id,gene_symbol,protein_name,tier,evidence_priority,has_structure,surface_class,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q5IJ48,,,Tier 1.5,0.593,1,unknown,1,76.44,0,0,,,0,0,,0,ventriculomegaly-cystic kidney disease,0.8112741813611002
Q5JTC6,,,Tier 1,0.59,1,unknown,3,48.31,0,0,,,0,0,,0,osteopathia striata with cranial sclerosis,0.8010289843367673
P43146,,,Tier 1,0.587,1,unknown,9,68.19,0,0,,,0,0,,0,mirror movements 1,0.7894844854575112
Q8WYB5,,,Tier 1,0.587,1,unknown,3,48.97,0,0,,,0,0,,0,genitopatellar syndrome,0.7887666805196595
Q92794,,,Tier 1,0.587,1,unknown,21,48.66,0,0,,,0,0,,0,autosomal dominant intellectual disability-craniofacial anomalies-cardiac defects syndrome,0.7908994336990406
O60828,,,Tier 1,0.586,1,unknown,3,70.56,0,0,,,0,0,,0,Renpenning syndrome,0.7876227110842514
O15297,,,Tier 1.5,0.583,1,unknown,1,67.88,0,0,,,0,0,,0,intellectual developmental disorder with gastrointestinal difficulties and high pain threshold,0.7779617805712467
Q09013,,,Tier 1,0.574,1,unknown,2,77.62,0,0,,,0,0,,0,myotonic dystrophy type 1,0.7480475113698601
O60930,,,Tier 1.5,0.574,1,unknown,7,79.56,0,0,,,0,0,,0,"progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 2",0.74733857283595
Q6IQ55,,,Tier 1,0.569,1,unknown,6,48.84,0,0,,,0,0,,0,spinocerebellar ataxia type 11,0.7308755447203157
O60882,,,Tier 1.5,0.568,1,unknown,1,83.31,0,0,,,0,0,,0,Hypomaturation amelogenesis imperfecta,0.7281006394540224
O75838,,,Tier 1.5,0.564,1,unknown,1,88.62,0,0,,,0,0,,0,"hearing loss, autosomal recessive",0.7117048435819099
Q15080,,,Tier 1,0.548,1,unknown,6,84.19,0,0,,,0,0,,0,chronic granulomatous disease,0.6592487859566178
Q9NUW8,,,Tier 1,0.538,1,unknown,48,80.62,0,0,,,0,0,,0,"spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1",0.6250066855961889
P39086,,,Tier 1,0.532,1,unknown,11,81.12,0,0,,,0,0,,0,epilepsy,0.6079292940174927
Q6PCD5,,,Tier 1,0.525,1,unknown,1,70.12,0,0,,,0,0,,0,"Fanconi anemia, complementation group W",0.5849156442856244
Q496J9,,,Tier 1,0.521,1,unknown,6,78.0,0,0,,,0,0,,0,botulism,0.569067134332723
P35568,,,Tier 1,0.518,1,unknown,8,49.0,0,0,,,0,0,,0,Abnormality of the skeletal system,0.5600726776459989
P29074,,,Tier 1,0.511,1,unknown,8,77.19,0,0,,,0,0,,0,neurodegenerative disease,0.5366583695296713
Q9BZC1,,,Tier 1,0.509,1,unknown,2,61.47,0,0,,,0,0,,0,major depressive disorder,0.5312056211019677
P01579,,,Tier 1.5,0.498,1,unknown,8,85.31,0,0,,,0,0,,0,Primary hemophagocytic lymphohistiocytosis,0.49197933519665166
Q96QB1,,,Tier 1,0.494,1,unknown,7,55.88,0,0,,,0,0,,0,Abnormality of the skeletal system,0.4815591361203349
