id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P23946,CMA1,Chymase,Tier 1,0.875,42,91.31,0,0,,,,1,1,30572223,0,pernicious anemia,0.17348905136256007
Q9UJA9,ENPP5,Ectonucleotide pyrophosphatase/phosphodiesterase family member 5,Tier 1,0.87,1,88.12,0,0,,,,0,0,,0,neurodegenerative disease,0.33211724272317855
Q31135,H2-Ab1,,Tier 1,0.83,12,85.12,0,0,,,,0,0,,0,,
P01236,PRL,Prolactin,Tier 1,0.795,12,85.56,0,0,,,,1,6,"40327044,30834248,29277631,28263753,27679852,16947086",0,AL amyloidosis,0.4619748183558772
O14788,TNFSF11,Tumor necrosis factor ligand superfamily member 11,Tier 1,0.79,2,79.19,0,0,,,,1,2,"15562003,41226313",0,osteoporosis,0.6957850224892792
A6ND01,IZUMO1R,Sperm-egg fusion protein Juno,Tier 1,0.773,7,87.38,0,0,,,,0,0,,0,placental retention,0.23306495563589497
A0A5H2UYS3,HLA-A,,Tier 1,0.77,20,85.25,0,0,,,,0,0,,0,,
P26951,IL3RA,Interleukin-3 receptor subunit alpha,Tier 1,0.767,4,85.25,0,0,,,,1,3,"40931580,36171541,31323275",0,acute myeloid leukemia,0.46904332714118013
P16471,PRLR,Prolactin receptor,Tier 1,0.747,12,61.03,0,0,,,,0,0,,0,familial hyperprolactinemia,0.5718636087471152
P01563,,,Tier 1,0.744,13,85.06,0,0,,,,0,0,,0,renal cell carcinoma,0.3938654263610389
K7N5M4,B2M,,Tier 1,0.72,24,90.94,0,0,,,,1,3,"41850110,40373155,38904251",0,,
Q16878,CDO1,Cysteine dioxygenase type 1,Tier 1,0.72,17,93.62,0,0,,,,0,0,,0,adolescent idiopathic scoliosis,0.3105991982786747
Q12918,KLRB1,Killer cell lectin-like receptor subfamily B member 1,Tier 1,0.719,3,81.0,0,0,,,,0,0,,0,sensory perception of smell,0.287724180593876
P42262,GRIA2,Glutamate receptor 2,Tier 1,0.715,16,84.94,0,0,,,,1,4,"28325839,19417060,17929944,17024188",0,neurodevelopmental disorder with language impairment and behavioral abnormalities,0.8328652004757138
Q99574,SERPINI1,Neuroserpin,Tier 1,0.712,3,88.12,0,0,,,,0,0,,0,familial encephalopathy with neuroserpin inclusion bodies,0.7162803151916303
A0A583ZB34,,,Tier 1,0.71,9,84.38,0,0,,,,0,0,,0,,
P14207,FOLR2,Folate receptor beta,Tier 1,0.701,5,89.12,0,0,,,,1,2,28686804,0,neoplasm,0.11545394821329319
P01374,LTA,Lymphotoxin-alpha,Tier 1,0.7,3,83.44,0,0,,,,1,3,"41810142,30576605",0,,
P15248,IL9,Interleukin-9,Tier 1,0.7,5,84.06,0,0,,,,1,1,40972397,0,neurodegenerative disease,0.40148548290272756
Q5Y7D3,HLA-DQB1,,Tier 1,0.7,6,85.31,0,0,,,,0,0,,0,,
P14555,PLA2G2A,"Phospholipase A2, membrane associated",Tier 1,0.7,17,91.0,0,0,,,,0,0,,0,familial colorectal cancer,0.3326218692162316
O43570,CA12,Carbonic anhydrase 12,Tier 1,0.695,40,87.81,0,0,,,,0,0,,0,isolated hyperchlorhidrosis,0.6794515382695604
Q95460,MR1,Major histocompatibility complex class I-related protein 1,Tier 1,0.693,79,87.5,0,0,,,,1,2,"41134135,20000526",0,Immunodeficiency,0.3336382138166145
Q96QV1,HHIP,Hedgehog-interacting protein,Tier 1,0.692,11,79.75,0,0,,,,0,0,,0,Abnormality of the skeletal system,0.5195282784554633
P04435,TRBV7-9,T cell receptor beta variable 7-9,Tier 1,0.691,2,90.06,0,0,,,,0,0,,0,neoplasm,0.11454334012562349
A0A9P1NJI6,,,Tier 1,0.69,6,,0,0,,,,0,0,,0,,
Q15788,NCOA1,Nuclear receptor coactivator 1,Tier 1,0.69,100,46.72,0,0,,,,0,0,,0,neurodegenerative disease,0.48697450901885614
Q9NPF0,CD320,CD320 antigen,Tier 1,0.69,6,63.81,0,0,,,,1,1,39493449,0,Methylmalonic aciduria due to transcobalamin receptor defect,0.49918945650121177
