id,gene_symbol,protein_name,tier,priority_score,pdb_count_total,alphafold_mean_pLDDT,has_cryoEM,has_activation_state_pdb_pair,activation_state_pdb_active,activation_state_pdb_inactive,drug_count_approved,has_known_aptamer,aptamer_count_pubmed,aptamer_pmids,in_cev_map,opentargets_top_disease_name,opentargets_top_disease_score
Q9NX14,NDUFB11,"NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial",Tier 1.5,0.86,0,77.56,0,0,,,,0,0,,1,Microphthalmia with linear skin defects syndrome,0.7364493324598024
P15260,IFNGR1,Interferon gamma receptor 1,Tier 1.5,0.804,5,66.0,0,0,,,,1,2,33667716,1,disseminated atypical mycobacterial infection,0.5414012388034828
Q9UBT7,CTNNAL1,Alpha-catulin,Tier 1.5,0.795,0,84.06,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.31316995706583495
P36888,FLT3,Receptor-type tyrosine-protein kinase FLT3,Tier 1.5,0.788,11,75.94,0,0,,,,1,6,"41733039,34364920,31434881,30237882,29299123,22411871",1,acute myeloid leukemia,0.8313389209288576
P02776,PF4,Platelet factor 4,Tier 1.5,0.77,10,75.06,0,0,,,,1,10,"33859620,32366845,31967847,23847186,23673861,34248840,32022468",1,systemic scleroderma,0.11523541376593864
P27037,ACVR2A,Activin receptor type-2A,Tier 1.5,0.769,5,83.56,0,0,,,,0,0,,1,hepatocellular carcinoma,0.4908023126074436
O14958,CASQ2,Calsequestrin-2,Tier 1.5,0.767,4,90.5,0,0,,,,0,0,,1,catecholaminergic polymorphic ventricular tachycardia,0.7718998507471558
Q9H3K6,BOLA2,BolA-like protein 2,Tier 1.5,0.765,0,92.69,0,0,,,,0,0,,1,hepatocellular carcinoma,0.08093942543094014
Q92956,TNFRSF14,Tumor necrosis factor receptor superfamily member 14,Tier 1.5,0.745,8,79.94,0,0,,,,0,0,,1,diffuse large B-cell lymphoma,0.5983171413833771
P98196,ATP11A,Phospholipid-transporting ATPase IH,Tier 1.5,0.735,0,82.94,0,0,,,,0,0,,1,"hearing loss, autosomal dominant 84",0.5506821963658654
P16389,KCNA2,Potassium voltage-gated channel subfamily A member 2,Tier 1.5,0.735,0,77.38,0,0,,,,0,0,,1,genetic developmental and epileptic encephalopathy,0.7513374591580034
P20702,ITGAX,Integrin alpha-X,Tier 1.5,0.732,9,88.0,0,0,,,,0,0,,1,neurodegenerative disease,0.41708750879240836
P09603,,,Tier 1.5,0.729,8,57.41,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.39219340856589974
Q9P2B2,PTGFRN,Prostaglandin F2 receptor negative regulator,Tier 1.5,0.728,0,84.12,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.48052208463481294
P22732,SLC2A5,"Solute carrier family 2, facilitated glucose transporter member 5",Tier 1.5,0.728,0,90.56,0,0,,,,0,0,,1,Prolonged QT interval,0.3326218692162316
Q92636,NSMAF,Protein FAN,Tier 1.5,0.725,0,88.31,0,0,,,,0,0,,1,placental retention,0.36802220150078147
P79483,HLA-DRB3,"HLA class II histocompatibility antigen, DR beta 3 chain",Tier 1.5,0.71,2,88.38,0,0,,,,0,0,,1,,
P41221,WNT5A,Protein Wnt-5a,Tier 1.5,0.71,0,87.69,0,0,,,,1,4,"40855286,32693649,22363130,18673242",1,Robinow syndrome,0.7220360983378594
O95562,SFT2D2,Vesicle transport protein SFT2B,Tier 1.5,0.71,0,78.5,0,0,,,,0,0,,1,neurodegenerative disease,0.38598268164814226
P03905,MT-ND4,NADH-ubiquinone oxidoreductase chain 4,Tier 1.5,0.705,0,93.94,0,0,,,,0,0,,1,Leber hereditary optic neuropathy,0.7517935125709835
P19021,PAM,Peptidyl-glycine alpha-amidating monooxygenase,Tier 1.5,0.695,0,71.69,0,0,,,,1,25,"41855944,41500123,41384307,41285544,41222440,40607956,39929897,39472107,38867016,38846799,37977804,37977780,37906116,37127012,36905684,35478209,33911033,33516855,32315032,32307868,30399413,30124431,26406332,22954359,14965210",1,type 2 diabetes mellitus,0.5754371880839976
P01615,IGKV2D-28,Immunoglobulin kappa variable 2D-28,Tier 1.5,0.695,0,91.0,0,0,,,,0,0,,1,cutaneous Leishmaniasis,0.5868213846274001
Q30154,HLA-DRB5,"HLA class II histocompatibility antigen, DR beta 5 chain",Tier 1.5,0.694,4,86.75,0,0,,,,0,0,,1,seasonal allergic rhinitis,0.19424611770933498
