id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q9Y2C5,SLC17A4,Probable small intestine urate exporter,Tier 1.5,0.878,0,83.69,0,0,,,,0,0,,0,inflammatory bowel disease,0.09896486250497885
P0DPK4,NOTCH2NLC,Notch homolog 2 N-terminal-like protein C,Tier 1.5,0.805,0,80.81,0,0,,,,0,0,,0,neuronal intranuclear inclusion disease,0.4999829066911242
Q14031,COL4A6,Collagen alpha-6(IV) chain,Tier 1.5,0.79,0,47.41,0,0,,,,0,0,,0,Dupuytren Contracture,0.5880367459451578
P37023,ACVRL1,Activin receptor type-1-like,Tier 1.5,0.779,7,82.0,0,0,,,,0,0,,0,"telangiectasia, hereditary hemorrhagic, type 2",0.7951167515831324
P01568,IFNA21,Interferon alpha-21,Tier 1.5,0.777,0,85.0,0,0,,,,0,0,,0,renal cell carcinoma,0.3695798546847018
P48023,FASLG,Tumor necrosis factor ligand superfamily member 6,Tier 1.5,0.775,3,80.19,0,0,,,,1,1,16581027,0,autoimmune lymphoproliferative syndrome type 1,0.6984292519156657
Q9BVX2,TMEM106C,Transmembrane protein 106C,Tier 1.5,0.77,0,80.81,0,0,,,,0,0,,0,prostate carcinoma,0.21737104399686757
P29017,CD1C,T-cell surface glycoprotein CD1c,Tier 1.5,0.77,10,88.56,0,0,,,,0,0,,0,neoplasm,0.1106047389635713
A0A1B0GTW7,CIROP,Ciliated left-right organizer metallopeptidase,Tier 1.5,0.764,0,73.44,0,0,,,,0,0,,0,"heterotaxy, visceral, 12, autosomal",0.6929422132808513
Q9BZR8,BCL2L14,Apoptosis facilitator Bcl-2-like protein 14,Tier 1.5,0.76,0,62.38,0,0,,,,0,0,,0,hypothyroidism,0.33117514363294837
Q9BWF2,TRAIP,E3 ubiquitin-protein ligase TRAIP,Tier 1.5,0.76,1,74.94,0,0,,,,0,0,,0,Seckel syndrome 9,0.683878095944948
O15370,SOX12,Transcription factor SOX-12,Tier 1.5,0.76,0,63.0,0,0,,,,0,0,,0,type 2 diabetes mellitus,0.3277369133971199
A6NI61,MYMK,Protein myomaker,Tier 1.5,0.758,0,90.44,0,0,,,,0,0,,0,Carey-Fineman-Ziter  syndrome,0.7790386256350393
Q16585,SGCB,Beta-sarcoglycan,Tier 1.5,0.75,0,76.44,0,0,,,,0,0,,0,autosomal recessive limb-girdle muscular dystrophy type 2E,0.8154766151472349
Q9GZU2,PEG3,Paternally-expressed gene 3 protein,Tier 1.5,0.75,1,44.53,0,0,,,,1,1,16595502,0,neurodegenerative disease,0.34815912577489827
P18075,BMP7,Bone morphogenetic protein 7,Tier 1.5,0.749,4,76.19,0,0,,,,1,1,30537181,0,Inguinal hernia,0.4420059023371716
P56730,PRSS12,Neurotrypsin,Tier 1.5,0.746,0,77.31,0,0,,,,0,0,,0,"intellectual disability, autosomal recessive 1",0.6621935416695687
Q8N6D2,RNF182,E3 ubiquitin-protein ligase RNF182,Tier 1.5,0.74,0,70.25,0,0,,,,0,0,,0,periapical tissue disease,0.304701328693288
Q14246,ADGRE1,Adhesion G protein-coupled receptor E1,Tier 1.5,0.74,0,76.69,0,0,,,,0,0,,0,diabetic ketoacidosis,0.20424823130055986
P16112,ACAN,Aggrecan core protein,Tier 1.5,0.74,4,51.91,0,0,,,,0,0,,0,Familial osteochondritis dissecans,0.7558487616449627
Q00LT1,PRCD,Photoreceptor disk component PRCD,Tier 1.5,0.737,0,63.97,0,0,,,,0,0,,0,retinitis pigmentosa,0.7650522818524582
Q9Y4U1,MMACHC,Cyanocobalamin reductase / alkylcobalamin dealkylase,Tier 1.5,0.735,7,85.62,0,0,,,,0,0,,0,"Methylmalonic acidemia with homocystinuria, type cblC",0.8478185420804271
Q9ULX7,CA14,Carbonic anhydrase 14,Tier 1.5,0.734,2,90.69,0,0,,,,0,0,,0,epilepsy,0.4397024990575866
Q99593,TBX5,T-box transcription factor TBX5,Tier 1.5,0.733,4,62.66,0,0,,,,0,0,,0,Holt-Oram syndrome,0.827317913681364
