88.12,0,0,,,1,7,"34208021,33869115,28942363,26792955,37041650",0,atopic eczema,0.5627493881195745
O95150,TNFSF15,Tumor necrosis factor ligand superfamily member 15,Tier 1,0.618,1,A_assoc,7,81.06,0,0,,,1,2,35026285,0,leprosy,0.5605330843692238
Q9UNA0,ADAMTS5,A disintegrin and metalloproteinase with thrombospondin motifs 5,Tier 1,0.613,1,A_assoc,7,77.56,0,0,,,1,3,"35700850,26594036",0,Abnormality of the skeletal system,0.5442996355354548
Q9HCB6,SPON1,Spondin-1,Tier 1,0.613,1,A_assoc,4,77.25,0,0,,,1,2,"31640794,27640094",0,atrial fibrillation,0.5420224587351377
Q8IU60,DCP2,m7GpppN-mRNA hydrolase,Tier 1,0.613,1,A_assoc,33,66.81,0,0,,,0,0,,0,neurodegenerative disease,0.5442061583114092
O00175,CCL24,C-C motif chemokine 24,Tier 1.5,0.613,1,A_assoc,2,82.12,0,0,,,0,0,,0,Iron deficiency anemia,0.5428194908352497
Q4VCS5,AMOT,Angiomotin,Tier 1,0.608,1,A_assoc,18,56.75,0,0,,,0,0,,0,neurodegenerative disease,0.5261379875719714
P56703,WNT3,Proto-oncogene Wnt-3,Tier 1.5,0.608,1,A_assoc,1,88.25,0,0,,,1,2,"40168709,18673242",0,neurodegenerative disease,0.5272184953415704
O14793,MSTN,Growth/differentiation factor 8,Tier 1,0.602,1,A_assoc,5,78.75,0,0,,,1,4,"41020397,40664633,40313273,33334063",0,myostatin-related muscle hypertrophy,0.5055829543398623
Q6IQ23,PLEKHA7,Pleckstrin homology domain-containing family A member 7,Tier 1,0.599,1,A_assoc,3,56.69,0,0,,,0,0,,0,open-angle glaucoma,0.49623877592982996
O15496,PLA2G10,Group 10 secretory phospholipase A2,Tier 1,0.597,1,A_assoc,7,88.0,0,0,,,1,1,9526554,0,neurodegenerative disease,0.48857112988743956