Q9Y678,COPG1,Coatomer subunit gamma-1,Tier 1.5,0.692,1,87.88,0,0,,,,0,0,,1,neurodegenerative disease,0.4905625531390244
P36980,CFHR2,Complement factor H-related protein 2,Tier 1.5,0.691,4,90.62,0,0,,,,0,0,,1,age-related macular degeneration,0.5100732932209376
P10586,PTPRF,Receptor-type tyrosine-protein phosphatase F,Tier 1.5,0.69,13,82.0,0,0,,,,1,4,"42101929,39087949,36594741",1,smoking initiation,0.4641111755355386
Q8IUH8,SPPL2C,Signal peptide peptidase-like 2C,Tier 1.5,0.69,0,67.06,0,0,,,,0,0,,1,"osteoarthritis, hip",0.35379836590273994
Q14520,HABP2,Factor VII-activating protease,Tier 1.5,0.686,0,77.62,0,0,,,,0,0,,1,follicular thyroid carcinoma,0.46213907606907034
O00501,CLDN5,Claudin-5,Tier 1.5,0.685,0,83.75,0,0,,,,1,1,18951306,1,genetic disorder,0.40861362787778505
Q96MP8,KCTD7,BTB/POZ domain-containing protein KCTD7,Tier 1.5,0.685,0,81.12,0,0,,,,0,0,,1,progressive myoclonic epilepsy type 3,0.8021556079083692
P14384,CPM,Carboxypeptidase M,Tier 1.5,0.68,1,90.31,0,0,,,,1,3,"38876068,38060303,36768220",1,hydronephrosis,0.3163273148871551
O94842,TOX4,TOX high mobility group box family member 4,Tier 1.5,0.68,1,54.72,0,0,,,,0,0,,1,neurodegenerative disease,0.43085410155338943
Q96DA2,RAB39B,Ras-related protein Rab-39B,Tier 1.5,0.678,1,88.38,0,0,,,,0,0,,1,early-onset parkinsonism-intellectual disability syndrome,0.7782306319395635
Q9UI42,CPA4,Carboxypeptidase A4,Tier 1.5,0.674,5,93.69,0,0,,,,0,0,,1,rheumatoid arthritis,0.19026118958920038
P78357,CNTNAP1,Contactin-associated protein 1,Tier 1.5,0.673,0,81.12,0,0,,,,0,0,,1,Hypomyelination neuropathy - arthrogryposis,0.8286745612673082
P09758,TACSTD2,Tumor-associated calcium signal transducer 2,Tier 1.5,0.673,7,82.69,0,0,,,,1,4,"41384307,41241473,40050871,39250993",1,gelatinous drop-like corneal dystrophy,0.7293087728162646
P08572,COL4A2,Collagen alpha-2(IV) chain,Tier 1.5,0.673,4,47.25,0,0,,,,0,0,,1,porencephaly 2,0.7294975109351518
P98066,TNFAIP6,Tumor necrosis factor-inducible gene 6 protein,Tier 1.5,0.671,5,81.12,0,0,,,,1,1,39263947,1,type 2 diabetes mellitus,0.30862220597837015
Q4L180,FILIP1L,Filamin A-interacting protein 1-like,Tier 1.5,0.67,0,67.56,0,0,,,,0,0,,1,Umbilical hernia,0.375022308318664
Q9NVH1,DNAJC11,DnaJ homolog subfamily C member 11,Tier 1.5,0.67,0,84.75,0,0,,,,0,0,,1,smoking initiation,0.2238015008808092
Q9BXX0,EMILIN2,EMILIN-2,Tier 1.5,0.67,0,65.12,0,0,,,,0,0,,1,type 2 diabetes mellitus,0.3471636502626859
Q92997,DVL3,Segment polarity protein dishevelled homolog DVL-3,Tier 1.5,0.67,9,58.91,0,0,,,,0,0,,1,autosomal dominant Robinow syndrome,0.7284158836126389
Q14C86,GAPVD1,GTPase-activating protein and VPS9 domain-containing protein 1,Tier 1.5,0.67,0,62.19,0,0,,,,0,0,,1,Abnormality of the skeletal system,0.46694942126454214
P22105,TNXB,Tenascin-X,Tier 1.5,0.669,3,87.81,0,0,,,,0,0,,1,Ehlers-Danlos syndrome due to tenascin-X deficiency,0.7916412481554758
P09693,CD3G,T-cell surface glycoprotein CD3 gamma chain,Tier 1.5,0.667,0,75.25,0,0,,,,0,0,,1,combined immunodeficiency due to CD3gamma deficiency,0.7703413570266988
Q15907,RAB11B,Ras-related protein Rab-11B,Tier 1.5,0.666,3,85.56,0,0,,,,0,0,,1,"neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter",0.7587294723766482
Q13049,TRIM32,E3 ubiquitin-protein ligase TRIM32,Tier 1.5,0.665,2,77.88,0,0,,,,0,0,,1,autosomal recessive limb-girdle muscular dystrophy type 2H,0.7844213789694698
P48509,,,Tier 1.5,0.662,0,88.25,0,0,,,,0,0,,1,"epidermolysis bullosa simplex 7, with nephropathy and deafness",0.7253740723597262
O94985,CLSTN1,Calsyntenin-1,Tier 1.5,0.662,0,77.25,0,0,,,,0,0,,1,atrial fibrillation,0.3229417277368247
Q13433,SLC39A6,Zinc transporter ZIP6,Tier 1.5,0.66,0,60.44,0,0,,,,1,1,40132409,1,breast cancer,0.11188167100061543