P53539,FOSB,Protein FosB,Tier 1.5,0.73,12,59.12,0,0,,,,0,0,,0,neurodegenerative disease,0.22246010664492422
O43914,TYROBP,TYRO protein tyrosine kinase-binding protein,Tier 1.5,0.728,5,64.62,0,0,,,,0,0,,0,Nasu-Hakola disease,0.7323368313860329
Q9Y5C1,ANGPTL3,Angiopoietin-related protein 3,Tier 1.5,0.727,1,79.62,0,0,,,,1,1,23770039,0,familial hypobetalipoproteinemia 2,0.6739043862507132
Q6MZM0,HEPHL1,Ferroxidase HEPHL1,Tier 1.5,0.72,0,89.44,0,0,,,,0,0,,0,pili torti-developmental delay-neurological abnormalities syndrome,0.40268634456935765
Q15399,TLR1,Toll-like receptor 1,Tier 1.5,0.72,6,87.19,0,0,,,,0,0,,0,asthma,0.5956884825296496
Q9NWH7,SPATA6,Spermatogenesis-associated protein 6,Tier 1.5,0.72,0,65.19,0,0,,,,0,0,,0,hypothyroidism,0.4205896274474635
P25100,ADRA1D,Alpha-1D adrenergic receptor,Tier 1.5,0.716,0,64.81,0,0,,,,0,0,,0,hypertension,0.6613200073424285
O60882,,,Tier 1.5,0.713,1,83.31,0,0,,,,0,0,,0,Hypomaturation amelogenesis imperfecta,0.7281006394540224
Q8N9I5,FADS6,Fatty acid desaturase 6,Tier 1.5,0.71,0,90.62,0,0,,,,0,0,,0,,
P30968,GNRHR,Gonadotropin-releasing hormone receptor,Tier 1.5,0.71,1,84.19,0,0,,,,0,0,,0,hypogonadotropic hypogonadism,0.83100005285263
Q9H2B4,SLC26A1,Sulfate anion transporter 1,Tier 1.5,0.707,0,82.62,0,0,,,,0,0,,0,nephrolithiasis susceptibility caused by SLC26A1,0.6690419713525324
P08620,FGF4,Fibroblast growth factor 4,Tier 1.5,0.7,1,81.5,0,0,,,,1,3,"35415885,33536494,7547864",0,cancer,0.6026669167438079
O95886,DLGAP3,Disks large-associated protein 3,Tier 1.5,0.7,0,50.16,0,0,,,,0,0,,0,benign neoplasm of adrenal gland,0.3188339358953556
A0A0C5B5G6,MT-RNR1,Mitochondrial-derived peptide MOTS-c,Tier 1.5,0.7,0,72.06,0,0,,,,1,1,35311942,0,,
Q96LB9,PGLYRP3,Peptidoglycan recognition protein 3,Tier 1.5,0.699,4,88.12,0,0,,,,0,0,,0,Romano-Ward syndrome,0.08833005834552343
Q01814,ATP2B2,Plasma membrane calcium-transporting ATPase 2,Tier 1.5,0.696,0,73.38,0,0,,,,0,0,,0,autosomal dominant nonsyndromic hearing loss,0.6637167639130592
Q16676,FOXD1,Forkhead box protein D1,Tier 1.5,0.695,0,56.75,0,0,,,,0,0,,0,neurodegenerative disease,0.45840779990331637
P21781,FGF7,Fibroblast growth factor 7,Tier 1.5,0.695,0,82.44,0,0,,,,1,5,"35415885,15719578,7547864,16462265",0,cancer,0.5963369026823151
P49895,DIO1,Type I iodothyronine deiodinase,Tier 1.5,0.695,0,92.12,0,0,,,,0,0,,0,"thyroid hormone metabolism, abnormal, 2",0.6505024812924749
P28039,AOAH,Acyloxyacyl hydrolase,Tier 1.5,0.695,2,90.38,0,0,,,,0,0,,0,type 2 diabetes mellitus,0.4486206035972812
O00337,SLC28A1,Sodium/nucleoside cotransporter 1,Tier 1.5,0.695,0,82.25,0,0,,,,0,0,,0,uridine-cytidineuria,0.5835072752618243
Q9UPX6,MINAR1,Major intrinsically disordered Notch2-binding receptor 1,Tier 1.5,0.69,0,49.62,0,0,,,,0,0,,0,Hypercholesterolemia,0.32960705987096356
P35712,SOX6,Transcription factor SOX-6,Tier 1.5,0.69,0,55.25,0,0,,,,0,0,,0,Tolchin-Le Caignec syndrome,0.7327592361597494
P10243,MYBL1,Myb-related protein A,Tier 1.5,0.687,0,57.31,0,0,,,,0,0,,0,neurodegenerative disease,0.5225910891181897
P01570,IFNA14,Interferon alpha-14,Tier 1.5,0.687,0,84.62,0,0,,,,0,0,,0,renal cell carcinoma,0.3695798546847018
O00624,SLC17A2,Sodium-dependent phosphate transport protein 3,Tier 1.5,0.687,0,83.12,0,0,,,,0,0,,0,Fuchs endothelial corneal dystrophy,0.07320524268733301