id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
O95255,ABCC6,ATP-binding cassette sub-family C member 6,Tier 1.5,0.809,1,A_surface,4,80.94,0,0,,,0,0,,0,Pseudoxanthoma elasticum,0.864631668818611
P07333,CSF1R,Macrophage colony-stimulating factor 1 receptor,Tier 1,0.802,1,A_surface,26,77.81,0,0,,,1,1,29277631,0,"leukoencephalopathy, diffuse hereditary, with spheroids 1",0.8391971566583056
P42262,GRIA2,Glutamate receptor 2,Tier 1,0.8,1,A_surface,16,84.94,0,0,,,1,4,"28325839,19417060,17929944,17024188",0,neurodevelopmental disorder with language impairment and behavioral abnormalities,0.8328652004757138
P30968,GNRHR,Gonadotropin-releasing hormone receptor,Tier 1.5,0.799,1,A_surface,1,84.19,0,0,,,0,0,,0,hypogonadotropic hypogonadism,0.83100005285263
P10912,GHR,Growth hormone receptor,Tier 1.5,0.799,1,A_surface,9,58.69,0,0,,,1,5,"38811951,38477735,31603904",0,Laron syndrome,0.8304020079647765
Q01974,ROR2,Tyrosine-protein kinase transmembrane receptor ROR2,Tier 1,0.794,1,A_surface,6,68.31,0,0,,,1,2,"41782379,18673242",0,autosomal recessive Robinow syndrome,0.8145559265435566
Q9UM73,ALK,ALK tyrosine kinase receptor,Tier 1,0.791,1,A_surface,79,68.19,0,0,,,1,6,"40347134,38604287,32218299,29205808,24116381,21281497",0,neuroblastoma,0.8016889264946979
Q12866,MERTK,Tyrosine-protein kinase Mer,Tier 1,0.79,1,A_surface,42,72.25,0,0,,,0,0,,0,retinitis pigmentosa,0.7985580877708576
Q4KMG0,CDON,Cell adhesion molecule-related/down-regulated by oncogenes,Tier 1,0.79,1,A_surface,3,62.03,0,0,,,1,3,"36333824,24629635,18698484",0,holoprosencephaly,0.800378039564866
P16871,IL7R,Interleukin-7 receptor subunit alpha,Tier 1,0.789,1,A_surface,8,67.44,0,0,,,0,0,,0,immunodeficiency 104,0.7983119488718231
O43525,KCNQ3,Potassium voltage-gated channel subfamily KQT member 3,Tier 1.5,0.789,1,A_surface,1,56.72,0,0,,,0,0,,0,Benign familial neonatal seizures,0.7961763561533409
P37023,ACVRL1,Activin receptor type-1-like,Tier 1.5,0.789,1,A_surface,7,82.0,0,0,,,0,0,,0,"telangiectasia, hereditary hemorrhagic, type 2",0.7951167515831324
P15509,CSF2RA,Granulocyte-macrophage colony-stimulating factor receptor subunit alpha,Tier 1,0.788,1,A_surface,2,82.0,0,0,,,0,0,,0,Congenital pulmonary alveolar proteinosis,0.7922592394513138
P16410,CTLA4,Cytotoxic T-lymphocyte protein 4,Tier 1.5,0.787,1,A_surface,22,80.12,0,0,,,1,26,"41907643,40972397,40870970,40811947,40536609,39417693,38473398,38158454,36966395,36831533,36603108,36015348,33970170,32929022,32840510,32280743,32024070,31405808,28918052,28082399,26030229,25565435,24892807,23460536,23460531,14612549",0,autoimmune lymphoproliferative syndrome due to CTLA4 haploinsufficiency,0.7906408646569979
P22223,CDH3,Cadherin-3,Tier 1,0.786,1,A_surface,19,76.75,0,0,,,1,1,41304780,0,EEM syndrome,0.7851776755128059
Q13698,CACNA1S,Voltage-dependent L-type calcium channel subunit alpha-1S,Tier 1.5,0.786,1,A_surface,2,71.81,0,0,,,0,0,,0,"hypokalemic periodic paralysis, type 1",0.7869997029542154
Q96MS0,ROBO3,Roundabout homolog 3,Tier 1.5,0.784,1,A_surface,3,63.69,0,0,,,1,2,32369590,0,horizontal gaze palsy with progressive scoliosis,0.7813306356858872