Q58F21,,,Tier 1,0.491,1,unknown,21,62.44,0,0,,,0,0,,0,male infertility with teratozoospermia due to single gene mutation,0.46995568999565185
Q9UHK0,,,Tier 1,0.491,1,unknown,1,55.25,0,0,,,0,0,,0,neurodegenerative disease,0.4706636090264093
O15075,,,Tier 1,0.474,1,unknown,11,72.19,0,0,,,0,0,,0,mathematical ability,0.414033055781774
P01563,,,Tier 1,0.468,1,unknown,13,85.06,0,0,,,0,0,,0,renal cell carcinoma,0.3938654263610389
P42679,,,Tier 1,0.459,1,unknown,3,83.75,0,0,,,0,0,,0,neurodegenerative disease,0.36332514256792015
Q1MX18,,,Tier 1,0.455,1,unknown,1,83.12,0,0,,,0,0,,0,diverticular disease,0.34835781104015423
P49765,VEGFB,Vascular endothelial growth factor B,Tier 1,0.451,1,unknown,4,73.5,0,0,,,1,2,27189805,0,diabetic macular edema,0.3361465485773345
Q99619,,,Tier 1,0.444,1,unknown,9,87.62,0,0,,,0,0,,0,neurodegenerative disease,0.31278070690952203
Q9H4Z3,,,Tier 1,0.441,1,unknown,3,80.12,0,0,,,0,0,,0,neurodegenerative disease,0.30499435066569835
Q8IVL8,CPO,Carboxypeptidase O,Tier 1,0.434,1,unknown,1,87.62,0,0,,,1,2,"39641920,39484557",0,Abruptio Placentae,0.2786958378972539
O95393,,,Tier 1,0.428,1,unknown,8,74.06,0,0,,,0,0,,0,colorectal neoplasm,0.25870589827929125
Q14451,,,Tier 1,0.416,1,unknown,14,78.0,0,0,,,0,0,,0,gallbladder disease,0.2185260074771684
O43715,,,Tier 1,0.384,1,unknown,6,87.62,0,0,,,0,0,,0,acquired thrombocytopenia,0.11295587996127908
O15232,,,Tier 1.5,0.354,0,unknown,0,79.38,0,0,,,0,0,,0,multiple epiphyseal dysplasia type 5,0.8302929519450023
P00323,,Flavodoxin,Tier 1,0.35,1,unknown,41,97.88,0,0,,,0,0,,0,,
P01631,,Ig kappa chain V-II region 26-10,Tier 1,0.35,1,unknown,19,97.62,0,0,,,0,0,,0,,
P00268,,Rubredoxin,Tier 1,0.35,1,unknown,45,96.94,0,0,,,0,0,,0,,
Q96JD1,,,Tier 1,0.35,1,unknown,3,96.5,0,0,,,0,0,,0,,
Q9V2J8,,,Tier 1,0.35,1,unknown,41,96.56,0,0,,,0,0,,0,,
P04213,,T-cell receptor beta chain V region C5,Tier 1,0.35,1,unknown,20,93.19,0,0,,,0,0,,0,,
Q9UL95,,,Tier 1,0.35,1,unknown,1,92.88,0,0,,,0,0,,0,,
P58154,,Acetylcholine-binding protein,Tier 1,0.35,1,unknown,67,92.06,0,0,,,0,0,,0,,
K7N5N2,,,Tier 1,0.35,1,unknown,14,91.5,0,0,,,0,0,,0,,
A0N8J3,,,Tier 1,0.35,1,unknown,9,91.25,0,0,,,0,0,,0,,
Q99T13,,Putative multidrug export ATP-binding/permease protein SAV1866,Tier 1,0.35,1,unknown,3,90.62,0,0,,,0,0,,0,,
P06897,,Histone H2A type 1,Tier 1,0.35,1,unknown,100,90.38,0,0,,,0,0,,0,,
O19626,B-3501,,Tier 1,0.35,1,unknown,5,89.75,0,0,,,0,0,,0,,
Q7NDN8,glvI,Proton-gated ion channel,Tier 1,0.35,1,unknown,100,89.31,0,0,,,0,0,,0,,