id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
P13747,HLA-E,"HLA class I histocompatibility antigen, alpha chain E",Tier 1,0.865,34,87.0,0,0,,,,1,1,38473398,1,COVID-19,0.4822929100647597
Q9NX14,NDUFB11,"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial",Tier 1.5,0.86,0,77.56,0,0,,,,0,0,,1,Microphthalmia with linear skin defects syndrome,0.7364493324598024
P01911,HLA-DRB1,"HLA class II histocompatibility antigen, DRB1 beta chain",Tier 1,0.84,100,88.44,0,0,,,,0,0,,1,rheumatoid arthritis,0.40051584219092445
Q15848,ADIPOQ,Adiponectin,Tier 1,0.806,3,79.88,0,0,,,,1,10,"41636061,38392020,36508319,35323639,34796696,34117903,33535822,31988066,25105541",1,hearing loss,0.25844907375917336
P15260,IFNGR1,Interferon gamma receptor 1,Tier 1.5,0.804,5,66.0,0,0,,,,1,2,33667716,1,disseminated atypical mycobacterial infection,0.5414012388034828
Q9UBT7,CTNNAL1,Alpha-catulin,Tier 1.5,0.795,0,84.06,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.31316995706583495
P36888,FLT3,Receptor-type tyrosine-protein kinase FLT3,Tier 1.5,0.788,11,75.94,0,0,,,,1,6,"41733039,34364920,31434881,30237882,29299123,22411871",1,acute myeloid leukemia,0.8313389209288576
P35555,FBN1,Fibrillin-1,Tier 1,0.78,11,,0,0,,,,0,0,,1,Marfan syndrome,0.8969300970597663
P01019,AGT,Angiotensinogen,Tier 1,0.779,22,86.44,0,0,,,,1,16,"35983901,34936368,34779902,34248841,32838280,23766021,17673982,11419945,38045440,34619249,29844151,27530235",1,renal tubular dysgenesis,0.7354947364860083
P02776,PF4,Platelet factor 4,Tier 1.5,0.77,10,75.06,0,0,,,,1,10,"33859620,32366845,31967847,23847186,23673861,34248840,32022468",1,systemic scleroderma,0.11523541376593864
P02671,FGA,Fibrinogen alpha chain,Tier 1,0.77,40,60.34,0,0,,,,0,0,,1,familial dysfibrinogenemia,0.7947496460990987
P03951,F11,Coagulation factor XI,Tier 1,0.77,100,86.88,0,0,,,,0,0,,1,factor XI deficiency,0.841884208404384
P61769,B2M,Beta-2-microglobulin,Tier 1,0.77,100,94.06,0,0,,,,1,15,"41850110,40373155,38904251,40658810,35026285,32631049,29281176,28960840,25100729,20616783,19137104,17878167",1,Immunodeficiency by defective expression of HLA class 1,0.6180318849819645
P27037,ACVR2A,Activin receptor type-2A,Tier 1.5,0.769,5,83.56,0,0,,,,0,0,,1,hepatocellular carcinoma,0.4908023126074436
O14958,CASQ2,Calsequestrin-2,Tier 1.5,0.767,4,90.5,0,0,,,,0,0,,1,catecholaminergic polymorphic ventricular tachycardia,0.7718998507471558
Q9H3K6,BOLA2,BolA-like protein 2,Tier 1.5,0.765,0,92.69,0,0,,,,0,0,,1,hepatocellular carcinoma,0.08093942543094014
P05546,SERPIND1,Heparin cofactor 2,Tier 1,0.752,9,79.62,0,0,,,,1,4,"20062917,20053992,34248840,31247951",1,heparin cofactor 2 deficiency,0.719744572767547
Q92956,TNFRSF14,Tumor necrosis factor receptor superfamily member 14,Tier 1.5,0.745,8,79.94,0,0,,,,0,0,,1,diffuse large B-cell lymphoma,0.5983171413833771
P05164,MPO,Myeloperoxidase,Tier 1,0.745,49,89.0,0,0,,,,1,16,"41629951,41316897,40501769,38127443,33534888,33495506,37991715,37277648,34183667,34117903,33869115,31210423,30431231",1,myeloperoxidase deficiency,0.7742533340195327
P98196,ATP11A,Phospholipid-transporting ATPase IH,Tier 1.5,0.735,0,82.94,0,0,,,,0,0,,1,"hearing loss, autosomal dominant 84",0.5506821963658654
P16389,KCNA2,Potassium voltage-gated channel subfamily A member 2,Tier 1.5,0.735,0,77.38,0,0,,,,0,0,,1,genetic developmental and epileptic encephalopathy,0.7513374591580034
Q9BY67,CADM1,Cell adhesion molecule 1,Tier 1,0.734,2,80.56,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.442731358018962
P20702,ITGAX,Integrin alpha-X,Tier 1.5,0.732,9,88.0,0,0,,,,0,0,,1,neurodegenerative disease,0.41708750879240836
P09603,,,Tier 1.5,0.729,8,57.41,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.39219340856589974