Q9H251,CDH23,Cadherin-23,Tier 1,0.781,1,A_surface,6,76.75,0,0,,,0,0,,0,Usher syndrome type 1,0.7713456285400272
Q8TDI8,TMC1,Transmembrane channel-like protein 1,Tier 1.5,0.781,1,A_surface,1,76.88,0,0,,,0,0,,0,autosomal recessive nonsyndromic hearing loss 7,0.7694318181814068
P21579,SYT1,Synaptotagmin-1,Tier 1,0.779,1,A_surface,24,81.81,0,0,,,0,0,,0,infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome,0.7640586502824556
Q9NUN7,ACER3,Alkaline ceramidase 3,Tier 1.5,0.777,1,A_surface,2,93.19,0,0,,,0,0,,0,alkaline ceramidase 3 deficiency,0.7575827142824458
P26678,PLN,Phospholamban,Tier 1,0.775,1,A_surface,7,81.88,0,0,,,1,9,"39536855,32382487,30777430,25240642,21848510,19158349",0,hypertrophic cardiomyopathy,0.750557685745381
Q9HBE5,IL21R,Interleukin-21 receptor,Tier 1,0.775,1,A_surface,6,64.12,0,0,,,1,2,"30800133,29244152",0,Cryptosporidiosis - chronic cholangitis - liver disease,0.7501392499286187
Q9Y6Q6,TNFRSF11A,Tumor necrosis factor receptor superfamily member 11A,Tier 1,0.775,1,A_surface,1,58.91,0,0,,,1,1,15562003,0,Osteopetrosis - hypogammaglobulinemia,0.7487328542164448
P40126,DCT,L-dopachrome tautomerase,Tier 1.5,0.774,1,A_surface,1,89.12,0,0,,,1,1,27245069,0,oculocutaneous albinism type 8,0.7468868816172217
Q9Y6J6,KCNE2,Potassium voltage-gated channel subfamily E member 2,Tier 1.5,0.772,1,A_surface,1,78.25,0,0,,,0,0,,0,Romano-Ward syndrome,0.739531738338193
Q9NR97,TLR8,Toll-like receptor 8,Tier 1,0.771,1,A_surface,39,86.12,0,0,,,1,4,"40085160,39956743",0,"immunodeficiency 98 with autoinflammation, X-linked",0.7360623201088097
O43914,TYROBP,TYRO protein tyrosine kinase-binding protein,Tier 1.5,0.77,1,A_surface,5,64.62,0,0,,,0,0,,0,Nasu-Hakola disease,0.7323368313860329
Q96E22,NUS1,Dehydrodolichyl diphosphate synthase complex subunit NUS1,Tier 1,0.769,1,A_surface,9,82.0,0,0,,,0,0,,0,congenital disorder of glycosylation type I,0.7309837554022756
P26842,CD27,CD27 antigen,Tier 1,0.763,1,A_surface,5,71.69,0,0,,,1,3,"39841045,30609550,26320067",0,lymphoproliferative syndrome 2,0.7084378623696481
P15941,MUC1,Mucin-1,Tier 1,0.761,1,A_surface,23,47.41,0,0,,,1,686,"42025056,41988862,41954302,41771296,41744704,41744190,41657320,41627316,41621292,41582516,41535857,41471303,41362016,41352919,41346179,41330302,41243570,41205458,41185018,41101154,41047832,41027169,40682599,40665615,40627939,40607530,40590839,40578633,40568899,40556592,40504676,40500890,40499867,40479828,40432219,40422041,40360093,40286646,40274149,40158809,40119836,39978149,39910821,39705316,39679901,39626346,39579679,39566700,39552005,39550818,41997681,41247195,40813258,39454542,39454415,39440615,39421884,39406784,39256285,39243449,39154820,39142532,39136402,39119745,39118454,38923850,38912896",0,"tubulointerstitial kidney disease, autosomal dominant, 2",0.7040398435219726
P48023,FASLG,Tumor necrosis factor ligand superfamily member 6,Tier 1.5,0.76,1,A_surface,3,80.19,0,0,,,1,1,16581027,0,autoimmune lymphoproliferative syndrome type 1,0.6984292519156657