Q02083,NAAA,N-acylethanolamine-hydrolyzing acid amidase,Tier 1,0.69,2,92.25,0,0,,,,0,0,,0,abscess,0.2726858643799341
Q9UBH0,IL36RN,Interleukin-36 receptor antagonist protein,Tier 1,0.687,3,92.44,0,0,,,,0,0,,0,"psoriasis 14, pustular",0.8155144873787125
A0A0C4DH28,TRGV4,T cell receptor gamma variable 4,Tier 1,0.681,4,84.06,0,0,,,,0,0,,0,Townes-Brocks syndrome,0.006652437384324632
Q16651,PRSS8,Prostasin,Tier 1,0.68,9,83.75,0,0,,,,0,0,,0,Alzheimer disease,0.4223067864061274
P39900,MMP12,Macrophage metalloelastase,Tier 1,0.68,86,86.94,0,0,,,,1,8,"41861669,38477735,38296402,37015819,35120890,34183667,27530235",0,atopic eczema,0.4795677061208266
U5YJJ6,HLA-A,,Tier 1,0.68,3,89.0,0,0,,,,0,0,,0,,
Q86Z14,KLB,Beta-klotho,Tier 1,0.676,5,89.38,0,0,,,,1,1,40514411,0,congenital hypogonadotropic hypogonadism,0.462898767992589
Q9GZX9,TWSG1,Twisted gastrulation protein homolog 1,Tier 1,0.67,6,80.38,0,0,,,,1,1,39299474,0,Abruptio Placentae,0.29495361755469174
P62576,nanA,Sialidase A,Tier 1,0.67,5,81.19,0,0,,,,1,4,"37350189,34976356,34341854,32034503",0,,
P14867,GABRA1,Gamma-aminobutyric acid receptor subunit alpha-1,Tier 1,0.667,0,81.69,0,0,,,,0,0,,0,"developmental and epileptic encephalopathy, 19",0.7734302780200346
O15169,AXIN1,Axin-1,Tier 1,0.664,22,61.09,0,0,,,,1,2,28129128,0,hepatocellular carcinoma,0.7864172882686208
P15941,MUC1,Mucin-1,Tier 1,0.66,23,47.41,0,0,,,,1,686,"42025056,41988862,41954302,41771296,41744704,41744190,41657320,41627316,41621292,41582516,41535857,41471303,41362016,41352919,41346179,41330302,41243570,41205458,41185018,41101154,41047832,41027169,40682599,40665615,40627939,40607530,40590839,40578633,40568899,40556592,40504676,40500890,40499867,40479828,40432219,40422041,40360093,40286646,40274149,40158809,40119836,39978149,39910821,39705316,39679901,39626346,39579679,39566700,39552005,39550818,41997681,41247195,40813258,39454542,39454415,39440615,39421884,39406784,39256285,39243449,39154820,39142532,39136402,39119745,39118454,38923850,38912896",0,"tubulointerstitial kidney disease, autosomal dominant, 2",0.7040398435219726
A0A0U5Q247,,,Tier 1,0.66,3,85.12,0,0,,,,0,0,,0,,
Q6IQ20,NAPEPLD,N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D,Tier 1,0.66,4,87.25,0,0,,,,0,0,,0,reticular dystrophy of the retinal pigment epithelium,0.3695798546847018
Q9UHV8,LGALS13,Galactoside-binding soluble lectin 13,Tier 1,0.66,11,97.5,0,0,,,,0,0,,0,preeclampsia,0.11027592759014439
Q8IYV9,IZUMO1,Izumo sperm-egg fusion protein 1,Tier 1,0.659,7,81.06,0,0,,,,0,0,,0,cholelithiasis,0.18873738346588434
Q92876,KLK6,Kallikrein-6,Tier 1,0.659,21,91.75,0,0,,,,1,2,"30114962,22505517",0,neuroinflammatory disorder,0.1901077464611955
P48552,NRIP1,Nuclear receptor-interacting protein 1,Tier 1,0.657,17,45.91,0,0,,,,0,0,,0,neurodegenerative disease,0.5654759320154787
P22894,MMP8,Neutrophil collagenase,Tier 1,0.655,25,90.38,0,0,,,,1,4,"35821507,34183667,33534888,30197987",0,acne,0.603247809982021
A8MUM7,LGALS16,Galectin-16,Tier 1,0.654,3,94.62,0,0,,,,0,0,,0,neurodegenerative disease,0.536067027639694
Q9NZK5,ADA2,Adenosine deaminase 2,Tier 1,0.653,2,95.81,0,0,,,,0,0,,0,deficiency of adenosine deaminase 2,0.8291292532404531
A0A592,TCRBV6S1A1N1,,Tier 1,0.65,1,88.31,0,0,,,,0,0,,0,,