Q9P2B2,PTGFRN,Prostaglandin F2 receptor negative regulator,Tier 1.5,0.728,0,84.12,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.48052208463481294
P22732,SLC2A5,"Solute carrier family 2, facilitated glucose transporter member 5",Tier 1.5,0.728,0,90.56,0,0,,,,0,0,,1,Prolonged QT interval,0.3326218692162316
Q92636,NSMAF,Protein FAN,Tier 1.5,0.725,0,88.31,0,0,,,,0,0,,1,placental retention,0.36802220150078147
Q99497,PARK7,Parkinson disease protein 7,Tier 1,0.723,88,98.44,0,0,,,,0,0,,1,Young adult-onset Parkinsonism,0.7264878745993893
P05187,ALPP,"Alkaline phosphatase, placental type",Tier 1,0.72,8,93.44,0,0,,,,1,7,"41329468,38238732,37425696,37047289,31687420,25919296,23467613",1,male reproductive organ cancer,0.16284411775950106
P29622,SERPINA4,Kallistatin,Tier 1,0.719,3,86.69,0,0,,,,1,4,"38904251,30297859,37351609,28794177",1,optic atrophy,0.28896631154492924
P79483,HLA-DRB3,"HLA class II histocompatibility antigen, DR beta 3 chain",Tier 1.5,0.71,2,88.38,0,0,,,,0,0,,1,,
P41221,WNT5A,Protein Wnt-5a,Tier 1.5,0.71,0,87.69,0,0,,,,1,4,"40855286,32693649,22363130,18673242",1,Robinow syndrome,0.7220360983378594
O95562,SFT2D2,Vesicle transport protein SFT2B,Tier 1.5,0.71,0,78.5,0,0,,,,0,0,,1,neurodegenerative disease,0.38598268164814226
Q96IY4,CPB2,Carboxypeptidase B2,Tier 1,0.709,10,94.12,0,0,,,,1,4,"37329944,36805075,35861072,30297859",1,type 2 diabetes mellitus,0.19338213943947646
P01889,HLA-B,"HLA class I histocompatibility antigen, B alpha chain",Tier 1,0.708,100,88.06,0,0,,,,0,0,,1,COVID-19,0.48417012135481613
P03905,MT-ND4,NADH-ubiquinone oxidoreductase chain 4,Tier 1.5,0.705,0,93.94,0,0,,,,0,0,,1,Leber hereditary optic neuropathy,0.7517935125709835
P25311,AZGP1,Zinc-alpha-2-glycoprotein,Tier 1,0.701,9,92.88,0,0,,,,1,1,41325160,1,neoplasm,0.10887540652591159
P08473,MME,Neprilysin,Tier 1,0.699,16,96.19,0,0,,,,0,0,,1,Charcot-Marie-Tooth disease axonal type 2T,0.7912653398252156
P19021,PAM,Peptidyl-glycine alpha-amidating monooxygenase,Tier 1.5,0.695,0,71.69,0,0,,,,1,25,"41855944,41500123,41384307,41285544,41222440,40607956,39929897,39472107,38867016,38846799,37977804,37977780,37906116,37127012,36905684,35478209,33911033,33516855,32315032,32307868,30399413,30124431,26406332,22954359,14965210",1,type 2 diabetes mellitus,0.5754371880839976
P01615,IGKV2D-28,Immunoglobulin kappa variable 2D-28,Tier 1.5,0.695,0,91.0,0,0,,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001
P00746,CFD,Complement factor D,Tier 1,0.695,40,91.0,0,0,,,,1,4,"38057414,38071633,28972568,25727321",1,recurrent Neisseria infections due to factor D deficiency,0.7726408204424132
Q30154,HLA-DRB5,"HLA class II histocompatibility antigen, DR beta 5 chain",Tier 1.5,0.694,4,86.75,0,0,,,,0,0,,1,seasonal allergic rhinitis,0.19424611770933498
Q9Y678,COPG1,Coatomer subunit gamma-1,Tier 1.5,0.692,1,87.88,0,0,,,,0,0,,1,neurodegenerative disease,0.4905625531390244
P36980,CFHR2,Complement factor H-related protein 2,Tier 1.5,0.691,4,90.62,0,0,,,,0,0,,1,age-related macular degeneration,0.5100732932209376
P10586,PTPRF,Receptor-type tyrosine-protein phosphatase F,Tier 1.5,0.69,13,82.0,0,0,,,,1,4,"42101929,39087949,36594741",1,smoking initiation,0.4641111755355386
Q8IUH8,SPPL2C,Signal peptide peptidase-like 2C,Tier 1.5,0.69,0,67.06,0,0,,,,0,0,,1,"osteoarthritis, hip",0.35379836590273994
Q92187,ST8SIA4,"CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase",Tier 1,0.69,3,86.44,0,0,,,,0,0,,1,systemic lupus erythematosus,0.43832763677821385
Q14520,HABP2,Factor VII-activating protease,Tier 1.5,0.686,0,77.62,0,0,,,,0,0,,1,follicular thyroid carcinoma,0.46213907606907034
O00501,CLDN5,Claudin-5,Tier 1.5,0.685,0,83.75,0,0,,,,1,1,18951306,1,genetic disorder,0.40861362787778505
Q96MP8,KCTD7,BTB/POZ domain-containing protein KCTD7,Tier 1.5,0.685,0,81.12,0,0,,,,0,0,,1,progressive myoclonic epilepsy type 3,0.8021556079083692