O14788,TNFSF11,Tumor necrosis factor ligand superfamily member 11,Tier 1,0.759,1,A_surface,2,79.19,0,0,,,1,2,"15562003,41226313",0,osteoporosis,0.6957850224892792
O00305,CACNB4,Voltage-dependent L-type calcium channel subunit beta-4,Tier 1.5,0.757,1,A_surface,1,71.81,0,0,,,0,0,,0,episodic ataxia type 5,0.6883498385715039
Q13002,GRIK2,"Glutamate receptor ionotropic, kainate 2",Tier 1.5,0.757,1,A_surface,2,83.56,0,0,,,0,0,,0,"intellectual disability, autosomal recessive 6",0.6913183275248935
Q9UL01,DSE,Dermatan-sulfate epimerase,Tier 1.5,0.755,1,A_surface,1,86.56,0,0,,,0,0,,0,"Ehlers-Danlos syndrome, musculocontractural type",0.6849286764746361
O43570,CA12,Carbonic anhydrase 12,Tier 1,0.754,1,A_surface,40,87.81,0,0,,,0,0,,0,isolated hyperchlorhidrosis,0.6794515382695604
Q02223,TNFRSF17,Tumor necrosis factor receptor superfamily member 17,Tier 1,0.753,1,A_surface,11,64.94,0,0,,,0,0,,0,multiple myeloma,0.6779550435975632
P32970,CD70,CD70 antigen,Tier 1.5,0.75,1,A_surface,1,83.19,0,0,,,1,1,30609550,0,severe combined immunodeficiency due to CD70 deficiency,0.6651491980619259
Q9NYG8,KCNK4,Potassium channel subfamily K member 4,Tier 1,0.749,1,A_surface,12,78.69,0,0,,,0,0,,0,"facial dysmorphism, hypertrichosis, epilepsy, intellectual/developmental delay, and gingival overgrowth syndrome",0.6619991022563834
Q9HCK4,ROBO2,Roundabout homolog 2,Tier 1.5,0.744,1,A_surface,6,67.38,0,0,,,1,2,"40616090,31640794",0,familial vesicoureteral reflux,0.6460375744556555
Q13454,TUSC3,Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit TUSC3,Tier 1,0.743,1,A_surface,4,84.75,0,0,,,0,0,,0,autosomal recessive non-syndromic intellectual disability,0.6445043495923901
P48551,IFNAR2,Interferon alpha/beta receptor 2,Tier 1,0.743,1,A_surface,9,64.44,0,0,,,1,1,35212764,0,COVID-19,0.6417504201511338
Q15116,PDCD1,Programmed cell death protein 1,Tier 1,0.738,1,A_surface,37,74.12,0,0,,,1,27,"41479885,40811947,40758411,39562585,37424077,34156677,33904236,33896107,33319876,33155587,32574155,32429721,31727249,31434881,28912094,28288993,41907643,41125194,38158454,37944524,36484532,36015348,34861397,34386332",0,melanoma,0.6260691959208758
Q9NR96,TLR9,Toll-like receptor 9,Tier 1,0.736,1,A_surface,3,86.75,0,0,,,1,30,"41617261,40657739,39841045,39830661,33896107,32143069,28594360,26003847,23046187,22174879,19325804,18495099,12828856,37161583,34730968,30526333,29450964,17665991",0,rheumatoid arthritis,0.6213924969410908
P19235,EPOR,Erythropoietin receptor,Tier 1,0.735,1,A_surface,21,66.94,0,0,,,1,6,"31904170,31279934,20142506,41207063",0,anemia (phenotype),0.6151472861334055
Q8N126,CADM3,Cell adhesion molecule 3,Tier 1.5,0.735,1,A_surface,1,84.38,0,0,,,1,2,39263947,0,"Charcot-Marie-Tooth disease, axonal, type 2FF",0.6157861516342734
P29274,ADORA2A,Adenosine receptor A2a,Tier 1,0.733,1,A_surface,99,80.38,0,0,,,0,0,,0,migraine disorder,0.6090172565654923
P40200,CD96,T-cell surface protein tactile,Tier 1,0.731,1,A_surface,1,64.94,0,0,,,0,0,,0,C syndrome,0.6042901819592128
O43613,HCRTR1,Orexin/Hypocretin receptor type 1,Tier 1,0.729,1,A_surface,14,78.81,0,0,,,0,0,,0,insomnia,0.5956659546129768